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Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?

Neural Regeneration Research 2019年第4期14卷 582-587页

作者： Elisa Piscianz liza vecchi brumatti Alberto Tommasini Annalisa Marcuzzi Department of Medicine Surgery and Health Sciences University of Trieste Institute for Maternal and Child Health-IRCCS "Burlo Garofolo"

The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders.

关键词： cholesterol inflammation apoptosis autophagy neurons inherited disease necroptosis neuronal dysfunction

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Evolution of liver transplantation in the metabolic dysfunctionassociated steatotic liver disease era: Tracking impact through time

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World Journal of Transplantation 2024年第4期14卷 84-94页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi Estefanía liza Zuly Placido-Damian Javier Diaz-Ferrer Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Medicine Faculty Universidad San Martin de PorresLima 02002Peru Gastroenterology Service Clinica InternacionalLima 02002Peru

Liver transplantation(LT)for metabolic dysfunction-associated steatotic liver disease(MASLD)is increasing globally due to rising rates of obesity and metabolic syndrome,posing significant *** patients typically present with advanced age,higher body mass index(BMI),and metabolic com-orbidities such as diabetes,hypertension,and *** pre-transplant evaluations are crucial for assessing surgical risks and preparing patients for *** patients with higher BMI may experience longer operative times,potentially affecting intraoperative *** the months following LT,MASLD recipients face persistent challenges,including a higher incidence of metabolic syndrome and cardiovascular events compared to non-MASLD ***,survival rates at 1-,3-,and 5-years post-LT do not markedly differ from other etiologies,indicating comparable surgical *** outcomes in MASLD patients undergoing LT demands a multidisciplinary approach from pre-transplant assessment to post-transplant *** must address metabolic comorbidities,manage cardiovascular health,and monitor steatosis recurrence,which can be exacerbated by obesity and *** approach aims to mitigate long-term graft complications and mortality risks,ultimately enhancing transplant success and patient *** research is essential to refine these approaches and meet the evolving challenges posed by MASLD as a leading indication for LT worldwide.

关键词： Liver transplantation Metabolic dysfunction-associated steatotic liver disease Alcohol liver disease Hepatitis C Hepatitis B Hepatocellular carcinoma

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带你走近量子科技前沿——重庆大学量子材料与器件研究中心科学家孙阳教授

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大学科普 2024年第3期18卷 69-70页

作者：丽扎•别克恩黄瑞重庆大学学生核学会重庆

聆听科普讲座,感受科学魅力。2024年3月20日,在重庆大学虎溪校区一食堂三楼1804,《大学科普》杂志编辑部的靳萍老师和重庆大学学生核学会成员,有幸邀请到了重庆大学量子材料与器件研究中心科学家兼任物理学院教授孙阳老师。孙阳老师为... 详细信息

聆听科普讲座,感受科学魅力。2024年3月20日,在重庆大学虎溪校区一食堂三楼1804,《大学科普》杂志编辑部的靳萍老师和重庆大学学生核学会成员,有幸邀请到了重庆大学量子材料与器件研究中心科学家兼任物理学院教授孙阳老师。孙阳老师为参加会议的核学会成员带来了有趣的有关量子科技与量子材料的前沿科学科普报告。

关键词：科普报告重庆大学老师科普讲座科技前沿前沿科学孙阳量子

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超高强微钢纤维增韧混凝土的制备及其力学性能研究

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土木工程学报 2009年第6期42卷 1-7页

作者：王冲 liza O'Moore 重庆大学重庆400045 University of Queensland QLD 4072Australia

高脆性是超高强混凝土难以被广泛应用的主要原因之一。为降低脆性,利用长度为6mm与13mm的三种微钢纤维,制备超高强微钢纤维混凝土,研究不同纤维长径比及掺量条件下混凝土的力学性能指标,其中包括ASTMC1018方法测试超高强微纤维混凝土的... 详细信息

