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Spectrofluorimetric and Spectrophotometric Stability- Iwndicating Methods for the Analysis of Veralipride in Presence of Its Degradants and in Spiked Human Plasma

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Chinese Journal of Chemistry 2012年第1期30卷 183-189页

作者： Salama,Nahla Nour el Din Ahmed Salem,Maissa Yacoub Abd el Halim,lobna Mohammed Abdel Fattah,Laila EI-Sayed National Organization for Drug Control and Research(NODCAR) 6 Abu Hazem StreetPyramids AveP.O.Box 29GizaEgypt Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyMisr University for Science and Technology6th of OctoberEgypt

Spectrofluorimetric and spectrophotometric stability-indicating methods were developed and validated for analysis of veralipride （Ver） in presence of its hydrolytic and oxidative degradants. The spectrofluorimetric method was based on direct measurement of the intrinsic fluorescence of Ver at 366 nm after excitation at 299 nm using sodium lauryl sulfate （SLS） as micelle enhancer. The fluorescence intensity plot was linear over the concentration range 1.0-10.0 ***-1. The high sensitivity of the method allowed its successful application to the analysis of Ver in spiked human plasma. Two other methods were developed. They are based on the oxidative coupling reac- tion of Vet with 3-methyl benzothiazolin-2-one hydrazone （MBTH） hydrochloride in presence of ceric ammonium sulphate in an acidic medium. The first method depends on spectrophotometric measurement of the stable green colored oxidative coupling product at 660 nm. The different experimental parameters affecting the reaction were optimized. Linearity range is 10.0--100.0 ~tgomL-1. The second method depends on a fluorescence quenching effect of Vet on the fluorescence of Ce3＋. The difference in fluorescence intensity was measured at 380 nm after excitation at 300 nm. This method is applicable over the concentration ranges 0.25-2.50 pg-mL-1. The methods were validated according to the ICH guidelines. They were successfully applied for the analysis of Ver in drug substance, drug product and in laboratory prepared mixtures containing different percentages of hydrolytic and oxidative degradants.

关键词： veralipride micelle-enhanced fluorescence MBTH validation stability fluorescence quenching Ce3+

Effects of water stress on growth phenology photosynthesis and leaf water potential in Stipagrostis ciliata(Desf.)De Winter in North Africa

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Journal of Arid Land 2023年第1期15卷 77-90页

作者： lobna MNIF FAKHFAKH Mohamed CHAIEB Laboratory of Ecosystems and Biodiversity in Arid Land of Tunisia(LEBIOMAT) Faculty of SciencesUniversity of SfaxSfax 3000Tunisia

Stipagrostis ciliata(Desf.)De Winter is a pastoral C4 grass grown in arid *** research work focused on assessing the growth of *** accessions derived from two different climate regions(a wet arid region in the Bou Hedma National Park in the central and southern part of Tunisia(coded as WA),and a dry arid region from the Matmata Mountain in the south of Tunisia(coded as DA))under water stress ***,the study aimed to investigate the phenological and physiological responses of potted *** seedlings under different water treatments:T_(1)(200 mm/a),T_(2)(150 mm/a),T_(3)(100 mm/a)and T_(4)(50 mm/a).Growth phenology,net photosynthesis(Pn),stomatal conductance(gs),midday leaf water potential(Ψmd),predawn leaf water potential(Ψpd),soil water content(SWC)and soil water potential(Ψs)were observed during the water stress cycle(from December 2016 to November 2017).The obtained results showed that the highest growth potential of the two accessions(WA and DA)was recorded under treatment T_(1).The two accessions responded differently and significantly to water *** parameters,such as Pn and gs,decreased sharply under treatments T_(2),T_(3)and T_(4)compared to treatment T_(1).The higher water stress increased the R/S ratio(the ratio of root dry biomass to shoot dry biomass),with values of 1.29 and 2.74 under treatment T_(4)for accessions WA and DA,*** component analysis(PCA)was applied,and the separation of *** accessions on the first two axes of PCA(PC1 and PC2)suggested that accession DA was detected in the negative extremity of PC1 and PC2 under treatments T_(1)and T_(2).This accession was characterized by a high number of *** treatments T_(3)and T_(4),both accessions were detected in the negative extremity of PC1 and *** were characterized by a high root dry ***,*** accessions responded to water stress by displaying significant changes in their *** WA

