检索结果-南通市图书馆

Is GDNF to Parkinson’s disease what BDNF is to Huntington’s disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 973-974页

作者： Francesca R.fusco Emanuela Paldino Laboratory of Neuroanatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neurotrophic factors,or neurotrophins,are a group of molecules supporting the growth,survival,and differentiation of developing and mature *** their role in the survival of neurons,and often of specific subsets of bra... 详细信息

关键词： Huntington supporting degenerative

Effect of Dietary Components on the Shear Bond Strength of Orthodontics Brackets after Thermal Aging

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2024年第6期14卷 309-315页

作者： Philip Punzalan Tanya Al Talib Anthony fusco Neamat Hassan Abubakr School of Dental Medicine University of Nevada Las Vegas Nevada USA

Introduction: The stability of orthodontic brackets throughout orthodontic treatment plays a critical role in the treatment’s effectiveness. The present in vitro study was designed to assess the impact of various dietary components on the performance of orthodontic brackets. Methods: Metal orthodontic brackets were bonded to 66 extracted anterior teeth divided into groups based on the solution type: Milk, Gatorade, Cold Coffee, and a control group using water. Each group consisted of 20 teeth except for the control group, which included six teeth. The bracketed teeth were submerged in their respective solutions for 15 minutes three times daily at different intervals to mimic an in vivo environment and were stored in artificial saliva at room temperature (23?C). The specimens underwent artificial aging through 10,000 cycles of thermocycling (representing one clinical year) between 5?C and 55?C. Shade measurements were taken using a VITA Easy Shade device, capturing the classic shade and L*, a*, and b* values. Delta E values were calculated immediately post-bonding and after 7 days, 1 month, 1, and 2 clinical years. The shear bond strength of each bracket was measured using an ultra-tester machine. Results: After two clinical years, significant differences in ΔE color values were observed across all groups, with the most substantial change noted in teeth immersed in cold coffee. Brackets submerged in milk demonstrated lower shear bond strength than other solutions, whereas the control group exhibited the highest shear bond strength (P = 0.01). Conclusion: The study indicates that dietary components significantly influence tooth color stability and the shear bond strength of orthodontic brackets, underscoring the importance of considering these factors in orthodontic treatment planning.

关键词： Shear Bond Orthodontic Brackets Color Stability Thermal Aging

HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第35期22卷 7926-7937页

作者： Nicola fusco Silvano Bosari Division of Pathology Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico 20122 Milan Italy Department of Pathophysiology and Organ Transplantation University of Milan

Management of cancers of the digestive system has progressed rapidly into the molecular era. Despite the significant recent achievements in the diagnosis and treatment of these patients, the number of deaths for these tumors has currently plateaued. Many investigations have assessed the role of HER2 in tumors of the digestive system in both prognostic and therapeutic settings, with heterogeneous results. Novel testing and treatment guidelines are emerging, in particular in gastric and colorectal cancers. However, further advances are needed. In this review we provide a comprehensive overview of the current state-ofknowledge of HER2 alterations in the most common tumors of the digestive system and discuss the operational implications of HER2 testing.

关键词： HER2 Digestive system Gastrointestinal tract Gastric cancer Colon cancer Esophageal cancer Gastroesophageal junction cancer Biliary tract cancer Gallbladder cancer Liver cancer Pancreas cancer

Biomarkers for targeted rehabilitation strategies after breast cancer: Proposal for the next-generation management of survivorship issues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第10期46卷 2221-2223页

作者： MARCO INVERNIZZI NICOLA fusco Translational Medicine Dipartimento AttivitàIntegrate Ricerca e Innovazione(DAIRI)Azienda Ospedaliera SS.Antonio e Biagio e Cesare ArrigoAlessandria15121Italy Physical and Rehabilitation Medicine Department of Health SciencesUniversity of Eastern PiedmontNovara28100Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan20122Italy

Breast cancer(BC)is the most common malignant tumor and one of the top causes of cancer-related death worldwide(Sung et al.,2021).The recent advances in early tumor diagnosis coupled with more effective treatment strategies resulted in a steady increase of long-term survivors(Nardin et al.,2020;Invernizzi et al.,2022).These improved survival rates led to a significantly higher incidence of disabling complications related to breast cancer and/or its treatment(Invernizzi et al.,2020a;D’Egidio et al.,2017;Zhong et al.,2020).

