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Association between body mass index and in vitro fertilization/intra-cytoplasmic sperm injection outcomes:An analysis of 15,124 normal ovarian responders in China

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Chinese Medical Journal 2024年第7期137卷 837-845页

作者： Danlei Zheng Yuanyuan Wang lixue chen Lin Zeng Rong Li Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China

Background:High body mass index(BMI)results in decreased fecundity,and women with high BMI have reduced rates of clinical pregnancy and live birth in in vitro fertilization/intra-cytoplasmic sperm injection(IVF/ICSI).Meanwhile,ovarian responses show great heterogeneity in patients with a high *** study aimed to analyze the effects of a high BMI on IVF/ICSI outcomes in the Chinese female with normal ovarian ***:We performed a retrospective cohort study comprising 15,124 patients from the medical record system of the Reproductive Center of Peking University Third Hospital,with 3530(23.3%)in the overweight group and 1380(9.1%)in the obese group,who had a normal ovarian response(5-15 oocytes retrieved)and underwent fresh embryo transfer(ET)cycles from January 2017 to December 2018,followed by linked frozen-thawed embryo transfer(FET)cycles from January 2017 to December *** live birth rate(CLBR)was used as the primary ***,a generalized additive model was applied to visually illustrate the curvilinear relationship between BMI and the *** used a decision tree to identify the specific population where high BMI had the greatest effect on IVF/ICSI ***:High BMI was associated with poor IVF/ICSI outcomes,both in cumulative cycles and in separate fresh ET or FET *** cumulative cycles,compared with the normal weight group,obesity was correlated with a lower positive pregnancy test rate(adjusted odds ratio[aOR]:0.809,95%confidence interval[CI]:0.682-0.960),lower clinical pregnancy rate(aOR:0.766,95%CI:0.646-0.907),lower live birth rate(aOR:0.706,95%CI:0.595-0.838),higher cesarean section rate(aOR:2.066,95%CI:1.533-2.785),and higher rate of large for gestational age(aOR:2.273,95%CI:1.547-3.341).In the generalized additive model,we found that CLBR declined with increasing BMI,with 24 kg/m^(2)as an inflection *** the decision tree,BMI only made a difference in the population aged≤34.5 years,with anti-Muller

关键词： Obesity Body mass index fertilization Live birth Decision trees Normal ovarian response

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Associations between thyroid function and autoimmunity indicators and in vitro fertilization/intracytoplasmic sperm injection outcomes in euthyroid PCOS women

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中华医学杂志(英文版) 2024年第16期137卷 2024 Apr 17页

作者： Jiang Huahua chen lixue Huang Ning Shi Huifeng Chi Hongbin Yang Rui Long Xiaoyu Qiao Jie Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Beijing China National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Beijing China Key Laboratory of Assisted Reproduction Peking University Ministry of Education Beijing China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing China Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China National Centre for Healthcare Quality Management in Obstetrics Beijing China Beijing Advanced Innovation Center for Genomics Peking University Beijing China Peking-Tsinghua Center for Life Sciences Peking University Beijing China

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基于高温超导的高精度电压互感器研究

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电测与仪表 2024年第4期61卷 48-55页

作者：刘浩刁赢龙何莹辉陈立学李小飞杨洪中国电力科学研究院有限公司武汉430074 华中科技大学电气与电子工程学院武汉430074

电压互感器的励磁误差由励磁电流在电压互感器绕组上的压降产生,是电压互感器误差的主要来源。双级励磁技术可以有效降低电压互感器的励磁电流,但绕组阻抗始终无法消除,励磁误差仍然存在。文中将77 K高温超导技术应用于电压互感器,绕组... 详细信息

