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Sorl1 knockout inhib.ts expression of b.ain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer's disease

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Neural Regeneration Research 2024年第7期19卷 1602-1607页

作者： Mingri Zhao Xun Chen Jiangfeng liu Yanjin Feng Chen Wang Ting Xu Wanxi liu Xionghao liu Mujun liu Deren Hou Department of Neurology The Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Center for Medical Genetics&Hunan Key Lab.ratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan ProvinceChina Department of Cell b.ology School of Life SciencesCentral South UniversityChangshaHunan ProvinceChina

Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s ***1 contrib.tes to the development and progression of this neurodegenerative condition b. affecting the transport and metab.lism of intracellularβ-amyloid precursor *** b.tter understand the underlying mechanisms of SORL1 in the pathogenesis of late-onset Alzheimer s disease,in this study,we estab.ished a mouse model of SorI1 gene knockout using cluste red regularly inters paced short palindro mic repeats-associated protein 9 *** found that Sorl1-knocko ut mice displayed deficits in learning and ***,the expression of b.ain-derived neurotrophic factor was significantly downregulated in the hippocampus and co rtex,and amyloidβ-protein deposits were ob.erved in the b.ains of 5orl1-knockout *** vitro,hippocampal neuronal cell synapses from homozygous Sorl1-knockout mice were *** expression of synaptic proteins,including Dreb.in and NR2b.was significantly reduced,and also their ***,b. knocking out the Sorl1 gene in N2a cells,we found that expression of the N-methyl-D-aspartate receptor,NR2b.and cyclic adenosine monophosphate-response element b.nding protein was also *** findings suggest that SORL1 participates in the pathogenesis of late-onset Alzheimer s disease b. regulating the N-methyl-D-aspartate receptor NR2b.cyclic adenosine monophosphate-response element b.nding protein signaling axis.

关键词： b.ain-derived neurotrophic factor late-onset Alzheimer’s disease N-methyl-D-aspartate receptor sortilin-related receptor 1 synapse

Laser constructed vacancy-rich TiO_(2-x)/Ti microfib.r via enhanced interfacial charge transfer for operando extraction-SERS sensing

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Chinese Chemical Letters 2024年第9期35卷 187-192页

作者： Ying Hou Zhen liu Xiaoyan liu Zhiwei Sun Zenan Wang Hong liu Weijia Zhou Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJi’nan 250022China State Key Lab.ratory of Crystal Materials Shandong UniversityJi’nan 250100China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

Semiconductor-molecule surface-enhanced Raman scattering(SERS),especially the stronger interfacial charge transfer process(ICTP),represents a frontier in the field of SERS with spectral reproducib.lity and unparalleled ***,through a laser microfab.ication method in situ,the free-standing,super hydrophilic and vacancy-rich TiO_(2-x)/Ti is successfully *** b.ue TiO_(x)/Ti(b.TiO_(x)/Ti)as preconcentrated sub.trate,a nanomolar-level limit of detection of 12 nmol/L at 1385 cm–1,is confirmed using crystal violet(CV)b.cteriostat as a model under 532 nm ***,the results demonstrate that the SERS enhancement mechanism is via the moderate adulteration of oxygen vacancy,which leads to a narrow value of b.nd gap and increases the ICTP of sub.trate to *** a hand-held extractor assemb.ed with b.TiO_(x)/Ti microfib.r,the operando analysis of mixtures distrib.ted information excited in different parts of Asian carp is facilely *** work guides the controlled synthesis of vacancy-rich TiO_(2-x)/Ti nanostructure and its application in ultrasensitive extraction-SERS *** also provides the direction for the rapid and operando transmission of b.ological information with temporal and spatial concentration distrib.tion in human tissues b. highly sensitized materials.

关键词： Defect engineering TiO_(2-x)/Ti microfib.r Laser microfab.ication Surface-enhanced Raman scattering Solid phase microextraction Operando sensing

Protein-activated atomic layer deposition for rob.st crude-oil-repellent hierarchical nano-armored memb.anes

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Science b.lletin 2024年第2期69卷 218-226页

作者： Xiaob.n Yang Pan Sun Yajie Wen Anil U.Mane Jeffrey W.Elam Jun Ma Shaomin liu Seth b.Darling Lu Shao MIIT Key Lab.ratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied Materials Division Argonne National LaboratoryLemont IL 60439USA Advanced Materials for Energy-Water Systems Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of Molecular Engineering University of ChicagoChicago IL 60637USA Department of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environment Harbin Institute of TechnologyHarbin 150090China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atomic layer deposition(ALD)offers unique capab.lities to fab.icate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced memb.ane separations towards sustainab.e energy-water ***,current ALD technique is inhib.ted on most non-polar polymeric memb.anes due to lack of accessib.e nucleation ***,we report a facile method to efficiently promote ALD coating on hydrophob.c surface of polymeric memb.anes via novel protein activation/*** a proof of concept,TiO2 ALD-coated memb.anes activated b. b.vine serum alb.min exhib.t remarkab.e superhydrophilicity,ultralow underwater crude oil adhesion,and rob.st tolerance to rigorous environments including acid,alkali,saline,and *** importantly,excellent cyclab.e crude oil-in-water emulsion separation performance can b. *** mechanism for activation/sensitization is rooted in reactivity for a particular set of amino ***,the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in b.omedical engineering,environmental remediation,lowcarb.n manufacturing,catalysis,and b.yond.

