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lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis

Frontiers of Medicine 2023年第2期17卷 317-329页

作者： Yuhua Fan yue Zhang hongrui Zhao Wenfeng liu Wanqing Xu Lintong jiang Ranchen Xu yue Zheng Xueqing Tang Xiaohan Li Limin Zhao xin liu yang hong Yuan Lin Hui Chen Yong Zhang Department of Pharmacology State–Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular Medicine ResearchMinistry of EducationCollege of PharmacyHarbin Medical UniversityHarbin 150081China Department of Pathology and Pathophysiology College of Basic Medical SciencesHarbin Medical University-DaqingDaqing 163319China Center for Drug Research and Development Guangdong Pharmaceutical UniversityGuangzhou 510006China

Long noncoding RNAs(lncRNAs)play a critical role in the regulation of ***,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in *** found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen ***,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial *** contrast,lncR-GAS5 knockdown promoted ***,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and ***,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of *** results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,***,miR-193-5p overexpression decreased plaque size and increased collagen ***,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial *** conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling ***,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis

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Associations of sex hormone levels with body mass index(BMI)in men:a cross-sectional study using quantile regression analysis

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Asian Journal of Andrology 2023年第1期25卷 98-102页

作者： xin Lv Yu-Ting jiang xin-yue Zhang Lei-Lei Li hong-Guo Zhang Rui-Zhi liu Center of Reproductive Medicine and Center of Prenatal Diagnosis The First Hospital of Jilin UniversityChangchun 130021China

Body mass index(BMI)has been increasing globally in recent *** studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of *** regression analysis can maximize the use of variable *** study compared the associations among different regression *** participants were recruited from the Center of Reproductive Medicine,The First Hospital of jilin University(Changchun,China)between June 2018 and June *** used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and *** total,448 men were included in this *** average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were *** levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and *** note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.

关键词： body mass index estradiol obesity overweight testosterone

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Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

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Chinese Chemical Letters 2014年第7期25卷 1017-1020页

作者： Shao-Hua liu Wei Peng Yan-Yan Qu Dan Xu hong-yue Li Dun-Lun Song hong-Xia Duan xin-Ling yang Department of Applied Chemistry College of ScienceChina Agricultural University Department of Entomology College of Agriculture and BiotechnologyChina Agricultural University

A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, 1H NMR, and HRMS （ESI）. Preliminary bioassay showed that some compounds, Sb and Sg, exhibited good activity against soybean aphids （Aphis glycines） at 100 mg L ^-1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

关键词： Clothianidin analogues Hydrazide group Insecticidal activity Molecular docking

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Numerical Study of Collision and Penetration Behavior Between Particles and Screen Plate

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Journal of China University of Mining and Technology 2006年第2期16卷 137-140,146页

作者： jiAO hong-guang ZHAO yue-min WANG Quan-qiang School of Material Science and Engineering Henan Polytechnic University Jiaozuo Henan 454003 China School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

For a screening process, the collision and penetration phenomena between particles and screen plate is standard behavior and with collision the mechanical energy of the vibrating screen can be transmitted to the feed. In order to recognize further the collision process and the law of penetrating motion, with the spring-dashpot-slider contact model of the distinct element method （DEM）, a mathematical model which can describe the collision process has been established and a program for simulating the motion of a single particle on the screen plate developed by VC＋＋. NET. To evaluate the handling capacity of the screen that deals with difficult screening material, an instantaneous penetrating coefficient is defined. The moving period of the screen plate is divided into four stages. By analyzing the state of contact collision at each stage, it is pointed out that the collision ranging from 3π/2 to 2π period is the most favorable aperture for penetration of particles, while the collision ranging from π/2 to n period is the most unfavorable. The numerical simulation result further indicates that increasing the amplitude of the screen plate has a much greater effect on the augmentation of instantaneous penetration coefficient than increasing the vibration frequency.

