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Controversies on the Values for Health Instruments of Chinese Medicine

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Chinese Journal of Integrative Medicine 2017年第2期23卷 146-152页

作者： HOU Zheng-kun CHANG Xiang liu feng-bin Nelson XIE Nicole GUO CHEN Xin-lin Gastroenterology Department First Affiliated HospitalGuangzhou University of Chinese Medicine，Medicine，Guangzhou，510405，China Encephalopathy Department Xi'an Hospital of Traditional Chinese Medicine，Xi’an，710001，China Department of Neurosciences School of Medicine University of California，San Diego，CA，92093，USA Department of Preventive Medicine and Health Statistics School of Medical and Molecular Biosciences University of Technology Sydney，Ultimo，2007Australia Nursing Department Repatriation General HospitalSA ，5041，Australia College of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou，510006，China

Currently, there are increasing debates on the necessity of health instruments in Chinese medicine（CM） emerging in China. This study aims to reevaluate its status and values. Analyzing the causes, limits, advantages, and properties characters of health instruments in CM, it is found that weak fundamental research, incomplete self-awareness, and complicated social factors are the primary causes of debates. A comprehensive analysis showed health instruments in CM have health evaluation benefits to people from a dominant Chinese culture, meet the requirements of cultural background, and bring long-term value to Chinese instrument researches. However, its values and status should be treated differently depending on various subtypes. Although little theoretical and practical evidences proved that patients-reported health instruments in CM should be proposed independently, the doctors- and nurses-reported questionnaires are necessary. With this in mind, the study group proposes the ＇Chinese cultural instruments（CCIs）＇ and ＇health-related CCIs＇. The latter one aims to evaluate the health status of people in a dominant Chinese culture. The CCIs theory represents Chinese instrument researches on a larger regional and higher level, and resolves the debates on instruments between CM and Western medicine in China. Health instruments in CM bring more scientific and social benefits for Chinese instrument researches. However, it does not include cultural demands, and lacks scientific significance. CCIs have all its virtues, and add solutions to the latter＇s theory bottleneck and scientific debates, thus bringing increased benefits to clinical assessment in complementary and alternative medicine researches.

关键词： Chinese culture Chinese medicine instrument clinical outcome assessment patient-reported outcome value

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan liu Jia-lin CHEN Geng-xin SHEN Dan-ting ZHU Wang CHEN Xin-lin liu feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

量表测评方法在中医临床疗效评价中的应用与展望

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中国中西医结合杂志 2007年第12期27卷 1129-1132页

作者：刘凤斌广州中医药大学第一附属医院广州510405

国外生存质量和患者报告的指标的评价内容与中医问诊的内容基本一致,故同是软指标的中医疗效评价可以借用量表作为评价工具,并逐渐被中医药专家接受和应用。但量表测评方法的应用和中医特色量表的研制等工作尚刚刚起步,存在对量表理论... 详细信息

国外生存质量和患者报告的指标的评价内容与中医问诊的内容基本一致,故同是软指标的中医疗效评价可以借用量表作为评价工具,并逐渐被中医药专家接受和应用。但量表测评方法的应用和中医特色量表的研制等工作尚刚刚起步,存在对量表理论的认识不足,中医特色量表体系尚未形成;量表的选择缺乏针对性,量表测评的实施过程尚不够规范等问题有待完善。有必要加强遵循中医理论,按照国际通用的量表研制规范开展相关研究,以推动量表测评方法在中医药疗效中应用的规范化发展。

关键词：量表中医药疗效评价

Racl＋ cells distributed in accordance with CD 133＋ cells in glioblastomas and the elevated invasiveness of CD 133＋ glioma cells with higher Racl activity

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Chinese Medical Journal 2012年第24期125卷 4344-4348页

作者： ZHANG bin SUN Jian YU Sheng-ping CHEN Cong liu bin liu Zhi-feng REN bing-cheng MING Hao-lang YANG Xue-jun Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Recent studies have suggested that cancer stem cells are one of the major causes for tumor recurrence due to their resistance to radiotherapy and chemotherapy. Although the highly invasive nature of glioblastoma （GBM） cells is also implicated in the failure of current therapies, it is not clear how glioma stem cells （GSCs） are involved in invasiveness. Racl activity is necessary for inducing reorganization of actin cytoskeleton and cell movement. In this study, we aimed to investigate the distribution characteristics of CD133＋ cells and Racl＋ cells in GBM as well as Racl activity in CD133＋ GBM cells, and analyze the migration and invasion potential of these cells. Methods A series of 21 patients with GBM were admitted consecutively and received tumor resection in Tianjin Medical University General Hospital during the first half of the year 2011. Tissue specimens were collected both from the peripheral and the central parts for each tumor under magnetic resonance imaging （MRI） navigation guidance. Immunohistochemical staining was used to detect the CD133＋ cells and Racl＋ cells distribution in GBM specimens. Double-labeling immunofluorescence was further used to analyze CD133 and Racl co-expression and the relationship between CD133＋ cells distribution and Racl expression. Serum-free medium culture and magnetic sorting were used to isolate CD133＋ cells from U87 cell line. Racl activation assay was conducted to assess the activation of Racl in CD133＋ and CD133- U87 cells. The migration and invasive ability of CD133＋ and CD133- U87 cells were determined by cell migration and invasion assays in vitro. Student＇s t-test and one-way analysis of variance （ANOVA） test were used to determine statistical significance in this study. Results In the central parts of GBMs, CD133＋ cells were found to cluster around necrosis and occasionally cluster around the vessels under the microscope by immunohistological staining. In the peripheral parts of the tumors, CD133＋ cells w

