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Co-occurrence of per- and polyfluoroalkyl substances, heavy metals and polycyclic aromatic hydrocarbons and their composite impacts on microbial consortium in soil: A field study

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Pedosphere 2024年第4期34卷 736-748页

作者： Meng ZHAng Qing WAng Xin SOng Mukhtiar ALI Zhiwen TAng Xin liu Zhuanxia ZHAng Shurong MA Jinhui BI Zhongyuan LI Key Laboratory of Saline-Alkali Vegetation Ecology Restoration Northeast Forestry UniversityHarbin 150040China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Center International Group Co. Ltd.Beijing 101160China China Construction Eighth Engineering Division Corp. Ltd.Shanghai 200122China

This is the first study to report the co-occurrence of per-and polyfluoroalkyl substances(PFASs),heavy metals,and polycyclic aromatic hydrocarbons(PAHs)and their impacts on the native microbial consortium in soil due to the long-term *** PFASs,heavy metals,and PAHs were detected in soil samples collected at 2–6 m below the ground surface at different sampling locations in a steel-making *** total concentrations of PFASs varied from 6.55 to 19.79 ng g^(-1),with perfluorooctane sulfonate(PFOS),perfluorobutane sulfonate,and 6:2 chlorinated polyfluorinated ether sulfonate(alternative of PFOS)being the predominant *** concentrations of arsenic,cadmium,and lead were detected in the ranges of 4.40–1270.00,0.01–8.67,and 18.00–647.00 mg kg^(-1),respectively,and the concentration of total PAHs was detected in the range of 1.02–131.60 mg kg^(-1).The long-term exposure to mixed contaminants of PFASs,heavy metals,and PAHs led to lower richness and diversity of microbial communities in *** soil bacterial communities were mainly composed of Pseudomonas,norank_p_GAL15,Leptothrix,norank_o_Rokubacteriales,and *** between soil environmental factors and microbial communities indicated that cation exchange capacity and total phosphorus were two key factors in shaping the composition of native microbial ***,Arthrobacter,Leptothrix,and Sphingobium were found to be significantly positively correlated with PFAS concentrations,indicating that these genera could tolerate the stress exerted by PFASs,along with the stress imposed due to the presence of heavy metals or/and PAHs.

关键词： arsenic cation exchange capacity mixed contaminant native microbial community perfuorooctane sulfonate total phosphorus

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Two nanobody‑based immunoassays to differentiate antibodies against genotype 1 and 2 porcine reproductive and respiratory syndrome virus

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Animal Diseases 2024年第2期4卷 98-114页

作者： Xu Chen Yueting Chang Lu Zhang Xinyu Zhao Zhihan Li Zhijie Zhang Pinpin Ji Qingyuan liu Jiakai Zhao Jiahong Zhu Baoyuan liu Xinjie Wang Yani Sun Qin Zhao Department of Preventive Veterinary Medicine College of Veterinary MedicineNorthwest A&F UniversityYanglingShaanxi 712100China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518100China

Porcine reproductive and respiratory syndrome virus(PRRSV)infection causes significant economic loss to the global pig *** 1 and 2 PRRSV(PRRSV-1 and-2)infections have been reported in China,Europe and *** accurate prevention,nanobodies were first used as diagnostic reagents for PRRSV *** this study three nanobodies targeting both PRRSV-1 and-2,two targeting PRRSV-1 and three targeting PRRSV-2,were screened and *** develop two competitive ELISAs(cELISAs),the g1-2-PRRSV-Nb3-HRP nanobody was chosen for the g1-2-cELISA,to detect common antibodies against PRRSV-1 and-2,and the g1-PRRSV-Nb136-HRP nanobody was chosen for the g1-cELISA,to detect anti-PRRSV-1 *** two cELISAs were developed using PRRSV-1-N protein as coating antigen,and the amounts for both were 100 ng/*** optimized dilution of testing pig sera was 1:20,the optimized reaction times were 30 min,and the colorimetric reaction times were 15 ***,the cut-off values of the g1-2-cELISA and g1-cELISA were 26.6%and 35.6%,*** of them have high sensitivity,strong specificity,good repeatability,and *** addition,for the 1534 clinical pig sera,an agreement rate of 99.02%(Kappa values=0.97)was determined between the g1-2-cELISA and the commercial IDEXX ELISA *** the g1-cELSIA,it can specifically detect anti-PRRSV-1 antibodies in the clinical pig ***,combining two nanobody-based cELISAs can differentially detect antibodies against PRRSV-1 and-2.

