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The effect of transposable elements on phenotypic variation： insights from plants to humans

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Science China(Life Sciences) 2016年第1期59卷 24-37页

作者： liya wei Xiaofeng Cao State Key Laboratory of Plant Genomics and National Plant Gene Research Center (Beijing) CAS Center for Excellence in Molecular Plant Sciences Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Collaborative Innovation Center of Genetics and Development Fudan University shanghai 200433 China

Transposable elements(TEs), originally discovered in maize as controlling elements, are the main components of most eukaryotic genomes. TEs have been regarded as deleterious genomic parasites due to their ability to undergo massive amplification. However, TEs can regulate gene expression and alter phenotypes. Also, emerging findings demonstrate that TEs can establish and rewire gene regulatory networks by genetic and epigenetic mechanisms. In this review, we summarize the key roles of TEs in fine-tuning the regulation of gene expression leading to phenotypic plasticity in plants and humans, and the implications for adaption and natural selection.

关键词： transposable elements gene expression phenotypic variation

低级别文物保护单位数字化保护修缮及活化利用研究

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建筑施工 2024年第9期46卷 1409-1412页

作者：赵彦韩晓杰卫丽亚上海市园林设计研究总院有限公司上海200000

历史建筑的保护和活化利用是城市更新中的关键环节。针对低级别文物保护在经费和工期的限制下缺乏轻量化、高效率的修缮技术,以及后续难以进一步激活利用的问题,创新出“数字+”全过程赋能文物保护修缮及活化利用的技术体系,包括文保数... 详细信息

历史建筑的保护和活化利用是城市更新中的关键环节。针对低级别文物保护在经费和工期的限制下缺乏轻量化、高效率的修缮技术,以及后续难以进一步激活利用的问题,创新出“数字+”全过程赋能文物保护修缮及活化利用的技术体系,包括文保数字化留存与测绘技术、三维残损分析、修缮工艺模拟、形制施工深化方法、环境提升虚拟设计、展陈数字化设计等。该体系在上海市嘉定区秀野堂修缮及周边环境提升工程中进行了应用,验证了城市更新过程中适宜低级别文物保护的个性化需求,并实现了其新颖有效的数字化活化利用。

关键词：低级别文物保护单位修缮保护活化利用数字化

Epigenetic regulation and epigenomic landscape in rice

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National Science Review 2016年第3期3卷 309-327页

作者： Xian Deng Xianwei Song liya wei Chunyan Liu Xiaofeng Cao State Key Laboratory of Plant Genomics and National Center for Plant Gene Research CAS Center for Excellence in Molecular Plant SciencesInstitute of Genetics and Developmental BiologyChinese Academy of Sciences College of Life Sciences Hebei University

Epigenetic regulation has been implicated in the control of complex agronomic traits in rice(Oryza sativa),a staple food crop and model monocot plant. Recent advances in high-throughput sequencing and the moderately complex genome of rice have made it possible to study epigenetic regulation in rice on a genome-wide scale. This review discusses recent advances in our understanding of epigenetic regulation in rice, with an emphasis on the roles of key epigenetic regulators, the epigenomic landscape, epigenetic variation, transposon repression, and plant development.

关键词： epigenetics DNA methylation histone modification non-coding RNAs transposable element epigenomics rice

An epiallele of rice AK1 affects photosynthetic capacity

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Journal of Integrative Plant Biology 2017年第3期59卷 158-163页

作者： Xiangjin wei Xianwei Song liya wei Shaoqing Tang Jing Sun Peisong Hu Xiaofeng Cao State Key Laboratory of Rice Biology Key Laboratory of Rice Biology and Breeding of Ministry of AgricultureChina National Rice Research InstituteHangzhou 310006China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research CAS Center for Excellence in Molecular Plant SciencesInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Life Sciences Hebei UniversityBaoding O71OO2China

