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食管鳞状细胞癌壁内转移的研究进展

肿瘤防治研究 2021年第2期48卷 191-195页

作者：程娜李卫华薛丽燕国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科北京100021

壁内转移是发生在消化道的原发肿瘤通过管壁内的淋巴管网转移至消化道其它部位所形成的与肿瘤原发灶不相连的转移灶,可发生在食管癌、胃癌和结直肠癌中,尤其在食管癌中高发。将组织学形态评估及分子病理手段相结合可辅助鉴别食管癌壁内... 详细信息

壁内转移是发生在消化道的原发肿瘤通过管壁内的淋巴管网转移至消化道其它部位所形成的与肿瘤原发灶不相连的转移灶,可发生在食管癌、胃癌和结直肠癌中,尤其在食管癌中高发。将组织学形态评估及分子病理手段相结合可辅助鉴别食管癌壁内转移灶及多原发灶。伴有壁内转移的食管鳞癌患者预后更差,同时是否伴有壁内转移影响治疗方式的选择。本文综述了食管鳞状细胞癌壁内转移的解剖及组织学基础、壁内转移及多原发灶的鉴别要点、壁内转移的临床病理特征、治疗和预后以及如何提高壁内转移的检出率,以指导精准诊治。

关键词：食管癌壁内转移多原发灶临床病理特征

Mechanisms behind the surprising observation of supra-thermal ions in NIF’s fusion burning plasmas

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Science Bulletin 2025年第3期70卷 359-364页

作者： Yuhan xue Dong Wu Jie Zhang Key Laboratory for Laser Plasmas and Department of Physics and Astronomy Collaborative Innovation Center of IFSA(CICIFSA)Shanghai Jiao Tong UniversityShanghai 200240China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Although ignition had been achieved at the National Ignition Facility(NIF),recent observations of the experiments indicate novel physics that beyond theoretical predictions emerge,e.g.,the neutron analysis of experiments has revealed deviations from the Maxwellian distributions in ion relative kinetic energies of burning plasmas,with the surprising emergence of supra-thermal deuterium and tritium(DT)ions that fall outside the predictions of macroscopic statistical hydrodynamic *** our newly developed hybrid-particle-in-cell code,incorporating the newly-proposed model of large-angle collisions,we infer that that this could be attributed to the increased significance of large-angle collisions among DT ions andα-particles in the burning *** and unprecedented kinetic investigations into the implications of large-angle collisions in the burning plasma have yielded several key findings,including an ignition moment promotion by~10 ps,the presence of supra-thermal ions below an energy threshold,and approximately twice the expected deposition ofα-particles *** rationality of our findings is confirmed through the congruency between the neutron spectral moment analyses conducted by the NIF and our kinetic simulations,both highlighting progressively widening disparities between neutron spectral moment analyses and hydrodynamics predictions,which becomes more pronounced as the yield *** kinetic simulations with large-angle collisions not only provide novel insights for experiment interpretation but also open new research opportunities for the largely unexplored regime of the nuclear burning plasmas,which are distinguished by their exceptionally high energy densities and hold immense potential for illuminating the intricate physics that underpins the evolution of the early universe.

关键词： lon kinetics Supra-thermal ions Large-angle collisions Non-equilibrium ignition Inertial confinement fusion Burning plasmas

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毛梾全光照喷雾嫩枝扦插繁殖试验

东北林业大学学报 2012年第11期40卷 10-13,18页

作者：薛利艳康永祥张丹苏悦西北农林科技大学杨凌712100

在全光照喷雾条件下,通过正交试验L16(45)研究了植物激素种类、处理时间、激素质量浓度、扦插基质以及插穗长度对毛梾嫩枝扦插的影响。结果表明:5个因子中除了插穗长度对生根指数的影响为显著外,其他因子对生根效果都有极显著的影响作用... 详细信息

在全光照喷雾条件下,通过正交试验L16(45)研究了植物激素种类、处理时间、激素质量浓度、扦插基质以及插穗长度对毛梾嫩枝扦插的影响。结果表明:5个因子中除了插穗长度对生根指数的影响为显著外,其他因子对生根效果都有极显著的影响作用,各因子的主次效应为:处理时间>激素种类>扦插基质>激素质量浓度>插穗长度。在全光照喷雾条件下,本次试验毛梾嫩枝扦插最佳组合为:选用16 cm长的插穗,用100 mg/L NAA浸泡1 h,扦插基质为河沙。毛梾嫩枝扦插以皮部生根为主,属于皮部生根类型。

