检索结果-南通市图书馆

CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第10期8卷 5010-5022页

作者： Tao Fan Chu Xiao hengchang liu Yu liu Liyu Wang He Tian Chunxiang Li Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 10o021China Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejingChina Department of Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Histone H3 lysine 4 trimethylation(H3K4me3)is a canonical chromatin modification associated with active gene transcription,playing a pivotal role in regulating various cellular *** of the H3K4me3 methyltransferase complex,known as the proteins associated with SET1(COMPASS),have been implicated in exerting cancer-protective or cancer-inhibitory effects through inducive H3K4me3 ***,the role of the indispensable non-catalytic component of COMPASS CXXC-type zinc finger protein 1(CFP1)in malignant progression remains unclear.

关键词： protective H3K4me3 bridges

达芬奇机器人辅助直肠及乙状结肠癌根治术的学习曲线分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华结直肠疾病电子杂志 2024年第3期13卷 205-208页

作者：陈海鹏张金珠关旭赵志勋刘恒昌姜争刘正王锡山国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科北京100021

目的分析达芬奇机器人辅助直肠及乙状结肠癌根治术的学习曲线,探索最佳的学习例数.方法回顾性分析2021年7月至2022年12月于中国医学科学院肿瘤医院由同一术者完成的93例达芬奇机器人辅助直肠及乙状结肠癌根治术的临床资料.根据手术时间... 详细信息

目的分析达芬奇机器人辅助直肠及乙状结肠癌根治术的学习曲线,探索最佳的学习例数.方法回顾性分析2021年7月至2022年12月于中国医学科学院肿瘤医院由同一术者完成的93例达芬奇机器人辅助直肠及乙状结肠癌根治术的临床资料.根据手术时间构建达芬奇机器人辅助直肠及乙状结肠癌根治术的学习曲线,根据曲线峰值确定最佳学习例数,并按照学习曲线将患者分为手术提高组(A组)及手术熟练组(B组),对比两组临床指标.结果93例患者顺利实施达芬奇机器人辅助乙状结肠或直肠癌根治术,最佳拟合曲线方程为:根据CUSUM值进行曲线拟合,曲线方程为y=0.006x3-1.183x2+58.840x-219.293,R2=0.857,P<0.01.达到学习曲线最佳手术例数为33例.将前33例患者列为A组,将之后的60例患者列为B组.与A组相比,B组的手术所需时间更短(144.3 min vs.179.1 min,P=0.008),失血量更少(21.7 mL vs.29.4 mL,P=0.010),术后住院时间更短(7.1 d vs.8.8 d,P=0.026)o结论达芬奇机器人手术需要一定的学习例数.本研究表明33例为最佳学习例数.完成33例达芬奇机器人手术学习后,患者手术时间更短,失血量更少,术后住院时间更短.

关键词：结直肠肿瘤达芬奇机器人辅助手术学习曲线

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

两面神胶束的构筑及应用

材料导报 2023年第10期37卷 211-218页

作者：刘恒昌陈凯南昌师范学院化学与食品科学学院南昌330032

近几年,具有不对称结构(即各向异性)的胶体颗粒的构筑及自组装行为越来越引起人们的研究兴趣。两面神颗粒(Janus particles,JPs)是指两侧具有不同物理或化学等性质的颗粒,故它是一种典型的各向异性的胶体粒子。JPs在物理、化学和生物科... 详细信息

近几年,具有不对称结构(即各向异性)的胶体颗粒的构筑及自组装行为越来越引起人们的研究兴趣。两面神颗粒(Janus particles,JPs)是指两侧具有不同物理或化学等性质的颗粒,故它是一种典型的各向异性的胶体粒子。JPs在物理、化学和生物科学等诸多领域表现出巨大的应用潜力,其相关研究受到人们广泛的关注。两面神胶束(Janus micelles,JMs)是一种通过嵌段共聚物自组装所构筑的“软的”JPs,其冠的两个半球分别由两种组分形成。目前,研究人员已经分别通过嵌段共聚物的本体和溶液自组装构筑了JMs。由于本体自组装构筑JMs所能用的嵌段共聚物种类非常有限,同时构筑过程繁琐且耗时,无法大规模应用,故嵌段共聚物溶液自组装是构筑JMs最主要的方式。但是,共聚物在溶液中自组装形成JMs绝非易事,因此目前构筑JMs依旧面临一定困难。本文综述了JMs领域近10多年的研究进展,重点归纳和总结了基于三嵌段、二嵌段、星型嵌段共聚物自组装构筑JMs的方法与形成机理,介绍了JMs的应用现状及构筑JMs的最新手段和方法,最后探讨了JMs领域存在的问题和挑战,并对JMs未来的发展趋势进行了展望。

关键词：两面神胶束两面神颗粒自组装嵌段共聚物软物质

Tailoring thermal conductivity of bulk graphene oxide by tuning the oxidation degree

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第5期29卷 711-715页

作者： Qing-Long Meng hengchang liu Zhiwei Huang Shuang Kong Peng Jiang Xinhe Bao State Key Laboratory of Catalysis CAS Center for Excellence in Nanoscience Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China School of Physical Science and Technology Shanghai Tech University Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100039 China

Bulk graphene oxide （GO） shows great potential in a variety of applications, such as sensors,photodetectors, supercapacitors, lithium ion batteries and catalysts. However, its thermal conductivity,one of the most important and fundamental physical properties, is still less known. Herein, we havesystematically investigated the thermal conductivity of bulk GOs and find that it can be tailored by tuningtheir oxidation degree during preparation process. Notably, the cross-plane thermal conductivity of bulkGO, in comparison with its precursor graphite, exhibits more than 100 times decrease at roomtemperature. The dependence of thermal conductivity of GO on oxidation degree is attributed to thechemical and structural changes by introducing oxygen atoms and oxygen-containing functional groups,which can lead to a significant enhancement in atomic- and nano-scale phonon scattering. Furthermore,we reveal that the thermal conductivity of bulk GOs exhibits evident anisotropic behavior. These resultsprovide fundamental understanding and valuable information on thermal transport properties of bulkGOs for various practical applications.

