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International Journal of Clinical Medicine 2014年第9期5卷 507-513页

作者： Natania Florentino Diniz1] Evelim Leal de Freitas Dantas Gomes1] Cristiane Aparecida Moran1] Silvana Alves Pereira1] livia Maria de Andrade Martins1] Luciana Carnevalli Pereira1] Universidade Nove de Julho(UNINOVE) Sao PauloBrazil 2Universidade Federal do Rio Grande do Norte(UFRN/FACISA)Santa CruzBrazil

Objectives: To evaluate the effect of manual chest compression (MCC) in the variables of oxygenation, hemodynamic and respiratory effeteness in infants suffering from respiratory diseases with atelectasis. Methods: Controlled clinical trial, in which 38 infants were evaluated,19 ineach study group (group A: atelectasis and group B: control). Data were measured before, immediately after and 10 minutes after the end of the technique’s application. Results: The average age was of 5.05 months. There was an increase of RR in group A immediately after the application of the technique and signs of respiratory distress with a decrease in the oxygen saturation. Conclusion: There was a reduction in SpO2, an increase of RR and a worsening of clinical signs of respiratory distress. Given this, one may consider that there is a controversy about the benefits, mechanism of action, physiological and therapeutic effects of MCC when applied to infants.

关键词： Pulmonary Atelectasis Physiotherapy Modality Respiratory Therapy Infant Infant Care Clinical Trials

论著中国妊娠期糖尿病短期健康与经济负担的建模研究

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英国医学杂志中文版 2018年第5期21卷 256-263页

作者：徐婷婷 livia Dainelli 余恺马良坤 Irma Silva Zolezzi Patrick Detzel 方海北京大学中国卫生发展研究中心中国北京雀巢研究中心瑞士洛桑雀巢研究中心中国北京北京协和医院中国北京

目的妊娠期糖尿病（GDM）属于高危妊娠，与母婴不良妊娠结局的发生密切相关。本研究目的是评估2015年中国的GDM的短期健康与经济总体负担。

关键词：妊娠期糖尿病经济负担

Subacute Cutaneous Lupus Erythematosus in Older Man: Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 25-33页

作者： Debora Trindade Martins Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Sebastiao Celio Horta Coelho Filho Vinicius Moreira Paladino Bruna Sande Miguel Vinicius Sande Miguel Daniel Almeida da Costa livia Cristina de Melo Pino The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly women, presents several clinical manifestations and has no known exact cause. The skin is one of the organs that can be affected, with subacute cutaneous lupus erythematosus (SCLE) being one of the classifications according to cutaneous lupus erythematosus lesions. SCLE is commonly found in young to middle age women and carries characteristics related to sun exposure. In this report, there is a rare case of a male and elderly patient that presents SCLE subgroup initially asymptomatic, with subsequent appearance of macular skin lesions and vitiligo appearance. This is an important case to alert health professionals that the disease can manifest itself and open its clinical profile even in patients of sex and unusual ages.

关键词： Autoimmune-Disease Skin Man Lupus

Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis——Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 44-50页

作者： Giovanna Lima Vaz livia Cristina de Melo Pino Aline Gabriela Santos Costa Ibrahim Yahia El Somailli Joao Roberto Resende Fernandes Elayne Christina Meireles Martins Daniel Cohen Goldemberg Aline Hellen da Silva Camacho Rhanna Neves Cirqueira Daniel Almeida da Costa College of Medicine of Valenca—FAA/Cesva ValencaBrazil National Cancer Institute—INCA Rio de JaneiroBrazil Centro Universitario de Belo Horizonte-UNIBH Belo HorizonteBrazil

Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is a fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis. This microorganism can penetrate the human body through direct contact and can cause intense lymphadenopathy, ulcerated lesions in the oral cavity and in the skin among other alterations. In this study, we report a case of paracoccidioidomycosis with unusual clinical presentation, as it manifested in the female sex and although it did not present any relevant complaints of respiratory focus, it presented a single ulcerated lesion in the buccal mucosa. A biopsy of the lesion and a mycological examination revealed Paracoccidioidesbrasiliensis infection.

