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Jianpi Huazhuo Tiaozhi granules reduce oxidative stress injury in macrophages by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase/reactive oxygen species-nuclear transcription factor kappa B pathway

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Journal of Traditional Chinese Medicine 2020年第6期40卷 922-927页

作者： liu yanwei liu Zhongyong School of Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China Department of Cardiology Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006China

OBJECTIVE:To assess the effect of Jianpi Huazhuo Tiaozhi granules(JHTG)on oxidative stress damage to macrophages and explore the relationship between the levels of this damage and the nicotinamide adenine dinucleotide phosphate oxidase(NOX)/reactive oxygen species(ROS)-nuclear transcription factor kappa B(NF-κB)signaling ***:Macrophages cultured in vitro were divided into seven groups:control,model control,inhibitor,positive control,2.5%JHTG,5%JHTG,and10%*** oxidative stress injury model was established by stimulating macrophages with oxidized low-density *** survival and apoptosis were detected by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide and flow cytometry assays,*** and superoxide dismutase levels were detected by enzyme-linked immunosorbent assays,while ROS levels were detected using a fluorescence *** and m RNAs associated with the NOX/ROS-NF-κB pathway,including NOX4,p22 phox,inhibitor of NF-κB kinase-α(IKK-α),inhibitor of NF-κB kinase-β(IKK-β),and NF-κB were detected by Western blot and PCR,***:After JHTG treatment,there were fewer damaged and apoptotic macrophages,while superoxide dismutase levels were *** JHTG-treated groups also showed reduced ROS *** molecular changes following JHTG treatment included decreased expression of NOX4 and p22 phox at the protein level and decreased IKK-α,IKK-β,and NF-κB expression at the m RNA *** of these effects were correlated with the JHTG ***:These results demonstrated that the molecular mechanism underlying the antioxidant activity of JHTG in macrophages is through inhibiting the NOX/ROS-NF-κB pathway.

关键词： Atherosclerosis Oxidative stress Macrophages NADPH oxidases Reactive oxygen species NF-kappa B Jianpi Huazhuo Tiaozhi granules

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Identifying the viscoelastic properties of soft matter from the indentation response of a hard film-soft substrate system

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 108-118页

作者： yanwei liu YueGuang Wei Hao Long Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China

The indentation technique is widely used in measuring the mechanical properties of soft matter at the microscale or nanoscale,but still faces challenges by these unique properties as well as the consequent strong surface adhesion, including the strong nonlinear effect, unclear judgment of the contact point, difficulties in estimating the contact area, and the risk of the indenter piercing the sample. Here we propose a two-step method to solve these problems: lay a hard film on a soft matter, and obtain the viscoelastic properties of this soft matter through the indentation response of this composite structure. We first establish a theoretical indentation model of the hard film-soft substrate system based on the theory of plates, elastic-viscoelastic correspondence principle and Boltzmann superposition principle. To verify the correctness of this method, we measure the mechanical properties of the methyl vinyl silicone rubber(MVSR) covered by a Cu nanofilm. Finally, we test the effectiveness and error sensitivity of this method with the finite element method(FEM). The results show that our method can accurately measure the mechanical properties of soft matter, while effectively circumventing the problems of the traditional indentation technique.

关键词： viscoelastic properties soft matter theoretical indentation model indentation technique finite element method

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Intrinsically flexible displays: key materials and devices

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National Science Review 2022年第6期9卷 171-188页

作者： Zhiyuan Zhao Kai liu yanwei liu Yunlong Guo Yunqi liu Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences

Continuous progress in flexible electronics is bringing more convenience and comfort to human lives. In this field, interconnection and novel display applications are acknowledged as important future ***, it is a huge scientific and technical challenge to develop intrinsically flexible displays due to the limited size and shape of the display panel. To address this conundrum, it is crucial to develop intrinsically flexible electrode materials, semiconductor materials and dielectric materials, as well as the relevant flexible transistor drivers and display panels. In this review, we focus on the recent progress in this field from seven aspects: background and concept, intrinsically flexible electrode materials, intrinsically flexible organic semiconductors and dielectric materials for organic thin film transistors(OTFTs), intrinsically flexible organic emissive semiconductors for electroluminescent devices, and OTFT-driven electroluminescent devices for intrinsically flexible displays. Finally, some suggestions and prospects for the future development of intrinsically flexible displays are proposed.

