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The development of laboratory animal legislation in the UK

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中国比较医学杂志 2013年第1期23卷 59-61页

作者： Paul Littlefair Maggy Jennings Barney reed RSPCA International Wilberforce WaySouthwaterHorsham RH13 9RSWest SussexUK Research Animals Department RSPCAWilberforce WaySouthwaterHorsham RH13 9RSWest SussexUK

The United Kingdom was the first country to pass legislation on the use of animals in scientific research, and is currently seen as having among the strongest laboratory animal regulations in the world. This brief paper will focus on three features which have characterised recent developments in laboratory animal welfare in the UK: the regulatory framework for laboratory animal use,the influence of public opinion on animal experimentation, and the importance of ethical review in weighing harms and benefits. Finally,attention will be given to the likely impact of the new European Union( EU) Directive.

关键词：基础医学呼吸生理呼吸运动人体生理学

Peanut Allergens Attached with p-Aminobenzamidine Are More Resistant to Digestion than Native Allergens

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Food and Nutrition Sciences 2016年第14期7卷 1352-1363页

作者： Si-Yin Chung Shawndrika reed Dunhua Zhang United States Department of Agriculture Agricultural Research Service Southern Regional Research Center New Orleans Louisiana USA United States Department of Agriculture Agricultural Research Service Aquatic Animal Health Research Unit Auburn Alabama USA

Despite being known as resistant proteins, peanut allergens (Ara h 1 and Ara h 2) can be digested and cause allergic reactions. Making the allergens more resistant to digestion may aid in non-absorption and excretion of the allergens. Our objectives were to make Ara h 1 and Ara h 2 more resistant to digestion and test them in a model system using trypsin as the digestive enzyme. The resistant allergens were prepared by covalently attaching p-aminobenzamidine (pABA), a protease inhibitor, to peanut allergens in an extract or on a PVDF membrane using glutaraldehyde, and were then tested for resistance to trypsin digestion. SDS-PAGE and Western blot were performed to determine the allergenic capacity of the modified allergens. A control was prepared using glycine instead. Results showed that Ara h 2, when covalently attached with pABA, was more resistant to trypin digestion than the native allergen. Similarly, Ara h 1, prepared on a PVDF membrane and treated with pABA, displayed a resistance to trypsin digestion. Treatment of the allergens with glycine (a control) instead of pABA showed that the modified allergens were as digestible as native allergens. Blot assays showed that the pABA-treated allergens exhibited a lower allergenic capacity than native allergens. It was concluded that pABA, when attached to peanut allergen Ara h 1 or Ara h 2, inhibited digestion of the allergen by trypsin and reduced their allergenic capacity as well.

关键词： p-Aminobenzamidine Peanut Allergens Ara h 1 and Ara h 2 Resistance to Digestion

Functional magnetic resonance imaging in an animal model of pancreatic cancer

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World Journal of Gastroenterology 2010年第26期16卷 3292-3298页

作者： Robert J Lewandowski Aaron C Eifler David J Bentrem Johnathan C Chung Gayle E Woloschak Robert Ryu Riad Salem Andrew C Larson reed A Omary Department of Radiology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Department of Surgical Oncology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Department of Radiation Oncology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States

AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer ***: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T MRI scanner. DWand TRIP-MRI were performed to determine if necrotic tumor core could be differentiated from viable tumor periphery. For each, we compared mean differences between tumor core/ periphery using a 2-tailed paired t-test (α = 0.05). Imaging was correlated with histopathology. RESULTS: Tumors were successfully grown in all rabbits, confirmed by necropsy. On DW-MRI, mean apparent diffusion coeffi cient (ADC) value was higher in necrotic tumor core (2.1 ± 0.3 mm2/s) than in viable tumor periphery (1.4 ± 0.5 mm2/s) (P < 0.05). On TRIP-MRI, mean perfusion values was higher in tumor periphery (110 ± 47 relative units) than in tumor core (66 ± 31 relative units) (P < 0.001). CONCLUSION: Functional MRI can be used to differentiate necrotic from viable tumor cells in an animal pancreatic cancer model using ADC (DW-MRI) and perfusion (TRIP-MRI) values.

关键词： Animal model Functional magnetic resonance imaging Pancreatic cancer

The Harmony of Civilizations and Prosperity for All——Asia's Opportunities and Development in Globalization

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The Harmony of Civilizations and Prosperity for All——Asia'...

文明的和谐与共同繁荣：全球化视野中亚洲的机遇与发展——北京论坛（2005）

作者： Joseph Verner reed Under-Secretary-General of the United Nations

It is a pleasure and a privilege for me to address the Opening Ceremony of the 2005 Beijing Forum with the main theme of"The Harmony of Civilizations and Prosperity for All".Let me congratulate the sponsors Peking University,the Korea Foundation for Advanced Studies and,of course,the Beijing Municipal Government on organizing this outstanding international academic event.I am convinced that the presentations at the Forum will be an important intellectual contribution to the ongoing search for the ways and means of achieving the goal of universal peace and prosperity for all.I also believe that nobody should or will underestimate Asia’s role in this endeavor.

