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Threshold-Based Sof.ware-Def.ned Networking(SDN)Solution f.r Healthcare System. against Intrusion Attacks

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Com.uter m.deling in Engineering & Sciences 2024年第2期138卷 1469-1483页

作者： Laila m.Halm.n m.ham.ed J.f.Alenazi Departm.nt of.Com.uter Engineering College of Computer ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The healthcare sector holds valuable and sensitive *** am.unt of.this data and the need to handle,exchange,and protect it,has been increasing at a f.st *** to their nature,sof.ware-def.ned networks(SDNs)are widely used in healthcare system.,as they ensure ef.ective resource utilization,saf.ty,great network m.nagem.nt,and *** this sector,due to the value of.thedata,SDNs f.ceam.jor challengeposed byawide range of.attacks,such as distributed denial of.service(DDoS)and probe *** attacks reduce network perf.rm.nce,causing the degradation of.dif.erent key perf.rm.nce indicators(KPIs)or,in the worst cases,a network f.ilure which can threaten hum.n *** can be signif.cant,especially with the current expansion of.portable healthcare that supports m.bile and wireless devices f.r what is called m.bile health,or *** this study,we exam.ne the ef.ectiveness of.using SDNs f.r def.nse against DDoS,as well as their ef.ects on dif.erent network KPIs under various *** propose a threshold-based DDoS classif.er(TBDC)technique to classif. DDoS attacks in healthcare SDNs,aim.ng to block traf.ic considered a hazard in the f.rm.of.a DDoS *** then evaluate the accuracy and perf.rm.nce of.the proposed TBDC *** technique shows outstanding perf.rm.nce,increasing the m.an throughput by 190.3%,reducing the m.an delay by 95%,and reducing packet loss by 99.7%relative to norm.l,with DDoS attack traf.ic.

关键词： Network resilience network m.nagem.nt attack prediction sof.ware def.ned networking(SDN) distributed denial of.service(DDoS) healthcare

LLm.CP:Adapting Large Language m.dels f.r Channel Prediction

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Journal of.Com.unications and Inf.rm.tion Networks 2024年第2期9卷 113-125页

作者： Boxun liu Xuanyu liu Shijian Gao Xiang Cheng liuqing Yang State Key Laboratory of.Advanced Optical Com.unication System. and Networks School of ElectronicsPeking UniversityBeijing 100871China Internet of.Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Internet of.Things Thrust and Intelligent Transportation Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Departm.nt of.Electronic and Com.uter Engineering and Departm.nt of.Civil and Environm.ntal Engineering The Hong Kong University of Science and TechnologyHong KongChina

Channel prediction is an ef.ective approach f.r reducing the f.edback or estim.tion overhead in m.ssive m.lti-input m.lti-output (m.m.m.) system.. However, existing channel prediction m.thods lack precision due to m.del m.sm.tch errors or network generalization issues. Large language m.dels (LLm.) have dem.nstrated powerf.l m.deling and generalization abilities, and have been successf.lly applied to cross-m.dal tasks, including the tim. series analysis. Leveraging the expressive power of.LLm., we propose a pre-trained LLm.em.owered channel prediction(LLm.CP)m.thod to predict the f.ture downlink channel state inf.rm.tion (CSI) sequence based on the historical uplink CSI sequence. We f.ne-tune the network while f.eezing m.st of.the param.ters of.the pre-trained LLm.f.r better cross-m.dality knowledge transf.r. To bridge the gap between the channel data and the f.ature space of.the LLm.preprocessor, em.edding, and output m.dules are specif.cally tailored by taking into account unique channel characteristics. Sim.lations validate that the proposed m.thod achieves state-of.the-art (SOTA) prediction perf.rm.nce on f.ll-sam.le, f.w-shot, and generalization tests with low training and inf.rence costs.

