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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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How ploughing and frictional melting regulate ice-skating friction

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Friction 2023年第11期11卷 2036-2058页

作者： feng DU Peng KE ping HONG School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Beijing Sports University Beijing 100084China

The slipperiness of ice is well known while,for ice skating,its mechanism still needs further investigation,where the complex interactions including the thermal conduction of the skate–meltwater–ice system,the ploughing and the frictional melting of ice to the friction force are still *** study presents a theoretical framework and a simplified analytical solution to unveil the friction mechanism when a curved skate sliding on *** theory is validated by experiments and the effects of these various factors,including the sliding velocity,the ice temperature,the supporting weight,and the geometry of the skate blade to the friction are revealed in *** study finds that the contribution of friction force from the ploughing deformation through skate indentation and that from the fluid friction through the shear motion of the meltwater layer is comparable with each other,which thus clarifies how the ploughing deformation of the ice substrate together with its frictional melting regulates the friction during skating.

关键词： ice friction skating ploughing frictional melting coefficient of friction

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Assessing the factors impacting the bioaccessibility of mercury(Hg) in rice consumption by an in-vitro method

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Journal of Environmental Sciences 2022年第9期34卷 119-129页

作者： Ze Wu ping Li Xinbin feng College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuiyang 550025China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Mercury(Hg) in rice is drawing mounting concern since methylmercury(MeHg) was found capable of accumulating in rice. In-vitro bioaccessibility is a feasible and reliable method to assess the health effects of Hg in rice and has been utilized in a number of studies. This study was done to investigate the impact of cultivar, planting location, and cooking on the total mercury(THg) and MeHg bioaccessibility of rice, for which multiple statistical analysis methods were used to analyze the significance of their effects. The THg concentrations of rice samples taken from non-Hg contaminated areas of China were all below 15 ng/g and their MeHg concentrations were below 2 ng/g. Cooking could significantly reduce the MeHg bioaccessibility of rice because the MeHg was mainly combined with protein and the protein will be denatured during the cooking process, and then the denatured MeHg is difficult to be dissolved into the liquid phase. Indica-and japonica-type rice cultivars did not show significant differentiation in either the concentration of Hg or its bioaccessibility. However, the glutinous rice type differed significantly from the above rice types, and it showed greater bioaccessibility of THg and MeHg due to its distinct protein contents and starch properties. Planting location can affect the Hg concentration in rice and THg bioaccessibility but has a limited impact on MeHg bioaccessibility. Based on these results, two macro factors(rice cultivar, planting location) are presumed to impact Hg bioaccessibility by how they affect micro factors(i.e., Hg forms).

关键词： Rice Bioaccessibility Mercury Impact factors

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An effective synthesis of β-aryl substituted isotetronic acids via Suzuki coupling

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Chinese Chemical Letters 2008年第11期19卷 1309-1311页

作者： Huan Sheng Chen Xia ping Ma Zhi Ming Li Quan Rui Wang feng gang Tao Department of Chemistry Fudan University Shanghai 200433 China

Isotetronic acids are of great agricultural and pharmacological relevance and occur in a number of natural products. A convenient synthetic pathway to β-aryl substituted isotetronic acid derivatives was developed via Suzuki cross-coupling of the corresponding β-bromo substituted isotetronic acid derivatives with arylboronic acids under palladium acetate catalysis. Good to excellent yields have been achieved

关键词： lsotetronic acids Palladium Suzuki coupling Arylboronic acids

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Synthesis and Crystal Structure of 3-Benzyl-5-cyclohexylamino-6-phenyl-3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one

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Chinese Journal of Structural Chemistry 2005年第4期24卷 439-443页

作者： ZHAOJun-feng WANGCheng-gang DINGMing-Wu KeyLaboratoryofPesticide＆ChemicalBiology MinistryofEducationCollegeofChemistryCentralChinaNormalUniversityWuhan430079China

The title compound 3-benzyl-5-cyclohexylamino-6-phenyl-3,6-dihydro-1,2,3- triazolo[4,5-d]pyrimidin-7-one (C23H24N6O, Mr = 400.48) has been synthesized by means of tandem aza-Wittig reaction, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/n with a = 6.5550(6), b = 10.3711(10), c = 31.265(3) ?, β = 93.827(2)o,V = 2120.8(4) ?3, Z = 4, Dc = 1.254 g/cm3, S = 1.025, μ(MoKa) = 0.081 mm-1, F(000) = 848, R = 0.0576 and wR = 0.1368. X-ray analysis reveals that all ring atoms in the triazolopyrimidinone moiety are almost coplanar and the cyclohexyl ring adopts a chair confor- mation.

