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Epigenetic modification in liver fibrosis:Promising therapeutic direction with significant challenges ahead

Acta Pharmaceutica Sinica B 2024年第3期14卷 1009-1029页

作者： Runping liu Yajing Li Qi Zheng Mingning Ding huiping Zhou Xiaojiaoyang Li School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102400China School of Life Sciences Beijing University of Chinese MedicineBeijing 102400China Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA 22460USA

Liver fibrosis,characterized by scar tissue formation,can ultimately result in liver ***’s a major cause of morbidity and mortality globally,often associated with chronic liver diseases like hepatitis or alcoholic and non-alcoholic fatty liver ***,current treatment options are limited,highlighting the urgent need for the development of new *** a reversible regulatory mechanism,epigenetic modification is implicated in many biological processes,including liver *** the epigenetic mechanisms involved in liver fibrosis could provide valuable insights into developing new treatments for chronic liver diseases,although the current evidence is still *** review provides a comprehensive summary of the regulatory mechanisms and critical targets of epigenetic modifications,including DNA methylation,histone modification,and RNA modification,in liver fibrotic *** potential cooperation of different epigenetic modifications in promoting fibrogenesis was also ***,available agonists or inhibitors regulating these epigenetic mechanisms and their potential application in preventing liver fibrosis were *** summary,elucidating specific druggable epigenetic targets and developing more selective and specific candidate medicines may represent a promising approach with bright prospects for the treatment of chronic liver diseases.

关键词： Liver fibrosis Epigenetics regulation DNA methylation Histone acetylation Histone methylation mRNA methylation Non-coding RNA Drug development

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Pd single atoms cooperate with S vacancies in ZnIn_(2)S_(4) nanosheets for photocatalytic pure-water splitting

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Science China Chemistry 2024年第3期67卷 855-861页

作者： Lin Sun huiping Peng Fei Xue Shangheng liu Zhiwei Hu Hongbo Geng Xiaozhi liu Dong Su Yong Xu Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China Max Planck Institute for Chemical Physics of Solids Nothnitzer Strasse 40Dresden 01187Germany School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

Photocatalytic water splitting has emerged as a new frontier for converting solar energy to green H_(2) and value-added ***,great challenges still remain for developing efficient photocatalysts for pure water splitting without sacrificial *** this work,we demonstrate that doping hexagonal ZnIn_(2)S_(4)(ZIS) with Pd single atoms(Pd_(0.03)/ZIS) can serve as a highly efficient photocatalyst for pure water splitting to simultaneously produce H_(2) and H_(2)O_(2) without any sacrificial *** from aberration-corrected high-angle annular dark field scanning transmission electron microscopy,X-ray fine spectroscopy,insitu electron paramagnetic resonance and diffuse Fourier transform infrared spectroscopy reveal that doping ZIS with Pd single atoms facilitates the formation of S vacancies(S_(v)),where the photogenerated electrons can transfer to Pd single atoms,as a result of enhanced separation of electron-hole pairs and improved photocatalytic ***,Pd_(0.03)/ZIS displays a stoichiometric ratio of H_(2) and H_(2)O_(2) with the productivity of 1,037.9 and 1,021.4μmol g^(-1)h^(-1),respectively,which has largely outperformed pure ZIS and other reported catalysts for pure water *** work provides an efficient photocatalyst for water splitting to produce H_(2) and H_(2)O_(2),which may attract rapid interest in materials science,chemistry,and heterogeneous catalysis.

关键词： ZnIn_(2)S_(4) Pd single atom S vacancy pure water splitting H_(2)O_(2)

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Ethylene thiourea exposure induces neurobehavioral toxicity in zebrafish by disrupting axon growth and neuromuscular junctions

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Journal of Environmental Sciences 2024年第3期137卷 108-119页