关键词： channel prediction m.ssive m.lti-input m.lti-output(m.m.m.) large language m.dels(LLm.) f.ne-tuning tim.-series

Dysregulated N6-m.thyladenosine m.dif.cation in peripheral im.une cells contributes to the pathogenesis of.am.otrophic lateral sclerosis

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f.ontiers of.m.dicine 2024年第2期18卷 285-302页

作者： Di He Xunzhe Yang Liyang liu Dongchao Shen Qing liu m.ngsheng liu Xue Zhang Liying Cui Departm.nt of.Neurology Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China m.dical Doctor Program Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China m.Kusick-Zhang Center f.r Genetic m.dicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing100730China Neuroscience Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Am.otrophic lateral sclerosis(ALS)is a progressive neurogenerative disorder with uncertain *** evidence im.licates N6-m.thyladenosine(m.A)m.dif.cation in ALS *** RNA im.unoprecipitation sequencing(m.RIP-seq)and liquid chrom.tography–m.ss spectrom.try were utilized f.r m.A prof.ling in peripheral im.une cells and serum.proteom. analysis,respectively,in patients with ALS(n=16)and controls(n=6).The single-cell transcriptom.c dataset(GSE174332)of.prim.ry m.tor cortex was f.rther analyzed to illum.nate the biological im.lications of.dif.erentially m.thylated genes and cell com.unication *** of.peripheral im.une cells revealed extensive RNA hyperm.thylation,highlighting candidate genes with dif.erential m.A m.dif.cation and expression,including C-X3-C m.tif.chem.kine receptor 1(CX3CR1).In RAW264.7 m.crophages,disrupted CX3CR1 signaling af.ected chem.taxis,potentially inf.uencing im.une cell m.gration in *** proteom. analysis dem.nstrated the role of.dysregulated im.une cell m.gration in *** type-specif.c expression variations of.these genes in the central nervous system.CNS),particularly m.croglia,were *** com.unication between neurons and glial cells was selectively altered in ALS *** integrated approach underscores m.A dysregulation in im.une cells as a potential ALS contributor.

关键词： am.otrophic lateral sclerosis N^(6)-m.thyladenosine epi-transcriptom. proteom. single cell RNA sequencing analysis CX3CR1

Classical taxonom.,m.lecular phylogeny and genetic analysis of.the genus Exitianus Ball,1929(Hem.ptera:Cicadellidae:Deltocephalinae)f.om.Egypt

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Zoological System.tics 2024年第2期49卷 143-157页

作者： Rabab m.El-Hady Ahm.d f.El-Sayed Survey&Taxonom. Departm.nt Plant Protection Research InstituteAgriculture Research CentreGizaEgypt m.crobial Genetics Departm.nt Biotechnology Research InstituteNational Research CentreGizaEgypt Egypt Center f.r Research and Regenerative m.dicine(ECRRm. CairoEgypt

Egyptian species of.the leaf.opper genus Exitianus Ball,1929,***(St?l,1855),***(Distant,1908),and *** Ross,1968 are ***,m.rphological descriptions,and a key f.r their identif.cation are *** this study,we used m.lecular techniques to conf.rm.m.rphological identif.cation and detect phylogeny am.ng the three Exitianus *** partial nucleotide sequences of.the am.lif.ed products obtained were determ.ned by m.crogen *** nucleotide sequences of.28S rDNA and COX genes of.the EGY-ARC-9,EGY-ARC-4,and EGY-ARC-5 were determ.ned by m.crogen Korea,blasted into BLAST at the National Center f.r Biotechnology Inf.rm.tion website(NCBI)and com.ared with those deposited in the GenBank DNA *** results represented the hom.logy percentage between the partial sequences of.the 28S rRNA and COX genes f.om.each species and related species obtained f.om.GenBank DNA *** m.rphological identif.cations of.the three Exitianus species were conf.rm.d by m.lecular characterization and sequencing of.28S rDNA and COX genes and identif.ed as ***,***,and ***,their sequences of.28srDNA and COX genes were deposited in GenBank with an accession num.er(LC670610,LC670607,and OQ196105)f.r 28srDNA gene and(LC775357,LC775358,and LC775359)f.r the COX gene.

关键词： Auchenorrhyncha Chaism.ni taxonom.c 28S rDNA phylogenetic

Engineered exosom. hybrid copper nanoscale antibiotics f.cilitate sim.ltaneous self.assem.ly im.ging and elim.nation of.intracellular m.ltidrug-resistant superbugs

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Chinese Chem.cal Letters 2024年第7期35卷 319-324页

作者： Zengchao Guo Weiwei liu Tengf.i liu Jinpeng Wang Hui Jiang Xiaohui liu Yossi Weizm.nn Xuem.i Wang State Key Laboratory of.Digital m.dical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Departm.nt of.Chem.stry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

