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基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

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Science Bulletin 2023年第18期68卷 2106-2114,M0004页

作者： Zhuo-yu An Ye-Jun Wu yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi liu Yong-Ping Song Lin-Hua Yang Mei-yun Fang Jian-Yong Li yun-Feng cheng Peng liu Ya-jing Xu zhao Wang Yi luo Zhen Cai Hui liu jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-yu Zhu Xin Wang Rong Fu Liang Huang Shao-yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun chen Dai-Hong liu Hong-Xia Yao Jia Feng Hong-yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-Xia Fu Xiao-lu Zhu yun He Qian Jiang Hao Jiang Jin lu Xiang-yu zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun Zhang zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun Dong chen Zhi-Shui chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang liu Qian lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang lu Cai-De lu Dong-Hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang chen Ying-Peng zhao Li Li Ze-Min Hu Qi-Jie luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

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男性不育患者指长比与BMI相关性分析

中华男科学杂志 2015年第11期21卷 977-981页

作者：于皓臣盛优静耿芝赵君利刘永杰霍正浩陆宏宁夏医科大学教育部生育力保持省部共建重点实验室/医学遗传与细胞生物学系/宁夏回族自治区生殖与遗传重点实验室宁夏银川750004 宁夏医科大学总医院生殖医学中心宁夏银川750004 宁夏银川市妇幼保健院宁夏银川750001

目的:研究宁夏汉族男性不育患者食环指长比(2D∶4D)与体质指数(BMI)的关系。方法:采用体质测量法,分析宁夏汉族男性345例(对照组:148例,原发不育组:197例)2D∶4D及BMI的均值,比较其差异性;分析2D∶4D与BMI间的关系。结果:对照组2D∶4D... 详细信息

目的:研究宁夏汉族男性不育患者食环指长比(2D∶4D)与体质指数(BMI)的关系。方法:采用体质测量法,分析宁夏汉族男性345例(对照组:148例,原发不育组:197例)2D∶4D及BMI的均值,比较其差异性;分析2D∶4D与BMI间的关系。结果:对照组2D∶4D均值均低于患者组,左手有显著性差异(P<0.05);对照组BMI均值低于患者组,差异显著(P<0.05);患者组左手2D∶4D与BMI显著正相关(P<0.05)患者的高2D∶4D组左手与BMI显著正相关,右手-左手(Dr-l)2D∶4D与BMI显著负相关(左手:P<0.01,Dr-l:P<0.05)。结论:2D∶4D与男性原发不育患者BMI具有一定的相关性。

关键词：男性不育指长比(2D:4D) 体质指数

天津降水季节特征及不同气团来向离子来源分析

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中国环境科学 2023年第4期43卷 1844-1856页

作者：杨璟爱韩少强杨健安王记鲁刘金冠田雨张亚尼薛鹏飞王艳丽赵志强陈晨崔连喜杨华张静天津市生态环境监测中心天津300191 天津市环鉴环境检测有限公司天津300300 天津天滨瑞成环境技术工程有限公司天津300190

基于天津2019年3月~2022年2月的大气降水样品,分析降水季节性变化及无机离子和有机酸来源,降水pH值均值为6.68,电导率均值为46.8μS/cm,总离子浓度均值为726μeq/L,降水离子整体呈现“冬高夏低”的季节特征,SO_(4)^(2-)和NO_(3)^(-)对... 详细信息

基于天津2019年3月~2022年2月的大气降水样品,分析降水季节性变化及无机离子和有机酸来源,降水pH值均值为6.68,电导率均值为46.8μS/cm,总离子浓度均值为726μeq/L,降水离子整体呈现“冬高夏低”的季节特征,SO_(4)^(2-)和NO_(3)^(-)对总自由酸度(TFA)的贡献率为89.6%,是主要致酸离子.基于HYSPLIT模型得出降水主要受5个来向气团影响,春冬季以离子浓度较高的北部气团和西北部气团来向为主,占比60.0%~62.5%,夏秋季离子浓度较低的南部气团、东部气团和东南部气团占比较大,达到60.0%~97.8%.富集因子分析表明Ca^(2+)、Mg^(2+)和K^(+)主要来源于土壤;Cl^(-)的主要来源为海洋;Na^(+)的来源包括土壤;SO_(4)^(2-)和NO_(3)^(-)主要来自人为源.根据有机酸来源判定,植物生长和土壤释放等直接来源对天津有机酸浓度贡献较大,不饱和烃类的大气光化学反应等间接来源贡献较小.正矩阵因子分析(PMF)源解析表明,天津大气降水离子来源包括生物质燃烧源、垃圾焚烧源、二次无机源、生物排放和二次有机源、海源及工业源、陆源及扬尘源.

