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Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan liu jia-lin CHEN Geng-xin SHEN Dan-ting ZHU Wang CHEN Xin-lin liu Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

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从“物理国际化”到“虚拟国际化”:高等教育国际化的范式转换

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清华大学教育研究 2024年第3期45卷 48-59页

作者：段世飞刘林佳钱跳跳浙江大学教育学院浙江杭州310058

高等教育国际化在其历史变迁中出现了多次转向。基于托马斯·库恩的范式理论,高等教育国际化范式在不同主体推动下,经历了前科学、常规科学、反常与危机、科学革命四个阶段,分别对应高等教育国际化范式的松散自发时期、物理国际化时期... 详细信息

高等教育国际化在其历史变迁中出现了多次转向。基于托马斯·库恩的范式理论,高等教育国际化范式在不同主体推动下,经历了前科学、常规科学、反常与危机、科学革命四个阶段,分别对应高等教育国际化范式的松散自发时期、物理国际化时期、在地国际化为代表的新形式时期、虚拟国际化渐趋主流时期。后疫情时代,高等教育国际化步入科学革命阶段,在数字与信息通讯技术的广泛渗透及新的全球化发展态势中,高等教育国际化范式的价值理念、模型框架、共有范例寻求新的常态。虚拟国际化强调协同高等教育国际化发展与数字化转型、消除高等教育国际化境外与在地的物理边界、重构不确定时代高等教育国际化之确定性,具有成为高等教育国际化新范式的潜能。

关键词：虚拟国际化物理国际化高等教育国际化范式转换

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外阴血管肌纤维母细胞瘤影像表现1例

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生物医学工程与临床 2024年第3期28卷 398-399页

作者：刘佳林张皓兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院放射科甘肃省放射影像医学临床医学研究中心甘肃兰州730000

1临床资料1例26岁女性患者,因“右侧外阴区胀痛不适5月余”就诊。患者1个月前因外阴不适就诊于当地医院,初诊为“前庭大腺囊肿”,行囊肿剥除术,术中探查肿物后建议转入上级医院,遂于2021年10月14日转入兰州大学第一医院。患者已婚,孕1... 详细信息

1临床资料1例26岁女性患者,因“右侧外阴区胀痛不适5月余”就诊。患者1个月前因外阴不适就诊于当地医院,初诊为“前庭大腺囊肿”,行囊肿剥除术,术中探查肿物后建议转入上级医院,遂于2021年10月14日转入兰州大学第一医院。患者已婚,孕1产1,平素月经规律,末次月经2021年9月23日。肿瘤标志物无异常。专科检查:全身浅表淋巴结无肿大,外阴局部可见硬结,右侧外阴区可触及一约4 cm×4 cm的肿块,活动度尚可,质韧,皮温正常。入院诊断:会阴部肿物。

关键词：血管肌纤维母细胞瘤体层摄影术 X线计算机(CT) 磁共振成像(MRI)

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反事实增强的对抗学习序列推荐

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计算机系统应用 2024年第4期33卷 235-245页

作者：刘珈麟贺泽宇李俊中国科学院计算机网络信息中心北京100083 北京信息科技大学计算机学院北京100101 中国科学院大学北京100049

最近,强化学习技术在序列推荐系统取得成功,它能从用户长期反馈信号中学习有效的推荐策略.然而,模型的激励函数设计面临区分度过低的难题.这限制了模型学习不同用户反馈信号间的价值差异的能力,并导致推荐策略总是次优的.现有工作主要... 详细信息

最近,强化学习技术在序列推荐系统取得成功,它能从用户长期反馈信号中学习有效的推荐策略.然而,模型的激励函数设计面临区分度过低的难题.这限制了模型学习不同用户反馈信号间的价值差异的能力,并导致推荐策略总是次优的.现有工作主要通过调节衰减因子来保证激励函数区分度,但它依赖专家先验知识缺乏理论基础.为了更合理地设计激励函数和提高其区分度,本文依据因果论来分析推荐系统,并提出一种基于反事实区分度增强的序列推荐算法CAL4Rec.首先,所提出方法用结构因果图描述序列推荐过程,并创造性地用因果图定义了因果可鉴别的价值激励区分度.其次,该方法用反事实生成对抗的自监督学习过程优化推荐策略网络,以学习用户的真实倾向.在一系列序列推荐基准数据集上,对CAL4Rec开展了广泛对比和消融实验,实验结果表明CAL4Rec的提升对多种网络实现结构有效(平均2.34%).

