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Association between Serum Uric Acid and the Early Marker of Kidney Function Decline among Chinese Middle-Aged and Older Population:Evidence from the China Health and Retirement Longitudinal Study

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Biomedical and Environmental Sciences 2023年第3期36卷 231-240页

作者： TANG Xu XU Lu MENG Ruo Gu DU Yi Qing liu shi jun ZHAN Si Yan XU Tao Department of Urology Peking University People’s HospitalBeijing 100044China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China National Institute of Health Data Science Center for Data Science in Health and MedicinePeking UniversityBeijing 100191China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Center for Intelligent Public Health Institute for Artificial IntelligencePeking UniversityBeijing 100191China

Objective To evaluate the association between serum uric acid(SUA)and kidney function decline.Methods Data was obtained from the China Health and Retirement Longitudinal Study on the Chinese middle-aged and older population for analysis.The kidney function decline was defined as an annual estimated glomerular filtration rate(e GFR)decrease by>3 mL/min per 1.73 m^(2).Multivariable logistic regression was applied to determine the association between SUA and kidney function decline.The shape of the association was investigated by restricted cubic splines.Results A total of 7,346 participants were included,of which 1,004 individuals(13.67%)developed kidney function decline during the follow-up of 4 years.A significant dose-response relation was recorded between SUA and the kidney function decline(OR 1.14,95%CI 1.03-1.27),as the risk of kidney function decline increased by 14%per 1 mg/d L increase in SUA.In the subgroup analyses,such a relation was only recorded among women(OR 1.22,95%CI 1.03-1.45),those aged5 mg/dL was associated with a significantly higher risk of kidney function decline.Conclusion The SUA level was associated with kidney function decline.An elevation of SUA should therefore be addressed to prevent possible kidney impairment and dysfunction.

关键词： Uric acid Glomerular filtration rate Kidney function decline

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强震作用下泄水建筑物混凝土损伤分析及抗震配筋措施研究

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水电能源科学 2024年第6期42卷 106-110页

作者：刘世骏戴波王亚坤南京水利科学研究院江苏南京210029

地震作用下混凝土结构会产生不同程度的损伤开裂,这直接影响强震频发区水电站的运行安全,在工程实践中配筋作为常见的抗震措施,但具体方案却不够明确。为此,以西南地区某水电站泄水建筑物为例,采用混凝土塑性损伤模型对溢流坝进行动力... 详细信息

地震作用下混凝土结构会产生不同程度的损伤开裂,这直接影响强震频发区水电站的运行安全,在工程实践中配筋作为常见的抗震措施,但具体方案却不够明确。为此,以西南地区某水电站泄水建筑物为例,采用混凝土塑性损伤模型对溢流坝进行动力时程有限元计算,分析强震荷载作用下坝体拉伸损伤的发展特性。在此基础上,考虑不同局部配筋加固方案,应用分离式模型模拟结构的动力特征和动力响应,研究不同局部配筋措施的抗震效果。结果表明,动力损伤分析得出的拉伸损伤严重部位作为配筋区域较为合理,局部配筋有效改善了坝体的抗震性能,且对钢筋数量与间距进行调整后可进一步优化抗震效果,为工程中溢流坝的抗震配筋加固设计提供了参考。

关键词：强震荷载泄水建筑物动力响应分析抗震措施

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基于互动模式的社区自我管理活动对老年糖尿病患者生存质量干预效果分析

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中国健康教育 2024年第1期40卷 56-60页

作者：付文徐珏刘庆敏刘仕俊裘欣杭州市疾病预防控制中心浙江杭州310017

目的分析基于互动模式的社区自我管理活动对老年糖尿病患者生存质量的干预效果及影响因素,为提高患者生存质量提供依据。方法2016—2020年杭州市依托医联体建设及家庭医生签约服务资源,组建干预团队,以患者小组为单位开展系列自我管理... 详细信息