关键词： Breast cancer Biomarkers Survivorship Rehabilitation Precision medicine

Effect of Dietary Components on the Shear Bond Strength of Orthodontics Brackets after Thermal Aging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules

Open Journal of Stomatology（口腔学期刊） 2024年第6期 309页

作者： Philip Punzalan Tanya Al Talib Anthony fusco Neamat Hassan Abubakr

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 161-177页

作者： Francesca Natale Salvatore fusco Claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro Cuore00168 RomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS 00168 RomeItaly.

Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of *** them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,representing the most disabling symptom on both personal and social *** molecular mechanisms underlying the onset and progression of dementia are still poorly understood,and include secretory factors potentially affecting differentiated neurons,glial cells and neural stem cell *** the last decade,much attention has been devoted to exosomes as novel carriers of information exchanged among both neighbouring and distant *** vesicles can be generated and internalized by different brain cells including neurons,neural stem cells,astrocytes,and microglia,thereby affecting neural plasticity and cognitive functions in physiological and pathological ***,we review data on the roles of exosomes as carriers of bioactive molecules potentially involved in the pathogenesis of neurodegenerative disorders and detectable in biological fluids as biomarkers of *** also discuss the experimental evidence of the therapeutic potential of stem cell-derived vesicles in experimental models of neurodegeneration-dependent cognitive decline.

关键词： Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline

Biobanking in the digital pathology era

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2021年第4期29卷 229-233页

作者： GIUSEPPINA BONIZZI LORENZO ZATTONI NICOLA fusco Biobank for Translational and Digital Medicine Unit Division of PathologyIEOEuropean Institute of Oncology IRCCSUniversity of MilanMilan20141Italy

Digital Pathology is becoming more and more important to achieve the goal of precision *** in whole-slide imaging,software integration,and the accessibility of storage solutions have changed the pathologists’clinical practice,not only in terms of laboratory workﬂow but also for diagnosis and biomarkers *** parallel with the pathology setting advancement,translational medicine is approaching the unprecedented opportunities unrevealed by artiﬁcial intelligence(AI).Indeed,the increased usage of biobanks’datasets in research provided new challenges for AI applications,such as advanced algorithms,and computer-aided *** this scenario,machine learning-based approaches are being propose in order to improve biobanks from biospecimens collection repositories to computational *** date,evidence on how to implement digital biobanks in translational medicine is still *** viewpoint article summarizes the currently available literature that supports the biobanks’role in the digital pathology era,and to provide possible practical applications of digital biobanks.

关键词： Biobank Pathology Digital pathology Biomarkers Translational research

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Impact of comorbidity in elderly prostate cancer patients treated with brachytherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2013年第3期25卷 274-280页

作者： Costanza Chiumento Alba Fiorentino Mariella Cozzolino Rocchina Caivano Stefania Clemente Piernicola Pedicini Vincenzo fusco Department of Radiation Oncology IRCCS-CROBRionero in Vulture 85028 Italy

Objective： To analyze the correlations among comorbidity and overall survival （OS）, biochemical progression-free survival （b-PFS） and toxicity in elderly patients with localized prostate cancer treated with 125I brachytherapy. Methods： Elderly men, aged ≥65 years, with low-intermediate risk prostate cancer, were treated with permanent 125I brachytherapy as monotherapy. Comorbidity data were obtained from medical reports using age-adjusted Charlson comorbidity index （a-CCI）. The patients were categorized into two age groups （〈75 and 〉75 years old）, and two comorbidity score groups （a-CCI ≤3 and 〉3）. Toxicity was scored with Radiation Therapy Oncology Group （RTOG） scale. Results： From June 2003 to October 2009, a total of 92 elderly patients underwent prostate brachytherapy, including 57 men （62%） with low-risk prostate cancer, and 35 men （38%） with intermediate-risk prostate cancer. The median age of patients was 75 years （range, 65-87 years）. Forty-seven patients （51%） bad a-CCI _〈3 and 45 patients （49%） a-CCI 〉3. With a median follow-up period of 56 months （range, 24-103 months）, the 5-year actuarial OS and b-PFS were 91.3% and 92.4% respectively, without statistical significance between two Charlson score groups. Toxicity was mild. None of the patients experienced gastrointestinal （GI） toxicity, and only 4 patiens （4%） experienced late genitourinary （GU） grade-3 （G3） toxicity. No correlation between acute GU and GI toxicity and eomorbidity was showed （P=0.50 and P=0.70, respectively）. Conclusions： Our data suggest that elderly men with low-intermediate risk prostate cancer and comorbidity can be considered for a radical treatment as 12Sl low-dose rate brachytherapy.

关键词： Prostate cancer braehytherapy elderly comorbidity toxicity overall survival biochemical control