Summary Epigenetic gene variants, termed epialleles, can broaden genetic and phenotypic diversity in eukaryotes. Here, we identify a natural epiallele of OsAK1, which encodes a rice adenylate kinase. The Epiak1 plants... 详细信息

关键词： gene Figure AK An epiallele of rice AK1 affects photosynthetic capacity

Degradome sequencing reveals endogenous small RNA targets in rice (Oryza sativa L. ssp. indica)

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Frontiers in Biology 2010年第1期5卷 67-90页

作者： Ming ZHOU Lianfeng GU Pingchuan LI Xianwei SONG liya wei Zhiyu CHEN Xiaofeng CAO State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Graduate School of the Chinese Academy of Sciences Yuquan RoadBeijing 100039China

MicroRNAs(miRNAs)and small interfering RNAs(siRNAs)regulate gene expression in *** miRNAs modulate their targets mainly via messenger RNA(mRNA)*** RNA(sRNA)targets have been extensively investigated in Arabidopsis using computational prediction,experimental validation,and degradome ***,small RNA targets are largely unknown in rice(Oryza sativa).Here,we report global identification of small RNA targets using high throughput degradome sequencing in the rice indica cultivar 93-11(Oryza sativa ***).One hundred and seventy-seven transcripts targeted by a total of 87 unique miRNAs were *** targets for the conserved miRNAs between Arabidopsis and rice,transcription factors comprise around 70%(58 in 82),indicating that these miRNAs act as masters of gene regulatory nodes in *** contrast,non-conserved miRNAs targeted diverse genes which provide more complex regulatory *** addition,5 AUXIN RESPONSE FACTORs(ARFs)cleaved by the TAS3 derived ta-siRNAs were also detected.A total of 40 sRNA targets were further validated via RNA ligasemediated 5′rapid amplification of cDNA ends(RLM 5′-RACE).Our degradome results present a detailed sRNAtarget interaction atlas,which provides a guide for the study of the roles of sRNAs and their targets in rice.

关键词： Degradome miRNA ta-siRNA small RNA targets rice

Preparation of Aluminium Oxynitride by Carbothermal Reduction of Aluminium Oxide in a Flowing N2 Atmosphere

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China's Refractories 1996年第1期5卷 24-29页

作者： liya－wei YUANRun－zhang 等 WuhanUniversityofMetallurgicalScienceandTechnology Wuhan430081China WuhanUniversityofTechnology Wuha

Carbothermal reduction of alumina into aluminium oxynitride(AlON) spinel in a flowing nitrogen atmosphere was *** effects of Al2O3/C ratio temperature,soaking time,heating rate molding pressure of samples,and nitrogen flow rate on reactions were *** the stability of AlON was elucidated and AlON wa confirmed as an intermediate compound in reduction of alumina.

关键词：制备氧氮化铝三氧化二铝氮气碳热还原反应耐火材料尖晶石结构

Effects of Processing Parameters on Carbothermal Reduction Synthesis of Aluminium Nitride

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China's Refractories 1995年第3期4卷 19-24页

作者： liya－wei YUANRun－zhang 等 InstituteofMaterialsScienceandEngineering WYUSTWuhan430081 AdvancedMaterialsInstitute WuhanUniversit

The reduction of carbon/alumina powder mixture in a flowing nitrogen stream was inve-tigated by the quantitiative analysis of X-ray *** results indicated that the reaction rate could be increased by increasing the nitrogen flow rate ,or treating temperature,The rate was also found to be increased by decreasing the alumina particle size and initial bulk density,And the calcined alumina was sup-posed to be the suitable source of aluminum ox-ide compared with the other types of *** final powder product of AlN was observed by SEM and analyzed by a prticle-size analyzer.