目的分析基于互动模式的社区自我管理活动对老年糖尿病患者生存质量的干预效果及影响因素,为提高患者生存质量提供依据。方法2016—2020年杭州市依托医联体建设及家庭医生签约服务资源,组建干预团队,以患者小组为单位开展系列自我管理活动干预。通过问卷调查方式收集基本信息、疾病状况、生存质量及自我管理行为情况。采用SPSS 19.0软件进行Friedman检验、Spearman相关检验及多重线性回归模型分析。结果共707例老年2型糖尿病患者纳入研究。干预前、干预4个月及干预10个月健康调查简表(SF-36)及2型糖尿病自我管理行为量表(2-DSCS)各维度得分差异具有统计学意义(χ^(2)>21.737,P0.125,P2.019,P<0.05)。结论基于互动模式的社区自我管理活动可有效改善患者管理行为,提升生存质量,且合并并发症、医疗费用支付能力对生存质量改善存在一定影响。

关键词： 2型糖尿病生存质量自我管理行为老年影响因素

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Metabolic syndrome and androgen deprivation therapy in metabolic complications of prostate cancer patients

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Chinese Medical Journal 2012年第20期125卷 3725-3729页

作者： YUAN Jia-qi XU Tao ZHANG Xiao-wei YU Lu-ping LI Qing liu shi-jun HUANG Xiao-bo WANG Xiao-feng Department or Urology Peking University People's HospitalPeking UniversityBeijing 100044China

Background Incidence of prostate cancer in Chinese males grows significantly in the past decades. Androgen deprivation therapy has been generally employed in the treatment of locally advanced and metastatic prostate cancer for many years, yet only little data was known about the metabolic syndrome in patients receiving hormonal therapy. This study described the prevalence and the changing trends of hormone-related metabolic complications, and analyzed their correlation with different therapies. Methods In 125 patients treated with castration or maximal androgen blockage for at least 12 months, metabolic indicators were analyzed. Results Totally, 13.5% patients in castration group and 30.1% patients in maximal androgen blockage group were diagnosed metabolic syndrome 12 months after the beginning of treatments （X2=4.739, P=0.029）. In castration group, increased triglyceride and decreased high-density lipoprotein-cholesterol were significant at the month 12, increased fasting plasma glucose and blood pressure were significant at the month 4. In maximal androgen blockage group, increased triglyceride and decreased high-density lipoprotein-cholesterol were significant at the month 4, increased fasting plasma glucose and blood pressure were significant at the month 8. Total testosterone and free testosterone in maximal androgen blockage group were significantly lower than castration group at all visits, which were proved to show positive or negative correlations with metabolic indications. Severity of metabolic complications in maximal androgen blockage group was generally more serious than people received castration, with significantly statistical difference or not. Trends of high-density lipoprotein-cholesterol and fasting plasma glucose were significant different between two kinds of therapy （P=0.005, P=-0.019, respectively）.

关键词： prostate cancer,＂ hormone therapy,＂ orchiectomy,＂ metabolic syndrome individualized medicine

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基于UPLC-MS/MS的夏枯草不同时期的果穗差异代谢物分析

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中国中药杂志 2024年第10期49卷 2734-2744页

作者：陆玉爱刘恃君林丽美侯师艺戈玉莹谢菁琛严婧夏伯候湖南中医药大学药学院湘产大宗药材品质评价湖南省重点实验室湖南长沙410208

夏枯草因夏至而枯得名,不同采收时期对其品质的形成影响重大。然而,目前对夏枯草不同时期果穗化学成分的变化研究较少,所涉及的代谢产物尚不清楚。为了阐明夏枯草果穗的代谢物及代谢通路,该实验采用超高效液相色谱串联质谱(UPLC-MS/MS)... 详细信息