关键词：降水无机离子有机酸后向轨迹正交矩阵因子模型(PMF)

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不同固液相组分下土壤蒽的激光诱导荧光发射光谱特性研究

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光电子．激光 2019年第3期30卷 272-278页

作者：黄尧赵南京孟德硕左兆陆陈宇男马明俊杨瑞芳刘建国刘文清中国科学院环境光学与技术重点实验室中国科学院安徽光学精密机械研究所合肥230031 中国科学技术大学合肥230026 安徽省环境光学监测技术重点实验室合肥230031

以蒽为研究对象,研究了不同土壤固、液相组分下蒽的激光诱导荧光发射光谱特性。结果显示,在266 nm激光激发下,土壤蒽在420 nm和444 nm附近分别具有荧光峰,当土壤的原生矿物和次生矿物比例发生变化时,蒽的荧光光谱峰位置未发生明显偏移,4... 详细信息

以蒽为研究对象,研究了不同土壤固、液相组分下蒽的激光诱导荧光发射光谱特性。结果显示,在266 nm激光激发下,土壤蒽在420 nm和444 nm附近分别具有荧光峰,当土壤的原生矿物和次生矿物比例发生变化时,蒽的荧光光谱峰位置未发生明显偏移,420 nm处荧光峰处强度的相对标准偏差为4.52%;土壤中腐殖质种类、浓度改变时,蒽的荧光强度随浓度增大而降低,在不同浓度的腐殖酸和富里酸的土壤中,420 nm处的荧光峰处强度的相对标准偏差分别为38.1%和27.4%,且正交实验的极差分析结果表明腐殖酸对强度影响大于富里酸;受到重金属污染后的土壤蒽的激光诱导荧光强度明显下降,但液相重金属不同浓度的土壤中,蒽在420 nm处的荧光强度差异不大,荧光峰位置未发生明显偏移.在土壤中含有不同浓度的Cd时,其相对标准偏差为1.60%,含有不同浓度的Cu时,其相对标准偏差为2.05%,含有不同浓度的Pb时,其相对标准偏差为4.54%。因此,采用荧光峰强度定标法测定时,应考虑固液组分变化导致的光谱强度差异。该研究结果为采用激光诱导荧光光谱技术对土壤蒽准确测量提供了基础数据。

关键词：激光诱导荧光光谱固液组分特性蒽定量

经皮肾动脉射频消融术对犬高血压影响机制的探讨

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中华心血管病杂志 2012年第1期40卷 14-17页

作者：卢成志刘佳夏大胜赵向东陈欣于翔徐建强张靖潘丽刘少颖王丽天津市第一中心医院心内科 300192

目的实验证明交感神经活性增强与高血压的发生有关,我们研究的旨在探讨去神经术对犬高血压的治疗,并评估其有效性与安全性.方法18只杂种犬随机分为干预组（n=10）和对照组（n=8）两组,制作成高血压模型,干预组给予经皮肾交感神经去神... 详细信息

目的实验证明交感神经活性增强与高血压的发生有关,我们研究的旨在探讨去神经术对犬高血压的治疗,并评估其有效性与安全性.方法18只杂种犬随机分为干预组（n=10）和对照组（n=8）两组,制作成高血压模型,干预组给予经皮肾交感神经去神经化治疗,实验对照组仅造成高血压模型,不行干预治疗.观察平均血压的变化,分别在术前和术后2、4、6、10周监测血压,同时在术后第2、6、10周监测血肾素活性、血管紧张素Ⅱ、醛固酮和肌酐等指标,通过对这些数据进行方差分析,来评价手术的有效性与安全性.结果在干预组,造模后平均血压增高明显,从（131.4±18.0）mm Hg（1 mm Hg =0.133 kPa）升至（150.6±18.8）mm Hg（P=0.001）；在去神经治疗后,平均血压在2、4、6和10周后分别降至（130.4±14.1）mm Hg、（136.2-17.1）mm Hg、（128.7±14.7）mm Hg和（126.1±12.7）mm Hg.同时肾素活性,血管紧张素Ⅱ、醛固酮水平都较术前下降（P＜0.05）,肌酐水平无明显变化（P＞0.05）.对照组各项指标均无明显变化.结论交感神经兴奋在高血压的产生和发展过程中发挥着重要的作用,经皮肾动脉射频消融术能够产生显著和持久的血压下降,并且手术过程没有造成严重肾功能受损.

关键词：高血压导管消融术去神经支配

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li luo Yong-Heng zhao Gang zhao Li-Cai Deng Xiao-Wei liu Yi-Peng jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan chen Jian-Jun chen Kun-Xin chen Li chen Xue-Lei chen Xiao-Yan chen Ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li yuan Liang Chien-cheng Lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi lu yu luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

排卵障碍性异常子宫出血证候分布特征的临床流行病学调查

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中国实验方剂学杂志 2021年第12期27卷 89-96页

作者：杨玉培刘杨杰马惠荣景晓昭杜煜晗陈俊潞王淑慧杜惠兰河北中医学院石家庄050091

目的:探究排卵障碍性异常子宫出血中医证候分布特征。方法:基于临床流行病学调查,对全国29个省、自治区、直辖市的省市县/区级医院的6 688例排卵障碍性异常子宫出血患者的中医证候特征进行分析。结果:全国范围内排卵障碍性异常子宫出血... 详细信息