关键词： Stipagrostis ciliata drought stress water deficit gas exchange arid regions Tunisia

Effects of temperature and water limitation on the germination of Stipagrostis ciliata seeds collected from Sidi Bouzid Governorate in Central Tunisia

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Journal of Arid Land 2018年第2期10卷 304-315页

作者： lobna M FAKHFAKH Naser A ANJUM Mohamed CHAIEB Department of Life Sciences Faculty of Sciences University of Sfax Centre for Environmental and Marine Studies and Department of Chemistry University of Aveiro

Most ecological studies in North Africa reveal a process of continuous degradation of rangeland ecosystems as a result of overgrazing. This degradation appears across the decreasing of perennial grass diversity. Indeed, the majority of steppe ecosystems are characterized by a low density of perennial grass species at present. This study evaluated the effects of temperature and water limitation on the seed germination of Stipagrostis ciliata（Desf.） de Winter, a perennial grass species. The seeds were collected from the Bou Hedma Park, Sidi Bouzid Governorate, Central Tunisia. The thermal time and hydrothermal time models were used to describe the seed germination of S. ciliata under different water potentials and temperatures. The germination response of S. ciliata seeds in darkness was evaluated over a range of temperatures（15°C, 20°C, 25°C, 30°C and 35°C） and across a wide range of osmotic potentials（0.0, –0.2, –0.6, –1.2, –1.6 and –2.0 MPa） of the polyethylene glycol（PEG6000） solutions at each temperature level. Among the tested temperatures, 25°C was found to be the optimal temperature to the germination of S. ciliata seeds. The final germination percentage（75.2%） was obtained with distilled water. The progressive decrease of osmotic potential of the PEG6000 solutions inhibited the seed germination. However, the number of days to first germination was increased with a reduction of osmotic potential. A significant positive relationship was identified between final germination percentage of S. ciliata seeds and osmotic potential of the PEG6000 solutions, with R^2 ranging from 0.5678 to 0.8761. Furthermore, a high degree of congruency between predicted and observed germination time course curves was observed. In general, S. ciliata exhibits a significant adaptation capacity for water limitation and high temperature in arid ecosystems.

关键词： Stipagrostis ciliata germination temperature water potential hydrothermal model arid zone Bou Hedma Park

Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study

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World Journal of Gastroenterology 2021年第14期27卷 1435-1450页

作者： Marwa Matboli Amany H Hasanin Reham Hussein Sarah el-Nakeep Eman K Habib Rawan ellackany lobna A Saleh Department of Biochemistry Ain Shams Faculty of MedicineCairo 11318Egypt Department of Clinical Pharmacology Ain Shams Faculty of MedicineCairo 11381Egypt Department of General Internal Medicine Ain Shams Faculty of MedicineCairo 11381Egypt Department of Anatomy&Embryology Ain Shams Faculty of MedicineCairo 11318Egypt Department of Undergraduate Faculty of MedicineModern University for Technology and InformationCairo 11381Egypt

BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer *** cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular *** To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar *** In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain *** examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were *** Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver ***,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle *** note,cyan decreased GSTP foci percent area and PCNA positively stained *** Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle.

关键词： Hepatocellular carcinoma therapy Hepatocellular-carcinoma growth Hepatocellular-carcinoma model Hepatocellular-carcinoma size

Morphological and physiological responses to drought stress of carob trees in Mediterranean ecosystems

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Journal of Arid Land 2023年第5期15卷 562-577页

作者： Khouloud ZAGOUB Khouloud KRICHEN Mohamed CHAIEB lobna F MNIF Laboratory of Ecosystems and Biodiversity in Arid Land of Tunisia Faculty of SciencesUniversity of SfaxSfax 3000Tunisia