关键词： intrinsically flexible display intrinsically flexible electrode organic semiconductor transistor driver electroluminescent device

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A Wheeled Wall-Climbing Robot with Bio-Inspired Spine Mechanisms

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Journal of Bionic Engineering 2015年第1期12卷 17-28页

作者： yanwei liu Shaoming Sun Xuan Wu Tao Mei Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 China Institute of Advanced Manufacturing and Technology Hefei Institute of Physical Science Chinese Academy of Sciences Changzhou 213164 China

This paper presents a wheeled wall-climbing robot with the ability to climb concrete, brick walls using circular arrays of miniature spines located around the wheel. The robot consists of two driving wheels and a flexible tail, just like letter “T”, so it is called Tbot. The simple and effective structure of Tbot enables it to be steerable and to transition from horizontal to vertical surfaces rapidly and stably. Inspired by the structure and mechanics of the tarsal chain in the Serica orientalis Motschulsky, a compliant spine mechanism was developed. With the bio-inspired compliant spine mechanism, the climbing performance of Tbot was improved. It could climb on 100° （10° past vertical） brick walls at a speed of 10 cm·s^-1. A mechanical model is also presented to analyze the forces acting on spine during a climbing cycle as well as load share between multi-spines. The simu- lation and experiment results show that the mechanical model is suitable and useful in the optimum design of Tbot.

关键词： biologically-inspired robots climbing robots compliant spine mechanisms mechanical model wheeled robots

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Trans-scale surface wrinkling model and scaling relationship analysis of stiff film-compliant substrate structures

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Science China(Technological Sciences) 2022年第11期65卷 2776-2786页

作者： liu yanwei ZHANG SiYuan LONG Hao WEI YueGuang Department of Mechanics and Enginering SCcience College of EngineeringBIC-ESATPeking UniversiyBeijing 100871China School of Mechanical Engineering University of Shanghai for SCcience and TechnologyShanghai 200093China

The self-assembly of surface-order structures based on the surface wrinkling of stiff film-compliant substrate structures(SFCS)is potentially useful in the fabrication of functional devices,the manufacture of superhydrophobic or self-cleaning surfaces,and so *** to the influence of the intrinsic characteristic length(g),the surface wrinkling behavior of SFCS at the micro scale is different from that at the macro *** this work,based on the strain gradient theory,a trans-scale surface wrinkling model for SFCS is ***,the effectiveness of this model is verified by previous ***,based on the model and dimensional analysis,the effect of g on the surface wrinkling behavior is investigated,and the scaling relationship of surface wrinkling of SFCS at different scales is *** results show that the influence of g cannot be neglected when the film thickness decreases to the one comparable to *** the micro scale,g will lead to the increase of the critical wrinkling wavelength and *** addition,the scaling relationship of surface wrinkling at the micro scale will not follow the traditional *** study explains the underlying mechanism of the dissimilarity of surface wrinkling behaviors of SFCS at different scales and lays a theoretical foundation for the precise control of surface-order structures.

关键词： stiff film-compliant substrate structures surface wrinkling trans-scale model dimensional analysis scaling relationship

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Bogdanov-Takens bifurcation with codimension three of a predator-prey system suffering the additive Allee effect

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International Journal of Biomathematics 2017年第3期10卷 261-284页

作者： yanwei liu Zengrong liu Ruiqi Wang College of MathemaLics and Information Science Zhengzhou University of Light Industry Zhengzhou 450002 P. R. China Department of Mathematics Shanghai University Shanghai 200444 P. R. China

In the present work, research efforts have focused on investigating codimension two and three Bogdanov-Takens bifurcations of a predator-prey system with additive Allee effect. According to the existence conditions of Bogdanov-Takens bifurcation, we give the associated generic unfolding, and derive the dynamical classification in the perturbation parameter plane using some smooth parameter-dependent transformations of coordinate. Moreover, some numerical examples and simulations are performed to complete and illustrate our results.

关键词： Bogdanov-Takens bifurcation Allee effect universal unfolding

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An optimal hydropower contract load determination method considering both human and riverine ecosystem needs

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Frontiers of Earth Science 2015年第3期9卷 546-554页

作者： Xin'an YIN Zhifeng YANG Cailing liu yanwei ZHAO State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China

In this research, a new method is developed to determine the optimal contract load for a hydropower reservoir, which is achieved by incorporating environ- mental flows into the determination process to increase hydropower revenues, while mitigating the negative impacts ofhydropower generation on riverine ecosystems. In this method, the degree of na^ral flow regime alteration is adopted as a constraint of hydropower generation to protect riverine ecosystems, and the maximization of mean annual revenue is set as the optimization objective. The contract load in each month and the associated reservoir operating parameters were simultaneously optimized by a genetic algorithm. The proposed method was applied to China＇s Wangkuai Reservoir to test its effectiveness. The new method offers two advantages over traditional studies. First, it takes into account both the economic benefits and the ecological needs of riverine systems, rather than only the economic benefits, as in previous methods. Second, although many measures have been established to mitigate the negative ecological impacts ofhydropower generation, few have been applied to the hydropower planning stage. Thus, since the contract load is an important planning parameter for hydropower generation, influencing both economic benefits and riverine ecosystem protection, this new method could provide guidelines for the establishment of river protection measures at the hydropower planning stage.

