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Microneedle-based skin patch for blood-free rapid diagnostic testing

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Microsystems & Nanoengineering 2020年第1期6卷 255-265页

作者： Xue Jiang peter b.Lillehoj Department of Mechanical Engineering Rice UniversityHoustonTX 77005USA Department of bioengineering Rice UniversityHoustonTX 77030USA

Rapid diagnostic tests are one of the most commonly used tests to detect and screen for infectious diseases in the developing *** these tests are simple,inexpensive,and readily available,they rely on finger-prick blood sampling,which requires trained medical personnel,poses risks of infection,and can complicate cooperation in young children,asymptomatic individuals,and communities with blood ***,we report a novel microneedle-based skin patch for the rapid detection of protein biomarkers in dermal interstitial *** collection is facilitated by a hydrophilic hollow microneedle array that autonomously extracts and transports interstitial fluid to an antibody-based lateral flow test strip via surface tension for colorimetric antigen *** employ a simple gold enhancement treatment to enhance the detection sensitivity of this colloidal gold-based lateral flow assay and elucidate the underlying mechanism of this enhancement mechanism through experimental *** proof-of-concept,this device was used to detect Plasmodium falciparum histidine-rich protein 2,a biomarker for malaria infection,which could be detected at concentrations as low as 8ng/*** test can be completed inbest of our knowledge,this work is the first demonstration of a microneedle-based lateral flow assay for rapid protein detection in dermal interstitial *** addition to its simplicity,minimally invasive nature,and low cost,this diagnostic device can be readily adapted to detect other protein biomarkers in interstitial fluid,making it a promising tool for point-of-care testing.

关键词： needle patch readily

Stair evacuation simulation based on cellular automata considering evacuees' walk preferences

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Chinese Physics b 2015年第6期24卷 687-693页

作者：丁宁张辉陈涛 peter b.Luh Department of Automation Tsinghua University Institute of Public Safety Research Tsinghua University Department of Electrical and Computer Engineering University of Connecticut

As a physical model, the cellular automata （CA） model is widely used in many areas, such as stair evacuation. However, existing CA models do not consider evacuees＇ walk preferences nor psychological status, and the structure of the basic model is unapplicable for the stair structure. This paper is to improve the stair evacuation simulation by addressing these issues, and a new cellular automata model is established. Several evacuees＇ walk preference and how evacuee＇s psychology influences their behaviors are introduced into this model. Evacuees＇ speeds will be influenced by these features. To validate this simulation, two fire drills held in two high-rise buildings are video-recorded. It is found that the simulation results are similar to the fire drill results. The structure of this model is simple, and it is easy to further develop and utilize in different buildings with various kinds of occupants.

关键词： building evacuation stair simulation cellular automata walk preferences

Tribological Properties of DLC Film Prepared by C^+ Ion beam-assisted Deposition (IbAD)

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Journal of Wuhan University of Technology(Materials Science) 2006年第1期21卷 49-52页

作者：白秀琴 peter bhm Reliability Engineering Institute Wuhan University of Technology Wuhan 430063ChinaWuhan Research Institute of Materials Protection Wuhan 430030 China IAVF Antriebstechnik AG 76187 KarlsruheGermany

C ^＋ ion beam-assisted deposition was utilized to prepare deposit diamond-like carbon （ DLC ） film. With the help of a series of experiments such as Raman spectroscopy, FT-IR spectroscopy, AFM and nanoindentation , the DLC film has been recognized as hydrogenated DLC film and its tribologicul properties have been evaluated. The bull-on-disc testing results show that the hardness and the tribologicul properties of the DLC film produced by C^ ＋ ion beam- assisted deposition are improved significantly. DLC film produced by C ^＋ ion beam- assisted deposition is positive to have a prosperous tribologicul application in the near future.

