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Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside

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Chinese Journal of Natural Medicines 2021年第3期19卷 231-240页

作者： LIANG Chun-Xia QI dong-Li ZHANG Li-Na LU Peng liu zhi-dong State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China

Salidroside(SAL)is a phenolic substance with high solubility and low permeability,which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora,resulting in lower *** aim of this study was to develop and optimize a water-in-oil nanoemulsion of SAL(w/o SAL-N)to explore its suitability in oral drug delivery *** this work,SAL-N was successfully prepared by water titration method at K_(m)=1 to construct the pseudo-ternary phase *** characterization including the average viscosity,pH,refractive index,particle size,PDI,TEM,DSC,the content of SAL,and stability study were *** was evaluated for drug release in vitro and pharmacokinetic studies in *** optimized nanoemulsion formulation consisted of Labrafil M 1944 CS(63%),Span-80/Tween-80/EtOH(27%)and 200 mg·mL^(-1) SAL solution(SAL-SOL)(10%).Low viscosity and suitable pH were expected for the *** spherical morphology and nanoscale size of SAL-N enhanced the stability of the nanoemulsion *** vitro drug release showed that SAL-N had a better controlled release property than SAL-SOL at earlier time *** pharmacokinetic studies exhibited that SAL-N had significantly higher in t_(1/2)(2.11-fold),AUC_(0-48 h)(1.75-fold)and MRT0-48 h(2.63-fold)than SAL-SOL(P<0.01).The w/o SAL-N prepared in this work can be effectively delivered via the oral *** can be seen w/o nanoemulsion is a strategy for the drug with polyphenols to delay the release,enhance oral absorption and reduce metabolic rate.

关键词： Salidroside Water-in-oil nanoemulsion Polyphenol Drug release Pharmacokinetics Bioavailability

Synthesis of Novel Chiral 7-Amide Substituted-4-androstene-3,17-dione Derivatives

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Chemical Research in Chinese Universities 2011年第4期27卷 604-609页

作者： CHEN Shao-rui ZHOU Xue-qin LI Wei liu dong-zhi School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China College of Science Hebei University of Science and Technology Shijiazhuang 050018 P. R. China

A series of novel 7-amide substituted-4-androstene-3,17-dione derivatives（8αa ＂8αh or 8βa ＂8βh） was synthesized from the important intermediates 5 by N-acylation and acidic *** 5α and 5β were obtained through the reaction sequence including acetalization,allylic oxidation,oximation and *** structures of the target compounds were characterized by MS,1H NMR,13C NMR and HRMS spectra and their stereo configurations were identified through DEPT（distortionless enhancement by polarization transfer）,HMQC（hetero-nuclear multiple quantum coherence） and NOE（nuclear overhauser effect） correlation.

关键词： Androstenedione Allylic oxidation Reduction N-Acylation

Evaluation of Slow Light Periodic Signals Considering the Distortion in EDF

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Chinese Physics Letters 2014年第3期31卷 82-85页

作者： WANG WU Chong-Qing WANG zhi liu Guo-dong liu Lan-Lan SUN Zhen-Chao Institute of Optical Information and Key Lab of Luminescence and Optical Information Technology Beijing Jiaotong University Beijing 100044

Based on the fundamental harmonic phase delay, a new definition of fundamental harmonic fractional delay （FHFD） is proposed to evaluate slow light with the consideration of signal distortion, to eliminate the dependence on the choice of the reference point. By solving the rate equation of erbium-doped fiber （EDF）, it is shown that the slow light always accompanies the signal distortion when the periodic signal propagates in EDF, and FHFD depends on the signal distortion, as well as the average input power, the modulation depth and the length of EDF. The results of simulations and experiments indicate that the definition of FHFD is reasonable and effective to evaluate the slow light of periodic signals.