关键词： screening numerical simulation particle motion collision

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Comparative genomics provide a rapid detection of Fusarium oxysporum f. sp. conglutinans

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Journal of Integrative Agriculture 2016年第4期15卷 822-831页

作者： LING jian ZHANG ji-xiang ZENG Feng CAO yue-xia XIE Bing-yan yang Yu-hong Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences

Fusarium oxysporum f. sp. conglutinans （Foc） is the causal agent of Fusarium wilt disease of Brassica oleracea. A rapid, accurate, and reliable method to detect and identify plant pathogens is vitally important to integrated disease management. In this study, using a comparative genome analysis among Fusarium oxysporum （Fo）, we developed a Foc-specific primer set （Focs-l/Focs-2） and established a multiplex-PCR assay. In the assay, the Focs-1/Focs-2 and universal primers for Fusarium species （W106PJF106S） could be used to detect Foc isolates in a single PCR reaction. With the optimized PCR parameters, the multiplex-PCR assay showed a high specificity for detecting Foc and was very sensitive to detect as little as 100 pg of pure Foc genomic DNAor 1 000 spores in 1 g of twice-autoclaved soil. We also demonstrated that Foc isolates were easily detected from infected plant tissues, as well as from natural field soils, using the multiplex-PCR assay. To our knowledge, this is a first report on detection Fo by comparative genomic method.

关键词： Fusarium oxysporum wilt disease cabbage multiplex-PCR molecular detection comparative genomics

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Vertically aligned W(Mo)S_(2)/N-W(Mo)C-based light-assisted electrocatalysis for hydrogen evolution in acidic solutions

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Rare Metals 2023年第5期42卷 1535-1544页

作者： Lan-Fang Wang Rui-Xia yang jin-Zhi Fu yue-yue Cao Rui-Fang Ding Xiao-hong Xu Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&School of Chemistry and Materials Science of Shanxi Normal University Taiyuan030032China Kunshan Superior Silk Screen Printing Material Co. Ltd.Suzhou215300China

The development of non-noble-metal hydrogen evolution electrocatalysts holds great promises for a sustainable energy ***,a hybrid W(Mo)S_(2)/NW(Mo)C nanosheet with array structures was reported for an efficient light-as sis ted hydrogen evolution electrocatalysts in acidic *** resulting vertically aligned W(Mo)S_(2)/N-W(Mo)C was supported on a conductive carbon fiber paper,which can be produced through annealing W(Mo)S_(2)nanosheets by simultaneous carbonization and N-doping in Ar/H_(2)*** optimized WS_(2)/NWC and MoS_(2)/N-MoC electrode exhibits remarkable lightassisted electrocatalysis activity with overpotentials of0.120 and 0.122 V at 10 mA·cm^(-1)in acidic solutions,*** high hydrogen evolution activities should be attributed to the electrocatalytic synergistic effects of the abundant active sites existing in different phase boundaries and the absorption for ultraviolet-visible *** study shows that synthesis of low-cost and highly active W(Mo)S_(2)-based hydrogen evolution electrocatalyst opens up a route toward the development of scalable production of hydrogen fuels.

关键词： W(Mo)S_(2)/N-W(Mo)C heterostructures Vertically aligned nanosheets Hydrogen evolution Lightassisted electrocatalysis

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Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 261-267页

作者： xin-yue Li Shu Wang Li Dong hong Zhang Eye Hospital the First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Eye Department Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China

AIM:To compare the assessment outcomes of the characteristics of mild to moderate non-proliferative diabetic retinopathy(NPDR) established by fundus photography and fundus fluorescein angiography(FFA).METHODS:The fundus photos and FFA results of 260 patients with diabetes mellitus were *** retinopathy(DR) severity was graded based on the international classification *** microaneurysms,hemorrhages,and intraretinal microvascular abnormalities(IRMA) in FFA images of patients with mild to moderate NPDR were *** differences between the fundus photos and the FFA results were summarized,analyzed,and ***:The counting of intraretinal hemorrhages identified by FFA revealed that only 9 eyes(1.9%) had more than 20 intraretinal hemorrhages in all four quadrants;15 eyes(3.1%) had more than 20 intraretinal hemorrhages in three quadrants;26 eyes(5.4%) had over 20 intraretinal hemorrhages in two quadrants;and 37 eyes(7.7%) had more than 20 intraretinal hemorrhages in only one ***,the number of IRMAs appeared ≥4 in 17 eyes,3 in 35 eyes,2 in 69 eyes,and 1 in 93 ***:FFA has higher detection accuracy of retinal angiopathy than fundus *** grading results are helpful for timely detection and proper treatment of lesions easily missed by fundus photography.

