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Neonatal Transfer Situation Following Implementation of a Perinatal Network: An Analysis in Douala, Cameroon

Open Journal of Pediatrics 2022年第1期12卷 148-161页

作者： Daniele Kedy Koum Diomede Noukeu Njinkui Monique Carole Magnibou loick pradel kojom foko Charlotte Eposse Rhita Mbono Patricia Epée Eboumbou Calixte Ida Penda Department of Clinical Science Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Department of Pediatrics Deido District Hospital Douala Cameroon Department of Pediatrics Douala Gyneco-Obstetrics and Pediatrics Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Department of Animal Organisms Faculty of Science The University of Douala Douala Cameroon Department of Pediatrics Douala General Hospital Douala Cameroon

Background: Postnatal transfer (PT) is interhospital transport of care-needing newborns. In 2016, a perinatal network was implemented to facilitate PT in the town of Douala, Cameroon. The network was supposed to improve PT-related care standards. This study aimed at determining characteristics of PT five years following the implementation of this network. Methods: A cross-sectional study was carried out from February to May 2021 at neonatology wards of six hospitals in Douala. Medical records of newborns transferred to the hospitals were scrutinized to document their characteristics. Parents were contacted to obtain information on PT route and itinerary. Data were analyzed using Epi Info software and summarized as percentages, mean and odds ratio. Results: In total, 234 of the 1159 newborns admitted were transferred, giving a PT prevalence of 20.2% (95% CI 17.9% - 22.6%). Male-to-female ratio of the transferred newborns was 1.3. Neonatal infection (26.5%), prematurity (23.5%) and respiratory distress (15.4%) were the main reasons for transfer. Only 3% of the PT was medicalized while only 2% of the newborns were transferred through perinatal network. On admission, hypothermia and respiratory distress were found in 31% and 35% of the newborns, respectively. The mortality rate among babies was 20% and these had a two-fold risk of dying (95% CI 1.58 - 3.44, p Conclusion: PT and the perinatal network are lowly organized and implemented in Douala. Sensitization of medical staff on in utero transfer, creating center for coordination of the network, and implementation of neonatal transport system could improve the quality of PT.

关键词： Postnatal Transfer Perinatal Network Characterization Douala

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Post-exercise heart rate variability recovery after 800-m endurance run load among Cameroonian adolescent's males

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Sports Medicine and Health Science 2023年第4期5卷 283-289页

作者： Jerson Mekoulou Ndongo Elysee Claude Bika Lele Wiliam Richard Guessogo Wiliam Mbang Mbian Clarisse Noel Ayina Ayina Jessica Guyot Christian Ngongang Ouankou Abdou Temfemo loick pradel kojom foko Ernest Tchoudjin Louis-Georges Gassina Bienvenu Bongue Frederic Roche Samuel Honore Mandengue Peguy Brice Assomo-Ndemba Physical Activities and Sport Physiology&Medicine Unit Faculty of ScienceUniversity of DoualaCameroon Faculty of Sciences University of DoualaCameroon National Institute of Youth and Sports Yaounde University of Yaounde ICameroon Mines Saint-Etienne INSERMU1059 Sainbiose42023Universit Jean Monnet Saint-EtienneFrancee Faculty of Medicine and Pharmaceutical SciencesUniversity of DschangCameroon Faculty of Medicine and Pharmaceutical Sciences The University of DoualaCameroon Faculty of Medicine and Biomedical Science University of Yaounde ICameroon

The 800-m(m)run is part of Physical Education classes in Cameroon,after which arrhythmias may occur during ***,this study aimed at determining relationship between 800-m run loads on cardiac autonomic recovery among school ***-two male adolescents(aged[17-1]years)performed ***-exercise heart rate variability(HRV)was recorded during 5-min(min)(HRV5-min)and 15-min(HRV15-min)in time:Standard deviation of normal to normal(SDNN);Root mean square of successive differences(RMSSD)and frequency domain(LH:Low frequency,HF:High frequency,TP:Total power).Rating of Perceived Exertion(RPE)and blood lactate concentration(BLa)were measured after *** HRV5-min,RPE was associated with SDNN(r=-0.44,p<0.01)and RMSSD(r=-0.38,p<0.05).BLa was correlated with SDNN(r=-0.38,p<0.05)and RMSSD(r=-0.56,p<0.001)in the time-domain,LF(r=-0.64,p<0.001),HF(r=-0.58,p<0.001)and TP(r=-0.61,p<0.001)in frequency***,RPE was correlated with LF(r=-0.44,p<0.01),TP(r=-0.49,p<0.01)while exercise duration with HF(r=-0.38,p<0.05).In HRV15-min,BLa was correlated with RMSSD(r=-0.53,p<0.001)and SDNN(r=-0.68,p<0.001).RPE was negatively correlated SDNN(r=-0.53,p<0.01)and RMSSD(r=-0.44,p<0.01).BLa was associated with HF(r=-0.55,p<0.001),TP(r=-0.50,p<0.01)and RPE with LF(r=-0.51,p<0.01),HF(r=-0.50,p<0.01),TP(r=-0.49,p<0.01).In addition,exercise duration was negatively linked to HF(r=-0.36,p<0.05).This study outlined that in untrained adolescents an increase of 800-m loads is associated with a slow vagal indexes of HRV during the recovery.

