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Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy

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Particuology 2022年第5期20卷 35-42页

作者： Wei Xiang xue liu Lili Zhang Chao liu Gang liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public Health.Xiamen UniversityXiamen 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and National Institute of Diagnostics and Vaccine Development in Infectious Disease School of Public HealthXiamen UniversityXiamen 361102China ShenZhen Research Institute of Xiamen University.Shenzhen 518057 China

Functionalized nanoparticles are widely used in drug targeted delivery and immune microenvironment *** a new type of biomaterial,cell-derived carriers are receiving considerable attention in clinical translation owing to their desirable biocompatibility and lower ***,cell membrane-encapsulated nanoparticles can achieve specific biological effects from the benefit of their parent cell *** this review,we introduce the cell membrane coating technologies that are under extensive investigation,we also summarize various applications that have been developed for immunotherapy,and discuss the prospects in this *** further understanding and integration with advanced biotechnology methods,it is believed that the continuing development of cell membrane-encapsulated nanoparticles will achieve promotion in clinical application.

关键词： Cell membrane Nanoparticle Vaccine Immunotherapy

PHASE BEHAVIOR OF CHARGE STABLIZED COLLOID DISPERSION WITH ADDED WATER SOLUBLE POLYMERS

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Chinese Journal of Polymer Science 2013年第9期31卷 1218-1224页

作者： Jia-xue liu Yong-feng Men State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Demixing and colloidal crystallization in the mixture of charge stabilized colloidal poly（methyl methacrylate） particles and soluble poly（ethylene oxide） were investigated by means of synchrotron small-angle X-ray scattering （SAXS） technique. Phase diagram of the mixture was obtained based on visual inspection and SAXS results. The phase behavior is determined as a function of the concentration of the polymer as well as the volume fraction of the colloidal particles. The system shows a one phase region when the concentration of the polymer is low, whereas a two-phase region is present when the concentration of the polymer is larger than a critical concentration at certain volume fraction of the colloids. Interestingly, a face centered cubic colloidal crystalline structure was formed under certain conditions, which has been rarely observed in experiments of colloid-polymer mixtures with competing interactions.

关键词： Colloid-polymer mixture Phase behavior Crystallization.

Separation of salidroside from the fermentation broth of engineered Escherichia coli using macroporous adsorbent resins

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Chinese Journal of Chemical Engineering 2022年第4期35卷 260-267页

作者： Xiaocui Sun xue liu Guang-Rong Zhao Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Georgia Tech Shenzhen Institute Tianjin UniversityShenzhen 518071China

Salidroside(8-O-β-D-glucoside of tyrosol),a plant-derived natural product,is used for treatment of hypoxia,fatigue and aging *** availability of salidroside is restricted since it is extracted from3-5 years old Rhodiola roots,which grow very slowly in the cold region of northern hemisphere of *** laboratory has constructed an engineered Escherichia coli and established a fermentation process to produce salidroside from *** this article,nine macroporous resins from polarity to non-polarity,including NKA-9,S-8,AB-8,SP825,D101,LSA-8,LX-12,LX-18 and LX-68 resins,were tested to separate salidroside from fermentation *** static and dynamic experiments,the weakly polar SP825 resin had a better separation efficiency among nine *** adsorption kinetic and isotherm of salidroside on the SP825 resin were determined,and the pseudo-second-order kinetic model and Langmuir model could be fitted *** effects of the pH on adsorption and ethanol concentration on desorption were investigated,and an optimal separation process was *** adsorption for salidroside in the SP825 resin column was conducted with loading 150 ml at pH 7,and desorpted by washing 50 ml of80%ethanol *** the best process conditions,the purity and yield of salidroside in the final product were 91.6%and 74.0%,*** results showed that the macroporous SP825 resin would be feasible and effective to prepare salidroside and has promising application in the downstream process of microbial fermentation.

