检索结果-南通市图书馆

Chinese Journal of Structural Chemistry 2006年第2期25卷 153-158页

作者： ZENG Xiang-Chao GU Jian XU Shi-Hai liu po-run Department of Chemistry Jinan University Guangzhou 510632 China

4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-（4,5-dibromo-1-methylpyrrole-2-carboxmido）-3-phenylpropanoate Ⅱ in 90.8% yield. Crystal data for Ⅰ： monoclinic system, space group P21/c with a = 8.595（3）, b = 10.900（4）, c = 12.321（5） ,A°,β = 92.292（7）°, V = 1153.4（8）A°^3, Dc = 2.213 g/cm^3, F（000） = 728, CTH4Br2Cl3NO, Mr = 384.28, λ = 0.71073 A°, μ（MoKa） = 7.688 mm^-1, Z = 4, R = 0.0338 and wR2 = 0.0840 for 1963 observed reflections with I 〉 2a（I）. Crystal data for Ⅱ： monoclinic system, space group P21 with a = 4.886（2）, b = 15.921（8）, c = 11.635（6） A°,β = 101.803（9）°, V = 885.9（7） A°^3, Dc = 1.665 g/cm^3, F（000） = 440, C16H16Br2N2O3, Mr = 444.13, λ = 0.71073 A°, μ（MoKa） = 4.590 mm^-1, Z = 2, R = 0.0335 and wR2 = 0.0837 for 3191 observed reflections with I 〉 2σ（I）. The crystal structure reveals that compound Ⅱ forms the one-dimensional chain structure via the intermolecular hydrogen bonds of N（2）-H…O（1）.

关键词： methyl 2-(4,5-dibromo-1-methylpyrrole-2-carbonylamino)-3-phenylpropanoate,synthesis crystal structure 4,5-dibromo-1-methyl-2-trichloroacetylpyrrole

Synthesis and Crystal Structure of 3-(Pyrrole-2′-carboxamido)propanoic Acid·(1/2)H_(2)O

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2005年第7期24卷 779-782,737页

作者： ZENG Xiang-Chao XU Shi-Hai GU Jian liu po-run Department of Chemistry Jinan UniversityGuangzhou 510632China

3-(Pyrrole-2?-carboxamido)propanoic acid I has been synthesized from the reaction of β-alanine methyl ester with 2-trichloroacetylpyrrole followed by saponifying and acidating in 85.4% yield, and the crystal structure of 3-(pyrrole-2?-carboxamido)propanoic acid· (1/2)H2O (C8H11N2O3.5, Mr = 191.19) was obtained and determined by X-ray diffraction method. The crystal is of monoclinic, space group C2/c with a = 19.010(4), b = 8.3515(17), c = 13.788(3) ?, β = 125.88(3)o, V = 1773.6(6) ?3, Z = 8, Dc = 1.432 g/cm3, λ = 0.71073 ?, μ(MoKα) = 0.114 mm?1 and F(000) = 768. The structure was refined to R = 0.0354 and wR = 0.0942 for 1642 observed reflections with I > 2σ(I). It is revealed that the title compound has one pyrrole ring and one propionic acid subchain linked by an amido bond at C(4), and there are 8 molecules of com- pound I and 4 crystal water molecules in each unit cell. The supramolecular layers are stabilized by the hydrogen bonds of N(2) H…O(2), N(1) H…O(4), O(4) H(1W)…O(2) and O(3) H…O(1).

关键词： 3-(pyrrole-2′-carboxamido)propanoic acid 2-trichloroacetylpyrrole crystal structure

β-邻苯二甲酰亚胺基丙醛缩乙二醇的新合成方法

在线全文

学校读者我要写书评

暂无评论

化学试剂 2006年第5期28卷 313-314页

作者：曾向潮刘珀润暨南大学化学系广东广州510632

以四丁基溴化铵为相转移催化剂,无水K2CO3为碱性催化剂,邻苯二甲酰亚胺与β溴代丙醛缩乙二醇经Gabriel反应合成了标题化合物。在邻苯二甲酰亚胺与β溴代乙二醇缩丙醛的物质的量比为1.1∶1,反应温度100～103℃,反应时间3.5h,在此条件下,... 详细信息

以四丁基溴化铵为相转移催化剂,无水K2CO3为碱性催化剂,邻苯二甲酰亚胺与β溴代丙醛缩乙二醇经Gabriel反应合成了标题化合物。在邻苯二甲酰亚胺与β溴代乙二醇缩丙醛的物质的量比为1.1∶1,反应温度100～103℃,反应时间3.5h,在此条件下,收率达95.9%。

关键词： β-邻苯二甲酰亚胺基丙醛缩乙二醇 Gabriel反应相转移催化合成

Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin liu run Hou Chenghao Wu Ruishan Xie Shujun Chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： run Song Shiyi Yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

