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Effects　of　He－Ne　laser　irradiation　on　acupuncture　points　on　Enzymic　activity　of　SDH，3β－HSDH　and　17β－HSDH　of　uteri　and　ovaria　in　rabbits

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Chinese Journal of Lasers 1994年第6期B3卷 565-569页

作者： HUANG Wenxin HUANG Ping CAI Shangda QIU yiguang LI Yan liu Riting(x Tab Department of Biochemistry The Depattment of Biology,Sun Yat--Sen University of Medical Science, Guangzhou 51 0089, China) Sun Yatsen Univ of Medical Science Guangzhou China

ＥｆｆｅｃｔｓｏｆＨｅ－ＮｅｌａｓｅｒｉｒｒａｄｉａｔｉｏｎｏｎａｃｕｐｕｎｃｔｕｒｅｐｏｉｎｔｓｏｎＥｎｚｙｍｉｃａｃｔｉｖｉｔｙｏｆＳＤＨ，３β－ＨＳＤＨａｎｄ１７β－ＨＳＤＨｏｆ ... 详细信息

ＥｆｆｅｃｔｓｏｆＨｅ－ＮｅｌａｓｅｒｉｒｒａｄｉａｔｉｏｎｏｎａｃｕｐｕｎｃｔｕｒｅｐｏｉｎｔｓｏｎＥｎｚｙｍｉｃａｃｔｉｖｉｔｙｏｆＳＤＨ，３β－ＨＳＤＨａｎｄ１７β－ＨＳＤＨｏｆｕｔｅｒｉａｎｄｏｖａｒｉａ ...

关键词： He-Ne laser SDH 3β-HSDH 17β-HSDH

Structural Insights into Transamination Mechanism of the Aminotransferase CrmG in Caerulomycin Biosynthesis

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Structural Insights into Transamination Mechanism of the Ami...

中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）

作者： Jinxin Xu yiguang Zhu Zhan Feng Changsheng Zhang Jinsong liu Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences South China Sea Institutes of Oceanology Chinese Academy of Sciences

Caerulomycin A(CRM A)belongs to a family of natural products containing a 2,2’-bipyridyl ring core structure,and is currently under development as a potent novel immunosuppressive *** aminotransferase Crm G was confirmed to catalyze a key transamination reaction to convert an aldehyde group to an amino group in CRM A biosynthetic pathway,preferring L-glutamate and

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高熵过渡金属碳化物陶瓷的研究进展

无机材料学报 2021年第4期36卷 355-364页

作者：王皓轩刘巧沐王一光西北工业大学超高温结构复合材料重点实验室西安710072 中国燃气涡轮研究院成都610500 北京理工大学先进技术结构研究院北京100081

高熵陶瓷作为新型材料,较大的构型熵赋予其独特的性能,其中高熵过渡金属碳化物有望成为高超声速飞行器热防护系统的备选材料。相比于单组元碳化物陶瓷,高熵化的单相陶瓷在综合性能上有较大地提高。目前,高熵过渡金属碳化物陶瓷的研究还... 详细信息

高熵陶瓷作为新型材料,较大的构型熵赋予其独特的性能,其中高熵过渡金属碳化物有望成为高超声速飞行器热防护系统的备选材料。相比于单组元碳化物陶瓷,高熵化的单相陶瓷在综合性能上有较大地提高。目前,高熵过渡金属碳化物陶瓷的研究还处于初始阶段,关于高熵过渡金属碳化物的成分设计和理论分析还缺少足够的研究支撑。另外,如何制备高纯度高熵过渡金属碳化物还需要进一步探索。在高熵过渡金属碳化物陶瓷的性能方面,还缺少深入的研究。本文针对高熵陶瓷的理论设计和制备方法展开综述,详细介绍了高熵过渡金属碳化物的力学、热导及抗氧化性能的研究进展,并指出了高熵过渡金属碳化物陶瓷在超高温陶瓷领域存在的科学问题,展望了高熵过渡金属碳化物陶瓷未来的发展方向。