关键词： Adsorption Desorption Fermentation Macroporous resin Salidroside

Therapeutic Value of Estrogen Receptorαin Hepatocellular Carcinoma Based on Molecular Mechanisms

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 140-146页

作者： Xiangzhe Meng xue liu Second Clinical College Jining Medical UniversityJiningShandongChina Department of Pathology College of Basic MedicineJining Medical UniversityJiningShandongChina

The incidence of hepatocellular carcinoma(HCC)is signifi-cantly lower in women than men,implying that estrogen receptors(ERs)may play an important role in this sex ***,considerable progress has been made in expanding our understanding of the mechanisms of ERs in *** one of the most important ERs,ERαfunctions as a tumor suppressor in the progression of HCC through various pathways,such as STAT3 signaling pathways,lipid metabolism-related signaling pathways,and non-coding ***,the function of ERαwas reduced with the changes of some molecules in the liver,which may develop further into HCC and make it difficult to achieve an effective hormone treatment ***,there are signs that individualized hormone therapy according to the activity of ERαwill overcome this *** on these observa-tions,it is particularly imperative to reassess and extend the function of ERα.In this review,we mainly elucidated molecular mechanisms associated with ERαin HCC and investigated the individualized hormone therapy based on these mechanisms,with the aim of providing new insights for HCC treatment.

关键词： Hepatocellular carcinoma Estrogen receptor Molecular mechanism Hormone therapy Precision medicine

Comparative analysis of the complete chloroplast genomes of six white oaks with high ecological amplitude in China

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Journal of Forestry Research 2021年第5期32卷 2203-2218页

作者： xue liu Ermei Chang Jianfeng liu Zeping Jiang Key Laboratory of Tree Breeding and Cultivation of National Forestry and Grassland Administration Research Institute of ForestryChinese Academy of ForestryBeijing 100091China Key Laboratory of Forest Ecology of National Forestry and Grassland Administration Environment and ProtectionResearch Institute of Forest EcologyEnvironment and ProtectionChinese Academy of ForestryBeijing 100091China

Quercus *** significant societal,ecological and economic benefits in the Northern ***,species identification among oaks is notoriously *** harbours highly diverse oaks,of which the diversity of white oaks is the most extensive;however,to date,the evolution of chloroplast(cp)genomes in white oaks in China has not been comprehensively ***,we sequenced the complete cp genomes(161,254 bp,161,229 bp and 161,254 bp in size)of three white oak species(Quercus serrata *** ***,Quercus wutaishansea Mary and Quercus mongolica Fischer ex Ledebour,respectively).Six white oak species(Quercus aliena Blume,Quercus dentata Thunb.,Quercus aliena Blume *** Maximowicz ex Wenzig,*** ***,*** and ***)and five other Fagaceae species(Quercus rubra L.,Quercus variabilis Bl.,Quercus *** *** Wils.,Fagus engleriana *** Castanea henryi Skan *** Wils.)were retrieved for comparative *** detected11 highly divergent regions(psbA,matK/rps16,rps16,trnSGCU/trnG-GCC,trnR-UCU/atpA,trnT-GGU/psbD,ndhJ,ndhJ/ndhK,accD,ndhF and ycfl)through comparative analyses and these regions might be used as molecular ***ωratio of the rps12,rpoC2 and ycf1 genes was greater than 1 in several comparison groups between white oaks and the petA gene was subjected to significant positive selection between the comparison of six white oaks and *** analyses revealed that six white oaks were grouped with ***,forming a single clade.