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粗针胰腺活检──39例分析

中华消化杂志 1994年第1期14卷 55-56页

作者：安子元 reed,WD 山西医学院第一医院澳大利亚伊丽沙白女王医学中心

粗针胰腺活检──３９例分析安子元，ＲｅｅｄＷＤ胰腺癌的诊断比较困难，目前最常用的诊断手段是细针穿刺吸引（Ｆｉｎｅ－ＮｅｅｄｌｅＡｓｐｉｒａｔｉｏｎＢｉｏ－ｐｓｙ，ＦＮＡＢ），其诊断正确率可达６０％～１００％［１］，而... 详细信息

粗针胰腺活检──３９例分析安子元，ＲｅｅｄＷＤ胰腺癌的诊断比较困难，目前最常用的诊断手段是细针穿刺吸引（Ｆｉｎｅ－ＮｅｅｄｌｅＡｓｐｉｒａｔｉｏｎＢｉｏ－ｐｓｙ，ＦＮＡＢ），其诊断正确率可达６０％～１００％［１］，而合并症发生率仅０％～７％［１，２］...

关键词：胰腺肿瘤活检穿刺术

经皮联合内镜放置支撑物内引流治疗恶性胆道梗阻

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中华内科杂志 1994年第6期33卷 379-381页

作者：安子元 reed,WD 太原山西医学院第一附属医院

对４４例失去手术机会并经内镜途径胆汁引流失败的恶性胆道梗阻病人做经皮联合内镜放置支撑物内引流，成功３７例（８４．１％）。并发症和３０天内死亡率在低位总胆管梗阻和肝门梗阻者分别为４６．７％、１６．７％和５０．０％２１．... 详细信息

对４４例失去手术机会并经内镜途径胆汁引流失败的恶性胆道梗阻病人做经皮联合内镜放置支撑物内引流，成功３７例（８４．１％）。并发症和３０天内死亡率在低位总胆管梗阻和肝门梗阻者分别为４６．７％、１６．７％和５０．０％２１．４％，总并发症和３０天死亡率为４７．７％１８．２％．经皮联合内镜放置支撑物内引流提供了恶性胆道梗阻姑息治疗的另一非手术途径，对单纯内镜放置ｓｔｅｎｔ失败是一种补救。

关键词：胆道疾病支撑物引流术内窥镜

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医学影像世界的人工智能:挑战与机遇

Science Bulletin 2023年第7期68卷 648-652页

作者：薛华丹胡歌洪楠 N.reed Dunnick 金征宇 Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking University People’s HospitalBeijing 100044China Department of Radiology University of MichiganAnn Arbor 48109USA

Medical imaging is involved in all processes of clinical *** 70%of diagnostic information originates from radiologic images,which also account for 90%of the digital data volume of a ***,the number of physicians has increased only modestly compared to the rapid growth in the number of medical *** China,data from medical imaging increases by 30%every year,whereas the number of radiologists increases by only 4%*** intelligence(AI),which is representative technology of the fourth industrial revolution,may alleviate the increasing pressure and job burnout,and further improve the diagnostic efficiency of radiology services[1].Despite the urgent and realistic demand for AI technology,many challenges remain in the development and translation of AI *** rate of the scientific translation of AI research into clinical applications is extremely ***,AI models that are applied in clinical settings exhibit unreliable performance and are often impractical[2].Therefore,radiologists may not have access to suitable medical imaging AI models to solve specific clinical *** paper analyzes and discusses this problem according to two aspects:the data sources and the AI algorithm(Fig.1).

关键词： spite 人工智能 annually

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种子质量对中国玉米产出的影响

华南农业大学学报（社会科学版） 2016年第3期15卷 19-27页

作者：陈龙江 Michael R.reed 广东外语外贸大学广州国际商贸中心重点研究基地 Department of Agricultural Economics University of Kentucky

推动玉米持续增产的核心是主攻单产,而影响单产的诸多因素中,种子质量的提升至关重要。采用玉米主产区20个省(市)2002—2012年的分省数据,实证评估了种子质量改进对中国玉米单位产出的影响。采用两种种子质量评估指标的估计结果均表明,... 详细信息

推动玉米持续增产的核心是主攻单产,而影响单产的诸多因素中,种子质量的提升至关重要。采用玉米主产区20个省(市)2002—2012年的分省数据,实证评估了种子质量改进对中国玉米单位产出的影响。采用两种种子质量评估指标的估计结果均表明,种子质量水平的提升显著地促进玉米单位产出的增加,但是品种质量改善的促进作用近年有所弱化。因此,应大力支持优良新品种选育,健全生产质量标准体系,提高种子品种和生产质量,并通过健全社会化技术服务体系,加快农户品种选用的更新换代。

关键词：玉米单产种子质量品种选育粮食供求

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《驱魔少年》——游走于黑白世界的少年

疯狂英语（初中天地） 2007年第2期 12-13页

作者： Bateszi reed 思苇

“恶魔”是一种怪物,由死去的灵魂被深爱的人错误地召回人间而产生,并被决心毁灭世界的千年伯爵用作武器。它们会发射有毒的子弹,这些子弹能将人类粉碎为尘土。杀生越多,它们就越强大。我们的主人公亚连·沃克受到诅咒。

关键词：少年漫画讽刺画