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Rainfall impacts on nonpoint nitrogen and phosphorus dynamics in an agricultural river in subtropical montane reservoir region of southeast China

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Journal of Environmental Sciences 2025年第3期149卷 551-563页

作者： Yuanyi Wang hai Xu Xingchen Zhao Lijuan Kang Yu Qiu Hans Paerl Guangwei Zhu Huiyun Li Mengyuan Zhu Boqiang Qin Yunlin Zhang Mingliang liu Key Laboratory of Lake and Watershed Science for Water Security Nanjing Institute of Geography&LimnologyChinese Academy of SciencesNanjing 210008China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Institute of Marine Sciences University of North Carolina at Chapel HillNC 28557USA Hangzhou Institute of Ecological and Environmental Sciences Hangzhou 310005China

The increased frequency and intensity of heavy rainfall events due to climate change could potentially influence the movement of nutrients from land-based regions into recipient ***,little information is available on how the rainfall affect nutrient dynamics in subtropicalmontane rivers with complex land *** study conducted high-frequency monitoring to study the effects of rainfall on nutrients dynamics in an agricultural river draining to Lake Qiandaohu,a montane reservoir of southeast *** results showed that riverine total nitrogen(TN)and total phosphorus(TP)concentrations increased continuously with increasing rainfall intensity,while TN:TP *** heavy rainfall and rainstorm drove more than 30%of the annual N and P loading in only 5.20%of the total rainfall period,indicating that increased storm runoff is likely to exacerbate eutrophication in montane ***_(3)^(−)-N is the primary nitrogen form lost,while particulate phosphorus(PP)dominated phosphorus *** source of N is cropland,and themain source of P is residential ***,forestedwatersheds have better drainage quality,while it is still a potential source of nonpoint pollution during rainfall *** and TP concentrations were significantly higher at sites dominated by cropland and residential area,indicating their substantial contributions to deteriorating river water ***,TN and TP concentrations reached high values in May-August when rainfall was most intense,while they were lower in autumn and winter than that in spring and summer under the same rainfall *** results emphasize the influence of rainfall-runoff and land use on dynamics of riverine N and P loads,providing guidance for nutrient load reduction planning for Lake Qiandaohu.

关键词： Non-point source pollution Rainfall events Land use type Mountain area Deepwater reservoir

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Nd@C3N4-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

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Chinese Chemical Letters 2025年第2期36卷 412-416页

作者： Hong-Tao Ji Yu-Han Lu Yan-Ting liu Yu-Lin Huang Jiang-Feng Tian Feng liu Yan-Yan Zeng hai-Yan Yang Yong-Hong Zhang Wei-Min He Department of Ophthalmology The Affiliated Nanhua Hospital Hengyang Medical School University of South China School of Chemistry and Chemical Engineering University of South China Department of Lung Cancer and Gastroenterology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University

The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.

关键词： Chlorine Dual catalysis Hydrogen atom transfer Redox catalyst Semiconductor

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Adsorbate-driven dynamic active sites in stannosilicate zeolites

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Fundamental Research 2025年第1期5卷 174-182页

作者： Yi, Xianfeng Xiao, Yao Xia, Changjiu liu, Fengqing liu, Yujia Hui, Yu Yu, Xin Qin, Yucai Chen, Wei liu, Zhiqiang Song, Lijuan zheng, Anmin State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Catalytic Materials and Reaction Engineering Research Institute of Petroleum Processing SINOPEC Beijing 100083 China Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Petrochemical University Fushun 113001 China

Elucidating the nature of the active sites in heterogeneous catalysts is fundamental for understanding their reactivity and catalytic performances. Although stannosilicate zeolites have tremendous application potential for catalyzing biomass-related compounds in aqueous media, the detailed local structures and features of the real active sites and their possible structural variations under reaction conditions are poorly understood to date. In this study, a dynamic transformation of framework Sn−O−Si sites to Sn−OH/Si−OH pairs and subsequently a pseudo-Brønsted acid in stannosilicate zeolites upon molecular adsorption, which is analogous to various adsorbates/reactants under working conditions, was identified by solid-state nuclear magnetic resonance (NMR) spectroscopy for the first time, which challenges the widespread assumption that the active center structures remain rigid/stable during the catalytic process. These results provide new comprehensive insights for the fundamental understanding of the dynamic and flexible active centers and involved reaction mechanisms of novel zeolite catalysts with heterometal atoms, such as Sn, Ti, and Zr. © 2023

关键词： Dynamic active sites Pseudo-Brønsted acid Reaction conditions Solid-state NMR Stannosilicate zeolites

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创新思维:广电体制改革的内在动力

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南京晓庄学院学报 2006年第1期22卷 56-59页

作者：刘正海江苏教育电视台江苏南京210036

思路决定出路,思路来自思维。通过创新思维,可以改变广电领域内传统的思维模式,变传统性思维为超前性思维,变依附性思维为独立性思维,变单向性思维为多维性思维,变两极式思维为中介性思维,从而推动现有广电体制的改革,探索出一条适合我... 详细信息