关键词： White oaks China Plastid genome Comparative analysis Positive selection petA

Magnesium-rich gangue dissolution in column bioleaching of chalcopyrite

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Rare Metals 2015年第5期34卷 366-370页

作者： xue liu Jian-Kang Wen Biao Wu Shuang liu National Engineering Labortory of Biohydrometallurgy General Research Institute for Nonferrous Metals

This study is to assess the effect of magnesiumrich gangue dissolution on the ore containing chalcopyrite and carrollite from Democratic Republic of the Congo （DRC）. The ore contains 11.0 wt% magnesium and 2.4 wt% copper. When Mg^2＋ concentration is over 20 g·L^-1 after 2 months in column bioleaching, the redox potential of leachate keeps stable, much less than that when Mg2＋ concentration is below 20 g·L^-1. Meanwhile, the extractions of Cu^2＋ and Co^2＋ from chalcopyrite with carrollite obviously inhibited by Mg^2＋ concentration of over 20 g·L^-1 were investigated. The extraction of cobalt depends on chalcopyrite dissolved in column reactor. The growth and oxidation activity of bacteria are affected by high Mg^2＋ concentration （〉20 g·L^-1） in leachate of column reactor. As the rate of gangue dissolution depends on the amount of sulfuric acid, the decrease of the particle size relates to the increase of the total particle surface area and acid consumption. Therefore, the operation of pre-leaching for magnesium removal is not the most effective and economical way to solve the problem of magnesium-rich gangue minerals dissolution.

关键词： Magnesium-rich Column bioleaching Chalcopyrite Carrollite

Towards a Cost-Efficient MapReduce:Mitigating Power Peaks for Hadoop Clusters

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Tsinghua Science and Technology 2014年第1期19卷 24-32页

作者： Nan Zhu xue liu Jie liu Yu Hua School of Computer Science McGill UniversityMontrealH3ACanada Microsoft Research RedmondWA 980526399USA WNLO School of ComputerHuazhong University of Science and Technology

Distributed data processing system is becoming one of the most important components for data-intensive computational tasks in the enterprise software infrastructure. Deploying and operating such systems require large amount of costs, including hardware costs to build clusters and energy costs to run clusters. To make these systems sustainable and scalable, power management has been an important research problem. In this paper, we take Hadoop as an example to illustrate the power peak problem which causes power inefficiency and provides in-depth analysis to explain issues with existing system designs. We propose a novel power capping module in the Hadoop scheduler to mitigate power peaks. Extensive simulation studies show that our proposed solution can effectively smooth the power consumption curve and mitigate temporary power peaks for Hadoop clusters.

关键词： power peaks power management MapReduce

Mixtures of Semiparametric Varying Coefficient Models for Longitudinal Data with Nonignorable Dropout

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Acta Mathematicae Applicatae Sinica 2010年第1期26卷 125-132页

作者： Zhi-qiang Li liu-gen xue College of Sciences Beijing University of Chemical Technology Beijing 100029 China College of Applied Sciences Beijing University of Technology Beijing 100022 China

Informative dropout often arise in longitudinal data. In this paper we propose a mixture model in which the responses follow a semiparametric varying coefficient random effects model and some of the regression coefficients depend on the dropout time in a non-parametric way. The local linear version of the profile-kernel method is used to estimate the parameters of the model. The proposed estimators are shown to be consistent and asymptotically normal, and the finite performance of the estimators is evaluated by numerical simulation.

关键词： Nonignorable dropout, Estimating equation, Profile-kernel, Local linear estimation, Longitudinal data Semiparametric varying coefficient

Variable Selection for Semiparametric Varying-Coefficient Partially Linear Models with Missing Response at Random

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Acta Mathematica Sinica,English Series 2011年第11期27卷 2205-2216页

作者： Pei Xin ZHAO liu Gen xue Department of Mathematics Hechi University Yizhou 546300 P. R. China College of Applied Sciences Beijing University of Technology Beijing 100124 P. R. China

In this paper, we present a variable selection procedure by combining basis function approximations with penalized estimating equations for semiparametric varying-coefficient partially linear models with missing response at random. The proposed procedure simultaneously selects significant variables in parametric components and nonparametric components. With appropriate selection of the tuning parameters, we establish the consistency of the variable selection procedure and the convergence rate of the regularized estimators. A simulation study is undertaken to assess the finite sample performance of the proposed variable selection procedure.

关键词： Semiparametric varying-coefficient partially linear model variable selection SCAD missing data