关键词：反事实推理生成对抗学习结构因果模型序列推荐

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Experimental,Numerical,and Analytical Studies on the Bending of Mechanically lined Pipe

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China Ocean Engineering 2024年第2期38卷 221-232页

作者： WEI Wen-bin YUAN lin ZHOU jia-sheng liu Zheng State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China School of Mechanical Engineering Tianjin UniversityTianjin 300072China

Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion *** installation and operation,the pipe may undergo severe bending deformation,which causes the liner to separate from the outer pipe and buckles,affecting the stability of the whole *** this paper,the buckling response of MLP subjected to bending is investigated to clarify its bending characteristics by employing both experiments,numerical simulation,as theoretical *** types of MLPs were manufactured with GB 45 carbon steel(SLP)and Al 6061(ALP)used as the outer pipe material,*** hydraulic expansion and bending experiments of small-scale MLPs are *** addition to the ovalized shape of the cross-section for the SLP specimens,the copper liner was found to wrinkle on the compressive *** contrast,the liner of ALP remains intact without developing any wrinkling and collapse *** addition,a dedicated numerical framework and theoretical models were also *** was found both the manufacturing and bending responses of the MLP can be well reproduced,and the predicted maximum moment and critical curvatures are in good agreement with the experimental results.

关键词： lined pipe bending nonlinear ring theory buckling plasticity

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紫苏花蚬子香菇复合保健风味酱的研制

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中国调味品 2024年第9期49卷 151-156,161页

作者：崔东波刘嘉琳高涵王心哲苑广志梁文珍辽宁农业职业技术学院辽宁营口115009

以紫苏叶、花蚬子、香菇、黄豆酱为主要原料,开发一种紫苏海鲜复合保健风味酱。在单因素试验的基础上,通过响应面试验结合感官评定法确定了紫苏花蚬子香菇复合保健风味酱的最佳制备工艺条件:蚬子肉烘干时间为60 min,辣椒片添加量为27.8... 详细信息

以紫苏叶、花蚬子、香菇、黄豆酱为主要原料,开发一种紫苏海鲜复合保健风味酱。在单因素试验的基础上,通过响应面试验结合感官评定法确定了紫苏花蚬子香菇复合保健风味酱的最佳制备工艺条件:蚬子肉烘干时间为60 min,辣椒片添加量为27.8 g,蚬子肉添加量为222.7 g,紫苏叶添加量为31.4 g,香菇添加量为180 g。并对产品进行了理化指标和微生物指标检测,结果均符合相关标准。研究开发的紫苏花蚬子香菇复合保健风味酱味道独特、营养丰富,不仅提高了紫苏、花蚬子的经济附加值,而且满足了人们对复合功能酱产品的需求,为今后开发复合功能酱产品提供了参考依据。

关键词：紫苏叶花蚬子保健风味酱响应面

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Combined effects of massive reclamation and dredging on the variations in hydrodynamic and sediment transport in lingdingyang Estuary,China

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Frontiers of Earth Science 2024年第1期18卷 127-147页

作者： Kanglin CHEN Yitong lin Jing liu Zixiao HE Liangwen jia School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China School of Marine Science Sun Yat-Sen UniversityGuangzhou 510275China School of Marine Engineering and Technology Sun Yat-Sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519080China Guangdong Province Engineering Research Center of Coasts Islands and ReefsGuangzhou 510275China

Anthropogenic disturbances associated with the rapid development of coastal cities have drastically influenced the hydrodynamics and sediment transport processes in many large estuaries *** Estuary(LE),located in the central and southern part of the Pearl River Delta,southern China with a long history of high-intensity anthropogenic disturbances,was studied to explore the contribution rate and mechanism underlying the alteration in hydrodynamics and sediment transport under each phase of human activity.A state-of-the-art modeling tool(TELEMAC-2D),was used to study the variations in the hydrodynamics and sediment transport,accounting for reclamation-induced shoreline and dredging-induced topography *** results indicated that:i)under the influence of successive land reclamation,the general distribution of the Confluence Hydrodynamic Zone(CHZ)in LE varied from scattered to concentrated,and these zones moved 3–5 km ***)Large-scale channel dredging weakened the residual flow in LE,decreasing the residual flow in the Inner-lingding Estuary(ILE)by 62.45%.This was initiated by the enhancement of tidal dynamics through changes in the bottom friction caused by dredging in the *** contrast,massive reclamation decreased the residual flow in the ILE by 17.55%and increased that in the Outer-lingding Estuary(OLE).iii)Despite disturbances related to land reclamation and dredging,the estuarine jet flow in LE remained a turbulent jet system,and the estuarine jet flow became more *** addition,the position of the estuarine jet source moved 6–13 km ***)Both reclamation and dredging decreased the SSC in the ILE and increased the SSC in the *** weakened the SSC in the ILE by 62.19%,whereas dredging enhanced the SSC in the OLE by 49%.Spatially,reclamation resulted in an increase in the SSC near the outlets and a decrease in the SSC in the northern portion of the Western *** mainly increased the SSC in the north

