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Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma

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Bioactive Materials 2022年第11期7卷 221-233页

作者： liwen fu Weiying Zhang Xiaojun Zhou Jingzhong fu Chuanglong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Department of Thoracic Oncology Jiujiang Cancer HospitalJiangxi ProvinceChina Health Management Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China

Osteosarcoma is a refractory bone disease in young people that needs the updating and development of effective *** nanotechnology is widely applied in cancer therapy,poor targeting and inadequate effi-ciency hinder its *** this study,we prepared alendronate(ALD)/K7M2 cell membranes-coated hollow manganese dioxide(HMnO_(2))nanoparticles as a nanocarrier to load Ginsenoside Rh2(Rh2)for Mag-netic Resonance imaging(MRI)-guided immuno-chemodynamic combination osteosarcoma ***-quently,the ALD and K7M2 cell membranes were successively modified on the surface of HMnO_(2) and loaded with *** tumor microenvironment(TME)-activated Rh2@HMnO_(2)-AM nanoparticles have good bone tumor-targeting and tumor-homing capabilities,excellent GSH-sensitive drug release profile and MRI capability,and attractive immuno-chemodynamic combined therapeutic *** Rh2@HMnO_(2)-AM nanoparticles can effectively trigger immunogenic cell death(ICD),activate CD4^(+)/CD8^(+)T cells in vivo,and upregulate BAX,BCL-2 and Caspase-3 in cellular *** results revealed that Rh2@HMnO_(2)-AM enhanced the secretion of IL-6,IFN-γand TNF-αin serum and inhibited the generation of FOXP3^(+)T cells(Tregs)in ***,the Rh2@HMnO_(2)-AM treatment significant restricted tumor growth in-situ tumor-bearing ***,Rh2@HMnO_(2)-AM may serve as an effective and bio-friendly nanoparticle platform combined with immuno-therapy and chemodynamic therapy to provide a novel approach to osteosarcoma therapy.

关键词： Ginsenoside Rh2 Hollow manganese dioxide Magnetic resonance imaging Chemodynamic therapy Immunotherapy

How long should a kiss last between a kinase and its substrate?

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Journal of Integrative Plant Biology 2022年第4期64卷 789-791页

作者： Chen Zhu liwen fu Yan Xiong Pengcheng Wang Shanghai Centre for Plant Stress Biology ChineseAcademy of Sciences Centre for Excellence in MolecularPlant Sciencesthe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Basic Forestry and Proteomics Research Centre HaixiaInstitute of Science and TechnologyFujian Agriculture andForestry UniversityFuzhou 350002Chin

The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly *** previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth.

关键词： plant phosphorylation thereby

Application of EDTMPS as a novel calcite depressant in scheelite flotation

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International Journal of Mining Science and Technology 2023年第5期33卷 639-647页

作者： Fen Jiao Wei Li Xu Wang Congren Yang Zhengquan Zhang liwen fu Wenqing Qin School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

In this study, the innovative use of ethylenediamine tetramethylene phosphonic sodium(EDTMPS) as a calcite depressant in scheelite flotation was investigated by flotation experiments, and its selective depression mechanism was revealed by contact angle measurement, FTIR analysis, Zeta potential test and XPS analysis. The flotation experiment results showed that scheelite and calcite could be efficiently separated under the following conditions: pulp p H=9.5, Na OL concentration of 1.5×10^(-4)mol/L, EDTMPS concentration of 3.0×10^(-5)mol/L, a scheelite concentrate with WO3grade of 65.49%, recovery of 83.29%and separation efficiency of 65.29% could be obtained from the artificially mixed minerals. The analysis results of mineral surface properties demonstrated that EDTMPS was strongly adsorbed onto the calcite surface through the reaction between the phosphonate group and the calcium ions, which hindered Na OL adsorption and increased the hydrophilicity of calcite. However, EDTMPS had weak adsorption strength on the scheelite surface, which didn’t affect further adsorption of Na OL, hence, the scheelite remained hydrophobic. Consequently, the selective adsorption of EDTMPS on the two minerals’ surfaces increased a difference in wettability and thus enabling them to be separated by flotation. Finally, the mechanism model of this flotation separation process was established.

关键词： Ethylenediamine tetramethylene phosphonic sodium Scheelite Calcite Flotation Selective depression

TOR kinase coordinates nutrient with hormone signaling to orchestrate plant growth,development and stress tolerance

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TOR kinase coordinates nutrient with hormone signaling to or...

