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Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma

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Bioactive Materials 2022年第11期7卷 221-233页

作者： liwen fu Weiying Zhang Xiaojun Zhou Jingzhong fu Chuanglong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Department of Thoracic Oncology Jiujiang Cancer HospitalJiangxi ProvinceChina Health Management Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China

Osteosarcoma is a refractory bone disease in young people that needs the updating and development of effective treatment.Although nanotechnology is widely applied in cancer therapy,poor targeting and inadequate effi-ciency hinder its development.In this study,we prepared alendronate(ALD)/K7M2 cell membranes-coated hollow manganese dioxide(HMnO_(2))nanoparticles as a nanocarrier to load Ginsenoside Rh2(Rh2)for Mag-netic Resonance imaging(MRI)-guided immuno-chemodynamic combination osteosarcoma therapy.Subse-quently,the ALD and K7M2 cell membranes were successively modified on the surface of HMnO_(2) and loaded with Rh2.The tumor microenvironment(TME)-activated Rh2@HMnO_(2)-AM nanoparticles have good bone tumor-targeting and tumor-homing capabilities,excellent GSH-sensitive drug release profile and MRI capability,and attractive immuno-chemodynamic combined therapeutic efficiency.The Rh2@HMnO_(2)-AM nanoparticles can effectively trigger immunogenic cell death(ICD),activate CD4^(+)/CD8^(+)T cells in vivo,and upregulate BAX,BCL-2 and Caspase-3 in cellular level.further results revealed that Rh2@HMnO_(2)-AM enhanced the secretion of IL-6,IFN-γand TNF-αin serum and inhibited the generation of FOXP3^(+)T cells(Tregs)in tumors.Moreover,the Rh2@HMnO_(2)-AM treatment significant restricted tumor growth in-situ tumor-bearing mice.Therefore,Rh2@HMnO_(2)-AM may serve as an effective and bio-friendly nanoparticle platform combined with immuno-therapy and chemodynamic therapy to provide a novel approach to osteosarcoma therapy.

关键词： Ginsenoside Rh2 Hollow manganese dioxide Magnetic resonance imaging Chemodynamic therapy Immunotherapy

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How long should a kiss last between a kinase and its substrate?

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Journal of Integrative Plant Biology 2022年第4期64卷 789-791页

作者： Chen Zhu liwen fu Yan Xiong Pengcheng Wang Shanghai Centre for Plant Stress Biology ChineseAcademy of Sciences Centre for Excellence in MolecularPlant Sciencesthe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Basic Forestry and Proteomics Research Centre HaixiaInstitute of Science and TechnologyFujian Agriculture andForestry UniversityFuzhou 350002Chin

The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth.

关键词： plant phosphorylation thereby

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Nanofibers for the Immunoregulation in Biomedical Applications

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Advanced Fiber Materials 2022年第6期4卷 1334-1356页

作者： liwen fu Qian Feng Yujie Chen Jingzhong fu Xiaojun Zhou Chuanglong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Department of Thoracic Oncology Jiujiang Cancer HospitalJiujiang 332000China

Despite great efforts and achievement of nanomaterials in immune-associated diseases,the selection of appropriate nanomaterials and preparation technology remain some challenges and vast room for improvement.Immunotherapy has received tremendous attention throughout the medical process due to its clinical successes with the pathways of immunoactivation or immunosuppression.Recently,fibrous nanomaterials have facilitated advances in tissue repair and cancer treatments owing to the superiority of multi-channel structure,biocompatibility,tunable size and controlled surface modification.The immunoactivation-based nanofibers can potentially deliver functional agents to lesions and further actively promote immunologic intervention.On the contrary,the immunosuppression-based nanofibers prevent the immune system from overreacting through the blockage of critical pathways in vivo.This review summarizes the current application of nanofiber materials in diverse diseases,including cancer therapy,tissue regeneration(cartilage/bone,skin,tendon,nerves),myocardial infarction,psoriasis and organ defects.Some common fabrication technologies of biomedical nanofibers are also introduced.Meanwhile,the existing technical barriers and perspectives are rationally discussed,providing a constructive inspiration for the follow-up basic research and clinical transformation of nanofibers in the vibrant biomedical fields.

