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Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve

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Chinese Journal of Integrative Medicine 2024年第8期30卷 729-741页

作者： WANG Yuan ZHENG A-ni yang Huan WANG Qiang DAI Biao WANG Jia-ju WAN Yi-tong liu Zhi-bin liu si-yang College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China Shaanxi Key Laboratory of Acupuncture and Medicine Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine XianyangShaanxi Province712000China Department of Traditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region014040China School of Basic Medical Sciences Xi’an Medical UniversityXi’an710021China

Objective To investigate the effects and mechanisms of olfactory three-needle(OTN)electroacupuncture(EA)stimulation of the olfactory system on cognitive dysfunction,synaptic plasticity,and the gut microbiota in senescence-accelerated mouse prone 8(SAMP8)*** Thirty-six SAMP8 mice were randomly divided into the SAMP8(P8),SAMP8+OTN(P8-OT),and SAMP8+nerve transection+OTN(P8-N-OT)groups according to a random number table(n=12 per group),and 12 accelerated senescence-resistant(SAMR1)mice were used as the control(R1)*** was performed at the Yintang(GV 29)and bilateral Yingxiang(LI 20)acupoints of SAMP8 mice for 4 *** Morris water maze test,transmission electron microscopy,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)staining,Nissl staining,Golgi staining,Western blot,and 16S rRNA sequencing were performed,*** Compared with the P8 group,OTN improved the cognitive behavior of SAMP8 mice,inhibited neuronal apoptosis,increased neuronal activity,and attenuated hippocampal synaptic dysfunction(Psion levels of synaptic plasticity-related proteins N-methyl-D-aspartate receptor 1(NMDAR1),NMDAR2B,synaptophysin(SYN),and postsynaptic density protein-95(PSD95)in hippocampus were increased by OTN treatment(Psignaling and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling compared with the P8 group(Psition of SAMP8 mice,while specifically increased the genera Oscillospira and Sutterella(Psity,Firmicutes/Bacter

关键词： Alzheimer's disease olfactory threeneedle electroacupuncture olfactory nerve synaptic plasticity gut microbiota Chinese medicine

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200 V全碳化硅集成技术

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电子学报 2024年第7期52卷 2183-2189页

作者：顾勇马杰刘奥黄润华刘斯扬柏松张龙孙伟锋东南大学集成电路学院江苏南京210096 南京电子器件研究所江苏南京210016

本文提出了一种基于N衬底P外延晶圆的全碳化硅(silicon Carbide,siC)集成工艺平台,该工艺平台兼容低压互补金属氧化物半导体场效应晶体管(Complementary Metal Oxide Semiconductor field-effect transistor,CMOS)、横向扩散金属氧化物... 详细信息

本文提出了一种基于N衬底P外延晶圆的全碳化硅(silicon Carbide,siC)集成工艺平台,该工艺平台兼容低压互补金属氧化物半导体场效应晶体管(Complementary Metal Oxide Semiconductor field-effect transistor,CMOS)、横向扩散金属氧化物半导体(Laterally-Diffused MOS,LDMOS)以及高压二极管等器件.采用P型缓冲层技术调节器件垂直方向电场分布,使高压器件垂直方向耐受电压提高212.4%;在1μm厚度的P型缓冲层和1μm厚度的P型外延层上,实现LDMOS、高压二级管和高侧区域耐受电压大于300 V.基于该工艺平台,搭建了siC CMOS反相器和反相器链电路,均实现了0~20 V轨至轨的电压输出;设计了半桥驱动电路,低压侧驱动电路由四阶反相器构成;高压侧驱动电路由电平移位电路和高侧区域反相器链电路组成,实现了180~200 V浮空栅极驱动信号输出.

关键词：碳化硅(siC) 集成碳化硅集成电路碳化硅反相器碳化硅横向扩散金属氧化物半导体

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教育生态视角下海外华文教育区域整合发展的路径研究

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齐齐哈尔大学学报（哲学社会科学版） 2024年第2期 168-172页

作者：杨岭纪梦茹刘思洋杨佳茵集美大学陈嘉庚研究院福建厦门361021 集美大学师范学院福建厦门361021

海外华文教育区域整合发展契合华文教育生态系统中生态因子的区域分化,是海外华文教育发展的内在需求,是构建“一带一路”教育共同体的重要基础,同时也是区城社会发展的客观需要。教育生态视角下海外华文教育区域整合发展要夯实科学、... 详细信息