State Forest Administration and Management System Reform in Austria and Germany and Experiences for China Reference

2018全国植物生物学大会

作者： Zhongpeng Li Pengcheng Wang liwen fu Jian-Kang Zhu Yan Xiong Basic Forestry and Proteomics Research Center Haixia Institute of Science and TechnologyFujian Agriculture and Forestry University Shanghai Center for Plant Stress Biology Chinese Academy of Science Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences

Sessile plants need to adjust their growth/stress tolerance mode constantly depending on the intensely changing ***,energy and hormone signaling mechanisms constitute the most ancient and fundamental regulatory networks in all life *** growth/stress plasticity is activated and switched by nutrient and hormone signaling remains enigmatic in photosynthetic *** target of rapamycin(TOR)kinase is an evolutionarily conserved master regulator that integrates energy,nutrients,growth factors and stress signals to promote survival and growth in all *** previous work has revealed that TOR integrates both nutrient and growth hormone signals to tightly control cell proliferation in meristems to stimulate plant *** can sense metabolic sugar signal and auxin level to modulate root and shoot meristem activation by phosphorylating cell cycle related E2 F transcription ***,we also found that plant stress hormone,ABA(Abscisic acid),strongly inhibited TOR kinase *** inhibition effect of ABA is dependent on the canonical ABA signaling ***2 s,the key downstream effector of ABA signaling,directly binds,phosphorylates Raptor(one of the components of TOR complex) to inhibit TOR kinase ***,our findings established a pivotal hub role of TOR signaling in integrating different environmental signals,nutrient status with plant growth and stress hormones to orchestrate plant growth and fitness.

关键词： glucose hormone target of rapamycin phosphorylation cell proliferation stress tolerance

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Chinese Forestry Science and Technology 2009年第1期8卷 41-46页

作者： ZHANG Zhida fu liwen ZHUANG Zuofeng Natural Forest Protection Center,State Forestry Administration,Beiiing 100714,P.R.China

Austria and Germany,the two forest developed countries,have drawn a lot of experiences in forest *** article summarizes the successful experiences of forest management reform in those two counties and puts forward pol... 详细信息

关键词： state forest administration experiences

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热电联产机组的热电函数模型研究

热力发电 2012年第4期41卷 4-5,9页

作者：赵会茹符力文华北电力大学经济管理学院北京102206

在以热定电法的基础上,通过引入热电负荷理论系数对工况图法进行完善,并得出热电函数模型。以某台300MW机组为例进行验证的结果表明,该模型可以较为准确、方便地构建热电机组的热电函数关系,以便热电厂和电网公司对热电机组运行进行调控。

关键词： 300MW机组热电联产以热定电热电函数模型热电负荷

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智能电网的低碳效益分析

电力建设 2011年第3期32卷 51-55页

作者：符力文华北电力大学经济管理学院北京市102206

分析智能电网的发展现状及社会发展低碳的背景及现状,重点是定量分析历年电力行业的碳排放影响,从侧面说明发展低碳电力的必要性。同时,结合智能电网的技术水平,提出如何利用智能电网的技术实现低碳电力的策略。最后,运用线性平滑法对... 详细信息

分析智能电网的发展现状及社会发展低碳的背景及现状,重点是定量分析历年电力行业的碳排放影响,从侧面说明发展低碳电力的必要性。同时,结合智能电网的技术水平,提出如何利用智能电网的技术实现低碳电力的策略。最后,运用线性平滑法对电力行业的碳排放值进行预测。根据国际碳市场中的碳排放价格,求出了碳排放的成本,并且将其与智能电力的建设及维护成本进行对比,分析得出智能电网的低碳效益,对未来智能电网的建设提供了一定的参考。

关键词：智能电网电力碳排放低碳电力低碳策略低碳效益线性平滑预测法

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周宁电厂发电机定子接地保护误动原因的探讨

福建水力发电 2018年第1期 38-38,40页

作者：傅丽文闽东水电开发有限公司福建宁德352100

通过对周宁电厂发电机定子接地保护误动原因的探讨,提出了通过调整消弧线圈来限制中性点位移电压来解决周宁电厂发电机定子接地保护误动办法。

关键词：定子接地保护消弧线圈周宁水电厂

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深基坑安全监测与预警平台的开发与应用

地下空间与工程学报 2018年第S1期14卷 423-429页

作者：傅理文彭渊翁湛梅智强浙江广川工程咨询有限公司，杭州310020 浙江省水利防灾减灾重点实验室，杭州310020 浙江省水利河口研究院，杭州310020 中国人民解放军战略支援部队信息工程大学地理空间信息学院，郑州450001

基坑开挖涉及大量不确定因素,其监测过程信息化受到越来越多的重视,兼容不同数据采集设备,选择恰当的预测模型与参数,提供方便、移动化的访问是信息化的难点。通过对监测流程的分析,提出了基坑监测平台体系结构,包括数据采集层、数据接... 详细信息

基坑开挖涉及大量不确定因素,其监测过程信息化受到越来越多的重视,兼容不同数据采集设备,选择恰当的预测模型与参数,提供方便、移动化的访问是信息化的难点。通过对监测流程的分析,提出了基坑监测平台体系结构,包括数据采集层、数据接口层、数据处理层、访问接口层、用户界面层。通过不同接口实现对不同通讯方式、协议的支持,并具可扩展性;针对不同监测项提供不同的预测模型库,通过强大的运算能力为每个监测点与监测项进行模型与参数的自适应选择与优化,提供最佳的模型与参数进行预测;平台采用J2EE架构开发,通过浏览器及APP提供图文丰富的监测与预测数据及报警信息。以该支护系统的某基坑监测应用,验证了平台的有效性及预测的准确性。

关键词：基坑监测预测模型数据分析监测平台