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Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

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Neural Regeneration Research 2024年第4期19卷 855-862页

作者： Mingyue Jin Shengming Wang Xiaodie Gao Zhenyou Zou Shinji Hirotsune liyuan sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

Source Apportionment Research of Fine Particulate Matter in the Atmosphere by PAHs

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Chemical Research in Chinese Universities 2016年第5期32卷 746-753页

作者： WANG Ju YANG Le MA Tianyi sun liyuan YU Liangui FANG Chunsheng Environmental Science Department College of Environment and Resources Jilin University Changchun 130012 P. R. China Key Laboratory of Groundwater Resources and Environment Ministry of EducationCollege of Environment and Resources Jilin University Changchun 130021 P. R. China College of Environmental Science and Engineering of Tong/i University Shanghai 200092 P. R. China Changchun Central Environmental Monitoring Station Changchun 130011 P. R. China

Haze weather frequently occurs in many cities in China. Polycyclic aromatic hydrocarbons（PAHs） in fine particulate matter（PM：.5） can adversely affect the environment and human health. In this paper, PM2.5 samples were collected at nine sites in a city in northeastern China from September 2013 to October 2014. Sixteen USEPA（US Evironment Protection Agency） priority PAHs in PM2.5 were analyzed to determine their spatial and temporal distri- bution characteristics. The source apportionment of PAHs was conducted with the Positive Matrix Factorization（PMF） model. The results indicate that the concentrations of total PAHs（T-PAHs） in PM2.5 are within the range of 0.26 to 72.48 ng/m3. The seasonal variation of T-PAHs is winter〉spring〉autumn〉summer, and the space distribution of PAHs is JZP〉DP〉BFH〉LP〉EESA〉IPT〉CP〉HZMC〉JYP. In all types of PAils, three-ring and five-ring PAHs are signifi- cantly prominent（62%） in the heating period due to petrogenic sources and traffic emissions. Middle- and high-ring PAHs in the non-heating period are caused by coal combustion and vehicle exhaust, which accounts for 77% of the total emissions. The source apportionment results obtained by the diagnostic ratio of PAHs reflect that coal burning, traffic and other sources have a distinct influence on PAH emissions in this city. Six factors are defined by PMF v5.0, namely, coke oven emissions（7.7%）, biomass burning（44.3%）, petrogenic sources（10.7%）, coal combustion（10.4%）, gasoline engine emissions（16.7%）, and diesel engine emissions（10.3%）. The results indicate that the PAHs in PM2.5 in the city are primarily caused by combustion processes and vehicle exhaust.

关键词： Polycyclic aromatic hydrocarbon(PAH) Pollution characteristics Diagnostic ratio Positive Matrix Factorization(PMF)

Studies on Factors Influencing Hydrodynamic Characteristics of Plates Used in Artificial Reefs

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Journal of Ocean University of China 2019年第1期18卷 193-202页

作者： TANG Yanli YANG Wenzhao sun liyuan ZHAO Fenfang LONG Xiangyu WANG Gang College of Fishery Ocean University of China Shandong Hydrobios Resources Conservation and Management Center

As a simplified model of artificial reefs, a series of plate models punched with square or circular openings are designed to investigate the effects of openings on the hydrodynamic characteristics of artificial reefs. The models are grouped by various opening numbers and opening-area ratios. They are physically tested in a water flume or used in the numerical simulation to obtain the drag force in the uniform flow with different speeds. The simulation results are found in good agreement with the experimental measurements. By the non-dimensional analysis, the drag coefficient specified to each model is achieved and the effects of openings are examined. It is found that the key factor affecting the drag coefficient is the open-area ratio. Generally, the drag coefficient is a linear function of the open area ratio with a minus slope. The empirical formulae for the square and circular openings respectively are deduced by means of the multiple regression analysis based on the measured and numerical data. They will be good references for the design of new artificial reefs. As a result of numerical simulation, the vorticity contours and pressure distribution are also presented in this work to better understand the hydrodynamic characteristics of different models.