关键词： DLC film C ^+ ion beam- assisted deposition (IbAD) tribological properties

Resistance to receptor tyrosine kinase inhibition in cancer： molecular mechanisms and therapeutic strategies

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Frontiers of Medicine 2015年第2期9卷 134-138页

作者： peter b. Alexander Xiao-Fan Wang Department of Pharmacology and Cancer biology Duke University Medical Center Durham NC 27710 USA

Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.

关键词： targeted therapy drug resistance receptor tyrosine kinases cancer

Xanthan Sulfuric Acid： An Efficient bio-supported and Recy- clable Solid Acid Catalyst for the Synthesis of 2-Aryl Thiadiazolo benzimidazoles

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Chinese Journal of Chemistry 2012年第4期30卷 947-950页

作者： Kuarm,b.Suresh Janardan,b. Crooks,peter A. Rajitha,b. Department of Chemistry National Institute of TechnologyWarangalAPIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockAR 72205U.S.A.

Xanthan sulfuric acid is an efficient solid acid catalyst for the preparation of 2-aryl benzimidazoles in excellent yields. This method is applicable for the reaction of benzo[c][ 1,2,5]thiadiazole-4,5-diamine with aldehydes by sim- ple physical grinding at room temperature. The salient features of the present methodology is cheaper process, easy synthesis of stable catalyst and the catalyst can be easily recycled without significant loss of activity.

关键词： benzimidazoles benzo[c]thiadiazole-4,5-diamine biodegradable recyclable xanthan sulfuric acid (XSA)

Integrated transcriptome and proteome analyses reveal potential mechanisms in Stipa breviflora underlying adaptation to grazing

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Grassland Research 2024年第1期3卷 1-17页

作者： Yanan Liu Shixian Sun Yanan Zhang Miaomiao Song Yunyun Tian peter J.lockhart Xin Zhang Ying Xu Zhenhua Dang Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhotInner MongoliaChina Institute of Grassland Research Chinese Academy of Agricultural SciencesHohhotInner MongoliaChina Ministry of Education Key Laboratory of Herbage&Endemic Crop biotechnology School of Life SciencesInner Mongolia UniversityHohhotInner MongoliaChina School of Natural Sciences College of SciencesMassey UniversityPalmerston NorthNew Zealand

background:Long-term overgrazing has led to severe degradation of grasslands,posing a significant threat to the sustainable use of grassland ***:based on the investigation of changes in functional traits and photosynthetic physiology of Stipa breviflora under no grazing,moderate grazing,and heavy grazing treatments,the changes in expression patterns of genes and proteins associated with different grazing intensities were assessed through integrative transcriptomic and proteomic ***:Differentially expressed genes and proteins were identified under different grazing *** were mainly related to RNA processing,carbon metabolism,and secondary metabolite *** findings suggest that long-term grazing leads to molecular phenotypic plasticity,affecting various biological processes and metabolic pathways in *** analysis revealed low correlation between the transcriptome and the proteome,indicating a large-scale regulation of gene expression at the posttranscriptional and translational levels during the response of *** to *** expression profiles of key genes and proteins involved in photosynthesis and phenylpropanoid metabolism pathways suggested their synergistic response to grazing in ***:Our study provides insight into the adaptation mechanisms of *** to grazing and provides a scientific basis for the development of more efficient grassland protection and utilization practices.

关键词： functional traits grazing adaptation photosynthetic physiology proteome Stipa breviflora transcriptome

On-site solar PV generation and use: Self-consumption andself-sufficiency

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building Simulation 2023年第10期16卷 1835-1849页

作者： Zheng Wang Mark b.Luther peter Horan Jane Matthews Chunlu Liu School of Architecture and built Environment Deakin UniversityGeelongAustralia