电压互感器的励磁误差由励磁电流在电压互感器绕组上的压降产生,是电压互感器误差的主要来源。双级励磁技术可以有效降低电压互感器的励磁电流,但绕组阻抗始终无法消除,励磁误差仍然存在。文中将77 K高温超导技术应用于电压互感器,绕组和互感器铁心均工作在高温超导环境,达到超导态时绕组的阻抗为零,励磁电流经过绕组引起的压降也为零,可以从根本上消除励磁误差。分析了高温超导下的铜损和铁心磁性能,重点针对铁心的磁滞和涡流损耗进行了理论分析并提出抑制措施,设计了一台变比为1 kV/10 V的电压互感器的铁心和绕组结构,研制了高温超导电压互感器样机,设计了低温杜瓦容器及其外部冷屏设计,减小热量损失温度场,开展温度场仿真分析温度分布梯度。最后开展了误差校准,校准结果表明,该样机在20%~120%额定电压范围内,比值误差优于4×10-6,相位误差优于5μrad,比常温电压互感器的误差减小一个数量级。77 K高温超导电压互感器对于提升电压互感器的精度具有重要意义,同时也可为更高电压等级的超导互感器研制提供理论支撑。

关键词：电压互感器高温超导精密测量

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Impact of vaccination against COVID-19 on the outcomes of in vitro fertilization–embryo transfer:a retrospective cohort study

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Chinese Medical Journal 2023年第2期136卷 207-212页

作者： Jingwen Yin Yang Wang Liyuan Tao lixue chen Ping Liu Rong Li Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital) Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China

Background: Vaccination against coronavirus disease 2019 (COVID-19) has become the primary approach in the fight against the spread of COVID-19. Studies have shown that vaccination against COVID-19 has adverse effects, particularly on human reproductive health, despite the fact that vaccination rates are still on the rise. However, few studies have reported whether vaccination affects the outcome of in vitro fertilization-embryo transfer (IVF-ET) or not. In this study, we compared the outcome of IVF-ET and the development of follicles and embryos between vaccinated and unvaccinated groups. Methods: A single-center retrospective cohort study of 10,541 in vitro fertilization (IVF) cycles was conducted from June 2020 to August 2021. 835 IVF cycles with a history of vaccination against COVID-19 and 1670 IVF cycles that served as negative controls were selected and analyzed utilizing the Matchlt package of R software (http://***/) and the nearest neighbor matching algorithm for propensity-matched analysis at a 1:2 ratio. Results: The number of oocytes collected in the vaccinated group and the unvaccinated group were 8.00 (0, 40.00) and 9.00 (0, 77.00) ( P = 0.073) and the good-quality embryo rates of the two groups were 0.56±0.32 and 0.56±0.31 averagely ( P = 0.964). Clinical pregnancy rates for the vaccinated group and unvaccinated group were 42.4% (155/366) and 40.2% (328/816) ( P = 0.486) and biochemical pregnancy rates were 7.1% (26/366) and 8.7% (71/816) ( P = 0.355). Two other factors were analyzed in this study;vaccination among different genders and different types (inactivated vaccine or recombinant adenovirus vaccine) showed no statistically significant effect on the above outcomes. Conclusions: In our findings, vaccination against COVID-19 showed no statistically significant effect on the outcomes of IVF-ET and the development of follicles and embryos, nor did the gender of the vaccinated person or the formulation of vaccines show significant eff

关键词： Assisted reproductive treatment COVID-19 Embryo development Pregnancy outcome Vaccination

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Improvement of antibacterial, anti-inflammatory, and osteogenic properties of OGP loaded Co-MOF coating on titanium implants for advanced osseointegration

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Journal of Materials Science & Technology 2023年第15期146卷 131-144页

作者： Bailong Tao Weiwei Yi Xian Qin Junjie Wu Kai Li Ai Guo Jie Hao lixue chen Laboratory Research Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Rehabilitation Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Obstetrics and Gynecology Chongqing Health Center for Women and ChildrenChongqing 401147China Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400016Chin

