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Transcriptional activation of Nlp by estrogen-ERa in breast cancer

Science Bulletin 2017年第21期62卷 1445-1454页

作者： jia li jie chen liyan xue qimin zhan State Key Laboratory of Molecular Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100021China Laboratory of Molecular Oncology Peking University Cancer HospitalBeijing 100142.China Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Estrogen Receptor-a （ERa） is the key transcription factor that regulates cell proliferation and homeosta- sis. In this pathway, estrogen plays an important role in genomic instability and cell cycle regulation pro- cesses and the mechanisms of its action are multifaceted. In this study, we showed that estrogen regulates genomic instability through promoting the expression of Nip, a BRCAl-associated centrosomal protein which is involved in microtubule nucleation, spindle formation, chromosomal missegregation and abnormal cytokinesis. We demonstrated that the expression of Nip is strongly associated with ERa and FOXAI level in clinical breast cancer samples with poor clinical outcomes to breast cancer patients. Addition of estrogen in the ER-positive breast cancer cells resulted in elevation of NLP mRNA. Significantly, we identified that estrogen-ERa is capable of regulating Nlp expression through specifically binding ERa to the proximal region and the Estrogen Responsive Elements （ERE） enhancer in the distal region of NLP gene. Reporter assays demonstrated that estrogen directly activated Nlp promoter. ChIP assay results showed that E2-ERa directly bound to the EREs of Nip. Therefore, overexpression of Nip in breast cancer exhibits a hormone-dependent pattern, and estrogen participates in the regulation of genome instability and cell cycle in breast cancer cells partially through transcriptional activation of NLP gene. Overexpression of Nlp enhances the malignant progression of ERa-positive breast cancer cells in vitro, whereas knockdown of Nip suppresses this biological effects in ERa-positive breast cancer ceils. ERa/NIp axis may serve as a promising target against breast cancer.

关键词： NipBreast cancerEstrogen receptor-or (ERct)1713-Estradiol (E2)Estrogen responsive elements (EREs)Transcriptional activation

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Neodymium and samarium codoped PLZT ferroelectric ceramics for potential betavoltaic nuclear batteries

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Journal of Rare Earths 2023年第10期41卷 1583-1589,I0004页

作者： Zhixiong Song Jizhen Liu liyan xue Zhengming Jiang Fan Yang Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China Fujian Province Joint Innovation Key Laboratory of Fuel and Materials in Clean Nuclear Energy System Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of SciencesXiamen361021China Nuclear Power Institute of China Chengdu610000China Sichuan Jcc Rare Earth Metals New Material Co. Ltd.Chengdu610000China

In this work,neodymium(Nd)and samarium(Sm)codoped lead lanthanum zirconate titanate(PLZT)ceramics were prepared by a high-temperature solid-state *** samples were characterized by X-ray diffraction,scanning electron microscopy and ferroelectric *** earth-doped PLZT ceramics show good phase *** appropriate rare earth element doping amount increases the densities of PLZT ceramics and reduces their resistivities,which is due to the role of rare earth elements in grain ***,the increase in the amount of grain boundaries caused by grain refinement also affects domain ***,with increasing doping concentration,the remnant polarization of PLZT gradually decreases,and the doping of rare earth elements also slightly reduces the band gap of *** irradiation with an X-ray simulated beta source with a particle energy of 10 keV(between the average energies of the beta particles of^3H and^(63)Ni),the ceramic sheets in this work produce current densities of up to 1.38 nA/cm^*** indicates that Nd and Sm codoped PLZT ceramics have a certain potential for application in betavoltaic batteries.

