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短时间110 K环境温度建筑结构的保温防冻处理

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冷藏技术 2024年第3期47卷 53-56页

作者：林宏方亮云长江刘立瑶王颖王强大连冰山冷热科技股份有限公司大连116630 中国空气动力研究与发展中心高速空气动力研究所绵阳621000

超低温环境试验过程中,低温试件通过运送通道,造成运送通道内环境温度降至110 K。保证运送通道的混凝土结构安全,通道内部需做保温防冻。受结构尺寸限制,不能按《冷库设计标准》计算保温厚度。需按照实际情况计算保温厚度。制作试验装置... 详细信息

超低温环境试验过程中,低温试件通过运送通道,造成运送通道内环境温度降至110 K。保证运送通道的混凝土结构安全,通道内部需做保温防冻。受结构尺寸限制,不能按《冷库设计标准》计算保温厚度。需按照实际情况计算保温厚度。制作试验装置,利用液氮提供稳定冷源,验证计算结果满足要求,可应用于实际工程。

关键词：环境实验室环境温度 PIR保温材料检测

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触/延手榴弹引信开闭功能测试方法研究

测试技术学报 2024年第4期38卷 395-400页

作者：蒲利森徐鹏于立峣付嘉琪牛安冬 63856部队吉林白城137001

针对性能鉴定试验需要考核测试触/延手榴弹引信第一碰撞信号的时阈和开闭灵敏度的问题,通过研制测试设备以及设计试验方案,实现了对触/延手榴弹引信开闭功能的考核评估。通过分析触/延引信的结构组成和作用机理,确定了引信中碰炸开关可... 详细信息

针对性能鉴定试验需要考核测试触/延手榴弹引信第一碰撞信号的时阈和开闭灵敏度的问题,通过研制测试设备以及设计试验方案,实现了对触/延手榴弹引信开闭功能的考核评估。通过分析触/延引信的结构组成和作用机理,确定了引信中碰炸开关可靠闭合的临界条件,结合产品性能指标规定的时阈要求,提出了基于PLC程序控制手榴弹保险握片松开至跌落中硬地面全流程精准管控的设备研制方案,确保了手榴弹的跌落高度和与中硬地面的碰撞时间,有效解决了触/延引信开闭时阈和开闭灵敏度无法考核测试的技术难题。

关键词：手榴弹触/延引信自适应开闭时阈开闭灵敏度 PLC程序

Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2017年第9期59卷 642-656页

作者： Jie Huang Dan Chen Hailong Yan Fei Xie Ying Yu liyao Zhang Mengxiang Sun Xiongbo Peng State Key Laboratory for Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China

The specific functions of the genes encoding arginine biosynthesis enzymes in plants are not well characterized. We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase （NAGK）, which catalyzes the second step of arginine biosynthesis. NAGK is a plastid-localized protein and is expressed during most developmental processes in Arabidopsis. Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium, nagk mutant pollen tubes grow more slowly than wild type pollen tubes and the phenotype is restored by either specifically through complementation by NAGK in pollen, or exogenous supplementation of arginine, nagk female gametophytes are defective in micropylar pollen tube guidance due to the fact that female gametophyte cell fate specification was specifically affected. Expression of NAGK in synergid cells rescues the defect of nagk female gametophytes. Loss- of-function of NAGK results in Arabidopsis embryos not developing beyond the four-celled embryo stage. The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation. In conclusion, our results reveal a novel role of NAGK and arginine in regulating gametophyte function and embryo development, and provide valuable insights into arginine transport during embryo development.

关键词： Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana Figure

电针预处理对AMI小鼠心肌局部炎症及DNA-PK/Rictor/Myc信号通路的影响

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南京中医药大学学报 2024年第6期40卷 589-597页

作者：江敏娇彭柔闫煜杭刘肖儿钱丹颖鲁晓涵陈栎遥于美玲卢圣锋南京中医药大学针药结合教育部重点实验室江苏南京210023 南京中医药大学附属张家港医院江苏苏州215600 南京中医药大学养老服务与管理学院江苏南京210023

目的观察内关穴电针预处理后急性心肌梗死小鼠(AMI)心功能、局部炎症水平及巨噬细胞M2型极化变化,并从调控DNA-PK/Rictor/Myc信号通路角度探讨其可能机制。方法将雄性C57BL/6J小鼠随机分为假手术组、模型组和电针组,每组10只。采用结扎... 详细信息

