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Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43

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World Journal of Gastroenterology 2025年第8期31卷 82-95页

作者： Wei Yang Rui liu feng Xu Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Medical School Xiangyang Vocational and Technical CollegeXiangyang 441021Hubei ProvinceChina

BACKGROUND Colonic motility dysfunction is a common symptom of ulcerative colitis(UC),significantly affecting patients’quality of *** suggests that glial cell line-derived neurotrophic factor(GDNF)plays a role in restoring colonic *** To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis via connexin 43(Cx43).METHODS An experimental colitis model was induced in male C57BL/6 mice using dextran sodium sulfate(DSS).The measurement of colonic transit time was conducted,and colon tissues were evaluated through transmission electron microscopy and hematoxylin and eosin *** mice were treated with exogenous GDNF and Gap 19,a selective Cx43 *** Cx43 and GDNF levels were detected via immunofluorescence,immunohistochemistry,and real-time polymerase chain *** levels of inflammatory markers,including interleukin-1β,tumor necrosis factor-α,interleukin-6,and C-reactive protein,were quantified using enzyme-linked immunosorbent *** Experimental colitis was successfully induced using DSS,and the findings exhibited that the colonic transit time was significantly delayed in colitis mice relative to the UC group(P<0.01).GDNF treatment improved colonic transit time and alleviated intestinal inflammation in DSS-induced colitis mice(P<0.05).In the UC+Gap19+GDNF group,colitis symptoms,colonic transit time,and inflammatory marker levels remained comparable to those in the UC group,indicating that the therapeutic effects of GDNF in UC mice were blocked by Gap *** GDNF improves colonic motility in mice with experimental colitis through a partially Cx43-mediated *** holds promise as a therapeutic option for improving colonic motility in patients with colitis.

关键词： Glial cell line-derived neurotrophic factor Ulcerative colitis Colonic motility Connexin 43 Dextran sodium sulfate model

Electrospun nanofibers for electrochemical reduction of CO_(2): From spinning fabrication techniques to electrocatalyst design

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Nano Research 2025年第2期18卷 80-100页

作者： Yanbiao liu Ping feng Zhenzhen Wang Yan Yan Yong Zheng Yu Zhang Mingkai liu Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110004China Institute for Technical Chemistry and Environmental Chemistry Friedrich-Schiller-Universitat JenaJena 07743Germany School of Chemistry&Chemical Engineering Anhui University of TechnologyMa’anshan 243002China College of Materials and Chemical Engineering Key Laboratory of inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

Electrochemical reduction of CO_(2)(ECO_(2)RR)into value-added fuels and chemicals presents a promising avenue for mitigating CO_(2) emissions while simultaneously contributing to economic growth,thereby addressing critical environmental and energy ***,the large-scale implementation of ECO_(2)RR is significantly impeded by the necessity to design efficient catalysts that exhibit both high activity and *** catalysts must overcome the sluggish kinetics associated with ECO_(2)RR as well as the competing hydrogen evolution *** recent decades,electrospun nanofibers have garnered considerable attention as potential catalysts for ECO_(2)RR,attributable to their high surface area with abundant active sites,tunable functionalities,and enhanced *** review comprehensively examines the rational design of ECO_(2)RR catalysts utilizing electrospinning *** commence with an in-depth exploration of the principles underlying the electrospinning process and subsequently summarize key factors influencing this process,including solution parameters,environmental conditions,and electrospinning operational ***,we discuss recent advancements in ECO_(2)RR catalysts synthesized through electrospinning,encompassing carbon nanofibers,composite nanofibers,and metal ***,we delineate future perspectives and the challenges that electrospun materials face in the context of ECO_(2)RR *** review aims to inspire high-quality research directed toward the advancement of electrospun materials for improved performance in ECO_(2)RR.

关键词： CO_(2)reduction reaction catalyst design electrospinning single-atom catalysts

ClBBM and ClPLT2 function redundantly during both male and female gametophytes development in watermelon

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Horticultural Plant Journal 2025年第1期11卷 323-335页

作者： Qiyan liu Dongfen Han Jinfan Chen Jie Wang Denghu Cheng Xiner Chen Jiao Jiang Shujuan Tian Jiafa Wang man liu Haizheng Xiong Li Yuan State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China Department of Horticulture University of ArkansasFayettevilleAR 72701USA