关键词：高熵过渡金属碳化物陶瓷构型熵力学性能热导性能抗氧化性能综述

High-throughput investigations of configurational-transformation-dominated serrations in CuZr/Cu nanolaminates

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Journal of Materials Science & Technology 2020年第18期52卷 192-199页

作者： William Yi Wang Bin Gana Deye Lin Jun Wang yiguang Wang Bin Tang Hongchao Kou Shunli Shang Yi Wang Xingyu Gao Haifeng Song Xidong Hui Laszlo J.Kecskes Zhenhai Xia Karin A.Dahmen Peter K.Liaw Jinshan Lia Zi-Kui liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an.710072China Beijing Key Laboratory of Advanced High Temperature Materials Central Iron and Steel Research InstituteBeijing100081China IMDEA Materials Institute Calle Eric Kandel 2GetafeMadrid28906Spain CAEP Software Center for High Performance Numerical Simulation Institute of Applied Physics and Computational MathematicsBeijing100088China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China Hopkins Extreme Materials Institute Johns Hopkins UniversityBaltimoreMD21218USA Department of Physics University of Illinois at Urbana ChampaignUrbanaIL61801USA Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996USA

Metallic amorphous/crystalline(A/C)nanolaminates exhibit excellent ductility while retaining their high ***,the underlying physical mechanisms and the resultant structural changes during plastic deformation still remain *** the present work,the structure-property relationship of CuZr/Cu A/C nanolaminates is established through integrated high-throughput micro-compression tests and molecular dynamics simulations together with high-resolution transmission electron *** serrated flow of nanolaminates results from the formation of hexagonal-close-packed(HCP)-type stacking faults and twins inside the face-centered-cubic(FCC)Cu nano-grains,the body-centered-cubic(BCC)-type ordering at their grain boundaries,and the crystallization of the amorphous CuZr *** serration behavior of CuZr/Cu A/C nanolaminates is determined by several factors,including the formation of dense dislocation networks from the multiplication of initial dislocations that formed after yielding,weak-spots-related configurational-transitions and shear-transition-zone activities,and deformation-induced *** present work provides an insight into the heterogeneous deformation mechanism of A/C nanolaminates at the atomic scale,and mechanistic base for the microstructural design of self-toughening metallic-glass(MG)-based composites and A/C nanolaminates.

关键词： Nanolaminates Serration Configurational transformation Molecular dynamics Metallic glass

Novel in vivo Evaluation of the Moisturizing Effect of A Lotion by Using Raman Microspectroscopy

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China Detergent & Cosmetics 2019年第2期4卷 47-51页

作者： Wang Zheng liu Jianning Guo yiguang Qiao Xiaoling Raoul Vyumvuhore Laurie Verzeaux Brigitte Closs Shanghai Jahwa United Co.Ltd. SILAB R&D DepartmentBrive la Gaillarde

Skin moisturization can be measured in vivo by Corneometer?, giving information about the hydration level of the skin. However, this approach cannot reveal the inner changes of lipid organization involved in the integrity of the skin barrier. Raman microspectroscopy is an in vivo and non-invasive method that assesses the lateral organization of lipids from the stratum corneum by measuring the νasymCH2/νsymCH2 ratio. In the present study, the aim is to evaluate the moisturizing effect of two skin care products (i.e. LOTION 1: GF deep-nourishing & skin-sturdy facial emulsion;LOTION 2: placebo formula) by using the Corneometer? and Raman microspectroscopy. Results demonstrates a significant improvement of lipids organization and thus a reinforcement of the barrier function associated with an increase of the hydration level with LOTION 1 compared to LOTION 2.

