检索结果-南通市图书馆

A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第9期14卷 1315-1320页

作者： xin-Shu liu Zi-yan Wu Si Chen Chan Zhao Fei Gao Ming-Hang Pei Shan-Shan Jia yong-Zhe Li Pei-zeng yang Mei-Fen zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Clinical Laboratory Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Clinical Laboratory Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing 400016China

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han ***:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX ***:A statistically significant association was observed between IL1RL1 rs12712142 and BD *** frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD ***:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

关键词： Behcet’s disease single nucleotide polymorphism Chinese Han population IL33 IL1RL1

近Bohr速度129Xeq+离子入射Ta靶发射近红外光谱线

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子与分子物理学报 2024年第6期41卷 84-91页

作者：王益军张颖张小安周贤明梅策香梁昌慧曾利霞李耀宗柳钰向前兰孟惠张艳宁咸阳师范学院离子束与光物理实验室咸阳712000 中国科学院近代物理研究所兰州730000

用动能一定的高电荷态^(129)Xe^(q+)(17≤q≤27)离子,分别入射洁净的Ta靶表面,测量中性化的激发态Xe原子从组态5p^(5)(^(2)P°_(3/2))nl退激到组态5p^(5)(^(2)P°_(3/2))ml’过程中辐射的近红外光谱线.实验结果表明:多激发态的空心原子... 详细信息

用动能一定的高电荷态^(129)Xe^(q+)(17≤q≤27)离子,分别入射洁净的Ta靶表面,测量中性化的激发态Xe原子从组态5p^(5)(^(2)P°_(3/2))nl退激到组态5p^(5)(^(2)P°_(3/2))ml’过程中辐射的近红外光谱线.实验结果表明:多激发态的空心原子退激发射其特征光谱线,部分典型的跃迁按照阶梯方式退激.Xe原子发射的谱线的单粒子荧光产额和激发的Ta原子发射谱线的单粒子荧光产额随入射离子电荷态的增加而增加,其增加的趋势与入射离子携带的势能随电荷态增加的趋势一致.证明在近Bohr速度的能区,经典过垒模型是成立的.

关键词：玻尔速度高电荷态离子经典过垒模型近红外光谱线空心原子

维普期刊数据库博看期刊

Phenological Complementarity Does not Enhance Ecosystem Production in Undisturbed Steppe Community

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2007年第5期49卷 582-587页

作者： Liang Zhao Gui-xia yang Zhong-Ling liu xiao-Ping xin yan-Jiang LUO Gang Wang Key Laboratory of Arid and Grassland Ecology at Lanzhou University Ministry of Education Lanzhou 730000 China Key Laboratory of Resources Remote Sensing and Digital Agriculture Ministry of Agriculture Beijing 100083 China Inner Mongolia University Huhhot 010021 China

Communities with more species could have a greater variety of species＇ characteristics, leading to more effective use of limiting resources through niche partitioning （complementarity） and therefore greater production. The effect of phenologlcal complementarity （PC） on ecosystem production has not been fully Investigated. The seasonal responses of all vascular plant species were tracked to test the effect of phenologlcal complementarity on ecosystem production within a natural stable steppe community. Although a significant phenologlcal pattern was observed, PC had no significant correlation with community production. The value of PC varied with years, but was observed only In a relatively narrow range during the experimental period. Species diversity （richness and evenness） had no correlation with the ecosystem production. The results suggest that the effect of PC may be saturated and has no contribution to the improvement of ecosystem production In a stable natural grassland community with abundant species.

关键词： ecosystem function phenological complementarity steppe community temporal variation total annual net primary productivity.

高效液相色谱-串联质谱法测定电子烟油中的替来他明和依托咪酯

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国司法鉴定 2024年第3期 55-59页

作者：马俊闫昕张腾雷佳眉李楠崔哲刘兴亮赵霞国家毒品实验室北京分中心北京100164

目的建立一种快速测定电子烟油中替来他明和依托咪酯的高效液相色谱-串联质谱方法。方法样品经甲醇稀释,经过滤膜过滤后测定。以C18色谱柱(2.1 mm×100 mm,2μm)为分离柱,以乙腈-0.1%(体积分数)甲酸水溶液为流动相进行梯度洗脱,采用多... 详细信息

目的建立一种快速测定电子烟油中替来他明和依托咪酯的高效液相色谱-串联质谱方法。方法样品经甲醇稀释,经过滤膜过滤后测定。以C18色谱柱(2.1 mm×100 mm,2μm)为分离柱,以乙腈-0.1%(体积分数)甲酸水溶液为流动相进行梯度洗脱,采用多反应监测正离子模式同时对替来他明和依托咪酯进行定性、定量分析。结果替来他明和依托咪酯分别在0.02~10.00 ng/mL、0.05~10.00 ng/mL范围内线性关系良好,相关系数均大于0.99。替来他明和依托咪酯的检出限分别为0.01、0.02 ng/mL,定量限分别为0.02、0.05 ng/mL,基质加标回收率为95.81%~102.05%。结论该方法操作简便、方法重现性好,可应用于电子烟油中痕量替来他明和依托咪酯的定性、定量检测。