关键词： hydropower electricity supply load reservoiroperation river protection

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Constitutive model for methane desorption and diffusion based on pore structure differences between soft and hard coal

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International Journal of Mining Science and Technology 2017年第6期27卷 937-944页

作者： liu yanwei Wang Dandan Hao Fuchang liu Mingju Mitri Hani S. School of Safety Science and Engineering Henan Polytechnic University Jiaozuo 454000 China The Collaborative Innovation Center of Coal Safety Production of Henan Province Jiaozuo 454000 China Department of Mining and Materials Engineering McGill University Montreal H3A0E8 Canada School of Civil Engineering Henan Polytechnic University Jiaozuo 454000 China

This paper aims to improve the accuracy and applicability of gas diffusion mathematical models from coal particles. Firstly, a new constitutive model for gas diffusion from coal particles with tri-disperse pore structure is constructed by considering the difference in characteristics between soft coal and hard *** analytical solution is then derived, that is, the quantitative relationship between gas diffusion rate(Qt/Q_∞) and diffusion time(t), The pore structure parameters of soft coal and hard coal from Juji coal mine are determined. Gas diffusion rules are numerically calculated and investigated by physical simulation methods. Lastly, the applicability of this model is verified. The results show that the homogeneous model only applies to the gas diffusion process of hard coal during the initial 10 min. The calculation results from this model and the physical experimental results of soft coal and hard coal are nearly identical during the initial 30 min.

关键词： Soft and hard coal Gas diffusion Pore structure Constitutive models Physical simulation

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The mechanism of inward and outward expansion of multiscale dynamic permeability of coalbed methane at different temperatures

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Deep Underground Science and Engineering 2023年第1期2卷 88-101页

作者： Zhiqiang Li Xiaoqiang Hao yanwei liu Lin Li MOE Engineering Center of Mine Disaster Prevention and Rescue Henan Polytechnic UniversityJiaozuoChina Collaborative Innovation Center of Coal Work Safety and Clean High Efficiency Utilization Henan Polytechnic UniversityJiaozuoChina Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic Region(Henan Province) Henan Polytechnic UniversityJiaozuoChina Henan Provincial Key Lab of Gas Geology and Control‐Cultivation Base of Provincial and Ministry Joint State Key Henan Polytechnic UniversityJiaozuoChina

The multiscale micro-nano pores in coal can result in the ultra-low permeability of coal,which restricts the efficiency of gas *** is difficult for the conventional seepage-enhancement measures to affect the nanoscale pores within the coal *** stimulation can reach deep into the micro-nano pores within coal matrix to improve the ***,it is important to study the diffusivity and permeability of the multiscale micro-nano pores at different *** this study,the experiments of diffusion-seepage measured by the methods of GRI(Gas Research Institution)and steady-state were conducted using a cylindrical coal at different temperatures and *** experimental results show that the apparent diffusion coefficient of cylindrical coal is not constant but variable dynamically;and the classical diffusion model fails to describe the full-time process of gas flow *** this basis,a model of multiscale dynamic apparent diffusion-seepage that can accurately describe the full-time flow process was *** is observed,the apparent permeability attenuates dynamically with time without stress loading,and the initial apparent permeability and the attenuation coefficient increase monotonically with the rise of *** the stress constraint,the steady-state permeability increases after a decrease as the temperature rises,displaying a“U-shaped”*** stress constraint,the increasing temperature causes the exterior multiscale pores to expand outward by different degrees so as to increase permeability,while the interior micro-nano pores show three inward and outward expansion *** stress constraint,at low temperature and high effective stress,the increasing temperature causes pores to expand inward and the permeability decreases *** temperature continues to increase,coal expands outward because the effective stress is counteracted by the thermal stress,leading to an increase in permea

关键词： diffusion dynamic gas permeability seepage temperature

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A Track-type Inverted Climbing Robot with Bio-inspired Spiny Grippers

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Journal of Bionic Engineering 2020年第5期17卷 920-931页

作者： yanwei liu Limeng Wang Fuzhou Niu Pengyang Li Yan Li Tao Mei School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Mechanical Engineering Suzhou University of Science and TechnologySuzhou 215009China Robotics Research Center Peng Cheng LaboratoryShenzhen 518055China

To enable the capacity of climbing robots to work on steep surfaces,especially on inverted surfaces,is a fundamental but challenging *** capacity can extend the reachable workspace and applications of climbing robots.A track-type inverted climbing robot called SpinyCrawler was developed in this *** a spiny track with an opposed gripping mechanism,the robot was experimentally demonstrated to have the ability of generating considerable adhesion to achieve stable inverted ***,to guarantee reliable attachment of the robot on rough ceilings,a spiny gripper inspired by the opposed gripping prolegs of caterpillars is designed,and a gripping model of the interaction between spines and the ceiling asperities is established and ***,a spiny track is developed by assembling dozens of spiny grippers to enable continuous attachment.A cam mechanism is introduced in the robot design without extra actuators to achieve stable attachment and easy detachment during continuous ***,climbing experiments are conducted on different surfaces,using a SpinyCrawler *** results demonstrated stable climbing ability on various rough inverted and vertical surfaces,including concrete walls,crushed stone walls,sandpaper walls,brick walls,and brick ceilings.

关键词： inverted climbing track-type robot rough ceiling bio-inspired spiny gripper

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