The bacterial infection,especially for methicillin-resistant Staphylococcus aureus(MRSA),and the associated severe inflammatory response could extremely limit the crosstalk of RAW264.7 cells and mesenchymal stem cells(MSCs)and lead to the undesirable osseointegration of peri–*** is highly demanded to modify the surface of titanium(Ti)implant to improve its anti-bacterial and anti-inflammatory properties and facilitate its disabled ***,in our study,a multifunctional coating of zeolitic imidazolate frameworks-67 encapsulated osteogenic growth peptide(OGP)(ZO)was fabricated on titanium dioxide nanotubes(TNT)substrates(TNT-ZO)via the electrophoresis deposition(EPD)*** TNT-ZO substrates exhibited excellent antibacterial activity indicated by the reactive oxygen species(ROS)generation,outer membrane(OM)and inner membrane(IM)permeabilization change,adenosine triphosphate(ATP)decrease,and intracellular compounds(DNA/RNA)***,the regulation effects of TNT-ZO coating modified titanium substrates on the RAW264.7-MSCs crosstalk could induce the anti-inflammatory and osteogenic microenvironment via multiple paracrine signaling of Runx2,BMP2,VEGF,and TGF-β*** promoted effects of coating structure were investigated in vivo,including antibacterial effect,osteogenic differentiation of mesenchymal stem cells,and anti-inflammation of RAW264.7 cells,as well as infected bone regeneration and repair in bone defect transplantation *** results demonstrated that MRSA was effectively eliminated by the hydrolysis of ZIF-67 nanoparticles on TNT-ZO ***,the excellent osseointegration of peri–implants was realized simultaneously by modulating the crosstalk of *** study could provide a novel approach to designing a multifunctional coating on the Ti implants for infected bone regeneration in orthopedic applications.

关键词： Titanium implants Osteogenic growth peptide Anti-inflammatory Antibacterial activity Osteoimmunomodulation

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Compositional and Hollow Engineering of Silicon Carbide/Carbon Microspheres as High-Performance Microwave Absorbing Materials with Good Environmental Tolerance

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Nano-Micro Letters 2024年第9期16卷 128-146页

作者： lixue Gai Yahui Wang Pan Wan Shuping Yu Yongzheng chen Xijiang Han Ping Xu Yunchen Du MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China Anhui Provincial Laboratory of Advanced Laser Technology College of Electronic EngineeringNational University of Defense TechnologyHefei 230037People’s Republic of China

Microwave absorbing materials(MAMs)characterized by high absorption efficiency and good environmental tolerance are highly desirable in practical *** silicon carbide and carbon are considered as stable MAMs under some rigorous conditions,while their composites still fail to produce satisfactory microwave absorption performance regardless of the improvements as compared with the ***,we have successfully implemented compositional and structural engineering to fabricate hollow Si C/C microspheres with controllable *** simultaneous modulation on dielectric properties and impedance matching can be easily achieved as the change in the composition of these *** formation of hollow structure not only favors lightweight feature,but also generates considerable contribution to microwave attenuation *** the synergistic effect of composition and structure,the optimized SiC/C composite exhibits excellent performance,whose the strongest reflection loss intensity and broadest effective absorption reach-60.8 dB and 5.1 GHz,respectively,and its microwave absorption properties are actually superior to those of most SiC/C composites in previous *** addition,the stability tests of microwave absorption capacity after exposure to harsh conditions and Radar Cross Section simulation data demonstrate that hollow SiC/C microspheres from compositional and structural optimization have a bright prospect in practical applications.

关键词： SiC/C composites Compositional engineering Hollow engineering Microwave absorption Environmental tolerance

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经颅彩色多普勒超声(TCCS)结合旋颈试验评估针刀治疗椎动脉型颈椎病的临床价值

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首都食品与医药 2024年第1期31卷 47-49页

作者：彭恭顺钟伟祝丽松范凌燕王宪瑞吴翠萍陈丽雪江西省赣州市南康区中医院江西赣州341400

目的探讨经颅彩色多普勒超声(TCCS)结合旋颈试验评估针刀治疗椎动脉型颈椎病(CSA)的临床价值。方法选取赣州市南康区中医院针灸康复科收治的60例CSA患者作为研究对象,通过TCCS结合旋颈试验观察经针刀治疗14天前后双侧椎动脉及基底动脉... 详细信息