高脆性是超高强混凝土难以被广泛应用的主要原因之一。为降低脆性,利用长度为6mm与13mm的三种微钢纤维,制备超高强微钢纤维混凝土,研究不同纤维长径比及掺量条件下混凝土的力学性能指标,其中包括ASTMC1018方法测试超高强微纤维混凝土的抗弯韧性。试验结果显示:随纤维掺量的增加,超高强混凝土能量吸收能力增加明显;与不掺纤维时相比,1.0%体积掺量下三种纤维混凝土的初始裂缝强度、抗折强度和韧性指数均有显著提高,掺量2.0%时初始裂缝强度、抗折强度和韧性指数的增加受到影响;长度为6mm的纤维在2.0%掺量时抗压强度相对较大,而长度为13mm的两种纤维在掺量1.0%时抗压强度较高;掺入3种纤维的混凝土劈拉强度和弹性模量也由于纤维的掺入而有所增加。结果表明,微钢纤维用于增韧超高强混凝土时,宜采用适宜掺量。

关键词：微钢纤维超高强混凝土制备力学性能

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同型半胱氨酸、低密度脂蛋白胆固醇及糖化血红蛋白在2型糖尿病视网膜病变的影响研究

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齐齐哈尔医学院学报 2024年第2期45卷 124-128页

作者：帕里杂·赛力克侯志梅舒哈尔新疆医科大学第二临床医学院新疆乌鲁木齐830000 克拉玛依市中心医院新疆克拉玛依834000

目的探讨血清同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(HbA1c)在2型糖尿病视网膜病变(DR)中的影响。方法回顾性分析2019年4月—2022年6月本院内分泌科住院的2型糖尿病患者有糖尿病视网膜病变组(DR组)患者150例和非... 详细信息

目的探讨血清同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(HbA1c)在2型糖尿病视网膜病变(DR)中的影响。方法回顾性分析2019年4月—2022年6月本院内分泌科住院的2型糖尿病患者有糖尿病视网膜病变组(DR组)患者150例和非糖尿病视网膜病变(NDR组)患者150例的临床资料,包括每位患者的一般资料、生化指标。比较两组间的一般信息;分析DR组与NDR组的影响因素;多元素回归分析DR的危险因素。结果DR及NDR组患者年龄、病程方面差距具有统计学意义(P<0.05)。DR组患者Hcy、FBG、TG、LDL-C、HbA1c水平明显高于NDR组(P<0.05)。Pearson相关系数分析,DR组患者的Hcy与年龄,病程FBG、TG、TC、LDL-c、HbA1c呈正相关关系(P<0.05)。Logistics回归分析结果显示病程、TG、LDL-c、Hcy、HbA1c均是影响2型糖尿病视网膜病变的独立因素(P<0.05)。结论Hcy、LDL-c、HbA1c水平在DR患者中远高于NDR患者,三者与DR发生、发展存在一定联系,临床可根据其表达水平对患者病情变化进行有效评估。

关键词：糖尿病视网膜病变同型半胱氨酸 2型糖尿病低密度脂蛋白糖化血红蛋白

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Pneumatosis cystoides intestinalis

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World Journal of Gastroenterology 2011年第44期17卷 4932-4936页

作者： Francesco Azzaroli Laura Turco liza Ceroni Stefania Sartoni Galloni Federica Buonfiglioli Claudio Calvanese Giuseppe Mazzella Department of Clinical Medicine Division of GastroenterologyS.Orsola-Malpighi HospitalUniversity of Bologna Department of Emergency General Surgery and TransplantationS.Orsola-Malpighi HospitalUniversity of Bologna