关键词： Nanofibers Immunoregulation Tissue repair Cancer therapy

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Application of EDTMPS as a novel calcite depressant in scheelite flotation

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International Journal of Mining Science and Technology 2023年第5期33卷 639-647页

作者： Fen Jiao Wei Li Xu Wang Congren Yang Zhengquan Zhang liwen fu Wenqing Qin School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

In this study, the innovative use of ethylenediamine tetramethylene phosphonic sodium(EDTMPS) as a calcite depressant in scheelite flotation was investigated by flotation experiments, and its selective depression mechanism was revealed by contact angle measurement, FTIR analysis, Zeta potential test and XPS analysis. The flotation experiment results showed that scheelite and calcite could be efficiently separated under the following conditions: pulp p H=9.5, Na OL concentration of 1.5×10^(-4)mol/L, EDTMPS concentration of 3.0×10^(-5)mol/L, a scheelite concentrate with WO3grade of 65.49%, recovery of 83.29%and separation efficiency of 65.29% could be obtained from the artificially mixed minerals. The analysis results of mineral surface properties demonstrated that EDTMPS was strongly adsorbed onto the calcite surface through the reaction between the phosphonate group and the calcium ions, which hindered Na OL adsorption and increased the hydrophilicity of calcite. However, EDTMPS had weak adsorption strength on the scheelite surface, which didn’t affect further adsorption of Na OL, hence, the scheelite remained hydrophobic. Consequently, the selective adsorption of EDTMPS on the two minerals’ surfaces increased a difference in wettability and thus enabling them to be separated by flotation. Finally, the mechanism model of this flotation separation process was established.

关键词： Ethylenediamine tetramethylene phosphonic sodium Scheelite Calcite Flotation Selective depression

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滦河水库群联合调度探索与实践

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中国防汛抗旱 2024年第7期34卷 29-31页

作者：刘兵超付立文谢敏水利部海河水利委员会引滦工程管理局天津300392 中国水利水电科学研究院北京100038

随着国家水网战略不断推进,滦河流城水工程调度坚持系统观念,不断优化和拓展调度方式和目标,积极实施水库群联合调度探索与实践,逐步形成了潘家口、大黑汀、桃林口水库相互补充、相互调剂的联合调度运用方式,保障滦河流域防洪安全、供... 详细信息

随着国家水网战略不断推进,滦河流城水工程调度坚持系统观念,不断优化和拓展调度方式和目标,积极实施水库群联合调度探索与实践,逐步形成了潘家口、大黑汀、桃林口水库相互补充、相互调剂的联合调度运用方式,保障滦河流域防洪安全、供水安全和生态安全。以潘家口、大黑汀、桃林口水库联合调度探索和实践为例,探索分析流域水工程联合调度的原则、机制,并结合近年水库群联合调度实践经验,提出了面临的问题及工作建议,为今后构建滦河流城水工程联合调度协作机制和联合调度决策提供参考依据。

关键词：滦河流域潘家口水库大黑汀水库桃林口水库水库群联合调度

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TOR kinase coordinates nutrient with hormone signaling to orchestrate plant growth,development and stress tolerance

TOR kinase coordinates nutrient with hormone signaling to or...

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2018全国植物生物学大会

作者： Zhongpeng Li Pengcheng Wang liwen fu Jian-Kang Zhu Yan Xiong Basic Forestry and Proteomics Research Center Haixia Institute of Science and TechnologyFujian Agriculture and Forestry University Shanghai Center for Plant Stress Biology Chinese Academy of Science Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences

Sessile plants need to adjust their growth/stress tolerance mode constantly depending on the intensely changing environments.Nutrient,energy and hormone signaling mechanisms constitute the most ancient and fundamental regulatory networks in all life forms.How growth/stress plasticity is activated and switched by nutrient and hormone signaling remains enigmatic in photosynthetic plants.The target of rapamycin(TOR)kinase is an evolutionarily conserved master regulator that integrates energy,nutrients,growth factors and stress signals to promote survival and growth in all eukaryotes.Our previous work has revealed that TOR integrates both nutrient and growth hormone signals to tightly control cell proliferation in meristems to stimulate plant growth.TOR can sense metabolic sugar signal and auxin level to modulate root and shoot meristem activation by phosphorylating cell cycle related E2 F transcription factor.Interestingly,we also found that plant stress hormone,ABA(Abscisic acid),strongly inhibited TOR kinase activity.This inhibition effect of ABA is dependent on the canonical ABA signaling pathway.SnRK2 s,the key downstream effector of ABA signaling,directly binds,phosphorylates Raptor(one of the components of TOR complex) to inhibit TOR kinase activity.Therefore,our findings established a pivotal hub role of TOR signaling in integrating different environmental signals,nutrient status with plant growth and stress hormones to orchestrate plant growth and fitness.

