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Journal of Materiomics 2021年第4期7卷 766-779页

作者： Qian Wang Junmiao Shi lixia Zhang Jiangtao xiong Jinglong Li Ninshu Ma Jicai Feng Joining and Welding Research Institute Osaka UniversityIbarakiOsaka567-0047Japan State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an710072China Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

A ZrC-SiC and TC4 gradient structure(ZTGS)was additively manufactured through the laser deposition technique and brazing *** research results indicated that SiC-reinforced TC4-based gradient layers could be obtained on the TC4 surface by laser ***-SiC and TC4 coated with gradient layers were brazed using an AgCuTi filler to fabricate the *** effects of the gradient structure and brazing parameters on the ZTGS strength were *** an increase in Layer II and Layer III thickness,the ZTGS shear strength *** brazing temperature and holding time affected the ZTGS shear strength by controlling the formation and distribution of the Cu4Ti phase in the brazing *** strengthening mechanism of the ZTGS was revealed by analyzing the residual stress distribution in the *** residual stress was formed in ZrC-SiC adjacent to the TC4 substrate or the deposited gradient layer,which was found to negatively affect the properties of the *** increase in gradient layer thickness reduced the maximum residual stress in ZrC-SiC,and the effect of Layer III on the residual stress was more significant than that of Layer *** calculated residual stress evolution matched the ZTGS property values well,revealing the strengthening mechanism.

关键词： Gradient structure Laser deposition Brazing Residual stress

凝结芽孢杆菌对油鸡生长性能、血清指标及脏器系数的影响

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北京农学院学报 2017年第2期32卷 75-79页

作者：张营营郭茜熊利霞张红星谢远红刘慧连正兴北京农学院食品科学与工程学院北京102206 中国农业大学动物科技学院北京100094

【目的】为探究凝结芽孢杆菌(Bacillus coagulans)Liu-g1对不同性别北京油鸡生长性能、血清指标及脏器系数的影响。【方法】选取4周龄北京油鸡240只,随机分为4组,每组公、母各3个重复,每个重复10只,分笼饲养:对照组饲喂基础饲粮,低、中... 详细信息

【目的】为探究凝结芽孢杆菌(Bacillus coagulans)Liu-g1对不同性别北京油鸡生长性能、血清指标及脏器系数的影响。【方法】选取4周龄北京油鸡240只,随机分为4组,每组公、母各3个重复,每个重复10只,分笼饲养:对照组饲喂基础饲粮,低、中、高剂量组饲喂添加*** Liu-g1冻干菌粉(7.3×1010CFU/g)的基础饲粮,添加量分别为10、100和1 000mg/kg,试验期70d。【结果】结果表明:(1)饲粮添加*** Liu-g1可有效降低公、母油鸡死亡率,对降低母油鸡死亡率效果更佳。(2)饲粮添加100 mg/kg *** Liu-g1显著提高公油鸡血清总蛋白和白蛋白含量,显著降低母油鸡血清甘油三酯和尿素含量(P<0.05)。(2)饲粮添加100mg/kg *** Liu-g1,母油鸡脾脏和肠道系数显著升高;添加1 000mg/kg *** Liu-g1,母油鸡法氏囊系数显著降低(P<0.05)。【结论】*** Liu-g1对不同性别北京油鸡作用效果存在差异,对母油鸡的作用更明显且最佳添加量为100mg/kg。

关键词：凝结芽孢杆菌性别油鸡生长性能血清

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创新主线式PBL在病理生理学教学中的应用

中华医学教育探索杂志 2021年第8期20卷 889-892页

作者：周晓燕应颖徐方云蔡震宇熊丽霞胡贞贞南昌大学基础医学院病理生理学教研室 330006

《病理生理学》是一门综合性学科,对培养医学生临床综合思维尤为关键。其涉及学科广泛、内容抽象,是基础医学的重点、难点课程之一。本教研室在多年教学探索与实践的基础上,开拓了主线式PBL(main-line-problem-based learning,ML-PBL)... 详细信息