关键词： Paracoccidioidomycosis Paracoccidioides brasiliensis Endemic Mycosis

Cutaneous Vasculitis with Renal Impairment in Octogenarian

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Journal of Biosciences and Medicines 2017年第6期5卷 37-45页

作者： Thiago Sande Miguel Bruna Sande Miguel Vinicius Sande Miguel Jair Baptista Miguel Sebastiao Celio Horta Coelho Filho Nayrton Kalys Cruz dos Anjos livia Cristina de Melo Pino Paola Stephanie Azevedo de Sa Vitor Araujo Goulart Daniel Almeida da Costa The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil The Medical School at the Center of Higher Education of Valenca ValencaBrazil

Henoch-Schönlein purpura is a vasculitis of small vessels, characterized by tissue deposition of IgA, affecting predominantly the skin, intestine, joints and kidneys. It mainly affects the pediatric age group, especially from 2 to 11 years old. Most often, it is preceded by episode of upper airway infection from days to weeks. The most common clinical manifestations are purpuric cutaneous lesions located in the lower limbs and buttocks, abdominal pain in colic, nausea, vomiting, diarrhea, in addition to arthralgia/arthritis, usually with spontaneous resolution. Renal impairment usually manifests with hematuria and proteinuria, and renal function may also be impaired. The case described refers to a female patient, 86 years old, with a previous history of infection of the upper airways, followed by purpura in the lower limbs and renal impairment: serum creatinine 3.1 mg/dL (N 0.5 - 1.2 mg/dL);glomerular filtration rate 15 ml/min (N > 60 ml/min);urea 118 mg/dL (N önlein purpura in an atypical age group, with significant renal impairment, improvement only with conservative treatment, thus avoiding the use of immunosuppressants and the risks of immunosuppression and toxicity related to such drugs.

关键词： Purple Henoch-Schonlein Vasculitis Renal Elderly Case Report

Secondary Syphilis in Man: Prozone Effect

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Journal of Biosciences and Medicines 2018年第2期6卷 1-8页

作者： Nayrton Kalys Cruz dos Anjos Daniel Almeida da Costa Thiago Sande Miguel livia Cristina de Melo Pino Sebastiao Celio Horta Coelho Filho Debora Trindade Martins Vinicius Sande Miguel Bruna Sande Miguel Fernando Antonio Galvao Pereira Jr Vinicius Moreira Paladino Faculdade de Medicina de Valenca Rio de JaneiroBrazil Universidade Unigranrio Rio de JaneiroBrazil

Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.

关键词： Secondary Syphilis Prozone Effect Treponema pallidum

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捷克中医药发展现状与分析

国际中医中药杂志 2021年第3期43卷 219-223页

作者：胥静 Ludmila Bendova Nesvadbova Tao livia Kusnierova canova Petra Urikova 魏竞竞赵静杨龙会许家杰曹洪欣中国中医科学院中医临床基础医学研究所2009年行业专项办公室北京100700 中国中医科学院眼科医院北京100040 捷克布拉格中医门诊 17000 捷克牡丹诊所全科医师诊所布拉格17000 捷克麦勒诺瓦斯联合会卢哈乔维采76326 捷克自执业医生卢科夫76317 中国中医科学院西苑医院北京100091 北京中医药大学 100029 中国中医科学院北京100700 美国洛杉矶加州大学东西医学中心 90024 中华中医药学会北京100029

捷克作为欧洲内陆的议会共和制国家,实施强制保险模式以保障民众健康。导致人口死亡的主要疾病为缺血性心脏病、脑卒中和肺癌,而糖尿病、AD及COPD近年来发病率显著增加。捷克的传统医学包括巴赫花疗法、特异性免疫调节自我疗法、法国耳... 详细信息

捷克作为欧洲内陆的议会共和制国家,实施强制保险模式以保障民众健康。导致人口死亡的主要疾病为缺血性心脏病、脑卒中和肺癌,而糖尿病、AD及COPD近年来发病率显著增加。捷克的传统医学包括巴赫花疗法、特异性免疫调节自我疗法、法国耳针治疗等。中医药在捷克具有一定的接受度,尤其是针灸已在神经性疾病中得到广泛应用。但中草药在捷克的使用受到限制,且中医药执业尚未合法化。建议深化多层次、多领域交流合作,并通过加强高水平中医药学位教育,加大中药与非药物疗法宣传和普及力度,推动中医药在捷克的发展。

关键词：医学传统捷克中医药保险健康国际合作发展现状

Effects of Probiotic Lactobacillus gasseri Strains of Breast-Fed Infant in a Murine Model