Pneumatosis cystoides intestinalis(PCI) is a rare condition that may be associated with a variety of *** presenting clinical picture may be very heterogeneous and represent a challenge for the *** the present paper we describe both a common and an uncommon clinical presentation of PCI and review the pertaining *** cases confirm that,apart from asymptomatic cases,the clinical presentation of PCI may be widely different and suggest that a new onset of stipsis might be the presenting *** might be suggested by a simple X-ray of the digestive tract showing a change in the characteristics of the intestinal wall in two-thirds of these ***,one third of the patients do not have a suggestive X-ray and require a computed tomography(CT) scan/nuclear magnetic resonance that may reveal a thickened bowel wall containing gas to confirm the diagnosis and distinguish PCI from intraluminal air or submucosal *** also allows the detection of additional findings that may suggest an underlying,potentially worrisome cause of PCI such as bowel wall thickening,altered contrast mucosal enhancement,dilated bowel,soft tissue stranding,ascites and the presence of portal *** results also point out that clinicians and endoscopists should be aware of the possible presentations of PCI in order to correctly manage the patients affected with this disease and avoid unnecessary *** increasing number of colonoscopies performed for colon cancer screening makes PCI more frequently casually encountered and/or provoked,therefore the possible endoscopic appearances of this disease should be well known by endoscopists.

关键词： Pneumatosis cystoides intestinalis Pneumoperitoneum Treatment Hyperbaric oxygen Endoscopy

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Falling Snow

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小学生时代（大嘴英语） 2023年第12期 26-28页

作者： Anonymous liza Woodruff 不详

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 755-756页

作者： Jaafar Juanarita Mohd Noor Raja Azmi Yaakub Azhany Ahmad Tajudin liza-Sharmini Department of Ophthalmology School of Medical SciencesUniversiti Sains Malaysia

A 24 year-old Malay lady presented with high grade fever,myalgia,generalized rashes,severe headache and was positive for dengue serology *** lowest platelet count was 45×10~9 cells/*** complained of sudden onset of painlessness,profound loss of vision bilaterally 7 days after the onset of *** examination,her right eye best corrected vision was 6/30 and left eye was6/*** anterior segment examination was *** revealed there were multiple retinal haemorrhages found at posterior pole of both fundi and elevation at fovea area with subretinal *** examination revealed normal findings except for residual petechial *** was managed *** vision improved tremendously after 2 *** retinal hemorrhages and foveal elevation showed sign of *** manifestations following dengue fever is ***,bilateral visual loss can occur if both fovea arc involved.

关键词： Dengue fever Maculopathy Foveolitis

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文化沟通或软实力 ——匈牙利孔子学院案例研究

文化沟通或软实力 ——匈牙利孔子学院案例研究

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作者： liza Hajdu 浙江大学

学位级别：硕士

This thesis investigates a much discussed,yet often misunderstood topic:Confucius Institutes(CIs)and their influence on foreign *** more than 500 CIs having opened worldwide during the last decade and a half,the Chinese government's cultural initiative has sparked large debates over the institutes' real *** a number of countries both scholars and politicians have been urging university staff members to close CIs at their university *** reason for the fierce opposition against CIs is that many perceive them as a tool in the hands of the Chinese government to shape foreign audiences' view of the country,and as a part of a soft power initiative that aims at attracting foreigners to Chinese values and political *** the other end of the debate there are a few scholars arguing for a more nuanced understanding of the CI network,suggesting that instead of furthering Chinese soft power advances,CIs serve the cause of building a deeper cultural understanding between China and other *** thesis aims at providing a fresh insight into this *** basis of this dissertation is a primary research which has been carried out to see how current and former Hungarian CI students' perception of China has changed due to them having studied at a *** the research both qualitative and quantitative data was collected,in which participants were asked to reflect on their own CI experiences and to recount how their cultural and non-cultural interest towards China has been transformed during their CI *** the data was collected,and the pre-and post-CI experiences were compared I came to the conclusion that CIs should not be regarded as vehicles of Chinese soft power advancement as their soft power effects are ***,I would suggest to see CIs as peaceful cultural institutions aiming at the enhancement of a deeper cultural understanding between China and other nations of the world.

关键词：硕士学位论文 engage claimed 文化沟通 interested courses political instance university institutions

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Friends

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小学生时代（大嘴英语） 2021年第6期 28-29页

作者： Diana Murray liza Woodruff(图) 不详

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