关键词： Heart rate variability Recovery 800-m load Adolescents Physical education classes

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Profiling and Determinants of Impaired Lipid Profile Parameters among Breast Cancer Women of Childbearing Age Living in Douala, Cameroon

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Journal of Biosciences and Medicines 2023年第5期11卷 193-211页

作者： Idriss Ntatou Lemouchele Suzi Pascale Mbougang Esther Dina Bell loick pradel kojom foko Eric Fouelifack Nzeko Cecile Okalla Ebongue Jean Pierre Nda Mefo’o Martin Luther Koanga Mogtomo Rosalie Anne Ngono Ngane Department of Biochemistry Faculty of Science The University of Douala Douala Cameroon Depatment of Biological Sciences Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon General Hospital Douala Douala Cameroon Depatment of Animal Organisms Faculty of Science The University of Douala Douala Cameroon

Objective: Breast cancer in women of childbearing age (WCBA) is a major public health concern. This study aimed to determine variation and determinants in lipid profile among Cameroonian WCBA diagnosed with breast cancer. Materials and Methods: A case-control study took place at two reference hospitals in Douala, Cameroon. A total of 176 WCBA (88 cases and 88 controls) were finally enrolled. Interviewer-administered questionnaires were used to collect sociodemographic, behavioural, clinical and anthropometric data. Three millilitres of venous blood were collected for analysis of total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and triglycerides (TG). Results: Overweight was predominantly seen in cases and controls. Serum levels of TC and LDL-c were significantly lower in cancer women (167.02 ± 45.46 vs 183.12 ± 27.38 mg/dL, p = 0.005 for TC;85.83 ± 40.34 vs 105.25 ± 29.95 mg/dL, p = 0.0004 for LDL-c), while HDL-c levels were higher in controls (45.09 ± 7.20 vs 38.24 ± 11.14 mg/dL, p Conclusion: This study suggests the influence of breast cancer on lipid profile parameters especially HDL-c and LDL-c, and possibly their putative clinical utility for early diagnosis in premenopausal women in Cameroon.

关键词： Breast Cancer Women of Childbearing Age Lipoprotein Impairment Determinants Cameroon

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Evaluation of Subacute Toxicity of Hydroethanolic Extracts Combinations from Gnetum africanum (Welv.) and Gnetum buchholzianum (Engl.) (Genetaceae) Leaves: Two Botanical with Antiproliferative and Antioxidant Potential

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Open Journal of Applied Sciences 2022年第6期12卷 944-963页

作者： Bertin Sone Enone Jean-Pierre Ngene Angèle Foyet Fondjo Charles Christian Ngoule Loé Gisèle Etame loick pradel kojom foko Christophe Manz Koule François Siewe Ronald Bidingha Goufani Josiane Etang Albert Mouelle Sone Laboratory of Microbiology Immunology-Hematology and Morphological Sciences Doctoral Training Unit of Health Sciences Faculty of Medicine and Pharmaceutical Sciences Douala University Douala Cameroon Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences Douala University Douala Cameroon Department of Medical Health Sciences Golf of Guinea University Institute (IUG) Douala Cameroon Department of Animal Biology and Physiology Faculty of Science University of Douala Douala Cameroon Department of Biochemistry and Nutrition Faculty of Science University of Douala Douala Cameroon Department of Technology and Biomedical Sciences Golf of Guinea University Institut (IUG) Douala Cameroon Laboratory of Animal Physiology Department of Animal Biology Faculty of Science University of Yaoundé I Yaoundé Cameroon

