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Distortions in focusing laser pulses due to spatio-temporal couplings:an analytic description

High Power Laser Science and Engineering 2024年第3期12卷 20-40页

作者： Klaus Steiniger Fabia Dietrich Daniel Albach Michael Bussmann Arie Irman Markus loeser Richard Pausch Thomas Püschel Roland Sauerbrey Susanne Schöbel Ulrich Schramm Mathias Siebold Karl Zeil Alexander Debus Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany CASUS-Center for Advanced Systems Understanding GörlitzGermany Technische Universität Dresden DresdenGermany

In ultra-short laser pulses,small changes in dispersion properties before the final focusing mirror can lead to severe pulse distortions around the focus and therefore to very different pulse properties at the point of laser±matter interaction,yielding unexpected interaction *** mapping between far-and near-field laser properties intricately depends on the spatial and angular dispersion properties as well as the focal *** a focused Gaussian laser pulse under the influence of angular,spatial and group-delay dispersion,we derive analytical expressions for its pulse-front tilt,duration and width from a fully analytic expression for its electric field in the time±space domain obtained with scalar diffraction *** expression is not only valid in and near the focus but also along the entire propagation distance from the focusing mirror to the *** relating angular,spatial and group-delay dispersion before focusing at an off-axis parabola,where they are well measurable,to the respective values in the pulse’s focus are obtained by a ray tracing ***,these formulas are used to show in example setups that the pulse-front tilts of lasers with small initial dispersion can become several tens of degrees larger in the vicinity of the focus while being small directly in the *** formulas derived here provide the analytical foundation for observations previously made in numerical *** numerically simulating Gaussian pulse propagation and measuring properties of the pulse at distances several Rayleigh lengths off the focus,we verify the analytic expressions.

关键词： group-delay dispersion pulse-front tilt spatio-temporal couplings third-order dispersion ultra-short laser pulses

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Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome

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Journal of Integrative Medicine 2019年第5期17卷 383-386页

作者： Rebecca Kulbida Alexander Mathes Johannes loeser Department of Anaesthesiology and Intensive Care Medicine University Clinic of Cologne

We report about hirudotherapy in a patient with chronic complex regional pain syndrome(CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches;however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In addition, the patient’s active and passive agility of the affected limb improved obviously.

关键词： Hirudotherapy Complex regional pain syndrome Chronic pain Medicinal leeches

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Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis

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Journal of Integrative Medicine 2020年第5期18卷 425-433页

作者： Johannes loeser Brigitte Layer Christopher Plata Klaus-Maria Perrar Tim Hucho Rebecca Kulbida Department of Anaesthesiology and Intensive Care Medicine University Clinic of CologneKoeln 50937Germany Department of Palliative Care University Clinic of CologneKoeln 50937Germany

Objective: Osteoarthritis is a degenerative disease that affects synovial joints. Micro-injuries of articular structures initiate inflammatory processes, leading to persistent pain. Due to various risk factors,osteoarthritis is often diagnosed in multimorbid patients. This makes pain management one of the key challenges, with a consistent need for new therapeutic strategies. Hence, complementary and integrative methods such as hirudotherapy have become increasingly important, even though their mechanisms of action are not entirely ***: We retrospectively analyzed the longitudinal effect of a single leech application on osteoarthritic joints in a heterogenic cohort of 24 cases with various chronic pain syndromes. We assessed articular pain intensity ratings and movability of the treated joint after one-time leeching for up to 12 *** further investigated the effect of hirudotherapy on the systemic pain status and multimodal treatment strategies of the ***: There was a significant reduction in pain intensity ratings at the joint of leech application for up to 12 months after treatment. The improvements in pain intensities were independent of the form of osteoarthritis treated. In addition, we saw a considerable enhancement in local movability of the treated joint. Hirudotherapy did not seem to influence the systemic pain status as well as the previously established individualized multimodal treatment model of the ***: Leeching as an adjuvant therapy has a great potential especially in terms of safety and longterm outcome.

关键词： Hirudotherapy Medicinal leeching Chronic pain syndromes Pain management Osteoarthritis

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Performance demonstration of the PENELOPE main amplifier HEPA I using broadband nanosecond pulses

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High Power Laser Science and Engineering 2019年第1期7卷 1-9页

作者： D.Albach M.loeser M.Siebold U.Schramm Helmholtz–Zentrum Dresden–Rossendorf Technische Universit?t Dresden

We report on the energetic and beam quality performance of the second to the last main amplifier section HEPA I of the PENELOPE laser project. A polarization coupled double-12-pass scheme to verify the full amplification capacity of the last two amplifiers HEPA I and II was used. The small signal gain for a narrow-band continuous wave laser was 900 and 527 for a broadband nanosecond pulse, demonstrating 12.6 J of output pulse energy. Those pulses, being spectrally wide enough to support equivalent 150 fs long ultrashort pulses, are shown with an excellent spatial beam quality. A first active correction of the wavefront using a deformable mirror resulted in a Strehl ratio of 76% in the single-12-pass configuration for HEPA I.