关键词： skin barrier Raman microspectroscopy lipid organization moisturization

Daicong solution effects on brain ultrastructure in a rat model of Alzheimer's disease

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Neural Regeneration Research 2008年第10期3卷 1107-1110页

作者： Qi＇an Yue Hongyan Wang Shumei Zhao Shengming Zhang Hongjuan Wu yiguang Wang Fengjie Li Yuanyuan Yang Juanjuan liu Yuling Ding Department of Microbiology Weifang Medical University Weifang 261042 Shandong Province China Department of Histology and Embryology Weifang Medical University Weifang 261042 Shandong Province China Department of Morphology Weifang Medical University Weifang 261042 Shandong Province China Department of Physiology Weifang Medical University Weifang 261042 Shandong Province China Central Laboratory Weifang Medical University Weifang 261042 Shandong Province China

BACKGROUND： Infusion of kainic acid into the basal nuclei induces neuronal excitotoxicity, degeneration and necrosis, resulting in disturbed learning and memory functions. OBJECTIVE： To explore the effects of different doses of traditional Chinese medicine Daicong solution on brain ultrastructure in a rat model of Alzheimer＇s disease. DESIGN, TIME AND SETTING： The randomized, controlled, cellular morphology experiment was performed at the Shandong Provincial Key Laboratory of Molecular Immunology of Weifang Medical University, China from October 2006 to March 2007. MATERIALS： Fifty healthy, Sprague Dawley rats, aged 22-months, were used to establish rat models of Alzheimer＇s disease. The Morris water maze was prepared at the Pharmacometrics Key Laboratory of Weifang Medical University in Shandong Province of China. Traditional Chinese medicine Daicong solution （crude drug 1 g/mL）, composed of radix ginseng, rehmannia dried rhizome, anemarrhenae and radix astragali, was produced by the Department of Pharmacy of Hospital Affiliated to Weifang Medical University. Kainic acid was provided by Professor Xiuyan Li from Weifang Medical University. METHODS： A total of 40 model rats were equally and randomly divided into four groups： dementia model, low-dose Daicong solution （5 g/kg/d）, moderate-dose Daicong solution （10 g/kg/d）, and high-dose Daicong solution （20 g/kg/d）. An additional 10 healthy rats served as the normal control group. Rats in the dementia model and normal control groups received saline （10 mL/kg/d）. MAIN OUTCOME MEASURES： Neural cell ultrastructure was observed utilizing electron microscopy after 1 month of respective treatments. RESULTS： Compared with the normal control group, electron density and the number of ribosomes were significantly reduced in neuronal cytoplasm, and many lipofuscin grains and vacuole-like changes were observed in mitochondria in the dementia model group. In addition, nuclear chromatin presented with different sizes of plaque-shape

关键词： Alzheimer's disease brain Daicong solution morphology

Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing:a systematic review and meta-analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1002-1013页

作者： Rui HUANG Pan liu yiguang BAI Jieqiong HUANG Rui PAN Huihua LI Yeping SU Quan ZHOU Ruixin MA Shaohui ZONG Gaofeng ZENG College of Public Hygiene of Guangxi Medical University Nanning 530021China Department of Spine Osteopathic the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Orthopaedics the Third Affiliated Hospital of Xinxiang Medical UniversityNanning 530022China Department of Orthopaedics Nanchong Central Hospitalthe Second Clinical Institute of North Sichuan Medical CollegeXinxiang 45300China Department of Wound Repair the First People’s Hospital of NanningNanchong 637000China

Background:Osteoporosis(OP)has become a major public health issue,threatening the bone health of middle-aged and elderly people from all around the *** in the gut microbiota(GM)are correlated with the maintenance of bone mass and bone ***,research results in this field remain highly controversial,and no systematic review or meta-analysis of the relationship between GM and OP has been *** paper addresses this shortcoming,focusing on the difference in the GM abundance between OP patients and healthy controls based on previous 16S ribosomal RNA(rRNA)gene sequencing results,in order to provide new clinical reference information for future customized prevention and treatment options of ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA),we comprehensively searched the databases of Pub Med,Web of Science,Embase,Cochrane Library,and China National Knowledge Infrastructure(CNKI).In addition,we applied the R programming language version 4.0.3 and Stata 15.1 software for data *** also implemented the Newcastle-Ottawa Scale(NOS),funnel plot analysis,sensitivity analysis,Egger’s test,and Begg’s test to assess the risk of ***:This research ultimately considered 12 studies,which included the fecal GM data of 2033 people(604 with OP and 1429 healthy controls).In the included research papers,it was observed that the relative abundance of Lactobacillus and Ruminococcus increased in the OP group,while the relative abundance for Bacteroides of Bacteroidetes increased(except for Ireland).Meanwhile,Firmicutes,Blautia,Alistipes,Megamonas,and Anaerostipes showed reduced relative abundance in Chinese *** the linear discriminant analysis Effect Size(LEfSe)analysis,certain bacteria showed statistically significant results consistently across different ***:This observational meta-analysis revealed that changes in the GM were correlated with OP,and variations in some adva

