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RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2

Science China(Life Sciences) 2024年第10期67卷 2186-2197页

作者： Lili Zhi Chaoqun Chen Ge zhang Tian Huang wenxia He Jinrui zhang Dan Chen Jiayi liu Jinyao Zhao Yangfan Qi Guiying Wang Wenjing zhang Yang Wang Sino-US Research Center for Cancer Translational Medicine of the Second Affiliated Hospital of Dalian Medical University&Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116023China Department of Immunology College of Basic Medical SciencesDalian Medical UniversityDalian 116044China Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian Medical UniversityDalian 116011China Department of General Surgery the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China The Second Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma Shijiazhuang 050001China

Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis;however,their specific involvement in colon cancer remains largely *** we report that the splicing factor RBM25 is overexpressed in colon cancer,and this increased expression correlates with a poor prognosis of patients with colon ***,RBM25 ablation suppresses the growth of colon cancer cells both in vitro and in ***,our transcriptome-wide analysis of splicing events revealed that RBM25 regulates a large number of cancer-related alternative splicing events across the human genome in colon ***,RBM25 regulates the splicing of MNK2 by interacting with the poly G rich region in exon 14a,thereby inhibiting the selection of the proximal 3'splice site(ss),resulting in the production of the oncogenic short isoform,*** of RBM25 leads to an increase in the MNK2a isoform and a decrease in the MNK2b ***,re-expression of MNK2b or blocking the 3′ss of the alternative exon 14a with ASO partially reverses the RBM25 knockdown mediated tumor ***,MNK2b levels were significantly increased in colon cancer tissues,which is positively correlated with the expression level of ***,our findings uncover the critical role of RBM25 as a key splicing factor in colon cancer,suggesting its potential as a prognostic marker and therapeutic target.

关键词： RBM25 colon cancer alternative splicing MNK2

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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing liu Yue Sui Cailu Song Jinhui zhang hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

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Targeting NRP1 axis as a strategy for treating energy metabolism impairment induced by SARS-CoV-2 spike

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Science China(Life Sciences) 2024年第10期67卷 2277-2279页

作者： Lihui zhang Wanting Hu Jingxuan Li Yuehan Li Feng liu Wenyi Xiao Ning Jiang Zhiyong Xiao Lu Han wenxia Zhou Beijing Institute of Pharmacology&Toxicology Beijing 100850China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China

Dear Editor,Free spike protein of SARS-CoV-2 alone can cause abnormal energy metabolism(Table S1 in Supporting Information),and limited research suggested a potential correlation between spike-induced mitochondrial da... 详细信息

关键词： metabolism ACE2

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Effects of Alexithymia to Stigma of Patients with Lymphedema

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Journal of Cancer Therapy 2024年第4期15卷 201-211页

作者： Qiaoling Zhong Huizhen zhang Liping zhang Qinghua Luo Huiting zhang Feng liu hailin Tang Na Li Lijuan zhang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou China

BACKGROUND: Secondary lymphedema is one of the common complications after malignant tumor surgery. It is a chronic and complex disease. Once lymphedema occurs, there will be discomfort such as limb swelling, pain, numbness and tension, which will eventually lead to changes in the appearance of the affected limb and will seriously affect the quality of life and require lifelong treatment and psychosocial support. This study investigated the current situation of stigma and alexithymia in patients with lymphedema, and discussed the impact of alexithymia on stigma in patients with lymphedema. AIMS: To understand the current situation of stigma and alexithymia in patients with lymphedema, and to analyze the influence of alexithymia on stigma. METHODS: 195 patients with lymphedema in a hospital were selected by convenient sampling. General information questionnaire, Toronto Alexithymia Scale and social impact scale were used to investigate respectively, to study the general situation, stigma and alexithymia of the respondents. RESULTS: The results showed that the total score of stigma in 195 patients with lymphedema was (60.36 ± 11.08), and the total score of alexithymia was (56.53 ± 8.43). Multiple linear regression analysis showed that alexithymia and family relationship were the influencing factors of stigma in patients with lymphedema. CONCLUSIONS: The patients with lymphedema have obvious stigma, and alexithymia and family relationship are the influencing factors.

