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A semantic web methodology for situation-aware curative food service recommendation system

通讯和计算机（中英文版） 2009年第8期6卷 31-36页

作者： lo chi-chun CHEN chi-hua CHENG Dmg-yuan KUO Ting-huan KUNG Hsu-yang Institute of Information Management National Chiao-Tung University Hsinchu 300 Taiwa Department of Computer Science National Chiao-Tung University Hsinchu 300 Taiwan Department of Management Information System National Pingtung University of Science ＆ Technology Pingtung 912 Taiwan

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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri chih Hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

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Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus

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World Journal of Gastroenterology 2014年第40期20卷 14589-14597页

作者： chi-Ruei Huang Szecheng John lo Institute of Microbiology and Immunology National Yang-Ming University Department and Institute of Biomedical Sciences College of Medicine Chang Gung University Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University

Viral hepatitis remains a worldwide public health *** hepatitis D virus(HDV)must either coinfect or superinfect with the hepatitis B virus(HBV).HDV contains a small RNA genome(approximately 1.7 kb)with a single open reading frame(ORF)and requires HBV supplying surface antigens(HBsAgs)to assemble a new HDV *** HDV replication,two isoforms of a delta antigen,a small delta antigen(SDAg)and a large delta antigen(LDAg),are produced from the same ORF of the HDV *** SDAg is required for HDV replication,whereas the interaction of LDAg with HBsAgs is crucial for packaging of HDV *** clinical outcomes of HBV/HDV dual infection have been reported,but the molecular interaction between HBV and HDV is poorly understood,especially regarding howHBV and HDV compete with HBsAgs for assembling *** this paper,we review the role of endoplasmic reticulum stress induced by HBsAgs and the molecular pathway involved in their promotion of LDAg nuclear *** the nuclear sublocalization and export of LDAg is regulated by posttranslational modifications(PTMs),including acetylation,phosphorylation,and isoprenylation,we also summarize the relationship among HBsAg-induced endoplasmic reticulum stress signaling,LDAg PTMs,and nuclear export mechanisms in this review.

关键词： Hepatitis B virus Hepatitis D virus Posttranslational modification Endoplasmic reticulum stress Nuclear export

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The Sum and Difference of Two Constant Elasticity of Variance Stochastic Variables

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Applied Mathematics 2013年第11期4卷 1503-1511页

作者： chi-Fai lo Department of Physics Institute of Theoretical Physics The Chinese University of Hong Kong Hong Kong China

We have applied the Lie-Trotter operator splitting method to model the dynamics of both the sum and difference of two correlated constant elasticity of variance (CEV) stochastic variables. Within the Lie-Trotter splitting approximation, both the sum and difference are shown to follow a shifted CEV stochastic process, and approximate probability distributions are determined in closed form. Illustrative numerical examples are presented to demonstrate the validity and accuracy of these approximate distributions. These approximate probability distributions can be used to valuate two-asset options, e.g. spread options and basket options, where the CEV variables represent the forward prices of the underlying assets. Moreover, we believe that this new approach can be extended to study the algebraic sum of N CEV variables with potential applications in pricing multi-asset options.

关键词： Constant Elasticity of Variance Stochastic Variables Probability Distribution Functions Backward Kolmogorov Equation Lie-Trotter Splitting Approximation

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Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

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Nano-Micro Letters 2020年第4期12卷 14-28页

作者： Mi Hyeon Cho Yan Li Pui‑chi lo Hyeri Lee Yongdoo Choi Division of Translational Science Research InstituteNational Cancer Center323 Ilsan‑roGoyangGyeonggi 10408Republic of Korea Department of Biomedical Sciences City University of Hong KongTat Chee AvenueKowloonHong KongChina

In this study, a fucoidan-based theranostic nanogel(CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve acti-vatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy(PDT) to induce the com-plete death of cancer cells. A CFN-gel has nanomolar a nity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention e ect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar a nity for the vascular endothelial growth factor, it also provides a significant anti-tumor e ect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high e cacy and specificity.