关键词： Osteoporosis Microbiome Intestinal 16S ribosomal RNA(rRNA)sequencing

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氧化物陶瓷闪烧机理及其应用研究进展

无机材料学报 2022年第5期37卷 473-480页

作者：刘金铃刘佃光任科王一光西南交通大学力学与航空航天学院成都611756 西南交通大学材料科学与工程学院成都610031 北京理工大学先进结构技术研究院北京100081

闪烧是近些年广受关注的一种电场辅助烧结技术。本文介绍了闪烧的起源与发展,并对闪烧的基本特征进行了分析。在闪烧孕育与引发过程的研究方面,发现了孕育阶段的非线性电导特征和电化学黑化现象,提出了氧空位主导的缺陷机制;在闪烧阶段... 详细信息

闪烧是近些年广受关注的一种电场辅助烧结技术。本文介绍了闪烧的起源与发展,并对闪烧的基本特征进行了分析。在闪烧孕育与引发过程的研究方面,发现了孕育阶段的非线性电导特征和电化学黑化现象,提出了氧空位主导的缺陷机制;在闪烧阶段的快速致密化研究方面,提出了电场作用导致的缺陷产生和运动会在粉体颗粒间产生库仑力,有利于烧结前期的致密化过程,同时发现闪烧致密化过程中还伴随着金属阳离子的快速运动;在闪烧阶段的晶粒生长和微结构演变方面,发现了试样温度沿电流方向呈非对称分布,试样中间位置的晶界迁移率明显提高,提出电化学缺陷对微观结构有重大影响。基于上述研究成果,本团队利用电场作用下出现的低温快速传质现象,发展了陶瓷闪焊技术,实现了同种陶瓷/陶瓷、陶瓷/金属,甚至异种陶瓷/陶瓷之间的快速连接;发展了陶瓷闪烧合成技术,不仅实现了典型氧化物陶瓷的快速合成,而且实现了高熵陶瓷和具有共晶形貌的氧化物陶瓷的快速合成;发展了氧化物陶瓷的电塑性成形技术,初步实现了氧化锆陶瓷低温低应力下的快速拉伸和弯曲变形。本文最后总结了闪烧机理研究面临的挑战,并从焦耳热效应和非焦耳热效应两方面展望了闪烧的发展方向,期望对闪烧技术在国内的发展有所裨益。

关键词：闪烧焦耳热缺陷连接合成成形综述

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利用光子筛产生局域空心光束

光学学报 2015年第7期35卷 64-69页

作者：程依光刘俊伯胡松何渝中国科学院光电技术研究所四川成都610209 中国科学院大学北京100049

为了寻找一种简单有效的产生局域空心光束的方法,提出了一种利用交错型光子筛产生空心光束的方法。通过光子筛的内部区域和外部区域相消达到轴上光强为零的目的。给出了光子筛的结构和设计参数,对空心光束中心暗斑尺寸和光子筛焦距、环... 详细信息

为了寻找一种简单有效的产生局域空心光束的方法,提出了一种利用交错型光子筛产生空心光束的方法。通过光子筛的内部区域和外部区域相消达到轴上光强为零的目的。给出了光子筛的结构和设计参数,对空心光束中心暗斑尺寸和光子筛焦距、环带数、小孔调制系数的关系进行了深入的研究,发现改变焦距和环带数可以得到微米甚至亚微米的中心暗斑的局域空心光束。理论推导和仿真分析验证了方法的可行性,该方法具有结构简单和能产生极小中心暗斑的优点,特别适用于光学镊子、原子冷却等。

关键词：衍射光子筛局域空心光束光镊