海外华文教育区域整合发展契合华文教育生态系统中生态因子的区域分化,是海外华文教育发展的内在需求,是构建“一带一路”教育共同体的重要基础,同时也是区城社会发展的客观需要。教育生态视角下海外华文教育区域整合发展要夯实科学、全面的宏观统筹与法律保障,打造华文教育生态链;明确区域华文教育的责任与使命,增强华文教育生态系统的协同互动;强化海外华人基本盘,以文化认同为枢纽建立华文教育群落生态;以可持续发展为原则,促进华文教育区域资源的高效整合;基于生态平衡法则,建立华文教育区城化发展评价体系。

关键词：教育生态学华文教育区域整合

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Over-sampling basis expansion model aided channel estimation for OFDM systems with ICI

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 7-13页

作者： liu si-yang liu Yuan-an WANG Fei-fei XIE Gang ZHANG Ran-ran Key Laboratory of Universal Wireless Communications (Beijing University of Posts and Telecommunications) Ministry of Education Beijing 100876 China

The rapid variation of channel can induce the intercarrier interference in orthogonal frequency-division multiplexing （OFDM） systems. Intercarrier interference will significantly increase the difficulty of OFDM channel estimation because too many channel coefficients need be estimated. In this article, a novel channel estimator is proposed to resolve the above problem. This estimator consists of two parts： the channel parameter estimation unit （CPEU）, which is used to estimate the number of channel taps and the multipath time delays, and the channel coefficient estimation unit （CCEU）, which is used to estimate the channel coefficients by using the estimated channel parameters provided by CPEU. In CCEU, the over-sampling basis expansion model is resorted to solve the problem that a large number of channel coefficients need to be estimated. Finally, simulation results are given to scale the performance of the proposed scheme.

关键词： OFDM ICI over-sampling basis expansion model (OBEM)

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基于一个四维超混沌系统的图像加密算法

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计算机仿真 2024年第4期41卷 237-244,259页

作者：王越安新磊施倩倩刘思洋兰州交通大学数理学院甘肃兰州730070

针对低维混沌系统复杂性低、应用在图像加密中效果差等问题,通过相图、分岔图、Lyapunov指数谱以及谱熵复杂度等方面探究了一个四维超混沌系统的动力学特性及其加密应用。仿真结果表明上述系统的混沌状态分布在较大的参数范围内并且具... 详细信息

针对低维混沌系统复杂性低、应用在图像加密中效果差等问题,通过相图、分岔图、Lyapunov指数谱以及谱熵复杂度等方面探究了一个四维超混沌系统的动力学特性及其加密应用。仿真结果表明上述系统的混沌状态分布在较大的参数范围内并且具有较大的复杂度值,说明上述系统能够很好的应用于图像加密。为此设计了一种基于四维超混沌的图像加密方案。算法主要利用改进的Arnold变换将明文图像的像素点位置进行扰乱,并通过加取模运算对置乱后的图像进行扩散,得到加密图像。最后通过密钥空间、相邻像素间相关性、信息熵、直方图以及差分攻击等方面分析了算法的安全性能。实验结果表明,上述加密算法不仅能够有效地对图像进行加密而且具有较高的安全性能。

关键词：超混沌系统置乱扩散图像加密

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晚期肺腺癌瘤内趋化因子CCR1、CXCR6和CXCL9对免疫治疗的预测及预后作用分析

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循证医学 2024年第2期24卷 107-114页

作者：钟思敏张东东李扬秋吴一龙刘思阳金真伊暨南大学生命科学技术学院广州510632 暨南大学第一附属医院胸外科广州510632 暨南大学基础医学与公共卫生学院血液学研究所再生医学教育部重点实验室广州510632 暨南大学第一附属医院血液科广州510632 暨南大学基础医学与公共卫生学院病理学系广州510632 广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080

目的构建能够预测晚期肺腺癌(lung adenocarcinoma,LUAD)患者免疫检查点阻断(immune checkpoint blockade,ICB)治疗疗效与预后的趋化因子模型。方法从既往研究数据中回顾性收集确诊为晚期LUAD且经过ICB治疗的42例患者(训练队列),取得其... 详细信息