思路决定出路,思路来自思维。通过创新思维,可以改变广电领域内传统的思维模式,变传统性思维为超前性思维,变依附性思维为独立性思维,变单向性思维为多维性思维,变两极式思维为中介性思维,从而推动现有广电体制的改革,探索出一条适合我国国情的广电发展之路。

关键词：创新思维广电体制改革

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A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke

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Neural Regeneration Research 2025年第12期20卷 3591-3605页

作者： Zhijian zheng Xiaohui Lin Zijun Zhao Qiang Lin Ji liu Manli Chen Wenwen Wu Zhiyun Wu Nan liu Hongbin Chen Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Department of Rehabilitation Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Molecular Neurology Fujian Medical UniversityFuzhouFujian ProvinceChina Institute of Clinical Neurology Fujian Medical UniversityFuzhouFujian ProvinceChina

Adipose-derived stem cell,one type of mesenchymal stem cells,is a promising approach in treating ischemia-reperfusion injury caused by occlusion of the middle cerebral ***,its application has been limited by the complexities of the ischemic *** scaffolds,which are composed of hyaluronic acid and chitosan,exhibit excellent biocompatibility and biodegradability,making them promising candidates as cell *** endothelial growth factor is a crucial regulatory factor for stem *** hyaluronic acid and chitosan have the potential to make the microenvironment more hospitable to transplanted stem cells,thereby enhancing the therapeutic effect of mesenchymal stem cell transplantation in the context of ***,we found that vascular endothelial growth factor significantly improved the activity and paracrine function of adipose-derived stem ***,we developed a chitosan-hyaluronic acid hydrogel scaffold that incorporated vascular endothelial growth factor and first injected the scaffold into an animal model of cerebral ischemiareperfusion *** loaded with adipose-derived stem cells,this vascular endothelial growth factor–loaded scaffold markedly reduced neuronal apoptosis caused by oxygen-glucose deprivation/reoxygenation and substantially restored mitochondrial membrane potential and axon *** in vivo experiments revealed that this vascular endothelial growth factor–loaded hydrogel scaffold facilitated the transplantation of adipose-derived stem cells,leading to a reduction in infarct volume and neuronal apoptosis in a rat model of stroke induced by transient middle cerebral artery *** also helped maintain mitochondrial integrity and axonal morphology,greatly improving rat motor function and ***,utilizing a hydrogel scaffold loaded with vascular endothelial growth factor as a stem cell delivery system can mitigate the adverse effects of ischemic microenvironment

关键词： adipose-derived stem cells chitosan hyaluronic acid hydrogel ischemia-reperfusion oxygen-glucose deprivation/reoxygenation stroke transient middle cerebral artery occlusion transplantation vascular endothelial growth factor

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Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi zheng Xiao-Sheng Li Qian-Jie Xu Wei Zhang Zhong-Li Liao hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao Yin-Long Xu Jia-Wei Chai Kai zheng Jun-Jie Kong Jun liu Shun-Zhen zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年第2期68卷 391-392页

作者： Yang LI Yuzhe GU Sheng QIAN Yuncong PANG Aoxi YU Shuwen zheng Wenjie XIA Yuan LIAO Baoguang liu Shujuan liu Qiang ZHAO College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM)Nanjing University of Posts&Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance.

关键词： Lithium Chloride

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi liu Ran zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 410-417页

作者： Ming-Zhi Hao hai-Lan Lin Yu-Bin Hu Qi-Zhong Chen Zhang-Xian Chen Lin-Bin Qiu Duan-Yu Lin Hui Zhang De-Chun zheng Zhu-Ting Fang Jing-Feng liu Department of Tumor Interventional Radiology Clinical Ocology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical UniversityFuzhou 350014Fujian ProvinceChina Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFuzhou 350014Fujian ProvinceChina Department of Hepatopancreatobiliary Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Radiology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Hepatobiliary Surgery Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)has become a growing health concern *** invasion and high tumor burden are key factors limiting the curative effect of selective internal radiation therapy(SIRT).CASE SUMMARY This case study reports a 49-year-old woman who was diagnosed with China Liver Cancer Staging(CNLC)IIIa HCC and>15 cm tumor ***,due to insufficient future liver remnant and vascular invasion,the tumor was unresectable;however,radical hepatectomy was performed after successful conversion therapy with SIRT using yttrium-90(90Y)resin microspheres followed by hepatic arterial infusion chemotherapy(haiC)with tyrosine kinase inhibitor(TKI)and anti-programmed death-1(PD-1)*** using 90Y resin microspheres was given by the right hepatic artery and chemoembolization was simultaneously performed in the tumor’s feeding vessels from the right diaphragmatic *** was followed every three weeks with lenvatinib and *** 4 months post-SIRT,the tumor was downstaged to CNLC Ib and the patient successfully underwent *** histopathological examination of the resected specimen showed extensive *** This case study provides evidence for an integrated treatment strategy combining SIRT and haiC with TKI and anti-PD-1 antibodies for patients with large HCC and microvascular *** confirmatory trials are required in the future.

关键词： Selective internal radiation therapy Hepatic arterial infusion chemotherapy Yttrium-90 resin microspheres Hepatocellular carcinoma Conversion therapy Case report

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