关键词： Signal distortion

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南极磷虾基调味料研究进展

食品安全质量检测学报 2024年第5期15卷 105-112页

作者：刘葭萌赵前程张忭忭刘志东大连海洋大学食品科学与工程学院大连116023 中国水产科学研究院东海水产研究所上海200090

南极磷虾是一种重要的海洋生物资源,生物资源量巨大。在食品领域,南极磷虾因其味道鲜美、营养丰富而备受青睐。由于其富含蛋白质、脂质、肽类、氨基酸、核苷酸、有机酸、甜菜碱、氨基葡萄糖等呈味物质以及矿物元素等呈味物质助剂,已经... 详细信息

南极磷虾是一种重要的海洋生物资源,生物资源量巨大。在食品领域,南极磷虾因其味道鲜美、营养丰富而备受青睐。由于其富含蛋白质、脂质、肽类、氨基酸、核苷酸、有机酸、甜菜碱、氨基葡萄糖等呈味物质以及矿物元素等呈味物质助剂,已经成为开发南极磷虾基调味料的良好来源。随着人们对健康饮食的关注日益增加,对于天然来源、营养丰富食材的需求不断提升,南极磷虾基调味料的应用前景十分广阔。积极推动南极磷虾基调味料的研发和创新,有望为南极磷虾产业注入新的活力,助推其可持续发展。本文综述了南极磷虾基调味料的呈味物质来源、制备方法、开发现状,并预测了其发展趋势,旨在为南极磷虾基调味料及南极磷虾产业的全面发展提供有力技术支持。

关键词：南极磷虾调味料呈味物质现状趋势

Synthesis and Antileishmanial Activities of Some New Azasterols

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Chemical Research in Chinese Universities 2010年第6期26卷 922-928页

作者： CHEN Shao-rui liu dong-zhi WU Xue-dan LI Wei ZHOU Xue-qin School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China College of Science Hebei University of Science and Technology Sho＇iazhuang 050018 P R. China

A series of novel azasterols 8a―8h and 10a―10c were synthesized from the key intermediate 6 by acylation and *** 6 was obtained through a series of reactions including Wittig reaction,etherification,ene reaction,oxidation,oximation and *** of the synthesized compounds were confirmed by IR,MS and 1H ***,all of these compounds were screened for in vitro antiparasitic activity against *** them,compounds 8h,10a and 10b showed a fair inhibition of leishmania promastigotes growth at 25 μg/mL,with potencies close to that of the reference drug,amphotericin *** results provide a starting point for the development of novel drugs to treat leishmaniasis.

关键词： Azasteroid Antileishmanial activity Synthesis

Green synthesis of luminescent La-MOF nanoparticle from waste poly(ethylene terephthalate) for high-performance in Fe(Ⅲ) detection

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Rare Metals 2024年第8期43卷 3833-3843页

作者： zhi Gong zhi-Kui Dai zhi-Yue dong Qiu-Xuan liu Valentin A.Milichko Hua-Jian liu Jie liu Ran Niu Jiang Gong Key Laboratory of Material Chemistry for Energy Conversion and Storage Hubei Key Laboratory of Material Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSemiconductor Chemistry CenterSchool of Chemistry and Chemical EngineeringMinistry of EducationHuazhong University of Science and TechnologyWuhan 430074China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430073China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China School of Physics and Engineering ITMO UniversitySt.Petersburg197101Russia School of Materials Science and Engineering Hubei UniversityWuhan430062China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing School of Mechanical and Automotive EngineeringKey Laboratory of Polymer Processing EngineeringMinistry of EducationSouth China University of TechnologyGuangzhou 510641China

Developing luminescent metal-organic frameworks(MOFs) capable of high-efficiency Fe^(3+)sensing has aroused great attraction in the fields of biology,chemistry,***,previous solvothermal methods are limited by organic solvent usage,time consuming,high pressure,and high-energy ***,we propose the waste-toMOF strategy towards the scale-up production of La-MOF nanoparticles through the ball milling of recycled poly(-ethylene terephthalate)(PET) bottles and La(NO_(3))_(3)·_(6)H_(2)*** goes on alkaline hydrolysis to form 1,4-benzenedicarboxylic acid sodium salt(Na_(2)BDC) and ethylene glycol by ball ***,BDC reacts with La^(3+)to form *** as-prepared La-MOF crystal nanoparticles possess a rod-like morphology with the size of few hundred ***,La-MOF nanoparticles display high selectivity and sensitivity for Fe^(3+)*** quenching constant and limit of detection are 5.29×10^(3)(mol·L^(-1))^(-1) and 0.147 μmol·L^(-1),respectively,thus surpassing many advanced Fe^(3+) *** to the result of density functional theory,the high Fe^(3+) detection performance of La-MOF is related to the complexing of Fe^(3+)with La-MOF,which leads to the gradual dissociation of the coordination bond between terephthalic acid and La^(3+).It is anticipated that the mechanochemistry milling-based wasteto-MOF strategy provides a new platform for the massive production of functional MOFs in a green manner.