夏枯草因夏至而枯得名,不同采收时期对其品质的形成影响重大。然而,目前对夏枯草不同时期果穗化学成分的变化研究较少,所涉及的代谢产物尚不清楚。为了阐明夏枯草果穗的代谢物及代谢通路,该实验采用超高效液相色谱串联质谱(UPLC-MS/MS)结合广泛靶向代谢组学技术整体表征夏枯草不同时期的果穗化合物差异性,利用主成分分析(PCA)和正交偏最小二乘判别分析法(OPLS-DA)等多元统计方法鉴定差异代谢物,并且对相关代谢通路进行分析。代谢组学的结果共鉴定出了602种代谢物,其中有机酸及其衍生物数量最多,黄酮类次之;根据VIP>1且P<0.05,发现羟基苯甲酸、没食子酸等为其主要差异代谢物;富集分析结果提示异黄酮类化合物的生物合成、氨基苯甲酸盐的降解、苯甲酸盐的降解、花青素的生物合成、代谢途径、不同环境中的微生物代谢、植物次级代谢物的生物合成、色氨酸的代谢、苯丙酸类物质的生物合成等代谢通路为主要通路。这些结果旨在阐明夏枯草差异代谢物的动态变化情况,为深入研究夏枯草果穗采收机制提供理论依据。

关键词：夏枯草不同时期 UPLC-MS/MS 代谢组学代谢通路

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基于电感耦合等离子体质谱分析金银花和山银花多元素差异的质量控制模式研究

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中国中药杂志 2024年第12期49卷 3263-3269页

作者：刘恃君汤杨黔南陆玉爱侯师艺戈玉莹严婧李亚梅夏伯候湖南中医药大学药学院湘产大宗药材品质评价湖南省重点实验室

大量研究表明金银花和山银花在有机物上的确具有显著性差异，但仍然缺少有关两者间无机元素方面的研究。该研究通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry, ICP-MS）建立非靶向元素组方法，比较金银花和... 详细信息

大量研究表明金银花和山银花在有机物上的确具有显著性差异，但仍然缺少有关两者间无机元素方面的研究。该研究通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry, ICP-MS）建立非靶向元素组方法，比较金银花和山银花在无机元素上的整体差异，并筛选其差异标志物。同时通过靶向方法定量分析这些差异标志物。非靶向元素组结果表明，得到的数学模型能够较好地反映金银花和山银花在元素含量的差异。以变量重要性投影值（VIP）>2.0,P1.2或<0.80为筛选原则，确认了锰(55Mn)、铋(209Bi)、镉(111Cd)、铷(85Rb)等4种无机元素为两者的差异标志物。靶向定量结果表明，金银花中209Bi的含量显著高于山银花，而山银花中55Mn、111Cd和85Rb显著高于金银花。该研究所建立的基于ICP-MS的非靶向和靶向元素组方法可显著反映金银花和山银花的无机元素的整体差异；从元素的角度探讨两者间差异，可部分反映两者药性上的差异，也为进一步研究金银花与山银花中无机元素质量控制模式的建立和其药理功效奠定了基础。

关键词：电感耦合等离子体质谱金银花山银花靶向非靶向

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The Effect of Dietary Vegetable Oilseeds Supplement on Fatty Acid Profiles in Milk Fat from Lactating Dairy Cows

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Agricultural Sciences in China 2007年第8期6卷 1002-1008页

作者： liu shi-jun WANG Jia-qi BU Deng-pan WEI Hong-yang ZHOU Ling-yun LUO Qiu-jiang The State Key Laboratory of Animal Nutrition/Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100094 P. R. China Xinjiang Agricultural University Urumchi 830052 P.R.China