目的探讨经颅彩色多普勒超声(TCCS)结合旋颈试验评估针刀治疗椎动脉型颈椎病(CSA)的临床价值。方法选取赣州市南康区中医院针灸康复科收治的60例CSA患者作为研究对象,通过TCCS结合旋颈试验观察经针刀治疗14天前后双侧椎动脉及基底动脉的收缩期流速(Vp)、舒张期流速(Vd)、平均速度(Vm)、搏动指数(PI)的血流参数变化,评估针刀治疗椎动脉型颈椎病的疗效及TCCS的临床价值。结果治疗14天后,CSA患者左侧椎动脉(LVA)的Vp、Vd、Vm与治疗前相比均升高,PI与治疗前相比降低,差异有统计学意义(P<0.05);治疗14天后,CSA患者右侧椎动脉(RVA)的Vp、Vd、Vm与治疗前相比均升高,PI与治疗前相比降低,差异有统计学意义(P<0.05);治疗14天后,CSA患者基底动脉(BA)的Vp、Vd、Vm与治疗前相比均升高,PI与治疗前相比降低,差异有统计学意义(P<0.05);治疗前,60例CSA患者旋颈试验均为阳性,治疗14天后,CSA患者旋颈试验阳性33例,与治疗前比较,差异有统计学意义(P<0.05)。结论采用TCCS评估针刀治疗CSA患者可以直观地识别颅内血管,动态观察颅内血管的走行及血流充盈情况,结合旋颈试验可以更准确地获得椎-基底动脉系统的血流动力学改变信息。

关键词：椎动脉型颈椎病经颅彩色多普勒超声旋颈试验针刀

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重复垂钓对鲫幼鱼易钓性和能量代谢及个性的影响

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生态学报 2023年第6期43卷 2228-2241页

作者：陈李雪曾令清重庆师范大学进化生理与行为学实验室动物生物学重庆市重点实验室重庆401331

先捕后放是一种重要的鱼类资源保护策略和渔业管理手段。经历先捕后放的被钓鱼类个体的生理与行为会发生变化。当这些个体再次面对人工垂钓诱饵时,可能会呈现更加谨慎的摄饵或鱼钩回避行为。为考察重复垂钓对鱼类易钓性、能量代谢和个... 详细信息

先捕后放是一种重要的鱼类资源保护策略和渔业管理手段。经历先捕后放的被钓鱼类个体的生理与行为会发生变化。当这些个体再次面对人工垂钓诱饵时,可能会呈现更加谨慎的摄饵或鱼钩回避行为。为考察重复垂钓对鱼类易钓性、能量代谢和个性的影响,本研究以鲤科鱼类鲫(Carassius auratus)幼鱼为实验对象,在(25.3±0.1)℃水温条件下对垂钓组和对照组进行3次的能量代谢(标准代谢率,SMR;最大代谢,MMR)和个性(勇敢性、活跃性)测定。其中,垂钓组需进行垂钓实验,而对照组不进行任何垂钓操作。研究发现:(1)重复垂钓显著降低鲫幼鱼的垂钓率,但明显增加单尾平均垂钓时间和整体死亡率。(2)重复垂钓降低鲫幼鱼的体重、肥满度、SMR、MMR、代谢空间(AS)和相对代谢空间(FAS),但整体上不影响勇敢性和活跃性。(3)在测定Ⅰ中,高易钓性个体的体长和开阔区运动时间比大于低易钓性个体,但前者的肥满度小于后者。然而,在测定Ⅱ和Ⅲ中,高易钓性个体的形态参数、能量代谢、个性(勇敢性和活跃性)与低易钓性个体并无差异。研究表明:重复垂钓明显降低鲫幼鱼的易钓性,并且种内个体易钓性的变化方向不尽相同;重复垂钓对鲫幼鱼的形态和有氧代谢能力产生负面影响,可能降低了其用于运动、生长和消化等生理功能的代谢潜能。

