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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou kai Tao Mengyang Li Bing Wei Hongjing Wu Mengyang Li Bing Wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption

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基于RPR的高生存性网络

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光子技术 2006年第1期 45-49页

作者：刘开银敖发良桂林电子科技大学通信与信息工程系广西桂林541004

弹性分组环(RPR)技术定义了一种新型的MAC层协议,采用了共享介质传输和空间复用协议以及低于50ms的故障恢复保护的弹性机制,支持业务的分级(Service Level Agreement),即插即用,基于MAC的高速交换,可承载具有突发性的IP业务,同时支持传... 详细信息

弹性分组环(RPR)技术定义了一种新型的MAC层协议,采用了共享介质传输和空间复用协议以及低于50ms的故障恢复保护的弹性机制,支持业务的分级(Service Level Agreement),即插即用,基于MAC的高速交换,可承载具有突发性的IP业务,同时支持传统的语音传送等特性,是未来城域网技术的重要发展方向。光纤技术的飞速发展使得RPR不再仅仅局限于城域网,还可以用于广域网。本文在基于弹性分组环的低于50ms的故障恢复保护的基础上,提出了具有高生存性的解决方案。

关键词：弹性分组环(RPR) 高生存性多环网

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论“东北大花布”的艺术社会学建构

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武汉纺织大学学报 2019年第3期32卷 8-12页

作者：刘寅凯马林兰吉林师范大学博达学院吉林四平136000 吉林师范大学美术学院吉林四平136000

艺术作品的创作总是与社会背景密切相关,“东北大花布”作为一种常见的印花布为大众所熟知,但由于种种原因被误认为是东北地区的独特产物。以“东北大花布”的起源为切入点,通过“东北大花布”在不同阶段社会背景下的审美心理分析,以艺... 详细信息

艺术作品的创作总是与社会背景密切相关,“东北大花布”作为一种常见的印花布为大众所熟知,但由于种种原因被误认为是东北地区的独特产物。以“东北大花布”的起源为切入点,通过“东北大花布”在不同阶段社会背景下的审美心理分析,以艺术社会学研究方法厘清“东北大花布”的审美趣味流变规律,对新时期大背景下“东北大花布”的传承与发展问题进行了探讨,并对艺术工作者的社会责任提出了意见和建议。

关键词：东北大花布印花布艺术社会学审美趣味艺术工作者文化自信

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地域文化与现实关切——东北“冰雪”题材版画的多维度书写

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吉林艺术学院学报 2021年第1期160卷 16-23页

作者：闫垒垒刘寅凯吉林艺术学院吉林长春130021 吉林师范大学博达学院吉林四平136000

东北"冰雪"题材版画具有双重指向,一方面指表现东北冬季环境的版画作品,另一方面指东北版画家创作的具有"冰雪"意象的作品。对东北"冰雪"题材版画从解放战争时期、"十七年"时期进行溯源,并着重分析新时期东北"冰雪"题材版画的表达内容... 详细信息

东北"冰雪"题材版画具有双重指向,一方面指表现东北冬季环境的版画作品,另一方面指东北版画家创作的具有"冰雪"意象的作品。对东北"冰雪"题材版画从解放战争时期、"十七年"时期进行溯源,并着重分析新时期东北"冰雪"题材版画的表达内容与方式。东北"冰雪"题材版画具有历史渊源和文化底蕴,是东北地域艺术家的有意识创作,同时也是各个历史时期社会需求的集中体现,对于塑造东北地域文化身份与形象都具有重要的意义。

关键词：东北地域冰雪题材版画

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Hydrogen and nitrogen absorption properties of Ce-added Zr_(2)(Fe_(1-x)Ni_(x)) alloys

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Journal of Rare Earths 2024年第6期42卷 1136-1141,I0005页

作者： kai yin Xiaopeng liu State Key Laboratory of Advanced Materials for Smart Sensing GRINM Group Co.Ltd.Beijing10088China GRIMAT Engineering Institute Co. Ltd.Beijing101407China General Research Institute of Nonferrous Metals Beijing100088China

To improve the nitriding resistance of Zr_(2)Fe alloy,the Ce-added Zr_(2)(Fe_(1-x)Ni_(x))(x=0,0.15,0.3,0.5)alloys were prepared by magnetic levitation melting *** effects of Ni substitution for Fe on the phase structure,hydrogen and nitrogen absorption properties of the alloys were investigated by X-ray diffraction,scanning electron microscopy and p-c isotherm *** experimental results show that Ni substitution can effectively inhibit the formation of both α-Zr and ZrFe_(2) phases and promote the formation of C16 structure Zr_(2)(Fe,Ni)phase,causing Ni-substituted alloys to exhibit low nitrogen absorption rate and *** 623 K under 0.5 MPa nitrogen pressure,the nitrogen absorption capacity of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy reaches to 0.8 mL/g,much lower than that of Zr_(2)Fe alloy(1.5 mL/g).Ni substitution decreases the crystal cell volume of the C_(16)Zr_(2)(Fe,Ni)phase,resulting in an increase in the hydrogen absorption equilibrium *** 623 K under 0.05 MPa hydrogen pressure,the hydrogen absorption capacity decreases from 1.46 wt%of Zr_(2)Fe alloy to 1.41 wt%of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy.

关键词： Zr_(2)Fe alloy Ce Pressure-composition isotherm Hydrogen absorption Nitrogen absorption Rare earths

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战“疫”主题民间美术作品的时代图像与精神抒写

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民族艺林 2020年第4期 5-12页

作者：崔景朋刘寅凯刘一洲吉林师范大学博达学院吉林四平136000 南京艺术学院美术学院江苏南京210013

新型冠状病毒肺炎暴发以来,民间美术工作者从艺术关怀角度创作了大量战“疫”主题民间美术作品,涵盖剪纸、绘画、刺绣、玩具、雕刻等多种类别,形成了特殊的“战疫文艺”现象。战“疫”主题民间美术构成了特殊的时代图像,记录了全民战“... 详细信息

新型冠状病毒肺炎暴发以来,民间美术工作者从艺术关怀角度创作了大量战“疫”主题民间美术作品,涵盖剪纸、绘画、刺绣、玩具、雕刻等多种类别,形成了特殊的“战疫文艺”现象。战“疫”主题民间美术构成了特殊的时代图像,记录了全民战“疫”期间的人物、时事和传统驱灾祈福主题,坚持了以人民为中心的创作导向,抒写了新时代的中国精神,具有深刻的艺术意蕴。面对“清高者”的诟病,文章认为,全民战“疫”为民间美术创作提供了创作主题和源泉,创作大量战“疫”主题民间美术作品是民间美术工作者的社会责任所在,这些作品符合美学观点和历史观点相结合的原则,是真诚的作品,是值得尊重的作品。

关键词：战“疫” 人民民间美术时代图像精神抒写

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang liu kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun liu kai Gao Jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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