目的:探究排卵障碍性异常子宫出血中医证候分布特征。方法:基于临床流行病学调查,对全国29个省、自治区、直辖市的省市县/区级医院的6 688例排卵障碍性异常子宫出血患者的中医证候特征进行分析。结果:全国范围内排卵障碍性异常子宫出血患者以肾气虚证(17.34%),脾气虚证(13.25%),气血两虚证(12.62%),气虚血瘀证(8.45%),肾阴虚证(6.88%)为常见中医证候。排卵障碍性异常子宫出血以气虚、阴虚、血虚为常见病性要素,并且多与肾、脾、肝密切相关。排卵障碍性异常子宫出血患者中医证候的地区分布具有一定规律,肾气虚证、脾气虚证、气血两虚证为共有证候;但因地域不同,各地区中医证候的分布也存在差异之处。华北、西北、西南、华东地区的肾气虚证出现频率较高,华中、东北、华南地区出现频率稍低。华中地区脾气虚证出现频率最高。华东地区气血两虚证频率最高。脾肾两虚证在华中、华北、西南地区分布较多。西北、华南、华北地区以气虚(肾虚)血瘀证为常见证候。华东、西北、东北地区以肾阴虚证较为多见,而虚热证主要分布在西南、华东地区。肾阳虚证则较多分布在华南地区。肝郁血热证在东北地区分布较多。肝郁脾虚证在华中地区频率较高。肾气虚证、脾气虚证、气血两虚证、气虚血瘀证、肾阴虚证与既往诊断标准差异不大。对肾气虚证有诊断意义的症状为阴道不规则流血,经量多,或月经周期缩短;腰酸痛,健忘。对脾气虚证有诊断意义的症状是月经周期缩短;神疲乏力,纳呆食少,便溏;苔白。对气血两虚证有诊断意义的症状是气短懒言,面色淡白无华,头晕,心悸。对气虚血瘀证有诊断意义的症状是经行不畅,经常或偶有血块;神疲乏力;舌紫暗。对肾阴虚证有诊断意义的症状是排卵期出血;头晕,耳鸣,五心烦热,盗汗。结论:排卵障碍性异常子宫出血中医证候类型分布具有一定规律性,地区分布存在差异,可为临床因地论治提供一定的参考依据。

关键词：排卵障碍性异常子宫出血中医证候流行病学调查

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广西柳城县VOCs组分特征、来源及其对臭氧生成的敏感性

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环境科学 2023年第1期44卷 75-84页

作者：吴影莫招育吴琴琴陆嘉晖毛敬英陈雪梅粟少丽覃纹刘慧琳韦敏广西壮族自治区环境保护科学研究院南宁530022 复旦大学环境科学与工程系上海200433 广西生态工程职业技术学院生态环境保护学院柳州545004 柳州市生态环境局柳州545001

位于广西柳州市郊区的柳城县存在突出的臭氧(O_(3))污染问题,但目前尚未有当地O_(3)污染成因分析的相关报道.为探究其O_(3)污染成因,在2021年10月1~15日开展了116种挥发性有机物(VOCs)的在线连续观测,并对O_(3)敏感性进行分析.结果表明... 详细信息

位于广西柳州市郊区的柳城县存在突出的臭氧(O_(3))污染问题,但目前尚未有当地O_(3)污染成因分析的相关报道.为探究其O_(3)污染成因,在2021年10月1~15日开展了116种挥发性有机物(VOCs)的在线连续观测,并对O_(3)敏感性进行分析.结果表明,观测期间φ[总挥发性有机物(TVOCs)]平均值为27.52×10^(-9),其中污染过程(10月1~6日)φ(TVOCs)的平均值为32.15×10^(-9),比非污染过程(10月8~15日)高32.79%.从物种浓度来说,含氧挥发性有机物(OVOCs)贡献最高,贡献率为43.70%,其次是烷烃(23.00%)、芳香烃(11.75%)和卤代烃(7.35%).从臭氧生成潜势(OFP)来说,OVOCs对OFP的贡献率最高(41.96%),其次是芳香烃(32.60%)和烯烃(17.92%).观测期间VOCs主要来自机动车排放(32.44%)、生物质燃烧源(29.31%)、溶剂使用源(16.43%)、植物源(11.34%)和化工企业排放(10.49%),溶剂使用源和植物源在污染过程贡献比例分别增加28.58%和28.53%.EKMA曲线结果显示柳城县在观测期间整体处于VOCs和氮氧化物(NO_(x))的协同控制区,因此,柳城县O_(3)高发的秋季应以VOCs和NO_(x)协同减排为重点.

关键词：臭氧(O_(3)) 挥发性有机物(VOCs) 臭氧生成潜势(OFP) 来源解析臭氧敏感性

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