The greatest failure rate of reforestation programs is basically related to water deficit,especially at the seedling ***,the main objective of this work is to investigate the responses of three accessions of carob trees(Ceratonia siliqua L.)with 2-year-old from different climate regions to drought generated by four water treatments:Tc(250 mm),T1(180 mm),T2(100 mm),and T3(50 mm).The first accession(A1)comes from the protected national park of Ichkeul in northern *** zone belongs to the bioclimatic sub-humid *** second accession(A2)comes from Melloulech,located in the center-east of Tunisia,belonging to the bioclimatic semi-arid *** third accession(A3)comes from the mountain of Matmata,located in the south of Tunisia,belonging to the bioclimatic hyper-arid *** experiment was undertaken in a *** exchange indices(net photosynthesis(A),stomatal conductance(gs),transpiration rate(E),and internal CO_(2) concentration(Ci))were ***(Ψpd)and midday(Ψmd)leaf water potentials,relative soil water content(SWC),and morphological parameters(plant height(H),number of leaves(NL),number of leaflets(Nl),and number of branches(NB))were *** results showed that significant differences(Pelations were found between SWC andΨpd for all studied accessions.Ψpd andΨmd decreased as water stress increased,ranging from–0.96 to–1.50 MPa at sunrise and from–1.94 to–2.83 MPa at midday,respectively,under control and T3 *** accessions responded to drought through exhibiting significant changes in their physiological and morphological *** accessions A1 and A2 showed greater drought tol

关键词： Ceratonia siliqua L. water stress soil moisture stomatal conductance predawn leaf water potential minimum water potential

Dielectric Studies on CuO-Na2O-B2O3Glasses

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New Journal of Glass and Ceramics 2020年第4期10卷 45-56页

作者： Norhan Atef Gomaa el Damrawi Abdelmagud Hassan lobna Sharaf el-Deen Physics Department Faculty of Science Mansoura University Mansoura Egypt Physics Department Faculty of Science Monofia University Egypt

This work is aimed to shed light on the dielectric behavior of CuO containing glasses, since no publications concerning this issue have been presented before. Different glasses in the binary Na2O-B2O3 system were prepared by melt annealing technique. XRD spectra have shown that the amorphous structure is dominant in all glasses containing mixed concentrations from CuO and Na2O. The crystalline phases appeared only in glass free from Na2O. The dielectric spectroscopy is applied to shed some light on the conduction mechanisms in terms of changing both the dielectric constant and the electrical modulus of the investigated glasses. The ac conductivity increases with increasing frequency and decreases with increasing CuO concentration. Both the dielectric constant and dissipation loss is decreased with increasing frequency. Correlated barrier hopping (CBH) is considered an appropriate conduction mechanism results from the increase of frequency.

关键词： electrical Measurement Cuo Borate Glasses Impedance Spectroscopy

A Unified Management for Spontaneous CSF Leak

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 141-147页

作者： lobna el Fiky Ali Kotb Badr eldin Mostafa Otolaryngology Department Ain Shams University Cairo Egypt Neurosurgery Department Ain Shams University Cairo Egypt

Background: Spontaneous CSF leak represents less frequent cause of CSF leak, but cases are more difficult to control, with the highest failure rate and recurrence despite adequate repair. The problems in these cases might be related to an underlying undiagnosed associated intracranial hyper-tension. Recognition and long-term treatment of elevated ICP is therefore critical to the successful management of these patients. Objective: To evaluate the CSF pressure in cases of spontaneous CSF rhinorrhea and to describe our same setting combined protocol to the repair of the leak, measurement and management of CSF pressure. Patients and Methods: All patients presenting to Ain Shams University Hospitals, Cairo, Egypt, with spontaneous CSF leak were included prospectively in the study. Clinical and radiologic data were collected to suspect elevated intracranial pressure. After CSF repair, CSF pressure was measured and if found to be more than 20 cmH2O, a lumboperitoneal shunt was used. Results: Twenty-seven cases, 23 women and 4 men, presented with spontaneous CSF leak. 23 patients had BMI above 30. All patients had empty sella syndrome (100%), and a meningoencephalocele was found in 13 cases (48%). CSF pressure ranged from 5 to 39 cmH2O (mean = 28.7). A pressure above 21 cmH2O was found in19 patients (70%) and subsequently had lumboperitoneal shunt in the same setting. No recurrence occurred in this subset of patients with 6 - 60 months follow-up period. Conclusion: A selective and specific same setting protocol can result in a better diagnosis and control of the accompanying elevated ICP in cases of spontaneous CSF leak. It avoids a second operative intervention, and shortens the hospital stay, with an increase in the success rate. In the same time, the smaller number of patients with normal ICP can avoid further drainage.