关键词： diode-pumped lasers laser amplifiers laser diagnostics pulse energy ytterbium

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Alternative uses of lumen apposing metal stents

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World Journal of Gastroenterology 2020年第21期26卷 2715-2728页

作者： Prabin Sharma Thomas R McCarty Ankit Chhoda Antonio Costantino Caroline loeser Thiruvengadam Muniraj Marvin Ryou Christopher C Thompson Department of Gastroenterology and Hepatology Yale-New Haven Health-Bridgeport HospitalBridgeportCT 06610United States Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Department of Internal Medicine Yale-New Haven Health-Bridgeport HospitalBridgeportCT 06708United States Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

The advent of lumen apposing metal stents(LAMS)has revolutionized the management of many complex gastroenterological conditions that previously required surgical or radiological *** procedures have garnered popularity due to their minimally invasive nature,higher technical and clinical success rate and lower rate of adverse *** virtue of their unique design,LAMS provide more efficient drainage,serve as conduit for endoscopic access,are associated with lower rates of leakage and are easy to be *** used for drainage of pancreatic fluid collections,the use of LAMS has been extended to gallbladder and biliary drainage,treatment of luminal strictures,creation of gastrointestinal fistulae,pancreaticobiliary drainage,improved access for surgically altered anatomy,and drainage of intra-abdominal and pelvic abscesses as well as post-surgical fluid *** new indications of endosonographic techniques and LAMS continue to evolve,this review summarizes the current role of LAMS in the management of these various complex conditions and also highlights clinical pearls to guide successful placement of LAMS.

关键词： Lumen apposing metal stents Walled off necrosis Gallbladder drainage Biliary drainage Gastric access temporary for endoscopy Gastric outlet obstruction Therapeutic endoscopy

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疼痛治疗的五项挑战

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中国疼痛医学杂志 2012年第8期18卷 468-469页

作者： loeser JD 任志伟胡永生机构不详

当今的疼痛治疗面对五项巨大的挑战：（1）提供给患者的绝大多数治疗都缺乏疗效证据；（2）基层医生的疼痛诊疗知识相关不足；（3）针对于阿片类药物治疗慢性非癌痛的价值，了解不多；（4）疼痛科医生的专项资助基金缺乏；（5）多学科... 详细信息

当今的疼痛治疗面对五项巨大的挑战：（1）提供给患者的绝大多数治疗都缺乏疗效证据；（2）基层医生的疼痛诊疗知识相关不足；（3）针对于阿片类药物治疗慢性非癌痛的价值，了解不多；（4）疼痛科医生的专项资助基金缺乏；（5）多学科治疗路径不畅。相比较其他国家，美国面对的上述挑战更加巨大。

关键词：药物治疗疼痛科基层医生慢性非癌痛多学科治疗阿片类

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Millijoule ultrafast optical parametric amplification as replacement for high-gain regenerative amplifiers

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High Power Laser Science and Engineering 2023年第4期11卷 33-44页

作者： Yannik Zobus Christian Brabetz Johannes Hornung Jonas BOhland Dirk Reemts Ji-Ping Zou Markus loeser Daniel Albach Ulrich Schramm Vincent Bagnoud Technische Universität Darmstadt DarmstadtGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses CNRSEcole PolytechniquePalaiseauFrance Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Helmholtz-Institut Jena JenaGermany

We report on the development of an ultrafast optical parametric amplifier front-end for the Petawatt High Energy Laser for heavy Ion eXperiments(PHELIX)and the Petawatt ENergy-Efficient Laser for Optical Plasma Experiments(PEnELOPE)*** front-end delivers broadband and stable amplification up to 1 mJ per pulse while maintaining a high beam *** implementation at PHELIX allowed one to bypass the front-end amplifier,which is known to be a source of *** the bypass,an amplified spontaneous emission contrast of 4.9×10^(−13)and a pre-pulse contrast of 6.2×10^(−11)could be *** to its high stability,high beam quality and its versatile pump amplifier,the system offers an alternative for high-gain regenerative amplifiers in the front-end of various laser systems.