作者： Jingming Wang Zhiquan Yu Yongfeng Wang Yuanyao Chen Lin Xiao Yanjun Zong Qiyuan Feng Lianqi Peng huiping Zhang Chunyan liu Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Ethylene thiourea(ETU)converted from ethylene bisdithiocarbamate(EBDC)fungicides has aroused great concern because of its prevalence and harmful *** ETU-induced neurotoxicity has been reported,the potential mechanisms remain *** study provided insights into its neurotoxic effects at environmentally relevant concentrations in *** findings showed that embryonic exposure to ETU decreased the hatch rate and delayed somite ***,ETU treatment significantly reduced the dark velocity in the locomotion *** upregulated tendency of the mitogen-activated protein kinases(MAPK)pathway(mknk1,atf4,mapkapk3)screened by transcriptome analysis implied motor neuron degeneration,which was validated by subsequent morphological observation,as axon length and branches were truncated in the 62.5μg/L ETU ***,although the rescue experiment with a p38 MAPK inhibitor(SB203580)successfully ameliorated axon degeneration,it failed to reverse the locomotion *** exploration of transcriptome data revealed the varied expression of presynaptic scaffold protein-related genes(pcloa,pclob,bsna),whose downregulation might impair the neuromuscular junction(NMJ).Therefore,we reasonably suspected that ETU-induced neurobehavioral deficits might result from the combined effects of the MAPK pathway and presynaptic *** this,we highlighted the necessity to take precautions and early interventions for susceptible ETU-exposed populations.

关键词： Ethylene thiourea(ETU) Behavior Neuromuscular junction MAPK signaling pathway Piccolo and bassoon Danio rerio

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Stabilizing semi-transparent perovskite solar cells with a polymer composite hole transport layer

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Nano Research 2024年第3期17卷 1500-1507页

作者： Yongbin Jin huiping Feng Zheng Fang liu Yang Kaikai liu Bingru Deng Jingfu Chen Xueling Chen Yawen Zhong Jinxin Yang Chengbo Tian Liqiang Xie Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Semi-transparent perovskite solar cells(ST-PSCs)have broad applications in building integrated ***,the stability of ST-PSCs needs to be improved,especially in n-i-p ST-PSCs since the doped 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9'-spirobifluorene(Spiro-OMeTAD)is unstable at elevated temperatures and high *** this work,aπ-conjugated polymer poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c:4',5'-c']dithiophene-4,8-dione)](PBDB-T)is selected to form a polymer composite hole transport layer(HTL)with *** sulfur atom of the thiophene unit and the carbonyl group of the polymer interact with the undercoordinated Pb2+at the perovskite surface,which stabilizes the perovskite/HTL interface and passivates the interfacial *** incorporation of the polymer also increases the glass transition temperature and the moisture resistance of *** a result,we obtain ST-PSCs with a champion efficiency of 13.71%and an average visible light transmittance of 36.04%.Therefore,a high light utilization efficiency of 4.94%can be ***,the encapsulated device can maintain 84%of the initial efficiency after 751 h under continuous one-sun illumination(at 30%relative humidity)at the open circuit and the unencapsulated device can maintain 80%of the initial efficiency after maximum power tracking for more than 1250 h under continuous one-sun illumination.

关键词： semi-transparent solar cells π-conjugated polymer composite hole transport layer building integrated photovoltaics

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Mannanase improves the growth performance of broilers by alleviating inflammation of the intestinal epithelium and improving intestinal microbiota

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动物营养学报 2024年第1期16卷 376-394页

作者： Xiaodan Zhang huiping Xu Lu Gong Jiao Wang Jianyang Fu Zengpeng Lv Liangjuan Zhou Xuejun Li Qiong liu Pingyu Xia Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and Technology China Agricultural University Beijing 100193 China Beijing Strowin Biotechnology Co. Ltd. Beijing 100094 China

This experiment aimed to discuss and reveal the effect and mechanism of mannanase on intestinal inflammation in broilers triggered by a soybean meal diet. In this experiment, 384 Arbor Acres broilers at 1 d old were randomly divided into 3 treatment groups. The broilers were fed a corn-soybean meal basal diet, a low-energy diet (metabolizable energy reduced by 50 kcal/kg), and a low-energy diet supplemented with 100 mg/kg mannanase for 42 d. The low-energy diet increased feed conversion ratio from 0 to 42 d, reduced ileal villus height and villus height-to-crypt depth ratio and upregulated the expression of nuclear factor kappa B ( NF-κB ) in the ileum ( P P P CLDN1 ) and zonula occludens-1 ( ZO-1 ) in the jejunum at 21 d, downregulated the expression of ilealNF-κB , and increased the content of isobutyric acid in the cecum of broilers ( P Lactobacillus reuteri in the ileum of broilers. The addition of mannanase increased the relative abundance ofLactobacillus-KC45b andLactobacillus johnsonii in broilers. Furthermore, a low-energy diet reduced the relative abundance ofButyricicoccus in the intestine of broilers and inhibited oxidative phosphorylation and phosphoinositol metabolism. Mannanase increased the relative abundance ofOdoribacter , promoted energy metabolism and N-glycan biosynthesis, and increased the activities of GH3 and GH18. It is concluded that mannanase could improve the growth performance of broilers by reducing the expression ofNF-κB in the ileum, increasing the production of SCFA in the cecum, suppressing intestinal inflammation, balancing the intestinal microbiota, reducing damage to the intestinal barrier, and improving the efficiency of nutrient utilization to alleviate the adverse effects caused by the decrease in dietary energy *** The PDF

关键词： Broiler Low-energy diet Mannanase Intestinal inflammatory response Intestinal microbiota Metagenome

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Effects of temperature and rare earth content on the oxidation resistance of a Ni-based superalloy

Effects of temperature and rare earth content on the oxidati...