N-(溴代-2-吡咯甲酰基)氨基酸甲酯的合成

在线全文

学校读者我要写书评

暂无评论

有机化学 2005年第11期25卷 1420-1426页

作者：曾向潮徐石海李毅群刘珀润李玉霞暨南大学化学系广州510632

在室温条件下,2-三氯乙酰基吡咯经溴代反应,再与氨基酸甲酯反应得到一系列N-(溴代-2-吡咯甲酰基)氨基酸甲酯,收率为64.8%～92.2%.通过元素分析,1HNMR,IR和MS对产物结构进行了表征,培养了N-(1-甲基-4,5-二溴-2-吡咯甲酰基)甘氨酸甲酯的... 详细信息

在室温条件下,2-三氯乙酰基吡咯经溴代反应,再与氨基酸甲酯反应得到一系列N-(溴代-2-吡咯甲酰基)氨基酸甲酯,收率为64.8%～92.2%.通过元素分析,1HNMR,IR和MS对产物结构进行了表征,培养了N-(1-甲基-4,5-二溴-2-吡咯甲酰基)甘氨酸甲酯的单晶并进行单晶X射线衍射分析.初步活性试验表明,目标产物对金黄色葡萄球菌、粪链球菌等五种细菌有一定的抑制作用.

关键词： N-(溴代-2-吡比咯甲酰基)氨基酸甲酯酰基化反应溴化反应合成抑菌活性氨基酸甲酯溴代反应甲酰基吡咯单晶X射线衍射分析

L-N-(2-吡咯甲酰基)-α-氨基酸甲酯的合成

在线全文

学校读者我要写书评

暂无评论

精细化工 2006年第2期23卷 148-153页

作者：曾向潮刘珀润徐石海邓芹英暨南大学化学系广东广州510632 中山大学化学与化学工程学院广东广州510275

2-三氯乙酰基吡咯（Ⅰ）与L-缬氨酸甲酯（Ⅱa）或L-苯丙氨酸甲酯（Ⅱb）在n（Ⅰ）：n（Ⅱ）=1：1，乙腈为溶剂，室温反应10-13h条件下，合成了系列标题化合物（Ⅲ），摩尔收率为71．3％-90．8％。通过元素分析、^1HNMR、IR和MS对产物结... 详细信息

2-三氯乙酰基吡咯（Ⅰ）与L-缬氨酸甲酯（Ⅱa）或L-苯丙氨酸甲酯（Ⅱb）在n（Ⅰ）：n（Ⅱ）=1：1，乙腈为溶剂，室温反应10-13h条件下，合成了系列标题化合物（Ⅲ），摩尔收率为71．3％-90．8％。通过元素分析、^1HNMR、IR和MS对产物结构进行了表征，培养了N-（4，5-二溴-2-吡咯甲酰基）-L-缬氨酸甲酯（Ⅲg）的单晶，并通过单晶X射线衍射分析研究了晶体结构。初步活性实验表明，部分目标产物对猪霍乱沙门氏菌、藤黄微球菌、粪链球菌、金黄色葡萄球菌和大肠埃希氏菌有抑制作用，其中化合物Ⅲg对粪链球菌的最小抑制质量浓度（MIC）为0．078mg／mL。

关键词： L-N-(2-吡咯甲酰基)-α-氨基酸甲酯酰基化反应抑菌活性

在线全文

学校读者我要写书评

暂无评论

Aldisin及其衍生物的合成和表征

化学试剂 2007年第2期29卷 65-68页

作者：徐石海刘铂润廖小建曾向潮暨南大学化学系广东广州510632

以五氧化二磷和甲基磺酸为环化试剂,N-(2-吡咯甲酰基)-β-丙氨酸经分子内酰化环化反应,合成了化合物Aldisin及其衍生物4-Bromoaldisin和4,5-Dibromoaldisin,通过1HNMR,13CNMR,IR,FABMS对其结构进行了表征。

关键词： Aldisin 4-Bromoaldisin 4,5-Dibromoaldisin 环化反应

在线全文

学校读者我要写书评

暂无评论

溴代2-三氯乙酰基吡咯的合成和表征

化学试剂 2005年第4期27卷 234-236页

作者：古健曾向潮徐石海刘珀润黎莹暨南大学化学系广东广州510632

以四氯化碳为溶剂,在室温下2-三氯乙酰基吡咯与溴进行溴代反应,通过控制反应物的物质的量比,方便地合成了4-溴-2-三氯乙酰基吡咯和4,5-二溴-2-三氯乙酰基吡咯等4种溴代产物,产率为90.5%-92.6%。以1HNMR、IR、MS和元素分析对目标产物的... 详细信息

以四氯化碳为溶剂,在室温下2-三氯乙酰基吡咯与溴进行溴代反应,通过控制反应物的物质的量比,方便地合成了4-溴-2-三氯乙酰基吡咯和4,5-二溴-2-三氯乙酰基吡咯等4种溴代产物,产率为90.5%-92.6%。以1HNMR、IR、MS和元素分析对目标产物的结构进行了表征。

关键词：溴代2-三氯乙酰基毗咯 2-三氯乙酰基吡咯溴代合成

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu Yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（po4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（po4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode