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Mechanical Analysis of Dead Load Crown and Structure Parameter of Hydraulic Elastic Bulging Roll

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Journal of Iron and Steel Research International 2003年第3期10卷 28-31页

作者： ZHAO Chang-cai LI Wei-min liu zhu-bai Yanshan University

The dead load crown of hydraulic elastic bulging roll was discussed using the theory of elastically supported beam,and the dead load experiment was carried out. The theoretical calculation is consistent with the experimental result. The structure parameters for the thickness of roll sleeve,the length of the oil groove and the crown of roll were discussed. The fundamental principle of determining the parameters was put forward. The theoretical basis of the application of the hydraulic elastic bulging roll was established.

关键词： hydraulic elastic bulging roll bulging crown dead load

Structure parameters and function of hydraulic elastic bulging roller

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中国有色金属学会会刊：英文版 2001年第2期11卷 188-191页

作者：李纬民刘助柏赵长才刘国晖 LI Wei-min School of Mechanical Engineering Yanshan University

The fundamental principle and method of the determining of structure parameters for the hydraulic elastic bulging roller were discussed. The relationship among crown of roller, hydraulic pressure and thickness of roller sleeve was studied. Aluminum was chosen as experimental material to accomplish the dynamic load experiment. The hydraulic elastic bulging roller exerts good effect on shape control and therefore has a broad application prospect in engineering. [

关键词： hydraulic bulging roller shape control structure parameters

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知识创新规律的理论框架

燕山大学学报（哲学社会科学版） 2001年第2期2卷 86-88页

作者：刘助柏燕山大学机械工程学院河北秦皇岛066004

知识创新是一项系统工程。知识创新系统工程图为知识创新规律提供了一个理论框架。围绕着这个理论框架的讨论,可得出很多新的有益结论。

关键词：知识创新理论框架温知认识感温具体

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang zhu Dan liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

水平V型砧锻造大型轴类锻件的数值模拟和实验

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塑性工程学报 2010年第1期17卷 15-17页

作者：倪利勇张永军刘助柏王贵广东海洋大学工程学院湛江524088 燕山大学机械工程学院秦皇岛066004 北京科技大学材料科学与工程学院北京100083

水平V型砧锻造法,可以通过控制锻件金属的流动方向减少轴类锻件力学性能的异向性,在锻件内部应力状态、金属纤维组织、锻件的整体性能、宏观几何形状等方面都优于普通平砧锻造法。采用有限元分析方法,对水平V型砧锻造法进行了数值模拟,... 详细信息

水平V型砧锻造法,可以通过控制锻件金属的流动方向减少轴类锻件力学性能的异向性,在锻件内部应力状态、金属纤维组织、锻件的整体性能、宏观几何形状等方面都优于普通平砧锻造法。采用有限元分析方法,对水平V型砧锻造法进行了数值模拟,结果显示,采用水平V型砧锻造法时,在砧宽比为1.0和料宽比为0.5的条件下,锻件心部的横向应力都处于压应力状态,而采用普通平砧锻造法使用相同工艺参数时,则会出现不利的拉应力状态。这表明水平V型砧锻造法比普通平砧锻造法在控制轴类锻件的横向应力上更有利,有更广泛的工艺参数范围。

关键词：锻造水平V型砧轴类锻件异向性

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锥形板镦粗新工艺的数值模拟

锻压技术 2005年第3期30卷 12-13,29页

作者：邓冬梅刘助柏倪利勇南京航空航天大学机电学院江苏南京210016 燕山大学机械工程学院河北秦皇岛066004

利用ANSYS软件对锥形板镦粗圆柱体的整个过程进行了数值模拟。介绍了模型建立时的简化及参数选取情况;给出了变形过程中,不同压下量下毛坯内部的变形过程及应力、应变分布情况;并对比分析了锥形板镦粗和普通平板镦粗时的应力、应变情况... 详细信息

利用ANSYS软件对锥形板镦粗圆柱体的整个过程进行了数值模拟。介绍了模型建立时的简化及参数选取情况;给出了变形过程中,不同压下量下毛坯内部的变形过程及应力、应变分布情况;并对比分析了锥形板镦粗和普通平板镦粗时的应力、应变情况。分析结果表明该新工艺对改善毛坯内部的应力、应变状态起到一定作用,从而定量地证明了锥形板镦粗圆柱体力学模型的正确性,对该理论的完善起到一定作用。

关键词：锥形板镦粗数值模拟工艺 ANSYS软件变形过程参数选取分布情况平板镦粗对比分析分析结果应变状态力学模型圆柱体应力压下量正确性内部毛坯

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水平V型砧连续拔长工艺的数值模拟

机械设计与制造 2009年第7期 231-232页

作者：张莉萍倪利勇刘助柏王贵邢台职业技术学院机电系邢台054035 广东海洋大学工程学院湛江524088 燕山大学机械工程学院秦皇岛066004

对水平V型砧锻造法进行了连续拔长过程的数值模拟。以前的研究仅仅给出了单次压下拔长模拟结果,忽略了上一次压下所产生的变形对后续压下的影响,采用ANSYS有限元分析软件对水平V型砧锻造法实现了矩形截面毛坯连续拔长过程的数值模拟,分... 详细信息

对水平V型砧锻造法进行了连续拔长过程的数值模拟。以前的研究仅仅给出了单次压下拔长模拟结果,忽略了上一次压下所产生的变形对后续压下的影响,采用ANSYS有限元分析软件对水平V型砧锻造法实现了矩形截面毛坯连续拔长过程的数值模拟,分析了锻件横截面上的中心轴线横向应力分布。

关键词：锻造平砧拔长数值模拟横向应力

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin liu Tao zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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科学知识创新规律的理论框架

科技成果管理与研究 2009年第8期 14-18,37页

作者：于建春刘助柏燕山大学经济管理学院河北秦皇岛066004 燕山大学机械工程学院河北秦皇岛066004

为了让科学研究者更好地掌握科学技术研究的规律，加速创新入门与缩短取得科研成果的时间，经本文研究，提出了科学知识创新规律的内容。它由五个阶段组成：形成科研问题、科学抽象、科学实验、科学结论和承认与评价。经实践验证，该规... 详细信息

为了让科学研究者更好地掌握科学技术研究的规律，加速创新入门与缩短取得科研成果的时间，经本文研究，提出了科学知识创新规律的内容。它由五个阶段组成：形成科研问题、科学抽象、科学实验、科学结论和承认与评价。经实践验证，该规律正确，对科学研究工作者有启迪作用。

关键词：科学创新理论框架