关键词： glucose hormone target of rapamycin phosphorylation cell proliferation stress tolerance

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Reciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response

Reciprocal regulation of the TOR kinase and ABA receptor bal...

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第七届长三角植物科学研讨会暨青年学术报告会

作者： Pengcheng Wang Yang Zhao Zhongpeng Li Chuan-Chih Hsu Xue Liu liwen fu Yueh-Ju Hou Yanyan Du Shaojun Xie Chunguang Zhang Jinghui Gao Minjie Cao Xiaosan Huang Yingfang Zhu Kai Tang Xingang Wang Andy W.Tao Yan Xiong Jian-Kang Zhu Shanghai Center for Plant Stress Biology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Department of Horticulture and Landscape Architecture Purdue University Department of Biochemistry Purdue University Division of Biological Sciences University of California

As sessile organisms,plants must adapt to variations in the environment.Environmental stress triggers various responses,including growth inhibition,mediated by the plant hormone abscisic acid(ABA).The mechanisms that integrate stress responses with growth are poorly understood.Here,we discovered that the Target of Rapamycin(TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants.This phosphorylation disrupts PYL association with ABA and with PP2 C phosphatase effectors,leading to inactivation of SnRK2 kinases.Under stress,ABA-activated Sn RK2 s phosphorylate Raptor,a component of the TOR complex,triggering TOR complex dissociation and inhibition.Thus,TOR signaling represses ABA signaling and stress responses in unstressed conditions,whereas ABA signaling represses TOR signaling and growth during times of stress.Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses.

关键词： Abscisic Acid Target of Rapamycin Phosphorylation SnRK2 Raptor ABA Receptor

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State Forest Administration and Management System Reform in Austria and Germany and Experiences for China Reference

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Chinese Forestry Science and Technology 2009年第1期8卷 41-46页

作者： ZHANG Zhida fu liwen ZHUANG Zuofeng Natural Forest Protection Center,State Forestry Administration,Beiiing 100714,P.R.China

Austria and Germany,the two forest developed countries,have drawn a lot of experiences in forest management.This article summarizes the successful experiences of forest management reform in those two counties and puts... 详细信息

关键词： state forest administration experiences

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智能电网的低碳效益分析

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电力建设 2011年第3期32卷 51-55页

作者：符力文华北电力大学经济管理学院北京市102206

分析智能电网的发展现状及社会发展低碳的背景及现状,重点是定量分析历年电力行业的碳排放影响,从侧面说明发展低碳电力的必要性。同时,结合智能电网的技术水平,提出如何利用智能电网的技术实现低碳电力的策略。最后,运用线性平滑法对... 详细信息

分析智能电网的发展现状及社会发展低碳的背景及现状,重点是定量分析历年电力行业的碳排放影响,从侧面说明发展低碳电力的必要性。同时,结合智能电网的技术水平,提出如何利用智能电网的技术实现低碳电力的策略。最后,运用线性平滑法对电力行业的碳排放值进行预测。根据国际碳市场中的碳排放价格,求出了碳排放的成本,并且将其与智能电力的建设及维护成本进行对比,分析得出智能电网的低碳效益,对未来智能电网的建设提供了一定的参考。

关键词：智能电网电力碳排放低碳电力低碳策略低碳效益线性平滑预测法

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支承脚手架结构对地下隧道影响

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低温建筑技术 2023年第8期45卷 56-59页

作者：戴郑新鲁晓莎左建宁傅丽雯江苏南京地质工程勘察院南京210041 南京江洲盛瑞置业有限公司南京210019

为评价支承脚手架结构对地下隧道影响,从某项目入手,采用Midas/GTS NX建模,分步进行三维数值模拟分析。并研究跨隧道高架桥梁施工中其支承脚手架结构对地下隧道的影响,分析原因提出针对性保护措施。结果表明采用满堂脚手架支撑后可以有... 详细信息

为评价支承脚手架结构对地下隧道影响,从某项目入手,采用Midas/GTS NX建模,分步进行三维数值模拟分析。并研究跨隧道高架桥梁施工中其支承脚手架结构对地下隧道的影响,分析原因提出针对性保护措施。结果表明采用满堂脚手架支撑后可以有效减少变形保护地下隧道安全,后期高架运营对隧道造成的影响也在安全范围内。可为类似工程项目提供参考依据。

关键词：支承脚手架地铁隧道结构施工数值模拟

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