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Journal of Materials Science & Technology 2021年第1期60卷 147-155页

作者： Haoxuan Wang Shouye Wang Yejie Cao Wen liu yiguang Wang Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China School of Materials Science and Engineering Zhengzhou UniversityZhengzhouHenan 450052PR China Institute of Advanced Structure Technology Beijing Institute of TechnologyHaidian District 100081BeijingPR China

In this work,high-entropy ceramics(Hf_(0.25) Zr_(0.25)Ta_(0.25)Nb_(0.25))C(HZTNC) and HZTNC doped with 20 vol%SiC(HZTNC-SiC) were fabricated by spark plasma *** oxidation behavior was investigated over the temperature range of 1300-1500℃ for up to 60 *** HZTNC and HZTNC-SiC exhibited good oxidation resistance,and their weight change as a function of oxidation time obeyed a parabolic *** XRD,microstructure observation,and elemental mapping analysis of the oxide layers,it was found that the formation of Nb_(2) Zr_(6) O_(17),Hf_(6) Ta_(2) O_(17),and(Ta,Nb)_(2) O_(5) mixed-oxide layers effectively protected the matrix from further *** began to appear on the oxide layer of HZTNC at high temperatures after 60 min of ***,the addition of SiC in HZTNC suppressed these microcracks at high temperatures due to the active oxidation of *** with the oxides formed on HZTNC,the additional formation of Hf(Zr)SiO_(4) on HZTNC-SiC could further improve its oxidation resistance over HZTNC ceramics.

关键词： High-entropy carbide Oxidation resistance Oxidation mechanism

In-situ synthesis of Al(76.8)Fe(24) complex metallic alloy phase in Al-based hybrid composite

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Journal of Materials Science & Technology 2017年第10期33卷 1177-1181页

作者： Ke Zhao Baobao Cao Jinling liu yiguang Wang Linan An Science and Technology on Therrnostruetural Composite Materials Laboratory Northwestern Polytechnical University Xi'an 710072. China School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Traction Power School of Mechanics and Engineering Southwest Jiaotong University Chengdu 610031 China Department of Materials Science and Engineering. Advanced Materials Processing and Analysis Center University of Central Florida Orlando FL 32816 USA

The complex metallic alloy（CMA）, Al（76.8）Fe（24）, was in-situ synthesized in the Al-based hybrid composite by powder metallurgy technique. The structural analysis by X-ray diffraction, scanning electron microscopy,and transmission electron microscopy indicated that the Al（76.8）Fe（24） CMA phase was formed by diffusion of Fe atoms into the Al matrix during the sintering stage. The formation of the CMA phase was mainly determined by the sintering temperature which was just above the eutectic temperature of Al–Fe. Moreover,the fully dense Al-based hybrid composite was obtained and exhibited ultrahigh strength ～1100 MPa,indicating that this method is expected to be effective in producing CMA particle reinforced Al-based hybrid composite.

关键词： Complex metallic alloy(CMA) Mechanical alloying Aluminum Hybrid composites

High-entropy rare-earth zirconate ceramics with low thermal conductivity for advanced thermal-barrier coatings

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Journal of Advanced Ceramics 2022年第6期11卷 961-973页

作者： Debao liu Baolu SHI Liyan GENG yiguang WANG Baosheng XU Yanfei CHEN Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Shanghai Space Propulsion Technology Research Institute Shanghai 201109China

The high-entropy rare-earth zirconate((La_(0.2)Nd_(0.2)Sm_(0.2)Gd_(0.2)Yb_(0.2))_(2)Zr_(2)O_(7),5RE_(2)Zr_(2)O_(7)HEREZs)ceramics were successfully prepared by a new high-speed positive grinding strategy combined with solid-state reaction *** microstructure,crystal structure,phase composition,and thermophysical and mechanical properties of the samples were systematically investigated through various *** indicate that the samples have a single-phase defect fluorite-type crystal structure with excellent high-temperature thermal *** as-prepared samples also demonstrate low thermal conductivity(0.9–1.72 W·m^(−1)·K^(−1)at 273–1273 K)and high coefficient of thermal expansion(CTE,10.9×10^(−6)K^(−1)at 1273 K),as well as outstanding mechanical properties including large Young’s modulus(E=186–257 GPa)and high fracture toughness(KIC).Furthermore,the formation possibility of the as-prepared samples was verified through the first-principles calculations,which suggested the feasibility to form the 5RE_(2)Zr_(2)O_(7)HE-REZs in the thermodynamic ***,in view of the excellent multifunctional properties exhibited by the as-prepared 5RE_(2)Zr_(2)O_(7)HE-REZs,they have great potential applications in next-generation thermal-barrier coatings(TBCs).