关键词： artificial reefs drag coefficient hydrodynamic characteristics model experiment

Effects of freeze-thaw cycle and dry-wet alternation on slope stability

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Research in Cold and Arid Regions 2019年第2期11卷 159-172页

作者： YaLing Chou liyuan sun BaoAn Li XiaoLi Wang School of Civil Engineering Lanzhou University of Technology Jiangsu JiaoTong Traffic Design Research Institute Co. Ltd.

The typical loess on high slopes along the BaoLan High-speed Rail, China, was selected as the research object. The influence of the freeze-thaw cycle and dry-wet alternation on the shear-strength parameters of the unsaturated loess was investigated by laboratory experimental methods. Moreover, the temperature field, seepage field, and stability of slopes with different gradients were simulated under the effect of the freeze-thaw cycle and dry-wet alternation by using the geotechnical analysis software Geo-Studio. The research results showed(1) when the freeze-thaw cycle was repeated on the slope, with the frozen depth increasing, the melted depth did the same; besides, the closed loop of isotherms formed on the slope;(2) under the action of dry-wet circulation, the negative pore-water pressure and volumetric water content showed an upward tendency. However, owing to the different slope gradients, rainfall infiltration was not the same. As time went by, the differences of the negative pore-water pressure and volumetric water content between the slopes of different gradients continued to increase;(3) with the freeze-thaw cycle and dry-wet alternation increasing, the slope-safety factor decreased. Especially in the early period, the slope-safety factor changed remarkably. For slopes undergoing freeze-thaw action, the slope-safety factor was negatively correlated with the gradient. However, with regard to slopes undergoing dry-wet alternation, the result became more complex because the slope-safety factor was related to both seepage strength and slope grade. Accordingly, further research is needed to study the effect of seepage strength and slope grade on the stability of loess slopes.

关键词： freeze-thaw action dry-wet alternation temperature field seepage field slope stability

Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells

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Chinese Chemical Letters 2022年第9期33卷 4229-4232页

作者： Yanyan sun Xiaonan Zhou liyuan sun Xiuxiu Zhao Yongrui He Ge Gao Weina Han Jin Zhou School of Pharmacy School of Rehabilitation MedicineWeifang Medical UniversityWeifang 261053China Weifang Maternal and Child Health Hospital Maternal and Child Health Hospital of Weifang Medical UniversityWeifang 261011China

Available online The abnormal carboxylesterase(CES)expression is closely related to many diseases such as hyperlipidemia,atherosclerosis,obesity,liver cancer,type 2 diabetes mellitus and gastrointestinal stromal *** detection of a single enzyme in practical samples is often constrained by the structural diversity of ***,the development of broad-carboxylesterase responsive fluorescent probe,which can detect the presence of wide variety of CESs,may provide overall or category information from another point of view,supplementing the deficiency of single detection for CES *** lysosome is involved in various cell processes,such as cell signaling,apoptosis,secretion,and energy *** to date,lysosome-targeted fluorescent probes,especially those with red emission(over 550 nm,with relatively low biological harmfulness),for CES detection are still rare.A lysosomes-targeted red fluorescent probe CES-Lyso was designed to monitor intracellular a variety of carboxylesterases alteration with wonderful selectivity and sensitivity,which was further applied to distinguish different derived breast cancer cells and monitor carboxylesterase activity in the anticancer drug treatment.