关键词： Graphene oxide Thermal conductivity Scattering center Anisotropy Oxidation degree

Role of the carrier gas flow rate in monolayer MoS2 growth by modified chemical vapor deposition

在线全文

学校读者我要写书评

暂无评论

Nano Research 2017年第2期10卷 643-651页

作者： hengchang liu Yuanhu Zhu Qinglong Meng Xiaowei Lu Shuang Kong Zhiwei Huang Peng Jiang Xinhe Bao Shanghai Advanced Research Institute Chinese Academy of Sciences 99 Hi-Tech Park Pudong Shanghai 200120 China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China University of Chinese Academy of Sciences Beijing 100039 China ShanghaiTech University 100 Haike Road Pudong Shanghai 201210 China

Monolayer molybdenum disulfide （MoS2） has attracted much attention because of the variety of potential applications. However, its controlled growth is still a great challenge. Here, we report a modified chemical vapor deposition method to grow monolayer MoS2. We observed that the quality of the MoS2 crystals could be greatly improved by tuning the carrier gas flow rate during the heating stage. This subtle modification prevents the uncontrollable reaction between the precursors, a critical factor for the growth of high-quality monolayer MoS2. Based on an optimized gas flow rate, the MoS2 coverage and flake size can be controlled by adjusting the growth time.

关键词： MoS2 monolayer carrier gas flow rate modified CVD

CO_2诱导的五嵌段非离子共聚物与阴离子氟碳表面活性剂的相互作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理化学学报 2019年第4期35卷 408-414页

作者：刘恒昌冯玉军中国科学院成都有机化学研究所成都610041 中国科学院大学北京100049 四川大学高分子研究所高分子材料工程国家重点实验室成都610065

聚合物-表面活性剂复合物在诸多工业领域都具有重要的应用潜力,但利用CO_2气体调节复合物的相互作用及微观聚集体形貌鲜见报道。本文基于三嵌段共聚物普兰尼克F127制备了五嵌段共聚物聚甲基丙烯酸二乙氨基乙酯-block-聚氧化乙烯-block-... 详细信息

聚合物-表面活性剂复合物在诸多工业领域都具有重要的应用潜力,但利用CO_2气体调节复合物的相互作用及微观聚集体形貌鲜见报道。本文基于三嵌段共聚物普兰尼克F127制备了五嵌段共聚物聚甲基丙烯酸二乙氨基乙酯-block-聚氧化乙烯-block-聚氧化丙烯-block-聚氧化乙烯-block-聚甲基丙烯酸二乙氨基乙酯(PDEAEAM-b-F127-b-PDEAEMA)。通过聚合物溶液pH和电导率的变化研究了PDEAEAM-b-F127-b-PDEAEMA的CO_2刺激响应性,应用动态光散射和透射电子显微镜考察了PDEAEAM-b-F127-b-PDEAEMA与阴离子氟碳表面活性剂在CO_2刺激作用下的相互作用。结果表明,CO_2/N_2的交替通入可以使PDEAEAM-b-F127-b-PDEAEMA产生相应的质子化/去质子化过程,从而可逆地改变PDEAEAM-b-F127-b-PDEAEMA溶液的pH值和电导率;质子化/去质子化过程可以"开关"共聚物与阴离子氟碳表面活性剂之间的静电吸引作用,使体系中的聚集体在球形胶束与蠕虫状胶束之间发生可逆转变。CO_2可控的聚合物-表面活性剂复合物的形貌转变为构建气体响应的软材料提供了一种新的思路。

关键词： CO2诱导聚合物-表面活性剂复合物自组装蠕虫状胶束普兰尼克

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

基于多惩罚因子优化VMD的滚动轴承故障特征提取方法

在线全文

学校读者我要写书评

暂无评论

系统工程与电子技术 2023年第11期45卷 3690-3698页

作者：李波胡哿郗石剑钧刘恒畅洪涛电子科技大学航空航天学院四川成都611731 飞行器集群智能感知与协同控制四川省重点实验室四川成都611731

针对变分模态分解(variational mode decomposition,VMD)在提取滚动轴承故障特征时预先设置多惩罚因子具有不确定性的问题,结合灰狼优化(grey wolf optimization,GWO)算法提出一种基于多惩罚因子优化VMD的滚动轴承故障特征提取方法。首... 详细信息

针对变分模态分解(variational mode decomposition,VMD)在提取滚动轴承故障特征时预先设置多惩罚因子具有不确定性的问题,结合灰狼优化(grey wolf optimization,GWO)算法提出一种基于多惩罚因子优化VMD的滚动轴承故障特征提取方法。首先利用GWO算法实现VMD的多惩罚因子自适应优化,再利用优化得到的参数将滚动轴承的振动信号分解为多个本征模态函数(intrinsic mode function,IMF),最后对各个IMF分量作包络解调提取滚动轴承的故障频率特征。研究结果表明,在优化VMD参数时,该方法相对其他方法优化效率有了明显提高,并且提取滚动轴承故障特征效果显著,得到特征频率幅值为其他方法的2~4倍,证明了该方法的有效性和优越性。

关键词：特征提取变分模态分解本征模态函数滚动轴承

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location