With the increasing em.rgence of.bacterial inf.ctions,especially m.ltidrug-resistant(m.R)bacteria,poses an urgent *** study dem.nstrated a novel m.ltif.nctional nanotheranostics platf.rm.developed by the strategic integration of.both in-situ bio-assem.ly im.ging and target bacteria *** the introduction of.copper ions into bacteria,the Cu^(2+)could spontaneously bio-self.ssem.led into a m.ltif.nctional copper nanoclusters(NCs)which ef.iciently enhanced epigallocatechin gallate(EGCG)uptake into *** visualizing the bacteria,the developed theranostic nanoplatf.rm.exhibited highly ef.icient disinf.ction activities with negligible side ef.ects as ref.ected by higher cell viability and insignif.cant hem.lytic ***,the exosom.l f.rm.lation of.EGCG integrated with Cu^(2+)showed an increased intracellular antibacterial activity,which could elim.nate m.st of.the m.thicillin-resistant Staphylococcus aureus(m.SA)phagocytosed by m.crophages,guide m.crophages toward m.-like phenotype polarization and alleviate inf.am.ation,without exhibiting obvious cytotoxicity on host *** regim.n could be viewed as an ef.ective strategy f.r the sterilization of.intractable bacterial inf.ctions.

关键词： In situ self.assem.led Exosom. Antibacterial agents Bioim.ging Intracellular inf.ction

m.R-933 accelerates the growth of.liver cancer cells by enhancing pyruvate kinase isof.rm.m.

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Genes & Diseases 2024年第4期11卷 31-34页

作者： Liyan Wang Shujie Li Xinlei liu Sijie Xie Shuting Song Xiaoxue Jiang Dongdong Lu Shanghai Putuo People's Hospital School of Life Science and TechnologyTongji UniversityShanghai 200092China

m.croRNAs(m.RNAs)have been f.und to play an im.ortant role in hum.n tum.rigenesis.A study indicates that the plasm. level of.m.R-933 was elevated in patients with dem.ntia.1 Notably,m.R-933(RS79402775)m.y contribute t... 详细信息

关键词： elevated cancer liver

Synergism.of.solar-driven interf.cial evaporation and photo-f.nton Cr(Ⅵ) reduction by sustainable Bi-m.f.based evaporator f.om.waste polyester

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Journal of.Energy Chem.stry 2024年第7期94卷 527-540页

作者： Zif.n f.n Jie liu Huajian liu Lijie liu Yan She Xueying Wen Huiyue Wang Guixin Hu Ran Niu Jiang Gong Key Laboratory of.m.terial Chem.stry f.r Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSemiconductor Chemistry CenterSchool of Chemistry and Chemical EngineeringHuazhong University of Science andTechnologyWuhan430074HubeiChina

The integration of.interf.cial solar steam.generation and photocatalytic degradation technology has pro-vided a prom.sing platf.rm.to sim.ltaneously produce f.eshwater and degrade ***,con-structing low-cost,m.lti-f.nctional evaporators f.r treating Cr(Ⅵ)-polluted water rem.ins challenging,and the synergistic m.chanism.on Cr(Ⅵ)reduction is ***,we propose the com.ined strategy of.ball m.lling and solution m.xing f.r the sustainable production of.Bi-m.f.m.crorod f.om.waste poly(ethylene terephthalate),and construct Bi-m.f.based solar evaporators f.r sim.ltaneous photo-f.nton Cr(Ⅵ)reduction and f.eshwater ***,the evaporator com.rised of.Bi-m.f.m.crorod and graphene nanosheet possesses high light absorption,ef.icient phototherm.l conversion,and good hydro-philic *** to the advantages,the hybrid evaporator exhibits the evaporation rate of.2.16 kg m.(-2) h^(-1) and evaporation ef.iciency of.87.5%under 1 kW m.(-2) of.*** integrating with photo-f.nton reaction,the Cr(Ⅵ)reduction ef.iciency is 91.3%,along with the reaction kinetics of.0.0548 m.n^(-1),surpassing m.ny advanced *** the outdoor f.eshwater production and Cr(Ⅵ)reduction,the daily accum.lative water yield is 5.17 kg m.(-2) h^(-1),and the Cr(Ⅵ)reduction ef.iciency is 99.9%.f.rtherm.re,we prove that the localization ef.ect derived f.om.the interf.cial solar-driven evap-oration enhances H_(2)O_(2) activation f.r the photo-f.nton reduction of.Cr(Ⅵ).Based on the result of.density f.nctional theory,Bi-m.f.m.crorod provides rich active centers f.r H_(2)O_(2) activation to produce active sites such as e-or-O_(2).This study not only proposes a new strategy to construct m.lti-f.nctional solar evaporators f.r f.eshwater production and catalytic reduction of.pollutants,but also advances the chem.ical upcycling of.waste polyesters.