关键词： CSF Rhinorrhea elevated ICP Spontaneous CSF Leak Lumbar Drain Acetazolamide Empty Sella Syndrome Intracranial Hypertension Endoscopic CSF Repair CSF Diversion Lumboperitoneal Shunts

Cardiac Arrhythmia Disease Classifier Model Based on a Fuzzy Fusion Approach

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Computers, Materials & Continua 2023年第5期75卷 4485-4499页

作者： Fatma Taher Hamoud Alshammari lobna Osman Mohamed elhoseny Abdulaziz Shehab Eman elayat College of Technological Innovation Zayed UniversityDubaiUAE Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaSaudi Arabia Department of electronics and Communications Engineering Delta Higher Institute for Engineering&TechnologyMansouraEgypt College of Computing and Informatics University of SharjahSharjahUnited Arab Emirates Department of Information Systems Mansoura UniversityMansoura35516Egypt Department of Teacher Preparation Faculty of Specific EducationMansoura UniversityMansouraEgypt

Cardiac diseases are one of the greatest global health *** to the high annual mortality rates,cardiac diseases have attracted the attention of numerous researchers in recent *** article proposes a hybrid fuzzy fusion classification model for cardiac arrhythmia *** fusion model is utilized to optimally select the highest-ranked features generated by a variety of well-known feature-selection *** ensemble of classifiers is then applied to the fusion’s *** proposed model classifies the arrhythmia dataset from the University of California,Irvine into normal/abnormal classes as well as 16 classes of ***,at the preprocessing steps,for the miss-valued attributes,we used the average value in the linear attributes group by the same class and the most frequent value for nominal ***,in order to ensure the model optimality,we eliminated all attributes which have zero or constant values that might bias the results of utilized *** preprocessing step led to 161 out of 279 attributes(features).Thereafter,a fuzzy-based feature-selection fusion method is applied to fuse high-ranked features obtained from different heuristic feature-selection *** short,our study comprises three main blocks:(1)sensing data and preprocessing;(2)feature queuing,selection,and extraction;and(3)the predictive *** proposed method improves classification performance in terms of accuracy,F1measure,recall,and precision when compared to state-of-the-art *** achieves 98.5%accuracy for binary class mode and 98.9%accuracy for categorized class mode.

关键词： Cardiac arrhythmia preprocessing missing values classification model fusion

BRCA1 and EGFR as prognostic biomarkers in triple negative metastatic breast cancer patients treated with cisplatin plus docetaxel

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The Chinese-German Journal of Clinical Oncology 2010年第12期9卷 700-707页

作者： lobna R Ezz elarab Manal el Mahdy Khaled Abdel Karim Clinical Oncology Department Faculty of MedicineAin Shams University Pathology Department Faculty of MedicineAin Shams University

Objective： The triple negative （TN） metastatic breast cancer （MBC） patients are known to have worse prognosis, shorter progressive free survival （PFS）, and overall survival （OS）, that mandates using aggressive chemotherapy regimens. This phase II study aimed at investigating the efficacy and safety of using cisplatin and docetaxel in patients with triple negative metastatic breast cancer, and the possibility of using breast cancer susceptibility genel （BRCA1） expression as a predictive marker of chemotherapy response, and epidermal growth factor receptor （EGFR） as prognostic marker. Method： Between January 2006 and March 2009, 40 eligible patients with TN MBC were included in the study. We examined BRCA1 expression and EGFR protein in their specimens using immunohistochemistry. The patients were treated with cisplatin 75 mg/m2 and docetaxel 75 mg/m2 every 3 weeks, TN measurable MBC patients previously treated with anthracycline in their adjuvant or neo adjuvant settings were included in the study. Results： The median age of the treated patients was 43.5 years. Nearly half of the patients had an ECOG performance status of 0 or 1, and about third of them had one metastatic site. These metastatic sites were predominantly visceral in 80% of the patients. Fifty-five percent of TNMBC stained positive for BRCA1 and sixty-five percent for EGFR. Positivity for both markers was significantly associated with grade III tumors （P = 0.004）, OS, and PFS （P = 0.001 and 0.009） respectively. Overall, the regimen was well tolerated as Gill vomiting and neurological side effects were observed in 20% of the patients. Other toxiciUes were generally mild and medically manageable; with no treatment mortality was recorded. The overall disease control rate （ODCR） was 60%; the median PFS was 8 months, with a median overall OS of 17.5 months; while the median OS among responders was 23 months （95% CI 21.35 to 25.32）. The patients with negative EGFR had a significantly better OR, PFS, and OS th

关键词： EGFR BRCA1 breast cancer metastatic triple negative cisplatin docetaxel