As a prerequisite for sexual reproduction,gametophyte development is an interesting process involving cell proliferation,differentiation and *** has been extensively explored in model plants,but the regulatory mechanism of gametophyte development largely remains unknown in Cucurbitaceae *** present study,we have shown that watermelon ClBBM and ClPLT2,two AP2/ERF transcription factors,participated in both male and female gametophyte *** and Clplt2 single mutants resembled wild-type phenotypes in both vegetative and reproductive *** Clbbm/Clplt2 double mutant showed partial pollen abortion and bore less seeds comparing to *** results indicated that the abnormal pollen grains were caused by premature tapetum degeneration,and reduced seed-set was due to faulty embryo sac *** and ClPLT2 were expressed in FG4 embryo sacs,and their transcripts were also detectable in the tapetum and microspore of stage 9 anthers,which was consistent with developmental stages of defective phenotypes observed in double *** expression of genes essential for tapetum development,ClATM1,ClAMS,ClMS1 and ClMS188,was decreased in Clbbm/Clplt2 double ***,the transcriptome analysis indicated that ClBBM and ClPLT2 participated in tapetum and pollen wall development by regulate cell cycle,transmembrane transport,glucan and cellulose metabolic ***,ClBBM and ClPLT2 were functionally redundant in regulating gametophyte development in watermelon,and their functions differ from their homologous genes in model plant Arabidopsis.

关键词： Watermelon Gametophyte Male sterility Seedless

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen feng Peng Yunpeng liu School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528000GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina Guangdong Key Laboratory for Hydrogen Energy Technologies Foshan 528000GuangdongChina

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction (OER)and chlorin ion oxidation reaction (ClOR),glycerol oxidation reaction (GOR) is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide (Ru-CoP_(2)) is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP_(2)to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP_(2)as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm^(-2),which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

DecMamba:Mamba Utilizing Series Decomposition for Multivariate Time Series Forecasting

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Computers, Materials & Continua 2025年第1期82卷 1049-1068页

作者： Jianxin feng Jianhao Zhang Ge Cao Zhiguo liu Yuanming Ding Communication and Network Key Laboratory Dalian UniversityDalian116622China

Multivariate time series forecasting iswidely used in traffic planning,weather forecasting,and energy *** decomposition algorithms can help models better understand the underlying patterns of the original series to improve the forecasting accuracy of multivariate time ***,the decomposition kernel of previous decomposition-based models is fixed,and these models have not considered the differences in frequency fluctuations between *** problems make it difficult to analyze the intricate temporal variations of real-world time *** this paper,we propose a series decomposition-based Mamba model,DecMamba,to obtain the intricate temporal dependencies and the dependencies among different variables of multivariate time series.A variable-level adaptive kernel combination search module is designed to interact with information on different trends and periods between *** backbone structures are proposed to emphasize the differences in frequency fluctuations of seasonal and trend *** with superior performance is used instead of a Transformer in backbone structures to capture the dependencies among different variables.A new embedding block is designed to capture the temporal features better,especially for the high-frequency seasonal component whose semantic information is difficult to acquire.A gating mechanism is introduced to the decoder in the seasonal backbone to improve the prediction accuracy.A comparison with ten state-of-the-art models on seven real-world datasets demonstrates that DecMamba can better model the temporal dependencies and the dependencies among different variables,guaranteeing better prediction performance for multivariate time series.

关键词： Data prediction time series Mamba series decomposition

基于空气质量指数AQI的污染集聚空间异质性分析

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经济地理 2016年第8期36卷 166-175页

作者：刘满凤谢晗进江西财经大学协同创新中心中国江西南昌330013 江西财经大学信息管理学院中国江西南昌330013

基于空气质量指数(AQI),检验了经济集聚与污染集聚之间存在的是强的正线性关系,并且验证了经济集聚、工业化加速、信息化加快都会使污染集聚加速;而科技创新投入和FDI增加则会化解污染集聚的形成。增加工业化与信息化协调融合变量的时... 详细信息

基于空气质量指数(AQI),检验了经济集聚与污染集聚之间存在的是强的正线性关系,并且验证了经济集聚、工业化加速、信息化加快都会使污染集聚加速;而科技创新投入和FDI增加则会化解污染集聚的形成。增加工业化与信息化协调融合变量的时空地理加权模型(GTWR)的估计结果表明,工业化与信息化协调融合可显著地降低污染的集聚,协调融合度越高,越能化解污染集聚的形成。在对策举措方面,北方地区省市污染集聚现象严重,可通过信息化加速发展提升工业化发展质量,促使重工业转型与升级,以缓解污染集聚形成;中、西部地区需进一步加大科技创新投入,严格控制污染集聚形成。

