检索结果-南通市图书馆

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1.JAK2/STAT3.signaling pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 434-439页

作者： Chenxi zhao Tiangang Zhou Ming Li Jie {1. Xiaoqing zhao Yilin Pang Xinjie {1. Jiawei Zhang lei Ma Wenxiang Li xue yao Shiqing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Orthopedic Research Center of Shandong University Cheeloo College of MedicineDepartment of OrthopedicsQilu Hospital of Shandong UniversityJinanShandong ProvinceChina

Argatroban is a synthetic thrombin inhibitor approved by *** and Drug Administration for the treatment of ***,whether it plays a role in the repair of spinal cord injury is *** this study,we established a rat model of T1. moderate spinal cord injury using an NYU Impactor ModerⅢand performed intraperitoneal injection of argatroban for 3.consecutive *** results showed that argatroban effectively promoted neurological function recovery after spinal cord injury and decreased thrombin expression and activity in the local injured spinal *** sequencing transcriptomic analysis revealed that the differentially expressed genes in the argatroban-treated group were enriched in the JAK2/STAT3.pathway,which is involved in astrogliosis and glial scar *** blotting and immunofluorescence results showed that argatroban downregulated the expression of the thrombin receptor PAR1.in the injured spinal cord and the JAK2/STAT3.signal *** also inhibited the activation and proliferation of astrocytes and reduced glial scar formation in the spinal *** together,these findings suggest that argatroban may inhibit astrogliosis by inhibiting the thrombin-mediated PAR1.JAK2/STAT3.signal pathway,thereby promoting the recovery of neurological function after spinal cord injury.

关键词： argatroban astrogliosis JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury thrombin vimentin

Study on Catalytic Behavior of Iron-based Catalyst with IITP as Electron Donor in the Polymerization of Butadiene

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Polymer Science 2024年第5期42卷 612-619,I0007页

作者： Shi-Liang Xu Ying-Nan zhao {1. Yu Qi Yang Li-Hua Na Heng liu Chun-Yu Zhang {3.-Quan Zhang key {1. of Advanced Rubber Material Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China Shandong Provincial College laboratory of Rubber Material and Engineering School of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China key Lab of Rubber-Plastics Ministry of Education/Shandong Provincial Key Lab of Rubber-plasticsSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China

In this study,a novel iron-based catalyst system,Fe(acac)3.(isocyanoimino)triptenylphosphorane(IITP)/AlR3.was employed for the synthesis of syndiotactic 1.2-polybutadiene in *** catalyst system exhibits remarkably high catalytic activity,achieving a polymerization activity of 762 kgpolymer·molcatalyst^(-1.·h^(-1.at 50℃with a[BD]/[Fe]molar ratio of ***,living polymerization characteristic were observed during the investigation of the polymerization kinetics of 1.3.butadiene *** characteristics were well demonstrated by a narrow molecular weight distribution(PDI≈2.0)of the resulting polybutadiene and a linear relationship between-ln(1.c)and polymerization time as well as number average molecular weight and polymer *** resultant polymer showed a 1.2-selectivity of approximately 76%and stereoregularity ranging from 62%to 73.(rrrr).Additionally,through kinetic studies on polymerization reaction,an apparent activation energy Ea value of this catalytic system was calculated to be 84.98 kJ·mol^(-1.,which suggests that high polymerization temperature favors efficient polymerization.

关键词： Iron catalyst Syndiotactic 1.2-polybutadiene Elastomers Donor Selectivity

Expressed sequence tag analysis and cloning of trehalose-6-phosphate synthase gene from marine alga Laminaria japonica(Phaeophyta)