关键词： high-entropy rare-earth zirconates(HE-REZs) first-principles calculations thermal conductivity thermal stability Young’s modulus thermal-barrier coatings(TBCs)

基于山水城市理论的青岛周戈庄空间形态塑造探析

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城市建筑 2022年第9期19卷 38-40,44页

作者：王勤林刘一光周依霖曹莎莎青岛理工大学建筑与城乡规划学院

在快速城镇化的进程中,现代因子打破了村落传统布局形式,进而改变了乡村传统的空间形态。对山水格局的有序利用,在传统村落空间形态塑造上展现了独特的艺术魅力,有利于创建和谐有序的空间体系。文章首先梳理山水城市的理论来源及概念,... 详细信息

在快速城镇化的进程中,现代因子打破了村落传统布局形式,进而改变了乡村传统的空间形态。对山水格局的有序利用,在传统村落空间形态塑造上展现了独特的艺术魅力,有利于创建和谐有序的空间体系。文章首先梳理山水城市的理论来源及概念,通过对周戈庄空间形态的实地调查,探讨山水形势对青岛周戈庄空间形态的塑造,概括分析山水格局对村落选址、空间布局、整体风貌的影响。以期认识“山水城市”理论的价值内涵,以尊重自然形势,关注生态文明,构建和谐的山水人文空间。

关键词：山水城市山水格局周戈庄生态和谐空间形态

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基于GIS分析的郑州地铁站点对周围住房价格的影响研究

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城市建筑 2022年第24期19卷 64-66页

作者：王勤林刘一光曹莎莎周依霖青岛理工大学建筑与城乡规划学院

城市轨道交通为人们带来便捷、舒适的同时,也增加了周边房地产的价格,科学分析轨道交通站点对周边房价的影响,对合理规划沿线房地产项目的开发和调整城市空间布局具有重大意义。本文以郑州市为研究对象,通过空间分析对郑州市地铁站与住... 详细信息

城市轨道交通为人们带来便捷、舒适的同时,也增加了周边房地产的价格,科学分析轨道交通站点对周边房价的影响,对合理规划沿线房地产项目的开发和调整城市空间布局具有重大意义。本文以郑州市为研究对象,通过空间分析对郑州市地铁站与住房的POI数据进行整理,探析地铁站对周边住房的影响规律,以此为城市交通的合理规划及空间布局提供有益参考,也为房地产市场的健康发展提供有力借鉴。

关键词：轨道交通地铁站住房价格 GIS技术空间分析

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Inhalable oridonin-loaded poly(lactic-co-glycolic)acid large porous microparticles for in situ treatment of primary non-small cell lung cancer

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Acta Pharmaceutica Sinica B 2017年第1期7卷 80-90页

作者： Lifei Zhu Miao Li Xiaoyan liu Lina Du yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation Medicine Anhui Medical University Department of Pharmacy Yangpu HospitalTongji University School of Medicine

Non-small cell lung cancer(NSCLC) accounts for about 85% of all lung cancers. Traditional chemotherapy for this disease leads to serious side effects. Here we prepared an inhalable oridonin-loaded poly(lactic-co-glycolic)acid(PLGA) large porous microparticle(LPMP) for in situ treatment of NSCLC with the emulsion/solvent evaporation/freeze-drying method. The LPMPs were smooth spheres with many internal pores. Despite a geometric diameter of 10 mm, the aerodynamic diameter of the spheres was only 2.72 mm, leading to highly efficient lung deposition. In vitro studies showed that most of oridonin was released after 1 h, whereas the alveolar macrophage uptake of LPMPs occurred after 8 h, so that most of oridonin would enter the surroundings without undergoing phagocytosis. Rat primary NSCLC models were built and administered with saline, oridonin powder, gemcitabine, and oridonin-loaded LPMPs via airway, respectively. The LPMPs showed strong anticancer effects. Oridonin showed strong angiogenesis inhibition and apoptosis. Relevant mechanisms are thought to include oridonin-induced mitochondrial dysfunction accompanied by low mitochondrial membrane potentials, downregulation of BCL-2 expressions, upregulation of expressions of BAX, caspase-3 and caspase-9. The oridonin-loaded PLGALPMPs showed high anti-NSCLC effects after pulmonary delivery. In conclusion, LPMPs are promising dry powder inhalations for in situ treatment of lung cancer.

关键词： Large porous microparticle Non-small cell lung cancer Oridonin Poly(lactic-co-glycolic) acid Pulmonary delivery

Strategies for mitigating detrimental effects in cyber-physical multiplex networks

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Science China(Information Sciences) 2024年第6期67卷 453-454页

作者： Yudong GONG Shenghai YANG Sanyang liu Pei WANG yiguang BAI School of Mathematics and Statistics Xidian University

Detrimental effects,such as widespread epidemics or rumors,can inflict significant damage on society in a remarkably short time[1].Various studies have focused on mitigating these effects independently within single-l... 详细信息

关键词： Cost effectiveness

Single-phase formation mechanism and dielectric properties of sol-gel-derived Ba(Ti_(0.2)Zr_(0.2)Sn_(0.2)Hf_(0.2)Ce_(0.2))O_(3) high-entropy ceramics

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Journal of Materials Science & Technology 2022年第35期130卷 103-111页

作者： Jia liu Cuiying Ma Lianli Wang Ke Ren Hongpei Ran Danni Feng Huiling Du yiguang Wang College of Materials Science and Engineering Xi’an University of Science and TechnologyXi’an 710054China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Advanced Materials and Electronic Components Guangdong Fenghua Advanced Technology Holding Co.Ltd.Zhaoqing 526020China