关键词：高效液相色谱-串联质谱法替来他明依托咪酯电子烟油

基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

维普期刊数据库博看期刊

Moderate quantity of lard mixed with sunflower oil attenuate lipid accumulation in mice

在线全文

学校读者我要写书评

暂无评论

Oil Crop Science 2020年第4期5卷 205-212页

作者： Sisi yan xin Li Linyu zhang Yu zeng Shuiping liu xiangyan liu Huijuan Zhou Lixin Wen Ji Wang Laboratory of Animal Clinical Toxicology Department of Clinical Veterinary MedicineCollege of Veterinary MedicineHunan Agricultural UniversityChangshaChina Hunan Collaborative Innovation Center of Animal Production Safety ChangshaChina

Lard,a fat rich in saturated fatty acids(SFAs),is regarded as a risk factor for metabolic *** the present study,effect of different lard blended with sunflower oil diets on lipid accumulation in adipose tissue,liver,and serum by mouse model was *** weight,body fat percentage,cross-sectional area of adipocytes,liver triglycerides(TGs),and oil red stained area in mice liver of lard blend sunflower oil(L-SFO)group were significantly lower than those of sunflower oil(SFO)group,whereas no significant differences were observed between mice of lard and L-SFO *** TG and free fatty acid levels were significantly lower in L-SFO group than in other two ***,data showed that sunflower oil decreased contents of hormonesensitive lipase and carnitine palmitoyl transferase 1(CPT-1)and increased fatty acid synthase activity in liver tissue.A mixture of lard and sunflower oil rather than only sunflower oil or lard might promote body fat loss and reduce lipid accumulation in adipose tissue,serum,and liver by promoting hydrolysis of TG,increasingβ-oxidation of fatty *** data suggested that mixing lard and vegetable oil(*** oil)for cooking,or alternate using lard and vegetable oil could be beneficial for reducing body fat.

关键词： Lard Sunflower oil Obesity Lipid accumulation Dietary fat

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-xin Hao Lu Feng Hugh RAJones Jian Li Jing Xu Li-yong liu Teng-Fei Song Jian-Feng Wang Hua-Lin Chen yan-Jie Xue Huang Shen yong-Heng Zhao Zhao-xiang Qi Jian-Rong Shi Yuan Tian Zheng Wang xia Wang Jin-Liang Hou Jin-Ming Bai Ji yang Xu Zhou yong-Qiang Yao Jia Yin Ali Esamdin Guang-xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma Xuan zhang Yu liu Chong Pei zhi-xia Shen Yun-Ying Jiang Jian-Feng Tian xian-Qun zeng zhi-Gang Hou Xu yang Jun-Bo zhang Shi-Long Liao Dong-Wei Fan Yun-Fei Xu Jian-Ping Xiong Tai-Sheng yan Xi zhang Chang-Hua Li Yi-Han Tao Si-Cheng Yu zhi-Song Cao hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

Oxygen-vacancy-related dielectric relaxation behaviours and impedance spectroscopy of Bi(Mg_(1/2)Ti_(1/2))O_(3) modified BaTiO_(3) ferroelectric ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2018年第3期4卷 194-201页

作者： Ming-Ding Li xin-Gui Tang Si-Ming zeng yan-Ping Jiang Qiu-xiang liu Tian-Fu zhang Wen-Hua Li School of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006People's Republic of China Laboratory Teaching Centre Guangdong University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006People's Republic of China

Lead-free ferroelectric ceramics(1-x)BaTiO_(3-x)Bi(Mg_(1/2)Ti_(1/2))O_(3)(x=0.0-0.07)were synthesized by conventional solid state reaction method and the correlation of structure,dielectric,ferroelectric and impedance properties were *** was found that T_(m) andε_(m) showed decreasing trend with the increase of BMT *** high-temperature dielectric relaxation behaviour was observed in all the *** activation energy calculated from impedance(E_(a))and conductivity(E_(cond)),which revealed that the relaxation behaviours were linked with the migration of *** values of E_(a)were almost equivalent to *** was concluded that the short-range hopping of oxygen vacancy contributed to the dielectric relaxation and long-distance movement of doubly ionized oxygen vacancies contributed to the *** the other hand,with increasing BMT contents,it was found that P-E loops became slimmer and slimmer,which indicated the increase of relaxor *** temperature dependence of P-E loops for 0.98BT-0.02BMT ceramic clearly showed the transition process from ferroelectric to relaxed ferroelectrics.

关键词： BTeBMT ceramic Dielectric Ferroelectric Impedance Oxygen vacancies

Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第29期24卷 3260-3272页

作者： Rui-Zhong zhang xin-Hao zeng Ze-Feng Lin Ming-Fu yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min xia yan Chen Department of Pediatric Surgery Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Department of Surgery and Pathology University of Hong KongHong KongChina Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondon SW7 2AZUnited Kingdom

AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture *** Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was *** Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.

关键词： Biliary atresia Rhesus rotavirus Hes1 EpCAM Epithelial cells 3D culture