目的构建能够预测晚期肺腺癌(lung adenocarcinoma,LUAD)患者免疫检查点阻断(immune checkpoint blockade,ICB)治疗疗效与预后的趋化因子模型。方法从既往研究数据中回顾性收集确诊为晚期LUAD且经过ICB治疗的42例患者(训练队列),取得其ICB治疗前肿瘤组织转录组测序数据,通过生物信息学方法,筛选出显著影响ICB治疗疗效与患者生存预后的趋化因子,通过无进展生存期(progression-free disease,PFS)评价疗效,通过总生存期(overall survival,OS)评价患者的预后。从高通量基因表达数据库(Gene Expression Omnibus,GEO)中的数据集(GSE 135222)下载25例非小细胞肺癌(non-small cell lung cancer,NSCLC)转录组测序数据和相关的生存数据,将其作为验证队列。结果通过单因素Cox回归分析,筛选出9个与晚期LUAD患者良好OS显著相关的趋化因子,其中CCR1、CXCR6和CXCL9高表达的患者明显具有更长的OS。基于这3个趋化因子的表达量构建风险模型,生存分析结果表明风险分数与患者的PFS和OS呈负相关,即低风险(risk score≤-1.33)的晚期LUAD患者在ICB治疗中明显获益更多。低风险组中位PFS为19.7个月对比高风险组(risk score>-1.33)2.9个月[95%可信区间(confidence interval,CI)为0.12~0.51,P-1.85)为2.7个月对比1.2个月(95%CI 0.12~0.93,P=0.009)。结论CCR1、CXCR6和CXCL9高表达表明晚期LUAD患者疾病进展的风险较低,与患者良好的PFS和OS相关,可能为晚期LUAD患者的ICB辅助治疗提供新的方向。

关键词： CCR1 CXCR6 CXCL9 肺腺癌免疫检查点阻断治疗

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Ferrihydrite transformation impacted by coprecipitation of lignin:Inhibition or facilitation?

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Journal of Environmental Sciences 2024年第5期139卷 23-33页

作者： Lin liu Zhihui yang Weichun yang Wen Jiang Qi Liao Mengying si Feiping Zhao School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution(CNERC-CTHMP) Changsha 410083China

Lignin is a common soil organic matter that is present in soils,but its effect on the transformation of ferrihydrite(Fh)remains *** matter is generally assumed to inhibit Fh ***,lignin can reduce Fh to Fe(Ⅱ),in which Fe(Ⅱ)-catalyzed Fh transformation ***,the effects of lignin on Fh transformation were investigated at 75℃ as a function of the lignin/Fh mass ratio(0-0.2),pH(4-8)and aging time(0-96 hr).The results of Fh-lignin samples(mass ratios=0.1)aged at different pH values showed that for Fh-lignin the time of Fh transformation into secondary crystalline minerals was significantly shortened at pH 6 when compared with pure Fh,and the Fe(Ⅱ)-accelerated transformation of Fh was strongly dependent on *** pH 6,at low lignin/Fh mass ratios(0.05-0.1),the time of secondary mineral formation decreased with increasing lignin *** high lignosulfonate-content material(lignin:Fh=0.2),Fh did not transform into secondary minerals,indicating that lignin content plays a major role in Fh *** addition,lignin affected the pathway of Fh transformation by inhibiting goethite formation and facilitating hematite *** effect of coprecipitation of lignin on Fh transformation should be useful in understanding the complex iron and carbon cycles in a soil environment.

关键词： Ferrihydrite transformation Lignin Hematite Goethite Fe(Ⅱ)-catalyzed Reactive Fe(Ⅲ)species

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中国MET异常非小细胞肺癌临床诊疗现状调研

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循证医学 2024年第2期24卷 97-106页

作者：甘彬刘思阳严红虹吴一龙广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080 暨南大学附属第一医院血液科广州510630

目的非小细胞肺癌(non-small cell lung cancer,NSCLC)中间充质上皮转化因子(mesenchymal epithelial transition factor,MET)异常主要包括MET基因第14号外显子(MET exon 14)跳跃突变(简称METex14跳突)、MET基因扩增及MET蛋白过表达等。METex14跳突是NSCLC的原发致癌驱动变异,在NSCLC患者中的发生率约为0.9%~4%,目前国内外已有多个针对METex14跳突的靶向药物获批上市。NSCLC中原发MET基因扩增发生率约为1%~5%,与不良预后相关。MET基因扩增更常继发于其他驱动基因阳性NSCLC患者靶向治疗后,是表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI)耐药的重要机制之一。本调研旨在了解国内MET异常NSCLC患者的诊疗现状、受访医师对MET抑制剂的认知、对于MET异常NSCLC患者治疗决策的考量,同时探求临床实践中未被满足的需求。方法限定时间内诊治过MET异常的医师通过在线问卷形式参与调研,并对结果进行汇总和描述性分析。结果调研共回收140份有效问卷。对于METex14跳突NSCLC,无论初治还是经治,超过50%的受访医师首选MET-TKI单药治疗。≥3级不良事件发生率是最为关注的安全性指标,最关注的不良反应有肺炎、肝毒性和胃肠道不良反应等,对于MET-TKI导致的外周水肿关注度不高。对于EGFR-TKI耐药后MET扩增NSCLC,受访医师首选MET-TKI和EGFR-TKI双靶联合的治疗方案。大型随机对照研究更充分证据、检测有待规范和临床共识是EGFR-TKI耐药后MET扩增NSCLC主要的未被满足的需求。结论MET-TKI在METex14跳突NSCLC的首选比例仍有待提升,对于METTKI导致的外周水肿的关注度需提高以帮助更科学地进行管理。针对不同类型的MET变异的检测还需进一步标准化和规范化。