This study was conducted to assess the toxic effect of hydroethanolic extract combinations of Gnetum africanum Welv. leaves and Gnetum buchholzianum Engl. (Gnetaceae) in experimental rats to test the validity of the treatment of liver disorders related to oxidative stress. The Combinations (m/m) 50-50 for E2 and 75-25 for E3 of ethanol-water extracts from plant leaves at the respective doses of 100, 200, and 400 mg/kg of body weight were used for 32-day toxicity. They were obtained after harvesting leaves, sorting, drying in the air cover for three weeks, and grinding. The resulting powder was doubly macerated with 70% ethanol for 48 hours and filtered. The filtrate was concentrated with the Heidolph-brand rotary rotavapor and each extract obtained was preserved. The administrations were carried out by gavage to wistar, male and non-pregnant female albino rats. In the end, the animals were sacrificed. The serum and organ homogenates were obtained for biochemical, tissue, and histopathological analyses respectively. The analyses revealed insignificant variations at the 5% probability threshold of the weight growth of experimental animals. These variations were found to be statistically significant at the same probability for biochemical and tissue parameters based on the dose of plant extracts and compared to control animals. Histopathological analysis of liver tissue showed leukodate infiltration that indicates extract-induced inflammation of the hepatocytes at the 400 mg/kg dose of body weight in females. However, this infiltration of the cells would have improved the regeneration of hepatocytes justified by the normal rate of transaminases. These results showed that combinations of hydroethanolic extracts of G. africanum and G. buchholzianumare non-toxicand may be potential candidates in the Cameroonian flora medicinal plant database shown in the monitoring of oxidative stress-related diseases.

关键词： Gnetum africanum Gnetum buchholzianum Subacute Toxicity Oxidative Stress Albino Rats

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Paediatric Mortality: Aetiologies and Predictors among Children Aged 1 Month to 15 Years in a Tertiary Hospital in Douala, Cameroon

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Open Journal of Pediatrics 2021年第3期11卷 360-378页

作者： Daniele Kedy Koum Calixte Ida Penda Laurent Mireille Endale Henri Essome Christiana Mpongo Moukongo loick pradel kojom foko Cecile Okalla Ebongue Diomede Noukeu Dominique Enyama Charlotte Eposse Mbono Rhita Patricia Epée Eboumbou Emile Telesphore Mboudou Paul Koki Ndombo Department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pediatrics Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Deido District Hospital Douala Cameroon Department of Internal Medicine Faculty of Health Sciences University of Buea Buea Cameroon Department of Internal Medicine Laquintinie Hospital Douala Cameroon Department of Surgery Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Department of Gynecology Laquintinie Hospital Douala Cameroon Department of Animal Organism Biology Faculty of Science The University of Douala Douala Cameroon Department of Biology Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Department of Gynecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaoundé Cameroon Chantal Biya Foundation Mother-Child Centre Yaoundé Cameroon

Background: Children and adolescent mortality remains a public health concern in developing countries. This study aimed to describe risk factors and aetiologies of mortality among children and young adolescents at a tertiary hospital in the town of Douala, Cameroon. Methods: We carried out a retrospective cohort study from January 1st to May 31st, 2019 among deceased patients aged 1 month to 15 years admitted to the paediatric ward of the Gynaeco-Obstetric and Paediatric Hospital. Data of interest were collected and analysed. Results: Out of 3088 children admitted, 123 death cases were recorded. The overall hospital mortality rate was 3.98%. Females accounted for 51% of the deceased patients. Fever was the main reason for consultation. Severe malaria was the most common diagnosis. In univariate logistic regression analysis, factors associated with mortality included hyperthermia (OR = 0.24;95% CI 0.80 - 1.33;p = 0.012), coma/impaired consciousness (OR = 0.30;95% CI 0.10

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Biogenic Synthesis of Silver Nanoparticles Using Guava (<i>Psidium guajava</i>) Leaf Extract and Its Larvicidal Action against <i>Anopheles gambiae</i>

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Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 49-66页

作者： Agnes Antoinette Ntoumba Francois Eya’ane Meva Wolfgang Eyisap Ekoko loick pradel kojom foko Etoile Ngo Hondt Carsten Schlüsener Bastian Moll Gisele Etame Loe Philippe Belle Ebanda Kedi Jean Yves Sikapi Fouda Christoph Janiak Leopold Gustave Lehman Department of Animal Biology and Physiology Faculty of Science The University of Douala Douala Cameroon Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Institute for Inorganic Chemistry and Structural Chemistry Heinrich-Heine-University Düsseldorf Universitätsstr 1 Düsseldorf Germany Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC) Yaoundé Cameroon

The progress in the field of nanotechnology has contributed to the development of tools for combating the most critical problems in developing countries. The requirements that such tools should meet are low-cost and resource settings, environmental protection, ease of use, and availability. The use of plant properties for the generation of nanoparticles (NPs), which serve as bioinsecticides to combat the plasticity and resistance of mosquitoes and parasites, is considered possible. Here, we report for the first time the larvicidal activity of silver (Ag) NPs (AgNPs) synthesized from Psidium guajava (P. guajava) extract, which targets the 4th instar larvae of Anopheles gambiae. Concentrations of AgNPs between 0 and 200 ppm were used and their LC50 at 24 h and 48 h were determined as 19.55 ppm and 8.737 ppm, respectively. The AgNPs were stable and highly effective against the larvae of A. gambiae and thereby we anticipate that they can be used to combat vector-borne diseases in developing countries.

关键词： Vector Control Anopheles gambiae Silver Nanoparticles Psidium guajava

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