关键词： Betavoltaic battery Rare earths Ferroelectric X-ray

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Novel Sc-doped Bi_(3)TiNbO_(9) ferroelectric nanofibers prepared by electrospinning for visible-light photocatalysis

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Journal of Rare Earths 2023年第3期41卷 365-373,I0002页

作者： Zhixiong Song Shuwen Yu Kaixian Wang Zhengming Jiang liyan xue Fan Yang Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350002China Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of SciencesXiamen 361021China CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Chinese Academy of SciencesXiamen 361021China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341001China

In this work,a novel Sc-doped Bi_(3)TiNbO_(9) ferroelectric nanofiber was first prepared by *** nanofibers are approximately 100 nm level in *** photocatalytic activity analysis reveals that the Bi_(3)TiNbO_(9) nanofibers synthesized by electrospinning are superior to powders prepared by the solid-state method,which is mainly attributed to the high specific surface area and high surface activity of the *** addition,doping Sc can reduce the band gap of Bi_(3)TiNbO_(9) and further improve the photocatalytic ***_(3)TiNbO_(9) nanofibers containing 5 mol%Sc have the highest photocatalytic activity,which can degrade 98.55%of RhB under 405 nm light irradiation for 120 *** addition,the catalytic mechanism of the catalyst was obtained by scavenger tests,active species capture tests and band structure *** three cycles of photocatalytic experiment,the degradation rate is decreased by only 2.42%,proving that the nanofibers catalyst has excellent *** work provides good prospects for the practical application of electrospinning technology in the field of photocatalysis.

关键词： Nanofibers Ferroelectric Scandium Visible-light photocatalysis Rare earths

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RASSF6-TRIM16 axis promotes cell proliferation,migration and invasion in esophageal squamous cell carcinoma

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Journal of Genetics and Genomics 2019年第10期46卷 477-488页

作者： Leilei Zheng Zitong Zhao Lulu Rong liyan xue Yongmei Song State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing W0021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital.Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Ras-association(RA) domain family number 6(RASSF6) is a member of the Ras-association domain protein *** is epigenetically inactive and negatively regulates the malignant progression of some ***,its precise role in esophageal squamous cell carcinoma(ESCC) has not been *** this study,we performed immunohistochemistry(IHC) *** results show that RASSF6 is upregulated in ESCC and that the elevated expression level of RASSF6 is associated with lymph node metastasis and poor survival of ESCC *** with the clinical obse rvations,the upregulation of RASSF6 greatly promotes ESCC cell proliferation,migration and invasion as well as the cell cycle transition to Gl/S phase in *** to models in vivo,the downregulation of RASSF6 considerably inhibits ESCC tumor growth and lung ***,RASSF6 negatively regulates the tumor suppressor tripartite-motif-containing protein 16(TRIM16) by promoting its ubiquitination-dependent degradation and eventually activates pathways associated with the cell cycle and epithelialmesenchymal transition(EMT).Together,these results indicate that the RASSF6-TRIM16 axis is a key effector in ESCC progression and that RASSF6 serves as a potential target for the treatment of ESCC.

关键词： Esophageal squamous cell cancer RASSF6 Cell cycle EMT TRIM16

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A novel(Sm_(0.2)Eu_(0.2)Gd_(0.2)Ho_(0.2)Yb_(0.2))CrO_(3)high-entropy ceramic nanofiber as a negative temperature coefficient thermistor

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Journal of Rare Earths 2024年第10期42卷 1937-1942页

作者： Weijun Zhao Meng Zhang liyan xue Kaixian Wang Fan Yang Jiuping Zhong Heng Chen School of Materials Sun Yat-sen UniversityShenzhen518107China Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of SciencesXiamen361021China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516003China Sichuan Jcc Rare Earth Metals New Material Co. Ltd.Chengdu610000China

The electrical properties of high-entropy ceramics(HECs)have been extensively studied in recent years due to their unique structural characteristics and fascinating functional properties induced by entropy *** high-entropy(Sm_(0.2)Eu_(0.2)Gd_(0.2)Ho_(0.2)Yb_(0.2))CrO_(3)(HE-RECrO_(3))nanofibers were prepared by electro *** work demonstrates that HE-RECrO_(3)nanofibe rs were successfully synthesized at a low temperature(800℃),which is approximately 400℃lower than the temperatures at which chromate ceramics were synthesized via the sol-gel method and the solid-state reaction *** resistivity of HE-RECrO_(3)nanofibers decreases exponentially with increasing temperature from 25 to600℃.The logarithm of the resistivity is linearly related to the inverse of the temperature,confirming the negative temperature coefficient property of HE-RECrO_(3)*** B_(25/50)value of the HERECrO_(3)nanofibers reaches 4072 *** conclusion,HE-RECrO_(3)nanofibers are expected to be potential candidates for negative-temperature-coefficient(NTC)thermistors.