Single-phase Ba(Ti_(0.2)Zr_(0.2)Sn_(0.2)Hf_(0.2)Ce_(0.2))O_(3)(BTZSHC) high-entropy ceramics(HECs) with the perovskite structure were successfully prepared via the sol-gel *** results reveal that the as-prepared ceramics exhibit a single cubic phase belonging to the Pm3 m space *** high entropy is the driving force of the formation of single-phase ceramics.A larger entropy(ΔS_(mix)) and a negative enthalpy(ΔH_(mix)) are conducive to the formation of single-phase ***,ΔS_(mix)=0.323 R mole-1andΔH_(mix)=43.88 kJ/*** sluggish-diffusion effect ensures the thermal stability of high-entropy *** measurements reveal that the as-prepared BTZSHC high-entropy ceramics are relaxor ferroelectrics,and the degree of relaxor(γ) is *** relaxor behavior of the as-prepared ceramics can be ascribed to the relaxation and thermal evolution of their polar units(PUs).The findings of this work provide a theoretical basis and technical support for the preparation of single-phase high-entropy ceramics.

关键词： High-entropy ceramics Single-phase formation mechanism Perovskite structure Sol-gel method Dielectric properties

Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2522-2532页

作者： Ting Chen Bo Zhuang Yueqi Huang Yan liu Bochuan Yuan Wanmei Wang Tianyu Yuan Lina Du yiguang Jin Guangdong Pharmaceutical University Guangzhou 510006China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Chemical Defense Institute of NBC DefenseBeijing 102205China

Radiation therapy is an effective method to kill cancer cells and shrink tumors using highenergy X-ray or γ-ray. Radiation pneumonitis(RP) is one of the most serious complications of radiation therapy for thoracic cancers, commonly leading to serious respiratory distress and poor prognosis. Here,we prepared curcumin-loaded mesoporous polydopamine nanoparticles(CMPN) for prevention and treatment of RP by pulmonary delivery. Mesoporous polydopamine nanoparticles(MPDA) were successfully synthesized with an emulsion-induced interface polymerization method and curcumin was loaded in MPDA via π-π stacking and hydrogen bonding interaction. MPDA owned the uniform spherical morphology with numerous mesopores that disappeared after loading curcumin. More than 80% curcumin released from CMPN in 6 h and mesopores recovered. CMPN remarkably protected BEAS-2 B cells from γ-ray radiation injury by inhibiting apoptosis. RP rat models were established after a single dose of15 Gy^(60)Co γ-ray radiation was performed on the chest area. Effective therapy of RP was achieved by intratracheal administration of CMPN due to free radical scavenging and anti-oxidation ability, and reduced proinflammatory cytokines, high superoxide dismutase, decreased malondialdehyde, and alleviated lung tissue damages were observed. Inhaled CMPN paves a new avenue for the treatment of RP.

关键词： Radiation pneumonitis Curcumin Mesoporous Polydopamine Nanoparticle Pulmonary delivery Inhalation Free radical scavenging

CmMYB3-like negatively regulates anthocyanin biosynthesis and flower color formation during the post-flowering stage in Chrysanthemum morifolium

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Horticultural Plant Journal 2024年第1期10卷 194-204页

作者： Lijie Zhou Shenhui liu yiguang Wang Yuxi Wang Aiping Song Jiafu Jiang Sumei Chen Zhiyong Guan Fadi Chen State Key Laboratory of Crop Genetics and Germplasm Enhancement The Key Laboratory of LandscapingMinistry of Agriculture and Rural AffairsCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

Color fading caused by a decrease in anthocyanin accumulation during the post-flowering stage significantly affects postharvest quality of ***,the underlying mechanism by which anthocyanin accumulation decreases during the post-flowering stage still unclear,which greatly restricts design of molecular breeding in ***,a chrysanthemum SG7 R2R3 MYB transcription factor(TF),CmMYB3-like,was identified to have a function in regulating anthocyanin biosynthesis during the post-flowering *** real time PCR(qRT-PCR)assays showed that the expression of CmMYB3-like was gradually downregulated when anthocyanin content increased during the flowering stage and was significantly upregulated during the post-flowering *** transformation of chrysanthemum and dual-luciferase assays in *** leaves showed that CmMYB3-like suppressed anthocyanin accumulation by inhibiting the transcription of CmCHS and CmANS directly and that of CmF3H ***,overexpression or suppression of CmMYB3-like did not affect the biosynthesis of flavones or *** transformation of chrysanthemum revealed that the overexpression of CmMYB3-like inhibited anthocyanin accumulation,but its suppression prevented the decrease in anthocyanin accumulation during the post-flowering *** results revealed a crucial role of CmMYB3-like in regulating the color of petals during the post-flowering stage and provided a target gene for molecular design breeding to improve the postharvest quality of chrysanthemum.

关键词： Post-flowering stage Color fading Anthocyanins CmMYB3-like Chrysanthemum Molecular breeding