关键词： Fucoidan Theranostic nanogel P-selectin Activatable Anti-angiogenic

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Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick chi-Wai Lui Oswens Siu-Hung lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

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The regulatory pathways leading to stem-like cells underlie prostate cancer progression

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Asian Journal of Andrology 2019年第3期21卷 233-240页

作者： chun-Jung Lin U-Ging lo Jer-Tsong Hsieh Department of Urology UT Southwestern Medical Center Dallas TX 75390 USA

Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention. Cancer stem cell (CSC) phenotypes characterized as poor differentiation, cancer initiation with self-renewal capabilities, and therapeutic resistance are proposed to contribute to the onset of CRPC. In this review, we discuss the role of CSC in CRPC with the evidence of CSC phenotypes and the possible underlying mechanisms.

关键词： cancer stem cell castration-resistant prostate cancer neuroendocrine differentiation transdifferentiation

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Cellular factors involved in the hepatitis C virus life cycle

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World Journal of Gastroenterology 2021年第28期27卷 4555-4581页

作者： Hui-chun Li Chee-Hing Yang Shih-Yen lo Department of Biochemistry Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 970Taiwan

The hepatitis C virus(HCV),an obligatory intracellular pathogen,highly depends on its host cells to propagate *** HCV life cycle can be simply divided into several stages including viral entry,protein translation,RNA replication,viral assembly and *** of cellular factors involved in the HCV life cycle have been identified over more than thirty years of *** of these cellular factors has provided extensive insight into HCV replication *** of these cellular factors are targets for anti-HCV *** this review,we summarize the well-characterized and recently identified cellular factors functioning at each stage of the HCV life cycle.

关键词： Hepatitis C virus Cellular factor Viral entry Translation Replication Assembly Release

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long noncoding RNAs in hepatitis B virus replication and oncogenesis

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World Journal of Gastroenterology 2022年第25期28卷 2823-2842页

作者： Hui-chun Li Chee-Hing Yang Shih-Yen lo Department of Biochemistry Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 97004Taiwan

Several diverse long noncoding RNAs(lncRNAs)have been identified to be involved in hepatitis B virus(HBV)replication and oncogenesis,especially those dysregulated in HBV-related hepatocellular carcinoma(HCC).Most of these dysregulated lncRNAs are modulated by the HBV X *** regulatory mechanisms of some lncRNAs in HBV replication and oncogenesis have been *** polymorphisms of several lncRNAs affecting HBV replication or oncogenesis have also been *** prognosis of HCC remains *** is important to identify novel tumor markers for early diagnosis and find more therapeutic targets for effective treatments of *** dysregulated lncRNAs in HBV-related HCC may become biomarkers for early diagnosis and/or the therapeutic targets of *** mini-review summarizes these findings briefly,focusing on recent developments.

关键词： Hepatitis B virus Hepatocellular carcinoma long noncoding RNAs Hepatitis B virus X protein Biomarker

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Hepatitis C virus:Virology,diagnosis and treatment

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World Journal of Hepatology 2015年第10期7卷 1377-1389页

作者： Hui-chun Li Shih-Yen lo Department of Biochemistry Tzu Chi University Department of Laboratory Medicine and Biotechnology Tzu Chi University Department of Laboratory Medicine Buddhist Tzu Chi General Hospital

More than twenty years of study has provided a better understanding of hepatitis C virus(HCV) life cycle,including the general properties of viral RNA and proteins. This effort facilitates the development of sensitive diagnostic tools and effective antiviraltreatments. At present,serologic screening test is recommended to perform on individuals in the high risk groups and nucleic acid tests are recommended to confirm the active HCV infections. Quantization and genotyping of HCV RNAs are important to determine the optimal duration of anti-viral therapy and predict the likelihood of response. In the early 2000 s,pegylated interferon plus ribavirin became the standard antiHCV treatment. However,this therapy is not ideal. To 2014,boceprevir,telaprevir,simeprevir,sofosbuvir and Harvoni are approved by Food and Drug Administration for the treat of HCV infections. It is likely that the new all-oral,interferon-free,pan-genotyping anti-HCV therapy will be available within the next few years. Majority of HCV infections will be cured by these antiviral treatments. However,not all patients are expected to be cured due to viral resistance and the high cost of antiviral treatments. Thus,an efficient prophylactic vaccine will be the next challenge in the fight against HCV infection.

关键词： Hepatitis C virus Diagnosis Treatment Hepatocellular carcinoma Nucleic acid test Enzymeimmunoassay Interferon Direct acting antivirals Hosttargetedagents Sofosbuvir

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