关键词： glioblastoma stem cells invasion migration Racl

Spinal surgeons＇ learning curve for lumbar microendoscopic discectomy： a prospective study of our first 50 and latest 10 cases

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Chinese Medical Journal 2008年第21期121卷 2148-2151页

作者： RONG Li-min XIE Pei-gen SHI De-hai DONG Jian-wen liu bin feng feng CAI Dao-zhang Department of Orthopaedics Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Microendoscopic discectomy （MED） is a minimally invasive operation that allows rapid recovery from surgery for lumbar disc herniation, but has replaced traditional open surgery in few hospitals because most surgeons avoid its long learning curve. We evaluated the effectiveness and safety of lumbar MED at stages of spinal surgeons＇ learning curve. Methods Fifty patients receiving MED from June 2002 to February 2003 were divided into chronological groups of ten each： A-E. The control group F was ten MED patients treated later by the same medical team （September-October 2006）. All operations were performed by the same team of spinal surgeons with no MED experience before June 2002. We compared groups by operation time, blood loss, complications and need for open surgery after MED failure. Results Operation times by group were： A, （107±14） minutes; B, （85±13） minutes; C, （55±19） minutes; D, （52±12） minutes; E, （51±13） minutes; and F, （49±15） minutes. Blood loss were： A, （131±73） ml; B, （75±20） ml; C, （48±16） ml; D, （44±17） ml; E, （45±18） ml; and F, （45±16） ml. Both operation time and blood loss in groups C, D, E and F were smaller and more stable compared with groups A and B. Japanese Orthopedic Association assessment （JOA） score of each group in improvement rate immediately and one year after operation were as follows （in percentage）： A, （79.8±8.8）/（89.8±7.7）; B, （78.6±8.5）/（88.5±7.8）; C, （80.8±11.3）/（90.8±6.7）; D, （77.7±11.4）/（88.9±9.3）; E, （84.0±8.7）/（89.6±9.0）; and F, （77.8±11.6）/ （86.9±8.4）. Groups showed no statistical difference in improvement rates. Complications developed in three patients in group A, two in group B, and none in the other groups. Conclusions Spinal surgeons performing MED become proficient after 10-20 operations, when their skill becomes fairly sophisticated. Patients＇ improvement rate is the same regardless of surgeons＇ phase of learning curve.

关键词： lumbar disc herniation microendoscopic discectomy learning curve spinal surgeons

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氢、氧终端掺硼金刚石薄膜的电子结构

物理学报 2008年第2期57卷 1171-1176页

作者：刘峰斌汪家道陈大融清华大学摩擦学国家重点实验室北京100084

利用氢微波等离子体溅射和浓酸中沸煮方法分别制备了氢、氧终端掺硼金刚石薄膜.借助X射线光电子能谱及接触角检测对两种终端薄膜表面进行了分析,通过扫描探针显微镜研究了针尖和样品间的扫描隧道谱.结果表明,氢终端掺硼金刚石表面能带... 详细信息

利用氢微波等离子体溅射和浓酸中沸煮方法分别制备了氢、氧终端掺硼金刚石薄膜.借助X射线光电子能谱及接触角检测对两种终端薄膜表面进行了分析,通过扫描探针显微镜研究了针尖和样品间的扫描隧道谱.结果表明,氢终端掺硼金刚石表面能带向上弯曲,在高于价带顶位置存在浅受主能级;氧终端表面能带向下弯曲,带隙较宽,带隙中不存在表面态.对两种终端金刚石薄膜的导电机理进行了讨论.

关键词：氢终端氧终端掺硼金刚石薄膜电子结构

沥青混凝土路面车辙环道试验的数值模拟及轴载换算

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公路 2009年第8期54卷 282-285页

作者：刘斌锋陕西省商洛公路管理局商洛市726000

应用有限元软件ABAQUS,分析了模型尺寸、单元类型、网格尺寸等对数值模拟的影响。结果表明模型尺寸越大、单元次数越高、网格越密,数值模拟的精度越高,但计算耗时也越长;采用等参8节点二次单元CPE8R、土基深度1.0 m以下为无限元、网格... 详细信息

应用有限元软件ABAQUS,分析了模型尺寸、单元类型、网格尺寸等对数值模拟的影响。结果表明模型尺寸越大、单元次数越高、网格越密,数值模拟的精度越高,但计算耗时也越长;采用等参8节点二次单元CPE8R、土基深度1.0 m以下为无限元、网格局部细化的模型,既能够合理地预测和分析路面车辙,又能减少计算耗时。

关键词：车辙环道试验数值模拟无限元

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基于能值分析的食用菌栽培生态经济效益评价

中国食用菌 2020年第7期39卷 238-240页

作者：刘彬凤四川大学锦江学院经济学院四川彭山620860

在能值分析理念下探讨食用菌栽培的生态效益评价问题,并尝试建立起可持续的食用菌产业发展路径。基于能值分析为沟通生态效益与经济效益间搭建起了桥梁,在乡村振兴战略背景下对食用菌栽培生态经济效益展开评价,意在探寻生态保护下的食... 详细信息

在能值分析理念下探讨食用菌栽培的生态效益评价问题,并尝试建立起可持续的食用菌产业发展路径。基于能值分析为沟通生态效益与经济效益间搭建起了桥梁,在乡村振兴战略背景下对食用菌栽培生态经济效益展开评价,意在探寻生态保护下的食用菌产业经济发展之路。提高食用菌栽培生态效益的措施包括加强食用菌栽培科学技术的应用推广、统筹食用菌栽培实现产地集约化生产、在食用菌栽培区域构建循环经济系统、提高栽培工效节约对物化劳动的投入。

关键词：能值分析食用菌栽培生态效益

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI feng WANG Tao DUAN Kaijie YANG bin YANG Chunmei WANG Xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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