关键词： Rare earths High-entropy ceramics Ceramic fiber materials Negative temperature coefficient thermistors

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Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 208-217页

作者： Lanfang Jiang Zitong Zhao Leilei Zheng liyan xue Qimin Zhan Yongmei Song State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Esophageal squamous cell carcinoma （ESCC） is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of micro- RNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Fur- ther investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpres- sion of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1.

关键词： Esophageal squamous cellcarcinoma miR-503 Cyclin D1 Proliferation Migration and invasion

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High-entropy rare earth stannate ceramics:Acid corrosion resistant radiative cooling materials with high atmospheric transparency window emissivity and high near-infrared solar reflectivity

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Journal of Advanced Ceramics 2024年第5期13卷 630-640页

作者： Tao Chen Yanyan He Yanyu Pan Kaixian Wang Minzhong Huang liyan xue Yazhu Li Fan Yang Yanchun Zhou Heng Chen Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In response to the development of the concepts of“carbon neutrality”and“carbon peak”,it is critical to developing materials with high near-infrared(NIR)solar reflectivity and high emissivity in the atmospheric transparency window(ATW;8–13μm)to advance zero energy consumption radiative cooling *** regulate emission and reflection properties,a series of high-entropy rare earth stannate ceramics(HE-RE_(2)Sn_(2)O_(7):(Y_(0.2)La_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Sn_(2)O_(7),(Y_(0.2)La_(0.2)Sm_(0.2)Eu_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7),and(Y_(0.2)La_(0.2)Gd_(0.2)Yb_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7))with severe lattice distortion were prepared using a solid phase reaction followed by a pressureless sintering method for the first *** distortion is accomplished by introducing rare earth elements with different cation radii and *** as-synthesized HE-RE_(2)Sn_(2)O_(7)ceramics possess high ATW emissivity(91.38%–95.41%),high NIR solar reflectivity(92.74%–97.62%),low thermal conductivity(1.080–1.619 W·m^(−1)·K^(−1)),and excellent chemical *** the one hand,the lattice distortion intensifies the asymmetry of the structural unit to cause a notable alteration in the electric dipole moment,ultimately enlarging the ATW *** the other hand,by selecting difficult excitation elements,HE-RE_(2)Sn_(2)O_(7),which has a wide band gap(Eg),exhibits high NIR solar ***,the multi-component design can effectively enhance radiative cooling ability of HE-RE_(2)Sn_(2)O_(7)and provide a novel strategy for developing radiative cooling materials.

关键词： radiative cooling materials high-entropy ceramics(HECs) rare earth stannate(RE_(2)Sn_(2)O_(7)) high atmospheric transparency window emissivity high near-infrared(NIR)solar reflectivity

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ⅢA-ⅡB multicomponent perovskite rare earth ferrites with promising electromagnetic wave absorption properties

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Journal of Rare Earths 2024年第6期42卷 1118-1127,I0005页

作者： Yanyan He Tao Chen Yanyu Pan Minzhong Huang Kaixian Wang liyan xue Yazhu Li Fengzhi Tan Fan Yang Tongkuan Xu Heng Chen School of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalian116034China Xiamen Institute of Rare EarthMaterials Haixi InstitutesChinese Academy of SciencesXiamen36021China Fujian Institute of Research on the Structure of Matter Chinese Academyof SciencesFuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Xiamen Key-Laboratoryof Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou3410ooChina