关键词： Alexithymia Lymphedema Stigma Influence Factor

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考虑调控和交易模式影响的中低压分布式光伏协调配置方法

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电网技术 2024年第2期48卷 577-586页

作者：刘文霞白亚玲吕笑影张帅王卓容张博鲁宇新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206 国网吉林省电力有限公司经济技术研究院吉林省长春市130022

为安全、经济、公平的消纳分布式光伏,以整县光伏为研究场景,提出了一种考虑调控和交易模式影响的中低压分布式光伏协调配置方法。首先,分析了多电压等级协调和交易模式对分布式光伏接纳能力的影响。其次,以两个电压等级光伏并网容量为... 详细信息

为安全、经济、公平的消纳分布式光伏,以整县光伏为研究场景,提出了一种考虑调控和交易模式影响的中低压分布式光伏协调配置方法。首先,分析了多电压等级协调和交易模式对分布式光伏接纳能力的影响。其次,以两个电压等级光伏并网容量为控制变量,建立联合考虑经济效益和调控能力多目标优化模型,目标一是多主体经济性最优,建立3种交易模式下各主体效益模型,并采用凸化和卡罗需-库恩-塔克条件转化为单层求解;目标二是计及电压调控能力的多电压等级消纳量最大,采用关联决策变量方法与目标一统一求解。最后通过中低压配网算例仿真,验证了所提模型的有效性和优越性,可为市场环境下分布式光伏多电压等级协调配置提供决策参考。

关键词：分布式光伏调控交易模式多电压等级协调协调配置

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Waypoints Trajectory Tracking Control for Nonholonomic Unmanned Surface Vehicle under Environment Disturbance

Waypoints Trajectory Tracking Control for Nonholonomic Unman...

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第32届中国控制与决策会议

作者： Yuan Jian liu hailin.zhang wenxia Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences) National Engineering and Technological Research Center of Marine Monitoring Equipment Shandong Provincial Key Laboratory of Ocean Environment Monitoring Technology Department of Mechanical and Electrical Engineering Qindao College

ISBN: (数字)9781728158556

ISBN: (纸本)9781728158563

The waypoints trajectory-tracking problem for Unmanned Surface Vehicle with environment disturbance is *** upper-triangle and diagonal matrix decomposition method of Unscented Kalman Filter（UD-UKF） for the environment noise is proposed.A nonlinear error system is derived based on the nonholonomic constraints equations and UD-UKF based finite-time tracking control algorithm for the nonlinear error system is *** we design a finite-time tracking control law to make the initial angle error states of the error system to drive towards a known sliding boundary layer in *** the estimated states using UD-UKF are used to construct a feedback control law in order to achieve finite-time stabilization for heading angle error states;meanwhile the estimated states of the position error for the reduced-order system are adopted to design a state feedback control law in order to achieve the finite time stabilization for position error ***,the effectiveness of control strategies is verified by numerical simulations and comparison results.

关键词： Nonholonomic Unmanned Surface vehicle Waypoints Trajectory-tracking Upper Triangular and Diagonal Matrix Decomposition Unscented Kalman Filter

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基于改进条件生成对抗网络的可控场景生成方法

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电力自动化设备 2024年第6期44卷 9-17页

作者：张帅刘文霞万海洋吕笑影 Nawaraj Kumar Mahato 鲁宇华北电力大学新能源电力系统国家重点实验室北京102206 国网吉林省电力有限公司经济技术研究院吉林长春130022

可再生能源发电具有较强的随机性和波动性,为实现高效可靠的场景建模,提出一种基于改进条件生成对抗网络的可控场景生成方法。提出基于条件生成对抗网络的场景生成框架,结合Transformer的全局注意力机制以及常规卷积和深度可分离卷积的... 详细信息

可再生能源发电具有较强的随机性和波动性,为实现高效可靠的场景建模,提出一种基于改进条件生成对抗网络的可控场景生成方法。提出基于条件生成对抗网络的场景生成框架,结合Transformer的全局注意力机制以及常规卷积和深度可分离卷积的局部泛化机制,设计适用于提取可再生能源发电不同维度特征的网络结构;利用条件生成对抗网络模型建立低维气象特征隐空间和高维可再生能源发电数据之间的映射关系,提出一种可控场景生成方法,并建立随机场景生成、场景约减、极端场景生成和连续日场景生成4种生成策略。基于实际光伏、风电数据和气象数据的仿真结果表明,所提模型与方法能够有效学习可再生能源发电的随机性、时序性、波动性及空间相关性,实现对不同策略下场景的可控生成。

关键词：场景生成条件生成对抗网络特征提取配电网可控生成

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PVP对有机无机复合绝缘FeSi粉芯力学性能与磁性能的影响