关键词： PRRSV Competitive ELISA Nanobody Antigen epitope

Efficacy and safety of Yangxinshi tablet for chronic heart failure:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第13期12卷 2218-2230页

作者： Sheng-Hua Lu Yun-Feng Yu Si-Si Dai Ya-Qi Hu Jian-He liu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National Clinical Research Center for Chinese Medicine Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The specific benefits of Yangxinshi tablet(YXST)in the treating chronic heart failure(CHF)remain *** To systematically evaluate the efficacy and safety of YXST in the treatment of *** Randomized controlled trials(RCTs)investigating YXST for CHF treatment were retrieved from eight public databases up to November ***-analyses of the included clinical studies were conducted using Review Manager *** Twenty RCTs and 1845 patients were *** meta-analysis results showed that the YXST combination group,compared to the conventional drug group,significantly increased the clinical efficacy rate by 23%[relative risk(RR)=1.23,95%CI:1.17-1.29],(Png/L[standardized MD(SMD)=-1.03,95%CI:-1.32 to-0.74,Png/L(MD=-80.95,95%CI:-143.31 to-18.59,P=0.01),left ventricular end-diastolic diameter by 3.92 mm(MD=-3.92,95%CI:-5.06 to-2.78,Png safety,neither group reported any serious adverse events during treatment(RR=0.54,95%CI:0.15-1.90,P=0.33).In addition,Egger's test results indicated no significant publication bias(P=0.557).CONCLUSION YXST effectively improves clinical symptoms and cardiac function in patients with CHF while maintaining a favorable safety profile,suggesting its potential as a therapeutic strategy for CHF.

关键词： Yangxinshi tablet Chronic heart failure Cardiac function Systematic evaluation Meta-analysis

Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2024年第5期44卷 981-990页

作者： ZHAng Fang YAN Cuina WEng Zhijun WU Luyi QI Li ZHAO Min XIN Yuhu WU Huangan liu Huirong Key Laboratory of Acupuncture and Immunological Effects Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Cancer Hospital Fudan University

OBJECTIVE: To investigate the role of satellite glial cells in irritable bowel syndrome(IBS) and the effect of electroacupuncture(EA) at the Tianshu(ST25) and Shangjuxu(ST37) combination. METHODS: A model for visceral hypersensitivity in IBS was induced through colorectal distension(CRD) stimulation. Clean-grade male Sprague-Dawley(SD) rats were randomly divided into four groups: a normal group(ng), a model group(MG), an electroacupuncture group(EA), and a glial cell inhibitor group(FCA). Bilateral EA(2/100 Hz, 1 mA, 30 min) was administered at the Tianshu(ST25) and Shangjuxu(ST37) in week 6. Abdominal withdrawal reflex(AWR) scores were used to assess the behavioral response associated with visceral hyperalgesia, while hematoxylin-eosin staining was employed to evaluate pathological changes in the colon. The protein and mRNA levels of glial fibrillary acidic protein(GFAP) in the colon and colon-related dorsal root ganglion(DRG) were analyzed using immun-ofluorescence, immunohistochemistry, Western blotting, real-time polymerase chain reaction. The impact of EA on electrophysiological properties of colon-related DRG neurons was observed through whole-cell patch clamp analysis. RESULTS: EA significantly reduced the visceral pain behavior scores in rats with IBS in response to graded(20, 40, 60, 80 mm Hg) CRD stimulation. Additionally, EA downregulated the protein and mRNA expression levels of GFAP in the colon and colon-related DRG of rats with IBS. EA also regulated the resting membrane potential, rheobase and action potential of colon-related DRG neurons in rats with IBS. CONCLUSIONS: EA can regulate the excitatory properties of colon-related DRG neurons by downregulating the protein and mRNA expression of GFAP in the colon and colon-related DRG, indicating a potential neurobiological mechanism by which EA relieves visceral hypersensitivity in rats with IBS.

关键词： electroacupuncture glial fibrillary acidic proteinSupporting information irritable bowel syndrome satellite glial cell visceral hypersensitivity

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微生物自修复混凝土的制备及性能研究

价值工程 2024年第10期43卷 74-76页

作者：李茜茜刘昭洋赵明敏 Serina ng 王进春石家庄市长安育才建材有限公司石家庄051430 石家庄市建筑功能材料产业技术研究院石家庄051430 四川砼道科技有限公司成都610200

通过嗜碱芽孢杆菌胶与匹配的胶结液制备微生物修复剂,并自主研发疏水剂,通过向混凝土中加入疏水剂,改变了混凝土颗粒结构、降低土微粒界面活性,使之可以更好地配合微生物胶结对混凝土的固化,固化后的混凝土韧性大大提升,避免混凝土发生... 详细信息