关键词：毛梾全光照喷雾嫩枝扦插生根指数

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稀土选矿药剂研究现状及展望

化学进展 2024年第5期36卷 741-756页

作者：谢美英杨帆薛丽燕王凯先江正明李亚祝白云鄂博稀土资源研究与综合利用全国重点实验室包头稀土研究院福建省清洁核能系统燃料与材料联合重点实验室中国科学院福建物质结构研究所厦门市稀土光电功能材料重点实验室厦门稀土材料研究所中稀(成都)稀土新材料科技有限公司

稀土拥有一系列优异的物理化学性质，在众多领域均有重要应用，是中国、美国、日本、澳大利亚等众多国家公认的关键矿产资源。然而稀土矿物种类繁多、品位低，常与性质相似的脉石矿物紧密共生，其选矿富集很大程度依赖于稀土选矿药剂的... 详细信息

稀土拥有一系列优异的物理化学性质，在众多领域均有重要应用，是中国、美国、日本、澳大利亚等众多国家公认的关键矿产资源。然而稀土矿物种类繁多、品位低，常与性质相似的脉石矿物紧密共生，其选矿富集很大程度依赖于稀土选矿药剂的发展。本文以稀土资源高效选矿富集为导向，总结了矿物型稀土矿浮选药剂，含捕收剂、抑制剂、活化剂、起泡剂的研发现状及其浮选作用机理，概述了离子型稀土矿化学选矿试剂，含浸出剂、沉淀剂的研究现状及其浸矿机理，并总结和评价了当前稀土浮选捕收剂现状，最后分析了未来稀土选矿药剂的研究方向。本综述将为从事稀土选矿和分离富集技术研究或相关药剂研发的企业和工作人员提供参考。

关键词：稀土选矿浮选药剂浸出剂沉淀剂

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

PbrMYB4,a R2R3-MYB protein,regulates pear stone cell lignification through activation of lignin biosynthesis genes

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Horticultural Plant Journal 2025年第1期11卷 105-122页

作者： Dongliang Liu Yongsong xue Runze Wang Bobo Song Cheng xue Yanfei Shan Zhaolong xue Jun Wu College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjingJiangsu 210095China Anhui Provincial Key Laboratoryof Horticultural Crop Quality Biology Schoolof HorticultureAnhui Agricultural UniversityHefeiAnhui 230036 China State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai'anShandong 271018China

Pear(Pyrus bretschneideri)fruit stone cells are primarily composed of lignin and have strongly lignified cell *** presence of stone cells has a negative influence on fruit texture and taste,and thus the reduction of stone cell content in pear fruit is a key goal of breeding ***,research into the key transcription factors and regulatory networks associated with pear fruit stone cell formation have been *** here used a combination of co-expression network and expression quantitative trait locus(eQTL)analyses in 206 pear cultivars with different stone cell contents to identify relevant genes;these analyses uncovered the gene PbrMYB4,a R2R3 MYB transcription factor *** was a strong positive correlation between relative PbrMYB4 expression levels in the fruit flesh and stone cell/lignin *** of PbrMYB4 significantly increased the lignin contents,whereas silencing of PbrMYB4 had the opposite effect,decreasing the contents of ***4 overexpression in pear calli significantly promoted lignin *** Arabidopsis thaliana,PbrMYB4 overexpression resulted in increasing lignin deposition,cell wall thickness of vessels and xylary fiber,and accelerating expression level of lignin biosynthetic ***4 was found to activate 4-Coumarate:Coenzyme A Ligase(Pbr4CL1)by binding to AC-I elements in the promoter regions,as demonstrated with dual-luciferase reporter assays and a yeast one-hybrid *** results demonstrated that PbrMYB4 positively regulated lignin biosynthesis in pear fruit stone cells by activating lignin biosynthesis *** study improves our understanding of the gene regulatory networks associated with stone cell formation in pear fruit,providing guidance for molecular breeding of pear varieties with low stone cell content.