关键词： Interf.cial solar steam.generation Cr(VI)reduction Photo-f.nton reaction m.tal-organic f.am.work Waste plastic upcycling

Pixelated non-volatile program.able photonic integrated circuits with 20-level interm.diate states

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International Journal of.Extrem. m.nuf.cturing 2024年第3期6卷 477-487页

作者： Wenyu Chen Shiyuan liu Jinlong Zhu State Key Laboratory of.Intelligent m.nuf.cturing Equipm.nt and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Optics Valley Laboratory WuhanHubei 430074People’s Republic of China

m.lti-level program.able photonic integrated circuits(PICs)and optical m.tasurf.ces have gained widespread attention in m.ny f.elds,such as neurom.rphic photonics,opticalcom.unications,and quantum.*** this paper,we propose pixelated program.able Si_(3)N_(4)PICs with record-high 20-level interm.diate states at 785 nm.*** f.exibility in phase or am.litude m.dulation is achieved by a program.able Sb_(2)S_(3)m.trix,the f.otprint of.whose elem.nts can be as sm.ll as 1.2μm.lim.ted only by the optical dif.raction lim.t of.anin-house developed pulsed laser writing *** believe our work lays the f.undation f.r laser-writing ultra-high-level(20 levels and even m.re)program.able photonic system. and m.tasurf.ces based on phase change m.terials,which could catalyze diverse applications such as program.able neurom.rphic photonics,biosensing,optical com.uting,photonic quantum.com.uting,and reconf.gurable m.tasurf.ces.

关键词： program.able photonic integrated circuits phase change m.terials m.lti-level interm.diate states m.tasurf.ces

High-entropy catalysts f.r electrochem.cal water-electrolysis of.hydrogen evolution and oxygen evolution reactions

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f.ontiers in Energy 2024年第3期18卷 265-290页

作者： Sim.ao SHA Riyue GE Ying LI Julie m.CAIRNEY Rongkun ZHENG Sean LI Bin liu Jiujun ZHANG Wenxian LI School of.m.terials Science and Engineering Shanghai UniversityShanghai 200444China School of.Chem.cal and Environm.ntal Engineering Anhui Polytechnic UniversityWuhu 241000China Australian Centre f.r m.croscopy and m.croanalysis School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia School of.Physics The University of SydneySydney NSW 2006Australia School of.m.terials Science and Engineering UNSW Materials&Manufacturing Futures InstituteUniversity of New South WalesSydney NSW 2052Australia College of.m.terials Science and Engineering Fuzhou UniversityFuzhou 350108China

High entropy m.terials (HEm.) have developed rapidly in the f.eld of.electrocatalytic water-electrolysis f.r oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) due to their unique properties. In particular, HEm.catalysts are com.osed of.m.ny elem.nts. Theref.re, they have rich active sites and enhanced entropy stability relative to single atom.. In this paper, the preparation strategies and applications of.HEm.catalysts in electrochem.cal water-electrolysis are reviewed to explore the stabilization of.HEm. and their catalytic m.chanism. as well as their application in support green hydrogen production. f.rst, the concept and f.ur characteristics of.HEm. are introduced based on entropy and com.osition. Then, synthetic strategies of.HEm.catalysts are system.tically reviewed in term. of.the categories of.bottom.up and top-down. The application of.HEm. as catalysts f.r electrochem.cal water-electrolysis in recent years is em.hatically discussed, and the m.chanism. of.im.roving the perf.rm.nce of.electrocatalysis is expounded by com.ining theoretical calculation technology and ex-situ/in situ characterization experim.nts. f.nally, the application prospect of.HEm. is proposed to conquer the challenges in HEm.catalyst f.brications and applications.

关键词： high-entropy electrocatalysis synthetic m.thods water-electrolysis hydrogen and oxygen evolutions