关键词： crystal structure 3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one aza-Wittig reaction synthesis

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Syntheses of 10-Hydroxy-5,10-dihydrophenophosphazine 10-Oxide and Its Methyl Derivatives

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Chemical Research in Chinese Universities 2003年第1期19卷 32-36页

作者： YIN Zhi gang ZHAO De feng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116012P.R.China Chemical Engineering Department Zhengzhou Institute of Light IndustryZhengzhou 450002P.R.China

Ph 2NH and PCl 3 interacted at a molar ratio of 1∶1 05 and slow elevated temperature and then at 210-220 ℃ for 6 h. The brown solution obtained was treated with H 2O to produce a very hard brown solid believed to be a mixture of 5,10 dihydrophenophosphazine 10 oxide(1a) and 10,10(5H,5H) spirobipenophosphazinium chloride(1b). This brown solid was directly oxidized with peracetic acid in HOAc prior to the separation of them to give compound 10 hydroxy 5,10 dihydropheno phosphazine 10 oxide(2) with a higher yield(45%) than that of the literature(27%). When treated with excess SOCl 2, compound 2 could quantitatively be converted to the corresponding phosphinyl chloride and the latter could further be transformed into 10 methoxy 5,10 dihydrophenophosphazine 10 oxide in 70% as treated with NaOMe in methanol. Compound 2 could also be converted to a bisanion when treated with NaH in DMF. The resulted bisanion reacted with MeI to give 5 methyl 10 hydroxy 5,10 dihydrophenophosphazine 10 oxide in a 73% yield which would be converted to 5 methyl 10 methoxy 5,10 dihydrophenophosphazine 10 oxide in a 56% yield by the same way of synthesizing 10 methoxy 5,10 dihydrophenophosphazine 10 oxide. All these compounds obtained were identified by surveying their melting points, and spectra and elemental analysis.

关键词： Synthesis 5,10-Dihydrophenophosphazine Derivative Structure identification

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Microwave-assisted synthesis of diaryl or aryl-alkyl sulfones without catalyst

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Chinese Chemical Letters 2009年第1期20卷 17-20页

作者： Jiong Zou feng Li feng gang Tao Department of Chemistry Fudan University Shanghai 200433 China

The microwave-assisted coupling reaction of electrondeficient aryl halides with sulfinic acid salts through SNAr-based addition reactions within 5-30 min. No catalysts were required under our conditions.

关键词： Microwave Sulfone SNAr-based addition reaction

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Stabilized Finite Element Methods for Biot’s Consolidation Problems Using Equal Order Elements

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Advances in Applied Mathematics and Mechanics 2018年第1期10卷 77-99页

作者： gang Chen Minfu feng School of Mathematics Sciences University of Electronic Science and Technology of ChinaChengduSichuan 611731China School of Mathematics Sichuan UniversityChengduSichuan 610064China

Using the standard mixed Galerkin methods with equal order elements to solve Biot’s consolidation problems,the pressure close to the initial time produces large non-physical *** this paper,we propose a class of fully discrete stabilized methods using equal order elements to reduce the effects of non-physical *** error estimates for the approximation of displacements and pressure at every time level are obtained,which are valid even close to the initial *** experiments illustrate and confirm our theoretical analysis.

关键词： Biot’s problem LBB condition stabilized method error estimates numerical experiments Terzaghi problem

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Mapping Seismic Hazard for Canadian Sites Using Spatially Smoothed Seismicity Model

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International Journal of Disaster Risk Science 2023年第6期14卷 898-918页

作者： Chao feng Han-ping Hong School of Civil Engineering Chang’an UniversityXi’an 710061China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Civil and Environmental Engineering University of Western OntarioLondon N6A 5B9Canada

The estimated seismic hazard based on the delineated seismic source model is used as the basis to assign the seismic design loads in Canadian structural design *** alternative for the estimation is based on a spatially smoothed source ***,a quantification of differences in the Canadian seismic hazard maps(CanSHMs)obtained based on the delineated seismic source model and spatially smoothed model is *** quantification is valuable to identify epistemic uncertainty in the estimated seismic hazard and the degree of uncertainty in the *** the present study,we developed seismic source models using spatial smoothing and historical earthquake *** quantified the differences in the estimated Canadian seismic hazard by considering the delineated source model and spatially smoothed source *** the development of the spatially smoothed seismic source models,we considered spatial kernel smoothing techniques with or without adaptive *** results indicate that the use of the delineated seismic source model could lead to under or over-estimation of the seismic hazard as compared to those estimated based on spatially smoothed seismic source *** suggests that an epistemic uncertainty caused by the seismic source models should be considered to map the seismic hazard.

关键词： Adaptive kernel smoothing Fixed kernel smoothing Ground motion model Probabilistic seismic hazard analysis Seismic hazard map Uniform hazard spectra

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Distributed Secondary Control and Optimal Power Sharing in Microgrids

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IEEE/CAA Journal of Automatica Sinica 2015年第3期2卷 304-312页

作者： gang Chen Ening feng the Key Laboratory of Dependable Service Computing in Cyber Physical Society of Ministry of Education and the College of Automation Chongqing University

We address the control problem of microgrids and present a fully distributed control system which consists of primary controller, secondary controller, and optimal active power sharing controller. Different from the existing control structure in microgrids, all these controllers are implemented as local controllers at each distributed generator. Thus, the requirement for a central controller is obviated. The performance analysis of the proposed control systems is provided, and the finite-time convergence properties for distributed secondary frequency and voltage controllers are achieved. Moreover, the distributed control system possesses the optimal active power sharing property. In the end, a microgrid test system is investigated to validate the effectiveness of the proposed control strategies. © 2014 Chinese Association of Automation.

关键词： Control system analysis Control systems Distributed parameter control systems Distributed parameter networks Electric power distribution

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