关键词： diabetic retinopathy fundus fluorescein angiography grading criteria

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Long-noncoding RNAs(lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance

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Acta Pharmaceutica Sinica B 2020年第1期10卷 105-112页

作者： yue Wang Zihui Fang Mei hong Da yang Wen Xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA College of Life Sciences South China Agricultural UniversityGuangzhou 510642China University of Pittsburgh Cancer Institute University of PittsburghPittsburghPA 15261USA Department of Computational and System Biology University of PittsburghPittsburghPA 15261USA Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15261USA

Drug metabolism is an orchestrated process in which drugs are metabolized and disposed through a series of specialized enzymes and *** in the expression and/or activity of these enzymes and transporters can affect the bioavailability(pharmacokinetics,or PK)and therapeutic efficacy(pharmacodynamics,or PD)of *** studies have suggested that the long non-coding RNAs(IncRNAs)are highly relevant to drug metabolism and drug resistance,including chemoresistance in cancers,through the regulation of drug metabolism and disposition related *** review summarizes the regulation of enzymes,transporters,or regulatory proteins involved in drug metabolism by IncRNAs,with a particular emphasis on drug metabolism and chemo-resistance in cancer *** perspective strategies to integrate multi-dimensional pharmacogenomics data for future in-depth analysis of drug metabolism related IncRNAs are also *** the role of IncRNAs in drug metabolism will not only facilitate the identification of novel regulatory mechanisms,but also enable the discovery of IncRNA-based biomarkers and drug targets to personalize and improve the therapeutic outcome of patients,including cancer patients.

关键词： LncRNA Drug metabolism Chemo-resistance Xenobiotic receptor Regulation

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Alleviating the sluggish kinetics of all-solid-state batteries via cathode single-crystallization and multi-functional interface modification

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Journal of Energy Chemistry 2024年第11期98卷 123-133页

作者： Wen-Zhe liu xin-Hai Meng Zi-Yi Zhou Qiang Zheng ji-Lei Shi yue Gong Yu-Guo Guo CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190China

The application of Li-rich Mn-based cathodes, the most promising candidates for high-energy-density Liion batteries, in all-solid-state batteries can further enhance the safety and stability of battery ***, the utilization of high-capacity Li-rich cathodes has been limited by sluggish kinetics and severe interfacial issues in all-solid-state batteries. Here, a multi-functional interface modification strategy involving dispersed submicron single-crystal structure and multi-functional surface modification layer obtained through in-situ interfacial chemical reactions was designed to improve the electrochemical performance of Li-rich Mn-based cathodes in all-solid-state batteries. The design of submicron single-crystal structure promotes the interface contact between the cathode particles and the solid-state electrolyte,and thus constructs a more complete ion and electron conductive network in the composite ***, the Li-gradient layer and the lithium molybdate coating layer constructed on the surface of single-crystal Li-rich particles accelerate the transport of Li ions at the interface, suppress the side reactions between cathodes and electrolyte, and inhibit the oxygen release on the cathode surface. The optimized Li-rich cathode materials exhibit excellent electrochemical performance in halide all-solid-state batteries. This study emphasizes the vital importance of reaction kinetics and interfacial stability of Lirich cathodes in all-solid-state batteries and provides a facile modification strategy to enhance the electrochemical performance of all-solid-state batteries based on Li-rich cathodes.

关键词： All-solid-state Li-ion batteries Li-rich Mn-based cathode materials Kinetics Interface Anion redox

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Feedforward Control for Wind Turbine Load Reduction with Pseudo-LIDAR Measurement

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International Journal of Automation and computing 2018年第2期15卷 142-155页

作者： jie Bao hong yue William E.Leithead ji-Qiang Wang Department of Electronic and Electrical Engineering University of Strathclyde jiangsu Province Key Laboratory of Aerospace Power System Nanjing University of Aeronautics and Astronautics

A gain-scheduled feedforward controller, based on pseudo-LIDAR （light detection and ranging） wind speed measurement, is designed to augment the baseline feedback controller for wind turbine＇s load reduction in above rated operation. The pseudo-LIDAR measurement data are generated from a commercial software- Bladed using a designed sampling strategy. The nonlinear wind turbine model has been simplified and linearised at a set of equilibrium operating points. The feedforward controller is firstly developed based on a linearised model at an above rated wind speed, and then expanded to the full above rated operational envelope by employing gain scheduling strategy. The combined feedforward and baseline feedback control is simulated on a 5MW industrial wind turbine model. Simulation studies demonstrate that the proposed control strategy can improve the rotor and tower load reduction performance for large wind turbines.

关键词： Wind turbine control light detection and ranging (LIDAR) measurement feedforward control load reduction gainscheduling disturbance rejection.

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