关键词： reclamation and dredging estuarine jet flow dynamics and sediment transport mechanism lingdingyang Estuary

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Paleogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1290-1325页

作者： jia liu Ai SONG lin DING Tao SU Zhekun ZHOU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Paleontology Yunnan UniversityKunming 650500China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

The Paleogene is a crucial period when terrestrial and marine ecosystems recovered from major disruptions and gradually approached their modern *** the Qinghai-Tibetan Plateau and its surrounding regions,the Paleogene also represents a significant phase of tectonic evolution in the Qinghai-Tibetan Plateau-Himalaya orogeny,reorganization of Asian climates,and evolution of *** to limitations in research conditions and understanding,there are still many controversies regarding stratigraphic divisions in the Qinghai-Tibetan Plateau and its surrounding *** recent years,extensive studies on sedimentary petrology,magnetostratigraphy,and isotope dating have been conducted in the *** fossils have been discovered and reported,contributing to a more systematic understanding of *** studies have laid a solid foundation for the comprehensive investigation of the stratigraphy,biotas and paleogeographic evolution of the Qinghai-Tibetan Plateau and its surrounding regions during the *** this paper,we integrate recent research on fossils,isotopic dating,magnetostratigraphy,and geochemistry to refine the stratigraphic divisions and correlation framework of different tectonic units in the region,building upon previous *** the Second Tibetan Plateau Scientific Expedition and Research,the knowledge of Paleogene floras has gradually *** paper discusses the biostratigraphic significance of extinct and newly appeared taxa based on the latest dating results of these plant *** new understanding of fossil species such as the“Eucalyptus”and Arecaceae establishes connections between the Paleogene flora of the Qinghai-Tibetan region and the biotas of Gondwana,specifically Oceania and South *** evolutionary history of key taxa near the Yarlung Zangbo suture zone indicates that the collision between the Indian and Eurasian plates occurred approximately 65-54 *** reconstructions,based o

关键词： Qinghai-Tibetan Plateau Fossils Biostratigraphy Paleoenvironment Paleogeography Paleogene

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Univariate Time Series Anomaly Detection Based on Hierarchical Attention Network

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Tsinghua Science and Technology 2024年第4期29卷 1181-1193页

作者： Zexi Chen Dongqiang jia Yushu Sun lin Yang Wenjie Jin Ruoxi liu State Grid Beijing Electric Power Company Beijing 100031China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

In order to support the perception and defense of the operation risk of the medium and low voltage distribution system, it is crucial to conduct data mining on the time series generated by the system to learn anomalous patterns, and carry out accurate and timely anomaly detection for timely discovery of anomalous conditions and early alerting. And edge computing has been widely used in the processing of Internet of Things (IoT) data. The key challenge of univariate time series anomaly detection is how to model complex nonlinear time dependence. However, most of the previous works only model the short-term time dependence, without considering the periodic long-term time dependence. Therefore, we propose a new Hierarchical Attention Network (HAN), which introduces seven day-level attention networks to capture fine-grained short-term time dependence, and uses a week-level attention network to model the periodic long-term time dependence. Then we combine the day-level feature learned by day-level attention network and week-level feature learned by week-level attention network to obtain the high-level time feature, according to which we can calculate the anomaly probability and further detect the anomaly. Extensive experiments on a public anomaly detection dataset, and deployment in a real-world medium and low voltage distribution system show the superiority of our proposed framework over state-of-the-arts.

关键词： edge computing anomaly detection univariate time series self-attention

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超声波提取黄芪多糖的工艺研究

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广州化工 2024年第1期52卷 54-56页

作者：欧阳婉洳李洪淼张利谢淑玲刘嘉琳辽宁农业职业技术学院辽宁营口115009

黄芪多糖是黄芪发挥生物活性和药理作用的重要物质之一,具有抗肿瘤、保护心脑血管、提高免疫功能、抗衰老等多种作用。本文采用超声辅助提取法提取黄芪多糖,以水为溶媒,分别研究提取时间、提取温度、提取功率、提取次数及料水比对多糖... 详细信息

黄芪多糖是黄芪发挥生物活性和药理作用的重要物质之一,具有抗肿瘤、保护心脑血管、提高免疫功能、抗衰老等多种作用。本文采用超声辅助提取法提取黄芪多糖,以水为溶媒,分别研究提取时间、提取温度、提取功率、提取次数及料水比对多糖提取的影响,旨在优化黄芪多糖的提取工艺。正交试验结果表明,黄芪多糖的最佳提取工艺参数为:料水比为1∶5、提取时间为70 min、提取功率为70%、提取温度为60℃。

关键词：黄芪多糖提取温度提取功率提取时间料水比

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