关键词： high-intensity laser temporal laser contrast ultrafast optical parametric amplification

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电子计算机的创造性活动和新逻辑学

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世界科学 1981年第1期 36-38页

作者： loeser 周邦新德意志民主共和国柏林大学教授哲学科学博士

电子计算机的迅速发展,和研究创造性思维规律的新逻辑学的诞生,使有可能提出这样一个合乎科学根据的问题:创造自动机的时候是否已经来到?这种自动机不仅能进行一般体力工作和最简单的脑力工作,而且能进行创造性活动。创造这类自动机是... 详细信息

电子计算机的迅速发展,和研究创造性思维规律的新逻辑学的诞生,使有可能提出这样一个合乎科学根据的问题:创造自动机的时候是否已经来到?这种自动机不仅能进行一般体力工作和最简单的脑力工作,而且能进行创造性活动。创造这类自动机是否能发展人长期以来连想还没有想到过的概念,或者帮助制订人自身该遵守的法规和道德准则? 显而易见,制成创造性的自编程序自动机将在人类生活上引起意义深远的变革,今天的科学还不能确定其范围。象这样的远景能否实现?许多学者对此表示怀疑。他们在科学上的怀疑首先基于下列情况:自动机只能处理给定的程序或算法。创造性思维的基础

关键词：自动机实际值给定值程序规定值创造性活动活动(心理学) 逻辑规律计算机社会科学逻辑学逻辑

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写在John ***诞辰100周年

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中国疼痛医学杂志 2018年第1期24卷 2-2页

作者： John D.loeser 宋学军马平川华盛顿大学神经外科、麻醉与疼痛医学系华盛顿州西雅图不详

Bonica在全世界开启了疼痛研究和治疗运动,一生致力于倡导跨学科的疼痛研究方法,并推动疼痛学科在世界范围的发展壮大。一百年前,John ***出生在西西里北部菲利库迪的伊奥利亚群岛。他11岁随父母迁往美国纽约之后迅速成长的故事成为美... 详细信息

Bonica在全世界开启了疼痛研究和治疗运动,一生致力于倡导跨学科的疼痛研究方法,并推动疼痛学科在世界范围的发展壮大。一百年前,John ***出生在西西里北部菲利库迪的伊奥利亚群岛。他11岁随父母迁往美国纽约之后迅速成长的故事成为美国式成功的典范之一。

关键词： J.Bonica诞辰100周年

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重离子储存环CSRe上激光冷却相对论能量类锂^(12)C^(3＋)离子束的实验研究进展

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中国科学：物理学、力学、天文学 2016年第5期46卷 98-108页

作者：汶伟强汪寒冰黄忠魁张大成海帮朱小龙啜晓亚赵冬梅杨杰李杰李小妮冒立军毛瑞士武军霞夏佳文杨建成原有进赵红卫赵铁成 EIDAM Lewin loeser Markus REIN Benjamin SIEBOLD Matthias WINTERS Danyal BUSSMANN Michael 马新文中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 GSI Helmholtzzentrum fur Schwerionenforschung GmbH Darmstadt D-64291Germany Helmholtz-Zentrum Dresden-Rossendorf Dresden D-01328Germany Technische Universitat Darmstadt Darmstadt D-64289Germany

激光冷却储存环中相对论能量的重离子束是最有希望得到高相空间密度离子束、实现离子束相变并且获得有序束和晶化束的一种方法.相对于已经比较成熟的随机冷却和电子冷却技术,储存环上重离子束的激光冷却具有冷却速度快,冷却作用力强的特... 详细信息

激光冷却储存环中相对论能量的重离子束是最有希望得到高相空间密度离子束、实现离子束相变并且获得有序束和晶化束的一种方法.相对于已经比较成熟的随机冷却和电子冷却技术,储存环上重离子束的激光冷却具有冷却速度快,冷却作用力强的特点,可以将离子束冷却到极低温度(mK),在激光冷却的同时还可以开展高电荷态离子的精细激光谱学实验.本文介绍了中国科学院近代物理研究所大科学装置重离子冷却储存环CSRe上开展激光冷却重离子束的实验原理和实验方法,给出了在CSRe上首次激光冷却能量为122 MeV/u的类锂^(12)C^(3+)离子束测试性实验结果,并且展望了在未来大型加速器HIAF上开展类锂类钠高电荷态离子的激光冷却和精细激光谱学实验.

关键词：激光冷却高电荷态离子重离子储存环晶化束束流动力学

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