目的观察内关穴电针预处理后急性心肌梗死小鼠(AMI)心功能、局部炎症水平及巨噬细胞M2型极化变化,并从调控DNA-PK/Rictor/Myc信号通路角度探讨其可能机制。方法将雄性C57BL/6J小鼠随机分为假手术组、模型组和电针组,每组10只。采用结扎冠状动脉左前降支制备心肌缺血模型。电针组接受双侧内关穴电针干预,疏密波,2/15 Hz,1 mA,每次20 min,每日1次,连续3 d,电针干预结束后30 min造模。采用超声心动图检测心脏射血分数(EF)和短轴收缩率(FS);HE、TUNEL染色观察小鼠心肌病理形态和心肌细胞凋亡;免疫组化和ELISA法检测梗死区心肌组织和外周血中IL-1β、TNF-α、NLRP3的表达水平;流式细胞术检测心脏中巨噬细胞极化状态,Western blot法检测梗死心肌中DNA-PK、p-DNA-PK、Rictor、Myc的蛋白表达水平。结果与假手术组相比,模型组的EF、FS明显降低(P<0.0001),炎性细胞浸润明显,心肌细胞凋亡指数显著升高(P<0.001),心肌组织和血清中IL-1β、NLRP3、TNF-α表达上调(P<0.01,P<0.001),巨噬细胞百分比明显增加(P<0.001),M2型巨噬细胞百分比下降(P<0.0001),心肌组织中p-DNA-PK、Rictor和Myc蛋白表达水平明显降低(P<0.05,P<0.0001);与模型组相比,电针组的EF、FS显著升高(P<0.0001),炎性细胞浸润减少,心肌细胞凋亡指数下降(P<0.01),心肌组织和血清中IL-1β、NLRP3、TNF-α表达下调(P<0.05,P<0.01,P<0.001),巨噬细胞百分比下降(P<0.05),M2型巨噬细胞百分比上升(P<0.01),心肌组织中p-DNA-PK、Rictor和Myc蛋白表达显著升高(P<0.05,P<0.01,P<0.0001)。结论电针预处理可能通过调控DNA-PK/Rictor/Myc信号通路,促进巨噬细胞M2极化,减轻局部炎症,减少心肌细胞凋亡,从而提高心功能,实现心肌保护效应。

关键词：心肌梗死电针预处理巨噬细胞极化 DNA-PK Rictor

A Comparative Analysis of English and Chinese News on MH370 Accident from the Appraisal Perspective

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International English Education Research 2017年第2期 108-110页

作者： PAN liyao Zhejiang University Hangzhou 310058 China

Appraisal Theory is a further development of interpersonal function in systemic functional linguistics. Based on the subsystem-attitude system in Appraisal Theory, an attempt is made to conduct a comparative analysis of attitudinal resources in English and Chinese news on MH370 accident. Meanwhile, certain attitudes or stances conveyed by the authors of these news will be revealed through some typical examples. Both quantitative and qualitative methods are adopted in the present study to make a statistical and interpretive analysis of the collected materials. It is found that both English and Chinese news contain many attitudinal resources. There are similarities and differences concerning the distribution of attitudinal resources between English and Chinese news. The findings suggest that though news is expected to be objective and factual, it may imply the authors＇ subjective attitudes to some extent. So readers should get hang of the different opinions and stances hidden behind different news reporting so as to improve abilities to appreciate and differentiate different news.

关键词： Appraisal Theory , attitudinal resources English and Chinese news comparative analysis MH370 accident

P2X7 receptor inhibitor suppressed extracellular ATP/LPS-primed human hepatic stellate cells activation via downregulating NLRP3 inflammasome

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中国药理学与毒理学杂志 2015年第S1期29卷 67-68页

作者： ShuangJIANG QuanJIN Yan-lingWU You-liyao Ji-xingNAN Li-huaLIAN Key Laboratory for Natural Resource of Changbai Mountain &Functional Molecules Ministry of Education College of Pharmacy Yanbian University Yanji 133022 China