关键词：非小细胞肺癌 METex14跳跃突变 MET基因扩增现状调研

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Facile synthesis of W-Mo bimetallic oxides with high adsorption properties from secondary resources

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Tungsten 2024年第4期6卷 806-820页

作者： Jia-Li Cheng yang-si liu Xiao-Li Xi Zuo-Ren Nie Collaborative Innovation Center of Capital Resource-Recycling Material Technology College of Materials Science and Engineering Beijing University of Technology National Engineering Laboratory for Industrial Big-Data Application Technology Beijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Beijing University of Technology

A simple solvothermal method was used to obtain W-Mo bimetallic oxides from W-Mo alloy scrap,and pure metal powders were also used as the raw materials to simulate *** products had a sea urchin-like structure with abundant oxygen vacancies and the products prepared at low temperatures forms a sosoloid resembling orthorhombic *** WMo bimetallic oxide prepared at the reaction temperature of 120 ℃ exhibited excellent selective adsorption performance for methylene blue（MB）,which the adsorption rate of MB reached 99% in 12 min and the adsorption rate reached 90% after6 adsorption *** the W-Mo molar ratio is 1:3,the maximum adsorption capacity of sample for MB can reach1148 mg·*** adsorption process followed the Langmuir and pseudo-second-order models,which is surface-controlled monolayer *** experimental results show the feasibility of preparing W-Mo bimetal oxide products from pure materials and *** process is simple and effective,which offered a potential approach for secondary resource recycling and reusing.

关键词： Oxygen vacancy Selective adsorption Solvothermal W–Mo alloy scrap W–Mo bimetallic oxide

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The codon-optimized capsid gene of duck circovirus can be highly expressed in yeast and self-assemble into virus-like particles

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Journal of Integrative Agriculture 2017年第7期16卷 1601-1608页

作者： yang Cui XU Yu JIA Ren-yong liu si-yang WANG Ming-shu ZHU De-kang CHEN Shun liu Ma-feng ZHAO Xin-xin SUN Kun-feng JING Bo YIN Zhong-qiong CHENG An-chun Avian Disease Research Centre Sichuan Agricultural UniversityChengdu 611130P.R.China Institute of Preventive Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130P.R.China Key Laboratory of Animal Disease and Human Health of sichuan Province Chengdu 611130P.R.China

The capsid （Cap） protein, which is the only structural protein of duck circovirus （DuCV）, is the most important antigen for the development of vaccines against DuCV and the virus＇s serological diagnostic methods. In order to use yeast expression system to produce a large quantities of DuCVCap protein which is close to its natural form to display the antigen peptides perfectly, the Cap gene was optimized into the codon-optimized capsid （Opt-Cap） gene towards the preference of yeast firstly. Then, the genes of Cap and Opt-Cap were separately cloned into pPIC9K plasmid and transformed into Picha pas- toris GSl15. The strains that displayed the phenotype of Mut~ and contained multiple inserts of expression cassette were selected from those colonies. After the induction expression, the secretory type of Cap protein, which was about 43 kDa, was best expressed under 0.5% （v/v） methanol and sorbitol induction. Compared with the Cap gene, the expression level of Opt-Cap gene was much higher. What＇s more, the purified Cap protein had a good reactivity to its specific polyclone antibody and DuCV-positive serum, and it was able to self-assemble into virus-like particles （VLPs）. These VLPs, with a diameter of 15-20 nm and without a nucleic acid structure, showed a high level of similarity to DuCV particles in size and shape. All of the resultsdemonstrated that, based on the codon-optimization, it is suitable to use the P. pastoris expression system to produce DuCV VLPs on a large scale. It is the first time that a large amounts of DuCV VLPs were produced successfully in P. pastoris, which might be particularly useful for the further studies of serological diagnosis and vaccines of DuCV.

关键词： capsid gene codon'optimization duck circovirus virus-like particles

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