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Expression and Significance of NF-κB, IL-1β and COX-2 in the Murine Model of Estrogen-dependent Experimental Vulvovaginal Candidiasis

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Journal of Reproduction and Contraception 2007年第4期18卷 253-260页

作者： Xue-rong CHEN Ya-li liu Dun-zhen xiao jun GAO Reproductive Medicine Center Research Institute of Family Planning Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective To investigate the possible role of estrogen in the pathogenesis of vulvovaginal candidiasis（VVC）. Methods Estrogen-dependent experimental murine model of C. albicans vaginal infection was established by injecting subcutaneously with estradiol benzoate and then 5 × 10^6 stationary-phase C. albicans blastoconidia was inoculated intravaginally to mice （group El）, and other 3 groups were set up.＂ estrogen-treated but not infected （group E）; estrogen-untreated but infected （group I）; normal control （group C）. The dynamic change of colony-forming unit （CFU） of cervivovaginal lavage fluid was observed. Vaginal tissues at different time points （d 2, d 4, d 7 and d 14） after inoculation of C. albicans were obtained. In situ hybridization staining was used to detect expression of cyclooxygenase-2 （COX-2） mRNA and expression of nuclear factor-κB （NF-κB） was examined by immuohistochemistry. ELISA was applied to determine the interlenkin-1β （IL-1β） level. Results The constitutional high level expression of COX-2 mRNA in the vaginal tissue of group E was significantly higher than that in group C on d 4 and d 7 （P〈0. 01）, and the optical density （OD） in group EI was higher than that in the other 3 groups （P〈0.05）. There were higher IL-1β levels in vaginal tissues from d 4 to d 7 postinoculation in group EI and group I than group C （P〈0.01）. Furthermore, IL-1β in group EI was markedly elevated on d 4 and d 7 compared with group I （P〈0.01）. Compared with group C, the expression of NF-κB in group E was increased obviously on d 4 （P〈0.01）, and there was significant difference between group E1 and group I on d 4 and d 7 （P〈0.01）. Conclusions In the murine model of estrogen-dependent experimental WC, estrogen promotes the infection establishment by up-regulating expression of COX-2 via activating NF-κB signal pathway, and the high expression of COX-2 promoted by the interaction of IL-1β and NF-κB after infection formation was involved in persistence of infection.

关键词： estrogen Candida albicans vaginitis COX-2 IL-1β NF-κB

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全向入射条件下一维固流周期结构中低频声裂隙变化特性研究

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物理学报 2013年第20期62卷 267-274页

作者：刘聪徐晓东刘晓峻南京大学近代声学教育部重点实验室南京210093

利用传递矩阵法,从理论上建立了全向入射条件下一维固-流周期结构中的声传播模型,在此基础上计算、分析并比较了无限周期结构的声能带结构和有限周期结构中的声传输特性.研究结果表明,当声波以一定的入射角入射时,固-流周期结构的低频... 详细信息

利用传递矩阵法,从理论上建立了全向入射条件下一维固-流周期结构中的声传播模型,在此基础上计算、分析并比较了无限周期结构的声能带结构和有限周期结构中的声传输特性.研究结果表明,当声波以一定的入射角入射时,固-流周期结构的低频通带区域存在一个声裂隙,该声裂隙所对应的入射角大小与构成周期结构的固体层和流体层的密度或结构尺寸无关,而仅取决于构成该周期性结构材料的波速.

关键词：传递矩阵全向入射固-流周期结构声裂隙

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Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan Wei Xue jun Huang xiao Zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much *** classification algorithms are susceptible to data skew to favor majority samples and ignore minority *** weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority *** this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these ***,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority *** that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate ***,data cleaning is performed on the processed data to further eliminate class *** on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering

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非自治分数阶Duffing系统的激变现象

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物理学报 2016年第18期65卷 226-233页

作者：刘晓君洪灵江俊西北农林科技大学理学院杨凌712100 西安交通大学机械结构强度与振动国家重点实验室西安710049

对一个非自治分数阶Duffing系统的激变现象进行了研究.首先介绍了一种研究分数阶非线性系统全局动力学的数值方法,即拓展的广义胞映射方法 (EGCM).该方法是基于分数阶导数的短记忆原理,并结合了广义胞映射方法和改进的预估校正算法,根... 详细信息

对一个非自治分数阶Duffing系统的激变现象进行了研究.首先介绍了一种研究分数阶非线性系统全局动力学的数值方法,即拓展的广义胞映射方法 (EGCM).该方法是基于分数阶导数的短记忆原理,并结合了广义胞映射方法和改进的预估校正算法,根据胞空间的特点,将胞尺寸作为截断误差的参考值,以此得到了一步映射时间的估算公式.用EGCM方法分别研究了分数阶Duffing系统随分数阶导数的阶数和外激励强度变化发生的边界激变和内部激变.并基于此,将激变拓展定义为混沌基本集与周期基本集之间的碰撞,其中混沌基本集包括混沌吸引子,边界上的混沌集合以及吸引域内部的非混沌吸引子的混沌集合.所得结果进一步说明了EGCM方法对于分析分数阶系统全局动力学的有效性.