《病理生理学》是一门综合性学科,对培养医学生临床综合思维尤为关键。其涉及学科广泛、内容抽象,是基础医学的重点、难点课程之一。本教研室在多年教学探索与实践的基础上,开拓了主线式PBL(main-line-problem-based learning,ML-PBL)教学方法。ML-PBL包括主线教学法、临床病例讨论法和主线串讲教学法,是一种多元化的教学。应用结果分析表明,ML-PBL教学提高了学生的成绩,更利于培养临床综合思维和自主学习能力,更充分地调动了学生学习的主动性。

关键词：基于问题的教学法教学方法病理生理学医学教育

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客机复材机身货舱门口框结构设计

科技和产业 2024年第1期24卷 195-202页

作者：文永洪李建军黄勋梅李霞熊盼江西航空研究院结构强度研究所南昌330213

探讨客机复合材料机身货舱门口框结构的设计技术,介绍复合材料的特点、优势和应用领域,以及机身货舱门口框结构的功能、要求和设计方法。从结构形式、材料选择、开口R角及铺层设计对蒙皮加强影响等方面分析复合材料机身货舱门口框结构... 详细信息

探讨客机复合材料机身货舱门口框结构的设计技术,介绍复合材料的特点、优势和应用领域,以及机身货舱门口框结构的功能、要求和设计方法。从结构形式、材料选择、开口R角及铺层设计对蒙皮加强影响等方面分析复合材料机身货舱门口框结构设计中的关键问题以及采取的相应措施和技术手段,给出一个复合材料机身货舱门口框结构在某型客机上的应用方案和效果评价,并与传统的金属结构进行比较分析。

关键词：机身开口门框复材蒙皮结构补强

Nitrogen addition promotes foliar litterfall and element return in a subtropical forest,southwestern China

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Journal of Forestry Research 2023年第4期34卷 939-948页

作者： Yue Zhang Shichen xiong Chengming You Sining Liu lixia Wang Li Zhang Han Li Bo Tan Yang Liu Zhenfeng Xu Forestry Ecological Engineering in the Upper Reaches of the Yangtze River Key Laboratory of Sichuan Province&National Forestry and Grassland Administration Key Laboratory of Forest Resources Conservation and Ecological Safety on the Upper Reaches of the Yangtze River&Institute of Ecology and Forestry Sichuan Agricultural UniversityChengdu 611130People’s Republic of China

Nitrogen deposition has a considerable impact on biogeochemical cycling in terrestrial ***,how litter production and element return respond to N addition remains poorly understood in nitrogen-rich subtropical *** this study,a 4-year nitrogen addition experiment explored its eff ects on foliar litter production and carbon,nitrogen and phosphorus in a subtropical Michelia wilsonii forest.A clear seasonal pattern in foliar litterfall was observed,regardless of nitrogen treatments,with a peak in spring and a smaller one in *** litter increased with increasing nitrogen but did not aff ect litter carbon concentrations and often decreased nitrogen and phosphorous *** eff ect of nitrogen addition was dependent on time(month/year).Carbon,nitrogen and phosphorous return showed similar bimodal seasonal *** addition increased carbon and nitrogen return but did not aff ect *** results suggest that the addition of nitrogen stimulates carbon and nutrient return via litterfall.

关键词： Nitrogen addition Litterfall Seasonal patterns Element return Subtropical forest

The developmental changes in intestinal epithelial cell proliferation,differentiation,and shedding in weaning piglets

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Animal Nutrition 2022年第2期9卷 214-222页

作者： Min Wang lixia Wang Xian Tan Lei Wang Xia xiong Yancan Wang Qiye Wang Huansheng Yang Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081HunanChina Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionKey Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina

Intestinal epithelial homeostasis plays an important role in intestinal morphology and ***,the developmental changes in intestinal epithelial cell turnover in piglets during early weaning are unknown so ***,the aim of this work was to detect changes in piglet gut development from weaning to post-weaning d ***,40 piglets were used in the present study,and 8 piglets were randomly selected for sampling at d 0,1,3,7 and 14 post-weaning,*** results showed that weaning stress significantly affected small intestinal morphological architecture,and this impact was the worst on d 3,and then returned to normal on d ***,the number of the marker of proliferation Ki-67(Ki67)positive cells was decreased on d 1 and 3,and then recovered on d 14(P<0.001).Also,weaning strikingly increased jejunal epithelial cell shedding on d 1 to 7 compared on d 0(P<0.05).Moreover,weaning remarkably affected the number of small intestinal enterocytes,goblets and endocrine cells(P<0.05),and there were also significant differences in genes expression related to proliferation and differentiation(P<0.05).Additionally,the mechanistic target of rapamycin(mTOR)phosphorylation level was higher on d 3(P<0.05).However,the Wingless/Int1(WNT)/b-catenin pathway was not influenced by post-weaning *** together,weaning induced noteworthy changes in intestinal epithelial cell proliferation,differentiation and shedding,and the mTOR signaling pathway was involved in this *** findings provide a cellular mechanism for intestinal developmental changes during weaning *** may provide nutritionists with better insight into designing efficient in-feed alternatives for preventing the unfavorable gut development in weaning piglets.

关键词： Intestinal epithelial cell Proliferation Differentiation Shedding Weaning piglet

Synthesis and modification of well-ordered layered cathode oxide LiNi_(2/3)Mn_(1/3)O_2

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Chinese Science Bulletin 2010年第30期55卷 3419-3423页

作者： xiong XiaoQin JIANG Yan XIA ShengAn ZHANG WuXing Yuan lixia LIU ShanTang HUANG YunHui School of Materials Science and Engineering State Key Laboratory of Materials Processing and Die & Mould Technology Huazhong Univer- sity of Science and Technology Wuhan 430074 China School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan 430073 China

Oxalic-acid-based co-precipitation method was employed to prepare LiNi2/3Mn1/3O2 sample with a high-ordered structure. Li+,Ni2+ and Mn2+ acetates were used as starting materials. The influence of the amount of lithium source in the starting materials on Li+ content,disorder of Li+-Ni2+ ions,and electrochemical performance has been investigated. Rietveld refinement shows that the sample prepared with 20% excess Li-source in the starting materials exhibits a perfect ordered structure. A specific discharge capacity is as high as 172 mAh/g at C/20 in the voltage range of 4.35?2.7 V. However,the cyclability is not satisfactory:about 25.3% fade in capacity was observed over 50 cycles. Chemically stable SiO2 was coated on the surface of LiNi2/3Mn1/3O2 particles. A significant improvement in cyclability was attained with 3 wt% SiO2 coating,which is ascribable to the protection of LiNi2/3Mn1/3O2 particles from being dissolved into the electrolyte.

关键词：二氧化硅涂层有序结构 Rietveld拟合正极层状修改合成起始原料

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枯草芽孢杆菌C3产抗菌物质发酵条件优化

中国酿造 2014年第3期33卷 28-31页

作者：杨永青谢远红张红星熊利霞马晓丹刘慧孔保华北京农学院食品科学与工程学院北京102206 农产品有害微生物及农残安全检测与控制北京市重点实验室食品质量与安全北京实验室北京102206 东北农业大学食品学院黑龙江哈尔滨150030

利用筛选的枯草芽孢杆菌(Bacillus subtilis)C3研究提高产抗菌物质的发酵条件。通过测定枯草芽孢杆菌C3抗菌物质对黑曲霉孢子萌发的抑制率,设计6因素3水平正交试验得到优化的发酵条件为:种子液的菌龄12h,种子液接种量2%,发酵培养基装液... 详细信息