关键词： Metal-organic framework Waste polyester Mechanochemistry milling Fluorescence sensor

Enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials Science & Technology 2024年第4期171卷 139-146页

作者： zhi Yun Yue zhi dong Zhang Zhan Jie Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching

Analysis of a Community-based Intervention to Reduce Heat-related Illness during Heat Waves in Licheng,China:a Quasi-experimental Study

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Biomedical and Environmental Sciences 2016年第11期29卷 802-813页

作者： LI Jing XU Xin WANG Jun ZHAO Yun SONG Xiu Ping liu zhi dong CAO Li Na JIANG Bao Fa liuQiYong Department of Epidemiology School of Public HealthShandong UniversityJinan 250012ShandongChina State Key Laboratory of lnfectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shandong University Climate Change and Health Center Jinan 250012ShandongChina Department of Dentistry Affiliated HospitalWeifang Medical UniversityWeifang 261000ShandongChina Licheng District Center for Disease Control and Prevention Jinan 250012ShangdongChina

Objective To reduce health-related threats of heat waves, interventions have been implemented in many parts of the world. However, there is a lack of higher-level evidence concerning the intervention efficacy. This study aimed to determine the efficacy of an intervention to reduce the number of heat-related illnesses. Methods A quasi-experimental design was employed by two cross-sectional surveys in the year 2024 and 2015, including 2,240 participants and 2,356 participants, respectively. Each survey was designed to include one control group and one intervention group, which conducted in Licheng, China. A representative sample was selected using a multistage sampling method. Data, collected from questionnaires about heat waves in 2014 and 2015, were analyzed using a difference-in-difference analysis and cost effectiveness analysis. Outcomes included changes in the prevalence of heat-related illnesses and cost-effectiveness variables. Results Relative to the control participants, the prevalence of heat-related illness in the intervention participants decreased to a greater extent in rural areas than in urban areas （OR=0.495 vs. OR=2.282）. Moreover, the cost-effectiveness ratio in the intervention group was tess than that in the control group （usS25.06 vs. us$25.69 per participant）. Furthermore, to avoid one additional patient, the incremental cost-effectiveness ratio showed that an additional USS14.47 would be needed for the intervention compared to when no intervention was applied. Conclusion The intervention program may be considered a worthwhile investment for rural areas that are more likely to experience heat waves. Meanwhile, corresponding improving measures should be presented towards urban areas. Future research should examine whether the intervention strategies could be spread out in other domestic or international regions where heat waves are usually experienced.

关键词： Effectiveness Intervention Quasi-experimental Heat waves Difference-in-differenceanalysis Cost-effectiveness analysis

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国产磁选态铯束频率标准环境特性研究

时间频率学报 2024年第1期47卷 1-7页

作者：郑宁张亮郝莉娜王骥杨军刘志栋陈江高望远兰州空间技术物理研究所真空技术与物理重点实验室兰州730000 战略支援部队航天系统部装备部装备保障队北京100000

铯原子频率标准具有长期稳定性好、可靠性高的优点,在导航定位、守时授时、通信电力、时频计量等领域有着广泛的应用。近年来由于军事领域对高精度时间频率源的需求,铯原子频标的使用环境从实验室走向了战车、舰船等机动平台。本文针对... 详细信息

铯原子频率标准具有长期稳定性好、可靠性高的优点,在导航定位、守时授时、通信电力、时频计量等领域有着广泛的应用。近年来由于军事领域对高精度时间频率源的需求,铯原子频标的使用环境从实验室走向了战车、舰船等机动平台。本文针对铯原子频标在战车、舰船、高原等复杂环境下的环境适应性,研究环境因素对整机指标的影响机理。通过仿真与试验对整钟设计进行优化,以提高整机在力学、热、磁场、低气压等复杂环境下的适应性。经过优化设计后的国产铯束频率标准样机通过了相关环境试验项目的考核,各项指标均满足要求。研究结果表明,铯原子钟电性能样机的稳定度优于8.73×10^(-15)/5 d,磁敏感度3.15×10^(-14)/Gauss,工作温度特性-8.18×10^(-14),这项工作为国产化铯钟的进一步应用提供了基础。

关键词：国产铯束频率标准环境适应性振动低气压稳定度