关键词： Pear Stone cell R2R3-MYBs Lignin

多种肿瘤标志物在肺腺癌中的表达及预后意义的研究

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中国肺癌杂志 2014年第3期17卷 243-253页

作者：杨欣薛丽燕郭蕾温芃林冬梅北京协和医学院中国医学科学院肿瘤医院病理科北京100021

背景与目的肺腺癌是最常见的肺癌组织学类型,发病率呈上升趋势。本研究旨在探讨Napsin A、TTF-1、ERCC1、RRM1、EGFR、HER2、ERα、ERβ、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建... 详细信息

背景与目的肺腺癌是最常见的肺癌组织学类型,发病率呈上升趋势。本研究旨在探讨Napsin A、TTF-1、ERCC1、RRM1、EGFR、HER2、ERα、ERβ、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建组织芯片。采用免疫组化方法检测10种靶蛋白标记物在肺腺癌中的表达,分析各蛋白表达与患者临床病理特征和预后的关系。结果 10种蛋白中仅Napsin A蛋白表达与性别有关(P=0.049);Napsin A、PR和EGFR蛋白表达与吸烟有关,TTF-1和ERCC1蛋白表达与肿瘤大小有关,Napsin A、TTF-1、ERα和PR蛋白表达与肿瘤分化程度有关,TTF-1、Bcl-2和ERCC1蛋白表达与病理分期有关(P0.05)。单因素生存分析显示,Napsin A、TTF-1和ERCC1蛋白表达与患者总生存相关;TTF-1蛋白表达与患者无病生存相关(P0.05)。经多因素生存分析,仅病理分期与患者总生存和无病生存相关(P0.05)。结论 Napsin A、TTF-1和ERCC1蛋白可能是提示肺腺癌患者预后较好的标记物。

关键词：组织芯片免疫组化肺肿瘤预后

Perspectives on additive manufacturing for warhead applications

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Defence Technology(防务技术) 2025年第1期43卷 225-251页

作者： Hao xue Qiang Zhou Chuan Xiao Guangyan Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Ordnance Science and Research Academy of China Beijing 100089China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

According to different damage modes,warheads are roughly divided into three types:fragmentation warheads,shaped charge warheads,and penetrating *** to limitations in material and structural manufacturing,traditional manufacturing methods make it difficult to fully utilize the damage ability of the *** manufacturing(AM)technology can fabricate complex structures,with classified materials composition and customized components,while achieving low cost,high accuracy,and rapid production of the *** maturity of AM technology has brought about a new round of revolution in the field of *** this paper,we first review the principles,classifications,and characteristics of different AM *** development trends of AM technologies are pointed out,including multi-material AM technology,hybrid AM technology,and smart AM *** our survey,PBF,DED,and EBM technologies are mainly used to manufacture warhead damage *** and DIW technologies are mainly used to manufacture warhead ***,the research on the application of AM technology in three types of warhead and warhead charges was reviewed and the existing problems and progress of AM technologies in each warhead were ***,we summarized the typical applications and look forward to the application prospects of AM technology in the field of warheads.

关键词： Additive manufacturing Fragmentation warhead Shaped charge warhead Penetrating warhead Warhead charge

Oxygen atmosphere enhances ball milling remediation of petroleum-contaminated soil and reuse as adsorptive/catalytic materials for wastewater treatment

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Journal of Environmental Sciences 2025年第1期147卷 652-664页

作者： Pingting Gao Simin Song Mingxin Wang Meng Yao Jinjuan xue School of Environmental Science and Engineering Changzhou UniversityChangzhou 213164China Jiangsu Petrochemical Safety and Environmental Protection Engineering Research Center Changzhou 213164China

Ball milling is an environmentally friendly technology for the remediation of petroleumcontaminated soil(PCS),but the cleanup of organic pollutants requires a long time,and the post-remediation soil needs an economically viable disposal/reuse strategy due to its vast *** present paper develops a ball milling process under oxygen atmosphere to enhance PCS remediation and reuse the obtained carbonized soil(BCS-O)as wastewater treatment *** total petroleum hydrocarbon removal rates by ball milling under vacuum,air,and oxygen atmospheres are 39.83%,55.21%,and 93.84%,*** Langmuir and pseudo second-order models satisfactorily describe the adsorption capacity and behavior of BCS-O for transition *** Cu^(2+),Ni^(2+),and Mn^(2+)adsorbed onto BCS-O were mainly bound to metal carbonates and metal ***,BCS-O can effectively activate persulfate(PDS)oxidation to degrade aniline,while BCS-O loaded with transition metal(BCS-O-Me)shows better activation efficiency and ***-O and BCS-O-Me activated PDS oxidation systems are dominated by^(1)O_(2)oxidation and electron *** main active sites are oxygen-containing functional groups,vacancy defects,and graphitized *** oxygen-containing functional groups and vacancy defects primarily activate PDS to generate^(1)O_(2)and attack *** carbon promotes aniline degradation by accelerating electron *** paper develops an innovative strategy to simultaneously realize efficient remediation of PCS and sequential reuse of the postremediation soil.

关键词： Petroleum-contaminated soil Ball milling Oxygen atmosphere Pyrolysis Resource utilization