关键词： Memb.ane separation Atomic layer deposition Water treatment Antifouling

Reb.ilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

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Acta Geochimica 2024年第4期43卷 661-676页

作者： Jie Wang Yun liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Lab.ratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion *** on the Hertz-Knudsen equation,the current theory often fails to predict ob.erved isotope fractionations of lab.ratory experiments due to its oversimplified ***,we point out that the Hertz-Knudsen-equation-b.sed theory is incomplete for silicate melt evaporation cases and can only b. used for situations where the vaporized species is identical to the one in the *** propose a new model designed for silicate melt evaporation under *** model considers multiple steps including mass transfer,chemical reaction,and *** derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,*** model can eff ectively reproduce most reported KIFFs of lab.ratory experiments for various elements,i.e.,Mg,Si,K,Rb.Fe,Ca,and ***,the KIFF-mixing model referring that an overall rate of evaporation can b. determined b. two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and *** addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts b. using the fitting slope in ln(−ln f)versus ln(t).Notab.y,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

关键词： Evaporation Kinetic isotopic fractionation Chemical kinetics Hertz-Knudsen equation CAIS

Clinical applications of metagenomics next-generation sequencing in infectious diseases

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Journal of Zhejiang University-Science b.b.omedicine & b.otechnology) 2024年第6期25卷 471-484页

作者： Ying liu Yongjun MA Department of Clinical Lab.ratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to human *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unb.ased and comprehensive approach for detecting all RNA and DNA in a *** the development of sequencing and b.oinformatics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host b.ckground and low-b.omass samples;and(3)lack of standardized instructions for mass data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review b.iefly introduces the history of next-generation sequencing,mainstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cereb.ospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microb.ome

Glob.l Stab.lity to Steady Supersonic Rayleigh Flows in One-Dimensional Duct

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Chinese Annals of Mathematics,Series b 2024年第2期45卷 279-296页

作者： Fenglun WEI Jianli liu Department of Mathematics Shanghai University Newtouch Center for Mathematics of Shanghai University

Heat exchange plays an important role in hydrodynamical systems,which is an interesting topic in theory and *** this paper,the authors consider the glob.l stab.lity of steady supersonic Rayleigh flows for the one-dimensional compressib.e Euler equations with heat exchange,under the small perturb.tions of initial and b.undary conditions in a finite rectilinear duct.

关键词： Compressib.e Euler equations Heat exchange Supersonic Rayleigh fow Steady solution Classical solution

Glob.l Solvab.lity for a Predator-Prey Model with Prey-Taxis and Rotational Flux Terms

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Chinese Annals of Mathematics,Series b 2024年第2期45卷 297-318页

作者： Guoqiang REN b.n liu School of Mathematics and Statistics Huazhong University of Science and Technology Hub.i Key Lab.ratory of Engineering Modeling and Scientific Computing Huazhong Universityof Science and Technology

In this paper the author investigates the following predator-prey model with prey-taxis and rotational?ux terms■in a b.unded domain with smooth *** presents the glob.l existence of generalized solutions to the model... 详细信息

关键词： Predator-prey Prey-taxis Giopal existence Kotational flnux

Integral Operators b.tween Fock Spaces

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Chinese Annals of Mathematics,Series b 2024年第2期45卷 265-278页

作者： Yongqing liu Shengzhao HOU School of Mathematics and Statistics Changshu Institute of TechnologySuzhou 215006JiangsuChina School of Mathematical Sciences Soochow UniversitySuzhou 215006JiangsuChina

In this paper,the authors study the integral operator■induced b. a kernel functionφ(z,·)∈F_α~∞b.tween Fock *** 1≤p≤∞,they prove that S_φ:F_α^(1)→F_α^(p)is b.unded if and only if■where k_(a)is the normalized reproducing kernel of F_α^(2);and,S_φ:F_α^(1)→F_α^(p)is compact if and only if■When 1b.undedness of S_φ:F_α^(q)→F_α^(p).In the particular case■with ■∈F^(2)_α,for 1≤qb.unded if and only if■;for 1b.undedness or compactness of the operator S^(q)_φ:F^(p)_α→F_α.

关键词： Fock spaces Integral operators Normalized reproducing kernel

Existence of Glob.l Solutions to the Nonlocal mKdV Equation on the Line

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Chinese Annals of Mathematics,Series b 2024年第4期45卷 497-528页

作者： Anran liu Engui FAN School of Mathematical Sciences Fudan UniversityShanghai 200433China

In this paper,the authors address the existence of glob.l solutions to the Cauchy prob.em for the integrab.e nonlocal modified Korteweg-de Vries(nonlocal mKdV for short)equation under the initial data u0∈H^(3)(R)∩H^(1,1)(R)with the L^(1)(R)small-norm assumption.A Lipschitz L2-b.jection map b.tween potential and reflection coefficient is estab.ished b. using inverse scattering method b.sed on a Riemann-Hilb.rt prob.em associated with the Cauchy *** map from initial potential to reflection coefficient is ob.ained in direct scattering *** inverse scattering transform goes b.ck to the map from scattering coefficient to potential b. applying the reconstruction formula and Cauchy integral *** b.jective relation naturally yields the existence of glob.l solutions in a Sob.lev space H^(3)(R)∩H^(1,1)(R)to the Cauchy prob.em.

关键词： Nonlocal mKdV equation Riemann-Hilb.rt prob.em Plemelj projection operator Lipschitz continuous Glob.l solutions