关键词：关键词分数阶系统混沌激变

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Polymer-to-Monomers Chemically Recyclable Poly(imide-imine)Plastics with Extreme-Condition Resistance and Flame Retardancy

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Chinese Journal of Polymer Science 2024年第10期42卷 1525-1535,I0012页

作者： Zhen-Yu Wang xiao-Kong liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Polyimides are a family of high-tech plastics that have irreplaceable applications in the fields of aerospace,defense,and opto-electronics,but polyimides are difficult to be reprocessed and recycled at the end of their service life,resulting in a significant waste of ***,it is of great significance to develop recyclable polyimides with comparable properties to the commercial ***,we report a novel polymer-to-monomers chemically recyclable poly(imide-imine)(PtM-CR-PII)plastic,synthesized by cross-linking the amine-terminated aromatic bisimide monomer and the hexa-vanillin terminated cyclophosphazene monomer via dynamic imine *** PtM-CR-PII plastic exhibits comparable mechanical and thermal properties as well as chemical stability to the commercial *** PtM-CR-PII plastic possesses a high Young’s modulus of≈3.2 GPa and a tensile strength as high as≈108 MPa,which also exhibits high thermal stability with a glass transition temperature of≈220℃.Moreover,the PtM-CR-PII plastic exhibits outstanding waterproofness,acid/alkali-resistance,and solvent-resistance,its appearance and mechanical properties can be well maintained after long-term soaking in water,highly concentrated acid and base,and various organic ***,the cyclophosphazene moieties endow the PtM-CR-PII plastic with excellent flame *** PtM-CR-PII plastic exhibits the highest UL-94 flame-retarding rating of V-0 and a limiting oxygen index(LOI)value of 45.5%.Importantly,the PtM-CR-PII plastic can be depolymerized in an organic solvents-acid mixture medium at room temperature,allowing easy separation and recovery of both monomers in high *** recovered pure monomers can be used to regenerate new PtM-CR-PII plastics,enabling sustainable polymer-monomers-polymer circulation.

关键词： Chemical recyclability Polyimides Polyimines Dynamic imine bonds Mechanical properties Chemical stability

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Experimental and numerical investigation of the impacts of rotor tip-rake on excitation forces of pump-jet propulsors

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Journal of Hydrodynamics 2024年第1期36卷 142-157页

作者： Xue-qin Ji xiao-song Zhang Chen-jun Yang xiao-qian Dong State Key Laboratory of Ocean Engineering Marine Numerical Experiment CentreSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China CSSC Shanghai Marine Energy Saving Technology Co. Ltd.Shanghai200011China China Ship Scientific Research Center Shanghai Branch Shanghai200011China

The tip-clearance flow in a pump-jet propulsor exerts great impacts on the fluctuating pressures and resultant unsteady forces,which are important sources of structural vibrations and radiated noise *** blade geometry close to the tip is an important factor determining the vortex strength in the tip-clearance *** the open-water condition,the effects of raking the rotor tips on the duct-surface fluctuating pressures and the resultant unsteady forces acting on different components of the propulsor are investigated via physical model experiments and the numerical solution of Reynolds-averaged Navier-Stokes(RANS)equations coupled with the SST k-ωturbulence *** measured and simulated results of hydrodynamic pressures are consistent to each other,and the simulated flows help better understand why the fluctuating pressures change with the tip *** strong fluctuations of duct-surface pressures are caused by intensive tip separation *** duct-surface pressure fluctuations are effectively reduced by using the rake distribution near the tip towards blade back side and,for the combination of the five-bladed rotor and the seven-bladed stator,the resultant unsteady horizontal(and vertical)forces acting on the duct and stator are also reduced;while increasing rake leads to negative effect on pressure fluctuations and unsteady horizontal(and vertical)forces acting on all the components of the propulsor.

关键词： Pump-jet tip-clearance tip-rake fluctuating pressures excitation forces

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Effect of solute Ce,Mn,and Si on mechanical properties of silicon steel:insights from DFT calculations

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Journal of Iron and Steel Research International 2024年第3期31卷 700-709页

作者： Xiang-jun liu Ji-chun Yang Hui-ping Ren xiao-bin Jia Ming-yi Zhang Chang-qiao Yang School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Key Laboratory of Integrated Exploitation of Bayan Obo Multi-Metal Resource Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Inner Mongolia North Heavy Industries Group Co. Ltd.Baotou 014010Inner MongoliaChina Inner Mongolia Metal Material Research Institute Baotou 014010Inner MongoliaChina

The influence of solute Ce,Mn,and Si on the mechanical properties of silicon steel was investigated by first-principles ***,Mn,and Si can all be solubilized in Fe *** significantly reduces the incompressibility and rigidity of the system but also significantly improves the toughness and *** effect of Mn on mechanical properties of the system is not *** has a significant effect on the improvement in incompressibility and rigidity but a limited effect on the improvement in toughness and *** metallic bond strength of Fe-Ce,Fe-Mn,and Fe-Si doped systems is weaker than that of the pure Fe system,which can be used to explain the reduction in the incompressibility and rigidity of these doped *** relatively high electron cloud density in the doped system may be responsible for the increase in toughness.

