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Induction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis C

World Journal of Gastroenterology 2008年第44期14卷 6844-6852页

作者： Yalena Amador-Caizares liz Alvarez-Lajonchere Ivis Guerra Ingrid Rodríguez-Alonso Gillian Martínez-Donato Julián Triana Eddy E González-Horta Angel Pérez Santiago Dueas-Carrera Centro de Ingeniería Genética y Biotecnología Ave 31e/ 158 and 190PlayaP.O. Box 6162HavanaCuba

AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4＋ or CD8＋ T cells, being the capsid poorly recognized. CONCLUSION： These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.

关键词： Hepatitis C Antibody response Lymphoproliferation Core Envelope

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Comparison of Blood Group Molecular Genotyping to Traditional Serological Phenotyping in Patients with Chronic or Recent Blood Transfusion

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Journal of Biosciences and Medicines 2016年第3期4卷 1-8页

作者： Zhan Ye Daoping Zhang Leonard Boral Counts liz John May Department of Pathology and Laboratory Medicine University of Kentucky Lexington KY USA Kentucky Blood Center 3121 Beaumont Centre Circle Lexington KY USA

Objectives: Accurately identifying the Antigens (Ags) on recipient red blood cells (RBCs) is critical in prevention of RBC alloimmunization in chronically transfused patients. The goal of this study was to compare RBC molecular genotyping to serological phenotyping in those patients. Methods: Serological phenotyping and molecular genotyping methods were used to study blood samples from 18 healthy blood donors and 16 transfused patients. Reticulocyte harvesting or hypotonic cell separation was added to recheck RBC phenotypes of the patients with discrepancies between phenotyping and genotyping. Results: No discrepancies were found between the two genotyping methods in all the donors and patients. 1 of 9 sickle-cell disease (SCD) patients and all 3 thalassemia patients demonstrated discrepancies in multiple blood groups between phenotyping and genotyping, which were not corrected by reticulocyte harvesting or hypotonic cell separation. Conclusions: These findings suggest that RBC molecular genotyping is superior to serological phenotyping in chronically transfused SCD or thalassemia patients.

关键词： Blood Group Molecular Genotyping Serological Phenotyping Chronic Blood Transfusion

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英国高校图书馆学科服务现状调查和分析

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图书情报工作 2017年第11期61卷 63-70页

作者：张毓晗 liz Waller Vanya Gallimore 凌世婷电子科技大学图书馆成都611731 约克大学图书馆Heslington YO105DD

[目的/意义]调查和分析英国高校图书馆学科服务的内容、组织结构、教学和培训的主要方式、技术手段和反馈模式,发掘其对国内学科服务的参考价值。[方法/过程]利用Qualtrics网上调查平台,对英国高校图书馆的学科服务内容、组织架构、教... 详细信息

[目的/意义]调查和分析英国高校图书馆学科服务的内容、组织结构、教学和培训的主要方式、技术手段和反馈模式,发掘其对国内学科服务的参考价值。[方法/过程]利用Qualtrics网上调查平台,对英国高校图书馆的学科服务内容、组织架构、教学和培训的方式、新技术和反馈手段等进行调查,收到来自英国50所高校图书馆的58份有效问卷,并利用Qualtrics和SPSS对数据进行分析。[结果/结论]英国高校图书馆的学科服务内容由传统的馆藏资源建设、学科联系、信息素养培训逐渐外延,面向用户提供多项科研支持服务。功能性组织架构成为英国高校图书学科服务的主流结构,但基于学科的服务模式依然占有一席之地,部分图书馆采用二元结构,兼顾功能角色和学科角色。通识教学和嵌入式教学相结合已成为英国高校图书馆教学和培训的主流方式,新技术在英国高校图书馆教学和培训中应用广泛,教学和培训的反馈方式多样化。

关键词：学科服务学科馆员英国大学图书馆

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侯垚庄婷你还是你

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尚舞 2018年第5期 16-23页

作者： liz 不详

今年3月,在世界职业拉丁舞超级大奖赛分站赛第一站意大利的比赛中,侯垚/庄婷再一次刷新了他们在国际上成绩,取得第2名,赢得了无数圈内人士的致敬。其实,自从2015年侯垚/庄婷升入职业组之后,我们似乎已经习惯了他们一次次给大家带来惊艳... 详细信息

今年3月,在世界职业拉丁舞超级大奖赛分站赛第一站意大利的比赛中,侯垚/庄婷再一次刷新了他们在国际上成绩,取得第2名,赢得了无数圈内人士的致敬。其实,自从2015年侯垚/庄婷升入职业组之后,我们似乎已经习惯了他们一次次给大家带来惊艳和震撼,也习惯了一遍遍刷新自己的认知:原来中国舞者也可以站上世界最顶级的舞台!然而,无论是曾经全国锦标赛上的黑马,世界拉丁舞公开赛业余新星拉丁舞冠军,还是如今世界职业拉丁舞的决赛圈选手,侯垚/庄婷都没有忘记最开始背起行囊走四方的他们,当时是怎样的心境。纵然时光荏苒、四季流转,侯垚/庄婷依然是最开始的那个自己:不低头、不彷徨,不哗众取宠,也无关乎名利,只遵从内心最本真的声音。