As energy storage systems are typically not installed with residential solar photovoltaic (PV) systems,any “excess” solar energy exceeding the house load remains unharvested or is exported to the *** paper introduces an approach towards a system design for improved PV self-consumptionand self-sufficiency. As a result, a polyvalent heat pump, offering heating, cooling and domestic hotwater, is considered alongside water storage tanks and batteries. Our method of system analysisbegins with annual hourly thermal loads for heating and cooling a typical Australian house inGeelong, Victoria. These hourly heating and cooling loads are determined using Transient SystemSimulation (TRNSYS) software. The house’s annual hourly electricity consumption is analysed usingsmart meter data downloaded from the power supplier and PV generation data measured with aPV system controller. The results reveal that the proposed system could increase PV self-consumptionand self-sufficiency to 41.96% and 86.34%, respectively, resulting in the annual imported energybeing reduced by about 74%. The paper also provides sensitivity analyses for the hot and coldstorage tank sizes, the coefficient of performance of the heat pump, solar PV and battery *** establishing the limits of thermal storage size, a significant impact on self-efficiency can berealised through battery storage. This study demonstrates the feasibility of using a polyvalent heatpump together with water storage tanks and, ultimately, batteries to increase PV self-consumptionand self-sufficiency. Future work will concentrate on determining a best-fit approach to systemsizing embedded within the TRNSYS simulation tool.

关键词： solar photovoltaic polyvalent heat pump energy storage self-consumption self-sufficiency

A Simple Kinetic Monte Carlo Approach for Epitaxial Submonolayer Growth

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Communications in Computational Physics 2008年第4期3卷 822-833页

作者： Robert Deak Zoltan Neda peter b.barna Eotvos Lor and University Department of Materials ScienceH-1117 BudapestHungary babe¸s-bolyai University Department of Theoretical and Computational PhysicsCluj-NapocaRO-400084Romania Research Institute for Technical Physics and Materials Science H-1525BudapestP.O box 49Hungary

Two-component submonolayer growth on triangular lattice is qualitatively studied by kinetic Monte Carlo *** hopping barrier governing surface diffusion of the atoms is estimated using pair interaction *** degrees of freedoms enhancing the surface diffusion of atoms are also *** main advantages of the presented technique are the reduced number of free parameters and the clear diffusion activated mechanism for the segregation of different types of *** potential of this method is exemplified by reproducing(i)phase-boundary creation and dynamics related to vacancies and stacking faults;(ii)a special co-deposition and segregation process where the segregated atoms of the second component surround the islands formed by the first type of atoms.

关键词： Submonolayer epitaxial growth kinetic Monte Carlo pattern formation twocomponent systems segregation.

Interplay of conducting and non-conducting walls on hydromagnetic natural convection flow in a vertical micro-channel with Hall current

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Propulsion and Power Research 2021年第2期10卷 155-168页

作者： basant K.Jha peter b.Malgwi Department of Mathematics Ahmadu Bello UniversityZariaNigeria Department of Mathematics Air Force Institute of TechnologyKadunaNigeria

Theoretical investigation on the interaction between conducting and nonconducting walls on hydromagnetic natural convection flow of viscous incompressible and electrically conducting fluid through a vertical micro-channel taking into account the effects of induced magnetic field in presence of Hall current is *** coupled equations responsible for the flow are obtained when either the micro-channel walls are electrically conducting or are electrically *** the method of undetermined coefficients,exact solution are obtained and presented in dimensionless form subject to relevant boundary *** for fluid velocity,induced magnetic field,skin friction,volume flow rate and induced current density in both primary and secondary flow directions are also *** of some governing parameters like Hall current parameter,rarefaction parameter and Hartmann number on the different flow situations are given using the aid of line graphs and *** main conclusion of the present analysis is that,in the existence of rarefaction parameter,primary fluid velocity could be enhanced with the increase in Hall parameter when the micro-channel walls are either insulated or when the left micro-channel wall is electrically *** obtained in this work are relevant in many magnetically controlled devices and could also be used as a benchmark in checking the accuracies of result obtained in some empirical experiments.

关键词： Magnetohydrodynamic(MHD) Hall current Micro-channel Velocity slip Temperature jump