OBJECTIVE To investigate the effect of P2X7receptor(P2X7r)inhibition,using a specific inhibitor(A438079)to prevent the development of liver fibrosis on human hepatic stellate cells,*** The supernatant from lipopolysaccharide(LPS)-stimulated RAW264.7 mouse macrophages was supplemented to LX-2 cells for 24 ***-2cells were primed with LPS for 4h and subsequently stimulated for 30 min with 3mmol·L-1 of adenosine 5′-triphosphate(ATP).A438079(10μmol·L-1)was supplemented to LX-2 cells 10 min prior to *** Directly treated with LPS on LX-2 cells,mRNA expressions of IL-1β,IL-18 and IL-6 were increased,as well as P2X7 *** caspase-1,ASC and NLRP3 mRNA expressions were increased with LPS *** stimulation also increasedα-SMA and collagenⅠ mRNA *** treatment of LX-2cells with mediums from LPS-primed RAW264.7mouse macrophages exhibited greater increase of mRNA expressions of above genes than those in LX-2directly treated with *** of directly or indirectly LPS-stimulated LX-2 cells with A438079 both suppressed IL-1βmRNA *** addition treatment of LPS-primed LX-2 cells with 3mmol·L-1 ATP induced the significant increase of IL-1β,IL-6,caspase-1,pannexin-1,α-SMA and collagenⅠ mRNA expression,the increasing ofα-SMA protein expression and cleavage of IL-1β.These events were significantly suppressed by pretreatment with P2X7 rantagonist A438079.P2X7 rblockade also significantly reduced the protein expression ofα-*** Our results suggest that the involvement of the P2X7r-NLRP3 inflammasome pathway in the secretion of IL-1βfrom extracellular ATP/LPS-stimulated human hepatic stellate *** study demonstrated that repression of the P2X7 rrepresents a novel potential therapeutic approach to control liver fibrosis.

关键词： liver fibrosis hepatic stellate cells P2X7receptor

Recent Advances in Molecular Design of Organic Thermoelectric Materials

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CCS Chemistry 2021年第10期3卷 2212-2225页

作者： Dongyang Wang liyao Liu Xike Gao Chong-an Di Daoben Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

Organic thermoelectric(OTE)materials have gained widespread attention because of their potential for wearable power generators and solid cooling ***,the development of state-ofthe-art OTE materials still suffers from limited molecular categories because of the rarity ofmolecular design strategies,which limits further development of this emerging ***,many efforts have been devoted to developing molecular design concepts for high performance OTE materials.

关键词： organic thermoelectric material structure-property relationship conjugated backbone side chain organic semiconductors

High throughput screening of single atomic catalysts with optimized local structures for the electrochemical oxygen reduction by machine learning

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Journal of Energy Chemistry 2023年第6期81卷 349-357,I0009页

作者： Hao Sun Yizhe Li liyao Gao Mengyao Chang Xiangrong Jin Boyuan Li Qingzhen Xu Wen Liu Mingyue Zhou Xiaoming Sun State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Single atomic catalysts(SACs),especially metal-nitrogen doped carbon(M-NC)catalysts,have been extensively explored for the electrochemical oxygen reduction reaction(ORR),owing to their high activity and atomic utilization ***,there is still a lack of systematic screening and optimization of local structures surrounding active centers of SACs for ORR as the local coordination has an essential impact on their electronic structures and catalytic ***,we systematic study the ORR catalytic performance of M-NC SACs with different central metals and environmental atoms in the first and second coordination sphere by using density functional theory(DFT)calculation and machine learning(ML).The geometric and electronic informed overpotential model(GEIOM)based on random forest algorithm showed the highest accuracy,and its R^(2) and root mean square errors(RMSE)were 0.96 and 0.21,respectively.30 potential high-performance catalysts were screened out by GEIOM,and the RMSE of the predicted result was only 0.12 *** work not only helps us fast screen high-performance catalysts,but also provides a low-cost way to improve the accuracy of ML models.

关键词： Single atomic catalysts Coordination sphere High throughput screening Machine learning Oxygen reduction reaction

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基于多源遥感数据的湖泊水体演变研究

测绘与空间地理信息 2024年第3期47卷 32-35页

作者：陈楚楚刘浩彭丽瑶滕飞宇曾平平天津城建大学地质与测绘学院天津300384

以天津市静海区的团泊湖为研究对象,基于Landsat TM、OLI遥感数据,采用MNDWI指数提取湖泊水体,获得湖泊水体信息;根据土地利用类型转移矩阵和土地类型动态度这两种方法来分析土地利用类型的演变特征。结果表明,1995—2020年总体上湖泊... 详细信息

以天津市静海区的团泊湖为研究对象,基于Landsat TM、OLI遥感数据,采用MNDWI指数提取湖泊水体,获得湖泊水体信息;根据土地利用类型转移矩阵和土地类型动态度这两种方法来分析土地利用类型的演变特征。结果表明,1995—2020年总体上湖泊水体面积减少。在1995—2020年这段时间内,城镇类型的土地面积增长最大,水体面积变化最小。植被面积减少较大,其中大部分转为城镇,少量转为水体。水体面积变化相对比较稳定,没有太大波动。

关键词： RS GIS 湖泊 MNDWI