关键词： Silicon steel Rare earth First-principles calculation Elastic modulus Electronic structure

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Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter

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Chinese Journal of Polymer Science 2024年第8期42卷 1060-1066页

作者： Fei-Fei Wang Tian-xiao liu Ze-Wei Cui Ling-Yuan Wang Yun-Jie Dou xiao-Yu Shi Si-Wei Luo xiao-Dong Hu Zhi-jun Ren Yang-Yang liu Yu Zhao Shang-Shang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 21003China

In prevailing p-i-n perovskite solar cells(PSCs),solution-processible fullerene molecules are widely used as electron-transporting layers(ETLs)but they typically suffer from poor uniformity and undesirable stability ***,a separate bathocuproine(BCP)layer is needed to block hole tran sfer,increasing fabrication complexity and ***,we address these limitations by develo ping a novel polymeric ETL(named PF BCP)synthesized by polymerizing C_(60)with *** innovative material achieves both efficient electron transport and hole blocking,while its excellent uniformity minimizes interface recombination and enhances ***,our blade-coated PSCs utilizing PFBCP achieve a high power conversion efficiency exceeding 22%and retain 91%of initial efficiency after 1200 h of light *** development not only paves the way for commercially viable PSCs but also opens avenues for future ETL design to realize even more efficient and stable PSCs.

关键词： Polyfullerene Perovskite solar cells Electron transporter Stability

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Skeletal phenotypes and molecular mechanisms in aging mice

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Zoological Research 2024年第4期45卷 724-746页

作者： Qiao Guan Yuan Zhang Zhi-Kun Wang xiao-Hua liu jun Zou Ling-Li Zhang School of Exercise and Health Shanghai University of SportShanghai 200438China College of Athletic Performance Shanghai University of SportShanghai 200438China

Aging is an inevitable physiological process,often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health *** on skeletal diseases caused by aging in humans is challenging due to lengthy study durations,difficulties in sampling,regional variability,and substantial ***,mice are preferred for such studies due to their similar motor system structure and function to humans,ease of handling and care,low cost,and short generation *** this review,we present a comprehensive overview of the characteristics,limitations,applicability,bone phenotypes,and treatment methods in naturally aging mice and prematurely aging mouse models(including SAMP6,POLG mutant,LMNA,SIRT6,ZMPSTE24,TFAM,ERCC1,WERNER,and KL/KL-deficient mice).We also summarize the molecular mechanisms of these aging mouse models,including cellular DNA damage response,senescence-related secretory phenotype,telomere shortening,oxidative stress,bone marrow mesenchymal stem cell(BMSC)abnormalities,and mitochondrial ***,this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout

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Understanding the mechanisms and potential pathways of soil carbon sequestration from the biogeochemistry perspective

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Science China Earth Sciences 2024年第11期67卷 3386-3396页

作者： xiaojuan FENG Guohua DAI Ting liu Juan JIA Erxiong ZHU Chengzhu liu Yunpeng ZHAO Ya WANG Enze KANG jun xiao Wei LI State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences China National Botanical Garden College of Resources and Environment University of Chinese Academy of Sciences Department of Earth Sciences National Natural Science Foundation of China

Soil carbon sequestration is listed by the United Nations Framework Convention on Climate Change as one of the key ways to achieve long-term “carbon neutrality” in the context of global warming. Soil carbon sequestration is a complex biogeochemical process that involves plants, microbes, and rock minerals at its core. Yet, its regulation mechanisms and promotion pathways remain unclear. This paper reviews recent progress in the related domestic and international research and provides an overview of the key processes and mechanisms of soil carbon sequestration. The main pathways for enhancing soil carbon sequestration(including plant inputs, mineral protection, microbial transformation, and rock weathering) are summarized. The paper also discusses and synthesizes how advanced biogeochemical methods and technologies may be employed to explore soil carbon sequestration mechanisms and potentials. The overall aim of this review is to improve our understanding of soil carbon sequestration as a nature-based solution to combatting climate change from the biogeochemistry perspective, and to highlight the role of fundamental research in Earth Sciences in helping to achieve China's carbon neutrality goals.

关键词： Carbon neutrality Plant input Microbial carbon pump Mineral protection Rock weathering

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