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2012年第6期31卷 139-148页

作者： XUAN Jinsong 1,4,FENG Yanbin 1,WENG Manli 1,zhao Ge 1,SHI Jinfeng 1,yao Jianting 2,WANG Xiuliang 2,GUO Baotai 3.QIAO Lixian 3.DUAN Delin 2,WANG Bin 1 1 The State key {3. of Plant Genomics,institute of Genetics and Developmental Biology,{3.,beijing 100101,china 2 The State key {3. of Marine Biology,institute of Oceanology,{3.,Qingdao 266071,china 3.College of Life {13.,Qingdao Agricultural University,Qingdao 266109,china 4 Department of Biological Science and Engineering,School of Chemical and Biological Engineering,University of Science and Technology beijing,beijing 100083.china 1. The State key {1. of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 4. Department of Biological Science and Engineering School of Chemical and Biological Engineering University of Science and Technology Beijing Beijing 100083 China 2. The State key {1. of Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China 3. College of Life {1. Qingdao Agricultural University Qingdao 266109 China

A high quality cDNA library was constructed from the brown alga Laminaria japonica,with the titer of 1.2×1. 5 pfu/*** average insert size of the cDNA library is about 1.6 *** the cDNA library,591.cDNA clones were randomly selected and *** a result,574 EST(expressed sequence tag) sequences were *** of the 574 ESTs were submitted to the dbEST database section of GenBank with the accession numbers from CX942625 to *** cDNA library was screened with a α-3. p labeled 453.bp T P S gene probe,which is a partial sequence yielded from Porphyra *** positive cDNA clones were screened and the sequencing data showed that these four cDNA clones covered majority of *** TPS cDNA *** PCR amplification,sequencing and assembling,the entire ORF(open reading frame) sequence of the T P S gene was obtained,which was named *** encodes a protein containing 908 amino acids with a calculated molecular mass of 1.1.674 *** LjTPS gene was successfully expressed in *** and *** LjTPS gene has potential application both in plant breeding to stress tolerance and in deciphering the T P S gene function and mechanism to stress tolerance.

关键词： cDNA library comparative study expressed sequence tag(EST) analysis Laminaria japonica trehalose-6-phosphate synthase(TPS) T P S gene

Identification and Characterization of glnA Promoter and its Corresponding Trans-regulatory Protein GlnR in the Rifamycin SV Producing Actinomycete,Amycolatopsis mediterranei U3.

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2006年第12期38卷 831-843页

作者： Hao YU~(1&) Wen-Tao PENG~1 Yang liu~1 Ting WU~2 Yu-Feng yao~1 Ming-xue CUI~1 Wei-{3. JIANG~1 Guo-Ping zhao~(1,3.4*) 1 laboratory of Molecular Microbiology,{3. of Plant Physiology and Ecology,Shanghai {3.s for Biological sciences,chinese academy of sciences,Shanghai 20003.,china 2 Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 20003.,china 3.State key laboratory of Genetic Engineering & Department of Microbiology,School of Life Science,Fudan University,Shanghai 20043.,china 4 laboratory of Disease and Health Genomics,chinese national Human Genome Center at Shanghai,Shanghai 201203.china laboratory of Molecular Microbiology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Department of Medicinal Chemistry School of Pharmacy Fudan University Shanghai 200032 China State key {1. of Genetic Engineering & Department of Microbiology School of Life Science Fudan University Shanghai 200433 China laboratory of Disease and Health Genomics Chinese National Human Genome Center at Shanghai Shanghai 201203 China

The genetic requirements for the transcription of glnA,encoding the major glutaminesynthetase in a rifamycin SV-producing Amycolatopsis mediterranei strain,U3.,were *** experiments showed that the promoter of U3. glnA （pglnA） was likely to have two transcriptioninitiation sites:P1.nd P2,located 1.7 and 45 nucleotides （nt） upstream of the translational start codon,*** mobility shift and DNase I footprinting analyses revealed a 3. bp cis-element locatedat 45 to 75 nt downstream of P1.or 3. to 68 nt upstream of *** sequence of the cis-element displayedhigh similarity to the corresponding regions of pglnA from Streptomyces coelicolor and *** as a reporter gene,the expression levels of U3. pglnA and its deletion derivatives under differentnitrogen-source conditions were analyzed by detecting the catechol dioxygenase activities in ***54,*** J508 and *** FS1. （glnR mutant）.These in vivo studies showed that theactivation of U3. pglnA in *** required GlnR,and its binding to the U3. pglnA was furtherconfirmed by the gel mobility shift *** and heterologous expression of the U3. glnR allowed usto detect the in vitro interaction between the U3. GlnR and the corresponding pglnA *** shown by in vivo glnR inactivation and complementation indicated that GlnR is essential for theactive transcription of glnA in U3..

关键词： glnA promoter cis-element glnR Amycolatopsis mediterranei

Response synchronization: New progress in brain-visual information processing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chinese Science Bulletin 1999年第16期44卷 1447-1458页

作者： zhao Songnian, XIONG Xiaoyun, {1. Guozheng and GUO Aike1. State key {3. of Atmospheric Boundary Layer Physics and Atmospheric Chemistry , institute of Atmospheric Physics , {3. , beijing 1.0029, china 2. Commission of the national Natural Science Foundation of china , beijing 1.0083. china 3. The Center of Information Science , Peking University, beijing 1.0871. china 4. Open {3. of Visual Information Processing , institute of Biophysics , {3. , beijing 1.01.1. china State key {1. of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Commission of the national Natural Science Foundation of {1. Beijing China The Center of Information Science Peking University Beijing China Open laboratory of Visual Information Processing Institute of Biophysics Chinese Academy of Sciences Beijing China

Studies on brain-vision have entered a new stage, after the stimulus-induced y synchronized oscillation of neuron group activities have been discovered in cat primary visual cortex. Naturally, how to understand the visual system became a very important methodological problem. From aspects such as information processing, nonlinear dynamics and neuronal network, some primary problems in vision studies have been deeply discussed, which are

关键词： neuron group (neural population) synchro-oscillation computational theory of vision response synchroniza-tion.

Efficient DPCA SAR imaging with fast iterative spectrum reconstruction method

在线全文

学校读者我要写书评

暂无评论

Science china(Information {1.) 2012年第8期55卷 1838-1851页

作者： FANG Jian1.ZENG JinShan1.XU ZongBen1.zhao {1.2 1. inistry of Education key Lab for Intelligent Networks and Network Security Xi'an Jiaotong University,Xi'an 71.049,{3. 2N ational key laboratory of Science and Technology on Microwave Imaging&{3. of Electronics,chinese academy of sciences,beijing 1.0049,{3. 1. Ministry of Education key Lab for Intelligent Networks and Network Security Xi’an Jiaotong University Xi’an 710049 China2. National Key Laboratory of Science and Technology on Microwave Imaging & Institute of Electronics Chinese Academy of Sciences Beijing 100049 China

The displaced phase center antenna(DPCA)technique is an effective strategy to achieve wide-swath synthetic aperture radar(SAR)imaging with high azimuth ***,traditionally,it requires strict limitation of the pulse repetition frequency(PRF)to avoid non-uniform ***,any deviation could bring serious ambiguity if the data are directly processed using a matched *** break this limitation,a recently proposed spectrum reconstruction method is capable of recovering the true spectrum from the nonuniform ***,the performance is sensitive to the selection of the *** regularization based imaging may provide a way to overcome this *** existing time-domain method,however,requires a large-scale observation matrix to be built,which brings a high computational *** this paper,we propose a frequency domain method,called the iterative spectrum reconstruction method,through integration of the sparse regularization technique with spectrum analysis of the DPCA *** approximately expressing the observation in the frequency domain,which is realized via a series of decoupled linear operations,the method performs SAR imaging which is then not directly based on the observation matrix,which reduces the computational cost from O(N2)to O(N log N)(where N is the number of range cells),and is therefore more efficient than the time domain *** sparse regularization scheme,realized via a fast thresholding iteration,has been adopted in this method,which brings the robustness of the imaging process to the PRF *** provide a series of simulations and ground based experiments to demonstrate the high efficiency and robustness of the *** simulations show that the new method is almost as fast as the traditional mono-channel algorithm,and works well almost independently of the PRF ***,the suggested method can be accepted as a practical and efficient wide-swath SAR imaging technique.

关键词： displaced phase center antenna sparse regularization iterative thresholding spectrum reconstruction

The pathogenic mechanism of syndactyly type V identified in aHoxd1.0}50R knock-in mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2024年第2期12卷 349-360页

作者： Han Wang Xiumin Chen Xiaolu Meng Yixuan Cao Shirui Han Keqiang liu Ximeng {1. Xiuli {1. {3. Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD1.0}in a large {1. family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd1.0}50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1.AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1.and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE1..5 to E1..5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E1..5, revealing 3. genes that exhibitednotable disparities in mRNA level between the Hoxd1.0}50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD1.0}50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

RST transforms resistant image watermarking based on centroid and sector-shaped partition

在线全文

学校读者我要写书评

暂无评论

Science china(Information {1.) 2012年第3期55卷 650-662页

作者： zhao {1.1.2*, NI RongRong1.2* & ZHU ZhenFeng1.2* 1.2} of Information Science, {3. Jiaotong University, {3. 1.0044, china 2{3. key laboratory of Advanced Information Science and Network Technology, {3. 1.0044, china 1. institute of Information Science Beijing Jiaotong University Beijing 100044 China2. Beijing Key Laboratory of Advanced Information Science and Network Technology Beijing 100044 China

A novel digital watermarking scheme featuring centroid-based sectoring is proposed in this paper. To get higher robustness against geometric attacks, such as rotation, scaling, and translation (RST), a delicate synchronization mechanism was developed and incorporated into the proposed approach. During the process of watermark embedding, the original image was partitioned into sectors based on the image centroid. Synchronization information as well as the message bits is then embedded into these sectors. With the help of the centroid-based sectoring and synchronization information, the proposed approach is capable of restoring the correct sectoring even if it has experienced severe geometric distortion. This attribute ensures the correct recovery of embedded watermarks and contributes to the robustness of the proposed scheme. A series of experiments have been conducted to verify the feasibility and effectiveness of the proposed approach. Experimental results show that the proposed scheme possesses good robustness against RST attacks and considerable robustness against other common image processing attacks.

关键词： digital watermarking geometrical transform attacks RST transforms

"Win-Win"Scenario of High Energy Density and Long Cycling Life in a Novel Na_(3.9)MnCr_(0.9)Zr_(0.1.(PO_(4))_(3.Cathode

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第1期7卷 83-90页

作者： yao Wang Yukun {1. Pingge He Junteng Jin Xudong zhao Qiuyu Shen Jie Li Xuanhui Qu Yongchang {1. Lifang Jiao beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 10083China Department of Chemistry and Biochemistry University of California1156 High StreetSanta CruzCA 95064USA Tianjin key {1. for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China key {1. of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

The development of high-energy and long-lifespan NASICON-type cathode materials for sodium-ion batteries has always been a research hotspot but a daunting *** Na_(4)MnCr(PO_(4))_(3.has emerged as one of the most promising high-energy-density cathode materials owing to its three-electron reactions,it still suffers from serious structural distortion upon repetitive charge/discharge processes caused by the Jahn-Teller active Mn^(3.).Herein,the selective substitution of Cr by Zr in Na_(4)MnCr(PO_(4))_(3.was explored to enhance the structural stability,due to the pinning effect of Zr ions and the≈2.9-electron reactions,as-prepared Na_(3.9)MnCr_(0.9)Zr_(0.1.(PO_(4))_(3./C delivers a high capacity retention of 85.94%over 500 cycles at 5 C and an ultrahigh capacity of 1.6.4 mAh g^(-1.at 0.1.C,enabling the stable energy output as high as 555.2 Wh kg^(-1..Moreover,during the whole charge/discharge process,a small volume change of only 6.7%was verified by in situ X-ray diffraction,and the reversible reactions of Cr^(3.)/Cr^(4+),Mn^(3.)/Mn^(4+),and Mn^(2+)/Mn^(3.)redox couples were identified via ex situ X-ray photoelectron spectroscopy *** intermittent titration technique tests and density functional theory calculations further demonstrated the fast reaction kinetics of the Na_(3.9)MnCr_(0.9)Zr_(0.1.(PO_(4))_(3./C *** work offers new opportunities for designing high-energy and high-stability NASICON cathodes by ion doping.

关键词： high energy density mechanism investigation NASICON-type cathodes sodium-ion batteries structure modification