Perovskite-type rare-earth ferrites(REFeO_(3))are promising materials for absorbing electromagnetic(EM)wave ***,insufficient dielectric loss and poor impedance matching are key factors that limit the broader implementation of REFeO_(3).Herein,a series of multicomponent perovskite-type ferrites with strong EM wave absorption capabilities was *** the synergistic effect of chemical constitution regulation and entropy regulation,optimization of the dielectric loss and impedance matching is achieved by strengthening the structural defect mechanism,thus further adjusting the EM wave absorption *** with(LaGdSmNdBa)FeO_(3)(HE-1)and(LaGdPrSmNdBa)FeO_(3)(HE-2),(LaGdBa)FeO_(3)(ME-1)and(LaGdSmBa)FeO_(3)(ME-2)exhibit favorable performance,with optimal minimum reflection loss(RL_(min))of-56.35 dB(at 11.12 GHz)and-63.25 dB(at 7.22 GHz)and effective absorption bandwidth(EAB)of 4.46 and 4.72 GHz,*** multicomponent design provides a new strategy for the development of EM wave absorption materials.

关键词： Rare earths Multicomponent design Rare earth ferrites Entropy regulation Electromagnetic wave absorption

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Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment

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Signal Transduction and Targeted Therapy 2023年第2期8卷 369-372页

作者： Zitong Zhao liyan xue Leilei Zheng Liying Ma Zhuo Li Ning Lu Qimin Zhan Yongmei Song State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Laboratory of Molecular Oncology Peking University Cancer HospitalBeijingChina

DEAREDITOR,Esophageal squamous cell carcinoma(ESCC)is one of the most common fatal malignancies worldwide and is especially common in East Asian regions,including *** lymph node metastasis(LNM)-related biomarkers and elucidating the mechanism could provide promising therapeutic targets and help ESCC patients to select reasonable individual therapies.

关键词： metastasis squamous esophageal

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Identification of plasma proteomic signatures associated with the progression of cardia gastric cancer and precancerous lesions

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Journal of the National Cancer Center 2023年第4期3卷 286-294页

作者： Jianhua Gu Shuanghua Xie Xinqing Li Zeming Wu liyan xue Shaoming Wang Wenqiang Wei Office of National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanChina Department of Central Laboratory Beijing Obstetrics and Gynecology HospitalCapital Medical University.Beijing Maternal and Child Health Care HospitalBeijingChina iPhenome Biotechnology(Dalian) Inc.DalianChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Considering that there are no effective biomarkers for the screening of cardia gastric cancer(CGC),we developed a noninvasive diagnostic approach,employing data-independent acquisition(DIA)proteomics to identify candidate protein ***:Plasma samples were obtained from 40 subjects,10 each for CGC,cardia high-grade dysplasia(CHGD),cardia low-grade dysplasia(CLGD),and healthy *** profiles were obtained through liquid chromatography-mass spectrometry(LC-MS/MS-based DIA *** plasma proteins were identified by weighted gene co-expression network analysis(WGCNA)combined with machine learning and further validated by the Human Protein Atlas(HPA)*** area under the receiver operating characteristic curve(AUC)was used to evaluate the performance of the biomarker ***:There was a clear distinction in proteomic features among CGC,CHGD,CLGD,and the healthy *** to the WGCNA,we found 42 positively associated and 164 inversely associated proteins related to CGC progression and demonstrated several canonical cancer-associated *** with the results from random forests,LASSO regression,and immunohistochemical results from the HPA database,we identified three candidate proteins(GSTP1,CSRP1,and LY6G6F)that could together distinguish CLGD(AUC=0.91),CHGD(AUC=0.99)and CGC(AUC=0.98)from healthy controls with excellent ***:The panel of protein biomarkers showed promising diagnostic potential for CGC and precancerous *** validation and a larger-scale study are warranted to assess its potential clinical applications,suggesting a potential avenue for CGC prevention in the future.

关键词： Cardia gastric cancer Proteomics Screening Precancerous lesion

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