关键词： Fluorescent probe Carboxylesterases Broad detection Breast cancerLysosome-targeting Red fluorescence

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在线社会网络多话题传播竞争特性的测量

清华大学学报（自然科学版） 2015年第11期55卷 1157-1162页

作者：孙立远管晓宏清华大学自动化系智能与网络化系统研究中心北京100084 国家计算机网络应急技术处理协调中心北京100029 西安交通大学智能网络与网络安全教育部重点实验室西安710049

网络上的话题纷杂多样而人们的注意力有限,势必导致多话题之间竞争稀缺的用户注意力资源,这种竞争关系影响了网络话题的传播和舆情的形成。已有的研究大多只针对单一话题的传播,该文研究了在线社会网络上多话题竞争的传播规律,提出多话... 详细信息

网络上的话题纷杂多样而人们的注意力有限,势必导致多话题之间竞争稀缺的用户注意力资源,这种竞争关系影响了网络话题的传播和舆情的形成。已有的研究大多只针对单一话题的传播,该文研究了在线社会网络上多话题竞争的传播规律,提出多话题传播竞争特性的测量方法。从话题和用户这2个层面设计了话题竞争的资源数变化规律、话题竞争激烈程度、用户注意力的转移规律及话题相关性等的测量方法,提出了话题资源数波动率、话题竞争激烈度和用户注意力转移率等定量测量指标。通过对新浪微博真实数据的测量发现:多话题竞争中用户资源总数基本稳定,用户的注意力大部分是从老话题转移到新出现的话题且发生在同类话题间。这些测量结果为建立多话题传播模型提供了基础。

关键词：在线社会网络多话题传播话题竞争用户行为

Data security governance in the era of big data: status, challenges, and prospects

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Data Science and Management 2021年第2期2卷 41-44页

作者： liyuan sun Hongyun Zhang Chao Fang National Computer Network Emergency Response Technical Team/Coordination Center Beijing100029China School of Management Xi’an Jiaotong UniversityXi’an710049China

At present,the global big data industry is experiencing vibrant development with technological evolution and application innovation speeding up side by *** technologies for data storage,computing and analytics,such as non-relational databases,distributed parallel computing,machine learning,and deep data mining have emerged and evolved *** data has gradually become a fundamental national strategic resource and a cornerstone factor in ***,increasing big data security problems are exposed and the number of big data security incidents occurring around the world is on the *** this background,this paper provides a summary of the present situation of global data security governance,points out the challenges,and then proceeds to raise solutions for further modernizing data security governance systems.

关键词： Data security Cyber security Data sharing Data privacy Big data

Rheological Behavior of Semisolid Al-6.5wt%Si Alloy under Cyclic Shear Deformation

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Rheological Behavior of Semisolid Al-6.5wt%Si Alloy under Cy...

The 1st International Congress on Advanced Materials 2011

作者： Hongchao Luo Junmei Yang liyuan sun Liping Ju School of Science Shenyang Aerospace University

In the present work, the MCF model for semisolid metal slurries (SSMS) is applied to investigate the thixotropy of the Al-6.5wt%Si alloy under cyclic shear deformation. The study shows that the semisolid Al-6.5wt%Si alloy has the behavior of thixotropy. The area of the hysteresis loop increases with decreasing the up-time, the initial shear rate and increasing resting time, solid volume fraction and maximum shear rate, respectively. These results have qualitative agreement with the experimental data. The origin of the hysteresis loop is atrributed to the difference between the deagglomeration rate and the agglomeration rate.

关键词： Semi-solid metal slurries (SSMS) Thixotropic behavior Hysteresis loop.

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对《招标投标法》及法律实施若干问题的思考

电力建设 2000年第4期21卷 1-2页

作者：孙力源中国电力企业联合会北京市100761

《中华人民共和国招标投标法》的实施 ,对我国社会主义市场经济活动定会起到指导和有力的规范作用。但根据我国工程建设实际情况 ,在招标范围、工程项目的分解、招投标活动中的“公开、公平和公正”及标底、履约保证金等问题上 ,应根据... 详细信息

《中华人民共和国招标投标法》的实施 ,对我国社会主义市场经济活动定会起到指导和有力的规范作用。但根据我国工程建设实际情况 ,在招标范围、工程项目的分解、招投标活动中的“公开、公平和公正”及标底、履约保证金等问题上 ,应根据实际情况制定出更加完善、更具操作性的法规 ,以便于更好地贯彻实施。

关键词：招标投标法法律实施工程建设项目