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Journal of Food Science and Engineering 2014年第6期4卷 271-281页

作者： Maria da Penha Piccolo Ramos Joao Alexandre Tres Pancoto Iracilda Zeppone Carlos Rogeria Comastri deCastro Almeida Danielle Cardoso Geraldo Maia livia Carolina de Abreu Ribeiro Femanda Paulin Benzatti Luciana Rodrigues Cunha Aline Costa e Silva Celia Lucia de Luces Fortes Ferreira Departamento de Ciencias da Saude Universidade Federal do Espirito Santo S6o Mateus Espirito Santo CEP. 29.932-540 Brazil Laboratorio de Imunonologia Clinica Universidade Estadual Paulista Faculdade de Ciencias Farmaceuticas Araraquara Sao Paulo CEP: 14.801-902 Brazil Departamento de Ciencia dos Alimentos Universidade Federal da Bahia Eseola de Nutricao Salvador Bahia CEP. 40.110-160 Brazil Departamento de Tecnologia de Alimentos Universidade Federal de Ouro Preto Ouro Preto Minas Gerais CEP: 35.400-970 Brazil Departamento de Tecnologia de Alimentos Universidade Federal de Vigosa Vigosa Minas Gerais CEP: 36.570-000 Brazil

The ingestion of probiotic lactic acid bacteria has been evaluated and noted that it has an effect on the balance of desirable microbiota in the gastrointestinal tract. Lactobacillus gasseri demonstrates good survival in the gastrointestinal tract, and it has been associated with a variety of probiotic activities and roles, including the reduction of fecal mutagenic enzymes, the production of bacteriocins and the stimulation of macrophages immunomodulation. The aim of the study was to evaluate the effects of a pool of L. gasseri strains isolated from the feces of breastfed infants added in the human milk of healthy women. The milk was both pasteurized and unpasteurized, to verify the cell cytotoxicity of macrophages and to quantify the production of immunologic mediators such as IL-4, IL-6, IFN-γ, TNF-α, NO and oxygen intermediary compounds （H2O2）. The administration of raw human milk and pasteurized human milk to infants is a regular, encouraged practice in units of intensive therapy （UITs） and our present investigation verified the beneficial effect of addition of a pool of L. gasseri to pasteurized human milk （PHML）. Our results show that probiotic supplementation helped to maintain cell viability, reduced IL-6 and IFN-γ production and stimulated TNF-α, NO, H2O2, IL-4 production. Nevertheless, the results indicate that the addition of lactobacillus to human milk was not a determinant in the production of TNF-α. L. gasseri added to breast milk did not present a cytotoxic risk, and the addition ofL. gasseri to pasteurized milk of human milk bank would benefit newborns that depend on milk banks for the colonization of more desirable microbiota.

关键词： Probiotic human milk bank immunology Lactobacillus gasseri.

Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

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Journal of Biosciences and Medicines 2017年第11期5卷 33-40页

作者： Eneas Van Der Maas do Bem Filho Laiza Maria dos Santos Couto Antonio Luiz da Costa Soares Jr Pedro Paulo Andrade Thiago Sande Miguel Sebastiao Celio Horta Coelho Filho Daniel Almeida da Costa livia Cristina de Melo Pino Thayro Van Der Maas do Bem The Medical School at the Center of Higher Education of Valenca ValencaBrazil

Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.

关键词： Nodular Amyloidosis Polymyositis

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优雅的力量来自哪里?

课堂内外(高中版) 2016年第1期 77-77页

作者：奥livia

优雅的过程和实现形式,每个人都不一样。可以是假借于经历、书本、电影、旅行、周边的人与物,得益于善于发现的眼睛,充满好奇的心,爱思考的大脑,懂生活的直觉。不是说抱着一本《3分钟成为—个优雅的人》《365天优雅不重样》或者《8小时... 详细信息

优雅的过程和实现形式,每个人都不一样。可以是假借于经历、书本、电影、旅行、周边的人与物,得益于善于发现的眼睛,充满好奇的心,爱思考的大脑,懂生活的直觉。不是说抱着一本《3分钟成为—个优雅的人》《365天优雅不重样》或者《8小时塑造优雅的你》,也不是喝杯红酒,买两件大牌,会胸法语,就能金灿灿发亮,明晃晃惹眼。

关键词：力量