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功能材料 2024年第6期55卷 6019-6025页

作者：李晶晶张学斌刘伟张华张博玮邹中秋苏海林合肥工业大学材料科学与工程学院安徽省先进功能材料与器件重点实验室合肥230009 合肥工业大学教育部铜合金及成形加工工程研究中心合肥230009 江苏瑞德磁性材料股份有限公司淮安市软磁粉芯与器件工程技术研究中心淮安211700 淮北瑞德磁电科技有限公司淮北235000

在FeSi粉芯的环氧树脂/SiO_(2)绝缘工艺流程中添加PVP作为增强剂,系统研究了PVP添加量对粉芯生坯强度、成品强度以及磁性能的影响规律。研究发现,PVP的引入可增加绝缘层各组分之间以及绝缘层和磁粉之间的粘结力,进而有利于生坯强度的提... 详细信息

在FeSi粉芯的环氧树脂/SiO_(2)绝缘工艺流程中添加PVP作为增强剂,系统研究了PVP添加量对粉芯生坯强度、成品强度以及磁性能的影响规律。研究发现,PVP的引入可增加绝缘层各组分之间以及绝缘层和磁粉之间的粘结力,进而有利于生坯强度的提高。在退火过程中,适量PVP的熔化还有助于SiO_(2)纳米粒子的均匀重排,从而增强成品强度。同时,适量PVP可促进稳定、均匀SiO_(2)绝缘层的形成,进而实现直流偏置性能的优化以及维持良好的磁导率频率稳定性和较低的磁芯损耗。PVP最佳添加量为0.3%(质量分数),相应的FeSi粉芯生坯强度为22 N,成品强度为305.76 N,有效磁导率在20~2000 kHz具有良好的频率稳定性,8000 A/m直流偏置场下的有效磁导率百分比高达86.5%,50 kHz/100 mT的损耗仅为522.7 kW/m^(3)。

关键词： FeSi PVP 软磁粉芯拉断强度磁性能

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文化认同:铸牢中华民族共同体意识的内生动力

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德州学院学报 2024年第3期40卷 36-41页

作者：刘文霞张东悦德州学院马克思主义学院山东德州253032 江南大学马克思主义学院江苏无锡214122

铸牢中华民族共同体意识是新时代民族工作的主线,是中华民族现代文明发展的必然要求。增进文化认同是铸牢中华民族共同体意识的先决条件和重要基石,对铸牢中华民族共同体意识具有增量赋能作用。形塑中国人民特有的文化认同与文化主体性... 详细信息

铸牢中华民族共同体意识是新时代民族工作的主线,是中华民族现代文明发展的必然要求。增进文化认同是铸牢中华民族共同体意识的先决条件和重要基石,对铸牢中华民族共同体意识具有增量赋能作用。形塑中国人民特有的文化认同与文化主体性是文化建设的现实诉求,是赓续中华优秀传统文化的重要实现方式。

关键词：文化认同铸牢中华民族共同体意识共同体建设

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考虑结构和功能耦合特征的电力信息物理系统随机加固规划

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华北电力大学学报（自然科学版） 2024年第1期51卷 20-29,I0003页

作者：张艺伟刘文霞黄少锋马伸铜新能源电力系统国家重点实验室(华北电力大学) 北京102206 国网徐州供电公司江苏徐州221005

为提升电力信息物理系统(electric cyber-physical system, ECPS)面对台风等极端灾害的抵抗力,基于两阶段随机优化方法,提出一种考虑双网结构和功能耦合特征的电力/通信网架随机加固规划模型。模型第一阶段计及电力/通信线路的结构耦合... 详细信息

为提升电力信息物理系统(electric cyber-physical system, ECPS)面对台风等极端灾害的抵抗力,基于两阶段随机优化方法,提出一种考虑双网结构和功能耦合特征的电力/通信网架随机加固规划模型。模型第一阶段计及电力/通信线路的结构耦合特征,以总加固投资和台风灾害损失期望最小为目标,确定加固的电力/通信线路,其中,台风灾害的损失期望由第二阶段计算;第二阶段考虑通信网络故障对电力系统应急调度的级联影响,最小化随机台风场景下ECPS的故障损失期望。为生成具有代表性的台风场景集,确保随机加固方案的适应性,根据台风场景毁伤特征与ECPS故障损失的映射关系,提出一种基于高斯混合模型(Gaussian mixture model, GMM)聚类的约简场景集生成方法。最后,基于逐步对冲算法求解随机加固模型,通过对IEEE RTS 79节点信息物理系统的仿真分析,证明了文章提出的电力/通信网架随机加固规划方法对ECPS具有较好的韧性提升效果。

关键词：电力信息物理系统韧性网架加固两阶段随机优化结构和功能耦合

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