关键词：易钓性能量代谢个性重复垂钓社会学习进化

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Rapid construction of phosphatase and tensin homolog-deleted on chromosome ten gene recombinant adenovirus using the AdEasy system

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Neural Regeneration Research 2010年第15期5卷 1166-1170页

作者： Yongqiong Wei lixue chen Zhaofang Zeng Chongbiao Shen Key Laboratory of Laboratory Medical Diagnostics Ministry of Education Chongqing Medical University Chongqing 400016 China Chongqing Key Laboratory of Neurology First Affiliated Hospital Chongqing Medical University Chongqing 400016 China

Recent studies have shown that phosphatase and tensin homolog-deleted on chromosome ten （PTEN） gene plays an important role in ischemic brain damage and synaptic plasticity. The AdEasy system, which has been widely used, greatly simplifies preparation of recombinant adenovirus. Therefore, recombinant defective adenovirus vector carrying human PTEN tumor suppressor gene （Ad-PTEN） was constructed using the AdEasy-1 system and was transfected into HEK293 cells for packaging and amplification. Infection efficiency and expression intensity were observed in primary cultured rat hippocampal neurons infected with Ad-PTEN in vitro. Results revealed a cytopathic effect in green fluorescent protein expression, which increased with prolonged time. After three cycles of amplification, the adenovirus titer was increased to an adequate titer for infecting hippocampal neurons. The entire process typically requires 4-5 weeks for completion. Results suggested that recombinant defective adenovirus vector carrying the PTEN gene was successfully and rapidly constructed using the AdEasy system.

关键词： phosphatase and tensin homolog-deleted on chromosome ten recombinant adenovirus AdEasy system vector construction nerve factors neural regeneration

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Distribution of phosphorylated Elk-1 in rat brain after Y-maze active avoidance training in a temporal manner

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Neural Regeneration Research 2006年第3期1卷 193-196页

作者： Xuhong chen Siyun Shu Zhenjiang Liang Xinmin Bao lixue chen Yongming Wu Research Room of Neurobiology. Second Affiliated Hospital of Southern Medical University. Guangzhou 510282 Guangdong Province China Department of Otolaryngology Shenzhen Children＇s Hospital Shenzhen 518026 Guengdong Province China

BACKGROUND： Elk-1 mRNA distributes extensively in the neurons of mice, rat and human brains, and the Elk-1 expression may be correlated with the synaptic plasticity, learning and memory. OBJECTIVE： To observe the distribution of phosphorylated Elk-1 （pEIk-1） in whole brain of rats received Y-maze active avoidance training and the changes of pEIk-1 expression at different time points after training. DESIGN ： A randomized controlled study SETTING ： Research Room of Neurobiology, the Second Affiliated Hospital of Southern Medical University MATERIALS ： Fifty-five male clean-degree SD rats of 3-4 months old, weighing 200-250 g, were provided by the Experimental Animal Center of Southem Medical University. The rabbit anti-monoclonal pEIk-1 antibody was purchased from Cell Signal Transduction Company, and ABC kit from Vector Company. METHODS ： The experiments were carried out in the Research Room of Neurobiology, Second Affiliated Hospital of Southern Medical University from September 2004 to February 2005. ① Grouping： The rats were randomly divided into training group （n = 25）, sham-training group （n = 25） and normal control group （n = 5）, and the training and sham-training groups were observed at 0, 1, 3, 6 and 24 hours after training, which represented the five phases in the process of leaming and memory. ② Y-maze training： The rats were preconditioned in the electrical Y-maze apparatus, 20 minutes a day for 3 days continuously, and training began from the 4^th day. In the training group, the rats were trained with the combination of light and electddty. Each rat repeated for 60 times in each training, and the correct times were recorded, those correct for less than 25 times were taken as unqualified, and excluded from the training group, and supplemented by other rats in time. In the sham-training group, there was no fixed correlation between the application of light and electricity. The rats in the normal contrel group were given not any training. ③Detection of pEIk-

关键词： Distribution of phosphorylated Elk-1 in rat brain after Y-maze active avoidance training in a temporal manner

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