关键词：加工参数氮化铝用碳高温还原合成 ALN 耐火材料

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中国蝗虫学研究60年

植物保护学报 2022年第1期49卷 4-16页

作者：康乐魏丽亚河北大学生命科学学院保定071002 中国科学院动物研究所北京100101

蝗虫灾害是人类历史上三大自然灾害之一,对农牧业、环境和经济构成严重威胁。我国是世界上遭受蝗灾最严重的国家之一,有关蝗虫学的研究有较长的历史。60年前,通过改治结合,我国控制了大规模的飞蝗Locusta migratoria蝗灾发生,取得了举... 详细信息

蝗虫灾害是人类历史上三大自然灾害之一,对农牧业、环境和经济构成严重威胁。我国是世界上遭受蝗灾最严重的国家之一,有关蝗虫学的研究有较长的历史。60年前,通过改治结合,我国控制了大规模的飞蝗Locusta migratoria蝗灾发生,取得了举世瞩目的成就。60年过去了,中国蝗虫学研究发生了翻天覆地的变化。该文主要综述了最近60年中国蝗虫学研究的发现与创新,展示蝗虫分类学、生态学、生殖与发育生物学、分子生物学、基因组学研究以及蝗虫控制技术研究等多个方面的成就。这些研究成果是世界昆虫学研究的重要组成部分。特别是近30年,我国科学家深入揭示蝗虫两型转变的遗传和表观遗传机制,在国际上产生了重要影响。飞蝗的综合生物学研究积累使飞蝗成为继果蝇之后又一个昆虫模式系统。更重要的是,我国科学家开发的真菌生物农药和群聚信息素可以作为重要的防治手段用于蝗灾的治理。

关键词：蝗灾型变信息素生态适应调控机制

Autologous hematopoietic stem cell transplantation and conventional insulin therapy in the treatment of children with newly diagnosed type I diabetes： long term follow-up

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Chinese Medical Journal 2014年第14期127卷 2618-2622页

作者： Gu Yi Gong Chunxiu Peng Xiaoxia wei liya Su Chang Qin Miao Wang Xi'ou Department of Endocrinology Genetics and Metabolism Beijing Children's Hospital Capital Medical University Beijing 100045 China Center of Clinical Epidemiology and Evidence Based Medicine Beijing Children's Hospital Capital Medical University Beijing 100045 China

Background It has been indicated that autologous hematopoietic stem cell transplantation （AHST） is a promising treatment to adults with type 1 diabetes, however, the application of AHST therapy to children with type 1 diabetes still needs more data. The aim of this study was to assess the clinical effect of immune intervention combined with AHST and conventional insulin therapy in the treatment of children with newly diagnosed type 1 diabetes. Methods This 1：2 matched case-control study was comprised of 42 children who were newly diagnosed with type 1 diabetes in the Department of Endocrinology, Beijing Children＇s Hospital from 2009-2010. The case group included 14 patients, who were treated with AHST within the first 3 months after being diagnosed with diabetes at request of their parents during 2009-2010. The control group included 28 patients with newly diagnosed type 1 diabetes at the same period of hospitalization. We compared the baseline and follow-up data of them, including ketoacidosis onset, clinical variables （glycosylated hemoglobin （HbAlc）, insulin dosage and serum C-peptide）. Results The clinical characteristics of the patients was comparable between the case group and the control group. At 6-12 months （（10.7±4.2） months） after AHST treatment, we found 11 patients in the case group did not stop the insulin therapy, three cases stopped insulin treatment for 2, 3 and 11 months, respectively. No diabetic ketoacidosis （DKA） occurred after transplantation in all the patients in the case group. HbAlc in the control group was significant lower than that in the case group （P 〈0.01）, while the insulin dosage and serum C-peptide were not significant different between the two groups （P 〉0.05）. In order to eliminate the honeymoon effect, we performed final follow-up at the 3-5 years （（4.2±1.8） years） after AHST treatment, and found that HbAlc in the control group was still lower than that in the case group （P 〈0.01）; however, the insulin dosage and serum C-peptide

关键词： autologous hematopoietic stem cell transplantation insulin therapy children type 1 diabetes