关键词：拉丁舞大奖赛

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起舞吧厦门 2016CBDF中国杯巡回赛——厦门站暨第四届CBDF福建公开赛

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尚舞 2016年第12期 42-47页

作者： liz

长春、上海、石家庄、武汉,终于,2016中国杯巡回赛跨过千山万水,掠过严寒酷暑,来到了5站巡回赛的最后一站——厦门站。厦门站的开启,意味着总决赛的即将来临,也意味着今年赛事即将结束。在这一整年的赛事即将逝去的时刻,大家是否有所思... 详细信息

长春、上海、石家庄、武汉,终于,2016中国杯巡回赛跨过千山万水,掠过严寒酷暑,来到了5站巡回赛的最后一站——厦门站。厦门站的开启,意味着总决赛的即将来临,也意味着今年赛事即将结束。在这一整年的赛事即将逝去的时刻,大家是否有所思考:你付出了多少?成长了多少?又获得了多少呢?中国杯巡回赛就像一面镜子,见证你的舞蹈之路,它时时刻刻提醒你:你准备好了吗?

关键词：国际标准舞福建省国标舞冠军奖杯厦门站公开赛

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英语畅谈青春文化50主题中英文本 4

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丛书名：英语国际人

2007年

作者：刘佳静（美）Jessica Robertson （美）liz Carter

本书分为十部分，包括工作、爱情、时尚、教育、新新人类、网络、健康、大学生活、文化差异、公益慈善。

ISBN: (数字)9787119048284

ISBN: (纸本)7119048287

本书分为十部分，包括工作、爱情、时尚、教育、新新人类、网络、健康、大学生活、文化差异、公益慈善。

关键词：英语汉语

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Comparing the biogeochemical functioning of two arid subtropical coastal lagoons:the effect of wastewater discharges

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Ecosystem Health and Sustainability 2021年第1期7卷 49-60页

作者： Julio Medina-Galván Carmen Cristina Osuna-Martínez Gustavo Padilla-Arredondo Martín Gabriel Frías-Espericueta Ramón Héctor Barraza-Guardado JoséAlfredo Arreola-lizárraga Facultad de Ciencias del Mar Universidad Autónoma de SinaloaMazatlánMéxico Programa de Planeación Ambiental y Conservación Centro de Investigaciones Biológicas del NoroesteS.C.GuaymasMéxico Departamento de Investigaciones Científicas y Tecnológicas de la Universidad de Sonora HermosilloMéxico

Nutrient flux,net metabolism,and N2 fixation and denitrification processes were estimated and compared in two semi-arid subtropical coastal lagoons in the Gulf of California:El Soldado(ES),where no wastewater is discharged,and El Rancho(ER),where shrimp farm effluents are regularly *** processes were evaluated with the LOICZ *** time was<2 days in both *** fluxes were higher in ER than in ES and both systems acted as nutrient sinks for most of the *** showed a larger nutrient flow rate in the summer and autumn due to the input of shrimp-farm *** fluxes increased in both ER and ES in the winter in response to the increased nutrient supply from coastal *** and ES both showed autotrophic metabolism and N2 fixation in the spring,autumn,and winter,but heterotrophic metabolism and denitrification in the *** dominated in ER(−2.21 mmol m^(2)day^(−1))and values were higher than those estimated in ES(−0.45 mmol m^(2)day^(−1)).The comparative analysis between ES and ER evidenced the significant changes in its biogeochemical performance caused by the input of anthropogenic nutrients,and can orient the environmental management of coastal lagoons.

关键词： Coastal lagoons nutrient budgets net ecosystem metabolism Gulf of California

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Simulation Is Not a Pedagogy

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Open Journal of Nursing 2017年第7期7卷 779-787页

作者： Gwen D. Erlam liz Smythe Valerie Wright-St Clair Department of Health and Environmental Sciences Auckland University of Technology (AUT) Auckland New Zealand

Simulation as a teaching/learning tool has evolved at an unprecedented pace which some believe has occurred despite a lack of research into pedagogies appropriate to guide this technology-based learning tool. There seems to be some confusion as to what simulation actually is. Some have called simulation a pedagogy, which is incorrect. Simulation is not a pedagogy, but an immersive teaching/learning platform which is a representation of a functioning system or process. Simulation has been used in undergraduate nursing education in a focused manner for nearly 20 years. Its effectiveness in improving clinical reasoning and critical thinking is not certain if overall instructional design principles do not reflect suitable philosophical paradigms. Simulation as a teaching/learning platform is maximized when instructional design includes the inspiration of behaviorism, cognitivism, and constructivism. Behaviorist design principles include rote learning, repetition, modular learning, stimulus-response, and conditioning. Cognitivist design principles include observational techniques, bootstrapping, and equilibration in the form of assimilation and accommodation. Constructivist design principles include new habit formation through experience and interaction with a “mature social medium” in the form of a simulation facilitator. All of these philosophical underpinnings have the potential to maximize simulation when used as underpinnings in the overall design.

关键词： Simulation Undergraduate Nursing Education Behaviorist Cognitivist Constructivist

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