通过嗜碱芽孢杆菌胶与匹配的胶结液制备微生物修复剂,并自主研发疏水剂,通过向混凝土中加入疏水剂,改变了混凝土颗粒结构、降低土微粒界面活性,使之可以更好地配合微生物胶结对混凝土的固化,固化后的混凝土韧性大大提升,避免混凝土发生破坏后强度瞬间丧失的情况发生。并通过大蒜素水溶液,在后期加强微生物对混凝土的加工作用,实现混凝土的“自愈合”效果。

关键词：微生物自修复疏水剂混凝土裂缝

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Deep CLSTM for Predictive Beamforming in Integrated Sensing and Communication-Enabled Vehicular Networks

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Journal of Communications and Information Networks 2022年第3期7卷 269-277页

作者： Chang liu Xuemeng liu Shuangyang Li Weijie Yuan Derrick Wing Kwan ng School of Electrical Engineering and Telecommunications the University of New South WalesSydneyNSW 2052Australia School of Electrical and Information Engineering the University of SydneySydneyNSW 2006Australia Department of Electrical Electronic and Computer Engineeringthe University of Western AustraliaPerth WA 6009Australia Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China

Predictive beamforming design is an essential task in realizing high-mobility integrated sensing and communication(ISAC),which highly depends on the accuracy of the channel prediction(CP),i.e.,predicting the angular parameters of ***,the performance of CP highly depends on the estimated historical channel stated information(CSI)with estimation errors,resulting in the performance degradation for most traditional CP *** further improve the prediction accuracy,in this paper,we focus on the ISAC in vehicle networks and propose a convolutional long-short term memory(CLSTM)recurrent neural network(CLRNet)to predict the angle of vehicles for the design of predictive *** the developed CLRNet,both the convolutional neural network(CNN)module and the LSTM module are adopted to exploit the spatial features and the temporal dependency from the estimated historical angles of vehicles to facilitate the angle ***,numerical results demonstrate that the developed CLRNet-based method is robust to the estimation error and can significantly outperform the state-of-the-art benchmarks,achieving an excellent sum-rate performance for ISAC systems.

关键词： integrated sensing and communication predictive beamforming deep learning convolutional longshort term neural network vehicular networks

In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

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Advanced Photonics 2024年第2期6卷 81-89页

作者： Xianghong Nan Wenduo Lai Jie Peng Haiquan Wang Bojun Chen Huifan He Zekang Mo Zikun Xia Ning Tan Zhong liu Long Wen Dan Gao Qin Chen Jinan University College of Physics & Optoelectronic Engineering Institute of Nanophotonics Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Tsinghua University Shenzhen International Graduate School State Key Laboratory of Chemical Oncogenomics Jinan University College of Life Science and Technology

Narrowband photodetection is an important measurement technique for material analysis and sensing, for example, nondispersive infrared sensing technique. Both photoactive material engineering and nanophotonic filtering schemes have been explored to realize wavelength-selective photodetection,while most devices have a responsive bandwidth larger than 2% of the operating wavelength, limiting sensing performance. Near-infrared photodetection with a bandwidth of less than 0.2% of the operating wavelength was demonstrated experimentally in Au/Si Schottky nanojunctions. A minimum linewidth of photoelectric response down to 2.6 nm was obtained at a wavelength of 1550 nm by carefully tailing the absorptive and radiative loss in the nanostructures. Multiple functions were achieved on chip with the corrugated Au film, including narrowband resonance, light harvesting for sensing and photodetection, and electrodes for hot electron emission. Benefiting from such a unity integration with in situ photoelectric conversion of the optical sensing signal and the ultranarrowband resonance, self-contained on-chip biosensing via simple intensity interrogation was demonstrated with a limit of detection down to 0.0047%in concentration for glucose solution and 150 ng∕m L for rabbit IgG. Promising potential of this technique is expected for the applications in on-site sensing, spectroscopy, spectral imaging, etc.

关键词： Photodetectors Plasmonics Biosensing Optical gratings Gold Absorption spectrum Acoustooptic tunable filters Absorption Sensors In situ remote sensing

Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min liu Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken HUAng Yun-ke ZHAO Qiu-long HUAng Wen-ya HUAng Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,Png-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system

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Journal of Molecular Cell Biology 2020年第5期12卷 327-336页

作者： Ya-Jie Xu Pei-Pei liu Shyh-Chang ng Zhao-Qian Teng Chang-Mei liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs(ncRNAs)involved in diverse cellular *** as epigenetic mediators play key roles in neuronal development,maintenance,and dysfunction by controlling gene expression at multiple *** may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group(PcG)proteins to drive orchestrated transcriptional *** significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional,post-transcriptional,and epigenetic *** importantly,dysregulation of ncRNAs,PcG proteins,and interplay among them is closely associated with the pathogenesis of central nervous system(CNS)*** this review,we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.

关键词： epigenetics Polycomb complexes non-coding RNAs central nervous system neurological diseases