关键词：空气质量指数时空地理加权回归信息化与工业化融合

我国工业化、城镇化与环境经济集聚的时空演化

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经济地理 2015年第10期35卷 21-28页

作者：刘满凤谢晗进江西财经大学协同创新中心中国江西南昌330013 江西财经大学信息管理学院中国江西南昌330013

为测度在工业化和城镇化进程中集聚带来的正效应和负效应,提出了环境经济一致性指数。环境经济一致性指数的时空演化说明,随着时间的推移,集聚的负效应逐渐增大,正效应逐渐减弱;而空间的演变是东中西部呈梯度状,集聚的正效应减弱,负效... 详细信息

为测度在工业化和城镇化进程中集聚带来的正效应和负效应,提出了环境经济一致性指数。环境经济一致性指数的时空演化说明,随着时间的推移,集聚的负效应逐渐增大,正效应逐渐减弱;而空间的演变是东中西部呈梯度状,集聚的正效应减弱,负效应增强。环境经济一致性指数的门槛效应模型检验结果显示,当财政支出占GDP比重小于19.2409时,在工业化与城镇化进程中,市场效应起主导作用;介于19.2409与20.6205之间呈现的是政府与市场并驾齐驱,双轮驱动现象;大于20.6205时是政府起主导作用。因此,中西部地区应该更多地发挥市场的调控作用,而东部地区则更多地应该发挥政府的调控作用。

关键词：新型工业化新型城镇化经济集聚污染集聚一致性指数门槛效应

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中国省域经济集聚性与污染集聚性趋同研究

经济地理 2014年第4期34卷 25-32页

作者：刘满凤谢晗进江西财经大学协同创新中心中国江西南昌330013 江西财经大学信息管理学院中国江西南昌330013

首先分别用Herfindahl指数、Gini指数、地理集中度指数测度了我国省级区域的经济集聚度水平与污染集聚度水平,通过空间相关性检验,证明了经济集聚度与污染集聚度存在很强的正相关关系,即经济的集聚加速了污染的集聚,并且污染的集聚态势... 详细信息

首先分别用Herfindahl指数、Gini指数、地理集中度指数测度了我国省级区域的经济集聚度水平与污染集聚度水平,通过空间相关性检验,证明了经济集聚度与污染集聚度存在很强的正相关关系,即经济的集聚加速了污染的集聚,并且污染的集聚态势趋同于经济的集聚态势。其次,应用空间误差模型分析了影响污染集聚的因素。经济集聚是引起污染集聚的首要决定因素,能源消费、城镇化进程、外商直接投资都会显著促进污染的集聚;技术创新则会显著降低污染的集聚;产业结构对污染集聚的作用不显著;人口的集聚性高则未必会引起污染的集聚性高,如我国的上海和北京等发达城市,尽管人口密度很大,但是由于污染处理及时得力,并没有引起污染的迅速集聚。

关键词：经济集聚污染集聚 Herfindahl指数地理集中度指数空间计量模型趋同

Adaptive Control of a Flexible manipulator With Unknown Hysteresis and Intermittent Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 148-158页

作者： Shouyan Chen Weitian He Zhijia Zhao Yun feng Zhijie liu Keum-Shik Hong School of Mechanical and Electrical Engineering Guangzhou University the School of Control Science and Engineering Shandong University IEEE the College of Electrical and Information Engineering Hunan University the National Engineering Research Center for Robot Visual Perception and Control Technology Hunan University the School of Intelligence Science and Technology University of Science and Technology Beijing (USTB) the Institute for Future the School of AutomationQingdao University the School of Mechanical Engineering Pusan National University

In this study, we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults. First, an inverse hysteresis dynamics model is introduced, and then the control input is divided into an expected input and an error compensator. Second,a novel adaptive neural network-based control scheme is proposed to cancel the unknown input hysteresis. Subsequently,by modifying the adaptive laws and local control laws, a fault-tolerant control strategy is applied to address uncertain intermittent actuator faults in a flexible manipulator system. Through the direct Lyapunov theory, the proposed scheme allows the state errors to asymptotically converge to a specified interval. Finally,the effectiveness of the proposed scheme is verified through numerical simulations and experiments.

关键词： Adaptive control flexible manipulator intermittent actuator faults inverse hysteresis dynamics vibration control