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2011中国材料研讨会

作者： Xiu Song 1,Lei Wang 1,Yang liu 1 and huiping Ma 2 1 The Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education),Northeastern University,2 Department of High-temperature Materials,Central Iron & Steel Research Institute

＜正＞The high-temperature oxidation behaviors of the Ni-22Cr-14W-2Mo superalloys with various La contents were investigated at 1000℃ and 1100℃ up to 500 h,*** phase constitution,composition and surface

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Experimental investigation of state-selective electron capture in C4+-He collisions

Experimental investigation of state-selective electron captu...

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第七届存储粒子原子物理合作组织国际会议

作者： Zhu Xiaolong 1 Ma Xinwen 1 2 Zhang Shaofeng 1 Feng Wentian 1 liu huiping 1 Qian Dongbin 1 Zhang Dacheng 1 2 Wen Weiqiang 1 2 Zhang Pengju 1 2 Yan Shuncheng 1 2 and Li Bin 1 2 1Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China 2Graduate University of Chinese Academy of Sciences Beijing 100049 China

＜正＞In last decade years,the state-selective charge transfer of highly charged ions with atom and molecules have become an extremely active fields of atomic/molecular physics since the cold target recoil ion momentum spectroscopy （COLTRIMS/reaction microscope）technique [1,2] was *** of the early theoretical and experimental works focused on the absolute cross ***,

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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye Chenguang Shen huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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原料肉冻藏品质劣变机制及其改善策略

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食品科学 2024年第8期45卷 321-330页

作者：刘嘉琪王慧平张鑫孔保华陈倩东北农业大学食品学院黑龙江哈尔滨150030

原料肉在冷冻、冻藏和解冻过程中会发生一系列物理化学变化,其品质特性不可避免地遭到破坏,主要表现为持水能力下降、色泽和质构劣变,采用新型冷冻及其辅助技术能够有效地降低由此造成的品质劣变。本文概述了原料肉在冷冻、冻藏过程中... 详细信息

原料肉在冷冻、冻藏和解冻过程中会发生一系列物理化学变化,其品质特性不可避免地遭到破坏,主要表现为持水能力下降、色泽和质构劣变,采用新型冷冻及其辅助技术能够有效地降低由此造成的品质劣变。本文概述了原料肉在冷冻、冻藏过程中品质劣变机制,综述了新型冷冻技术、抗冻保护剂、新型包装技术以及新型解冻技术等提升原料肉品质的方法,以期为原料肉冻藏品质的改善提供理论依据和技术指导。

关键词：原料肉冷冻冻藏品质抗冻保护剂辅助冷冻技术

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Pathway to energy technical innovation and commercialization based on Internet plus DES

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Frontiers in Energy 2016年第1期10卷 65-78页

作者： huiping liu Shanghai Academy of Development and Reform Shanghai 200032 China

The distributed energy system （DES） is a type of energy cascade utilization on the client side or close to the client, and it has become an important option of global energy transformation. In China, based on the experience of demonstration projects, the DES is now being commercialized. Under the new opportunity of energy production and consumption promoted by the national ＂Internet Plus＂ action plan, the development of the DES was reviewed in this paper; four categories of market demand and five key issues for DES deployment were analyzed; five types of potential DES users and five key points of technical path implementation proposed based on many years of engineering practices and hundreds of project case studies were proposed. 4E elements should be used to evaluate and choose the project and lead the innovation model of DES by energy production and consumption revolution with the sustainable development of the Intemet plus DES. The future innovation models include intelligent energy modularity and menu-type services with the demands of the client side, and the kind of new thinking for DES services that ＂you are in charge of your own energy production and consumption, while we are also at service when needed for installation and maintenance.＂ The aim of innovation mode is to give the energy sovereign back to the people, and form a perfect Intemet plus DES ecosystem.

关键词： "Intemet Plus" distributed energy system (DES) business model technical innovation commercialization DES industry ecosystem energy revolution

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