利用筛选的枯草芽孢杆菌(Bacillus subtilis)C3研究提高产抗菌物质的发酵条件。通过测定枯草芽孢杆菌C3抗菌物质对黑曲霉孢子萌发的抑制率,设计6因素3水平正交试验得到优化的发酵条件为:种子液的菌龄12h,种子液接种量2%,发酵培养基装液量75mL/250mL,发酵培养基初始pH 7.0,发酵温度37℃,发酵时间48h。在优化发酵条件下,枯草芽孢杆菌C3产抗菌物质的抑菌活性比优化前提高了26.52%。

关键词：枯草芽孢杆菌抗菌物质发酵条件优化

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益生菌发酵复方中草药产多糖的工艺优化

北京农学院学报 2018年第3期33卷 83-87页

作者：李嘉懿张红星谢远红熊利霞高秀芝刘慧连正兴北京农学院食品科学与工程学院食品质量与安全北京实验室微生态制剂关键技术开发北京市工程实验室农产品有害微生物及农残安全检测与控制北京市重点实验室北京102206 中国农业大学动物科技学院北京100094

【目的】利用复合益生菌(植物乳杆菌植物亚种Zhang-LL和副干酪乳杆菌KL1)发酵复方中草药,考察发酵过程中的影响因素,确定发酵工艺参数。【方法】Zhang-LL和KL1菌株经活化、扩增后发酵复方中草药,从发酵液提取多糖。通过单因素多水平试验... 详细信息

【目的】利用复合益生菌(植物乳杆菌植物亚种Zhang-LL和副干酪乳杆菌KL1)发酵复方中草药,考察发酵过程中的影响因素,确定发酵工艺参数。【方法】Zhang-LL和KL1菌株经活化、扩增后发酵复方中草药,从发酵液提取多糖。通过单因素多水平试验(复方中药发酵温度、培养基初始pH、接种量、发酵时间)和正交试验设计,以苯酚-硫酸法测定发酵后多糖含量和得率,确定最优条件。【结果】结果表明,最佳发酵工艺条件为初始pH5.0,接种量5%,发酵温度34℃,时间72h。在此优化条件下,发酵复方中药液的多糖得率为1.13%,是优化前的1.65倍,未发酵的2.51倍。

关键词：植物乳杆菌植物亚种副干酪乳杆菌复方中草药发酵多糖

Epidermal growth factor improves intestinal morphology by stimulating proliferation and differentiation of enterocytes and mTOR signaling pathway in weaning piglets

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Science China(Life Sciences) 2020年第2期63卷 259-268页

作者： lixia Wang Fan Zhu Huansheng Yang Jianzhong Li Yali Li Xueqin Ding Xia xiong Fengjie Ji Hanlin Zhou Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-CentralMinistry of AgricultureHunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionKey Laboratory of Agroecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Academician Workstation of Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

Epidermal growth factor(EGF) has been shown to improve piglet intestinal morphology and epithelial recovery. In an attempt to further understand the mechanisms behind these improvements, this study tested the hypothesis that dietary EGF may affect intestinal morphology by stimulating the proliferation and differentiation of enterocytes in weaning piglets. In piglets receiving200 μg kg^-1 EGF, crypt depth and villus height increased(P<0.05). Adding 400 μg kg^-1 EGF increased villus height-to-crypt depth ratio(P<0.05), but reduced crypt depth(P<0.05). Dietary supplementation with 200 μg kg^-1 EGF significantly increased the number of Ki67-positive cells(P<0.01) and tended to increase the mRNA level of proliferating cell nuclear antigen(P<0.10).However, this supplementation decreased the expression level of intestinal fatty acid-binding protein(P<0.05). Piglets fed with400 μg kg^-1 EGF had an increased mRNA level of intestinal alkaline phosphatase(P<0.05). The phosphorylation of m TOR(mammalian target of rapamycin) was observed in the 200 μg kg^-1 EGF group. These results suggest that dietary supplementation with a low level of EGF improved piglet intestinal morphology through stimulating the proliferation and differentiation of enterocytes, and the mTOR signaling pathway may partly be involved in this process.

关键词： epidermal growth factor enterocyte proliferation differentiation mTOR signaling weaning piglets