To determine the effect of dietary supplementation with vegetable oilseeds on the composition of bovine milk fatty acids （FAs）, 40 Holstein dairy cows were used with a complete randomized design. At the beginning of the experiment, the cows were 150±25 day in milk （DIM）. Total duration of the experiment was six weeks. Measurements were made during the last three weeks. Cows in four treatments were fed with a basal diet （CT） or basal diet supplemented with either whole full fat soybean （WFS）, full fat expanded soybean （FPS） or whole full fat soybean with whole cottonseed and full fat expanded soybean （MIX）. The composition of the milk fat was analyzed by gas chromatography. Relative to control, the conjugated linoleic acid （CLA） concentration in milk fat from cows on FPS was significantly increased by 83.88% （P〈 0.05）. The proportions of C12：0 were decreased by 35.7, 35.51, and 38.65% in milk fat from cows on WFS, MIX, and FPS compared with cows on CT. Similar decreases in C 14：0 were 23.83, 24.85, and 31.48% in WFS, MIX, and FPS treatments, respectively. Feeding vegetable oilseeds increased the proportion of healthy FAs （mainly CLA）, whereas decreased the concentratiofi of C12：0 and C14：0. Therefore, milk and dairy products would have higher nutritive and therapeutic value.

关键词： dairy cattle vegetable oilseed conjugated linoleic acid milk fat

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Effect of health education based on information-motivationbehavioral skills model on patients with unilateral vestibular dysfunction

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World Journal of Clinical Cases 2024年第5期12卷 903-912页

作者： Qiong shi Ruo-jun Wu Jiang liu Department of Neurology Wuahan Fourth HospitalWuhan 430000Hubei ProvinceChina Department of Critical Care Medicine Wuhan No.1 HospitalWuhan 430033Hubei ProvinceChina

BACKGROUND Vestibular dysfunction(VH)is a common concomitant symptom of late peri-pheral vestibular lesions,which can be trauma,poisoning,infection,heredity,and neurodegeneration,but about 50%of the causes are unknown.The study uses the information-motivation-behavioral skills(IMB)model for health education,effectively improve the quality of life,increase their self-confidence,reduce anxiety and depression,and effectively improve the psychological state of patients.AIM To explore the effect of health education based on the IMB model on the degree of vertigo,disability,anxiety and depression in patients with unilateral vestibular hypofunction.METHODS The clinical data of 80 patients with unilateral vestibular hypofunction from January 2019 to December 2021 were selected as the retrospective research objects,and they were divided into the control group and the observation group with 40 cases in each group according to different nursing methods.Among them,the control group was given routine nursing health education and guidance,and the observation group was given health education and guidance based on the IMB model.The changes in self-efficacy,anxiety and depression,and quality of life of patients with unilateral VH were compared between the two groups.RESULTS There was no significant difference in General Self-Efficacy Scale(GSES)scale scores between the two groups of patients before nursing(P>0.05),which was comparable;after nursing,the GSES scale scores of the two groups were higher than those before nursing.The nursing group was higher than the control group,and the difference was statistically significant(P0.05).After nursing,the HADS score,anxiety,and depression subscale scores of the two groups of patients were lower than those before nursing,and the nursing group was lower than the control group,and the difference was statistically

关键词： Information-motivation-behavioral skills model Health education Vestibular function Quality of life Selfefficacy

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Microstructural characterization and mechanical properties of(TiC+TiB)/TA15 composites prepared by an in-situ synthesis method

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China Foundry 2024年第2期21卷 168-174页

作者： Zhi-yong Zhang Jiao-jiao Cheng Jia-qi Xie shi-bing liu Kun shi jun Zhao Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National Key Laboratory of Advanced Casting Technologies Shenyang 110022China

Titanium matrix composites reinforced with ceramic particles are considered a promising engineering material due to their combination of high specific strength,low density,and high modulus.In this study,the TA15-based composites reinforced with a volume fraction of 10% to 25%(TiB+TiC)were prepared using powder metallurgy and casting technique.Microstructural characterization and phase constitution were examined using optical microscopy(OM),scanning electron microscopy(SEM),and X-ray diffraction(XRD).In addition,the microhardness,room temperature(RT)and high temperature(HT)tensile properties of the composites were evaluated.Results revealed that the reinforcements are distributed uniformly even in the composites with a high volume of TiB and TiC.However,as the volume fraction exceeds 15%,TiB and TiC particles become coarsening and exhibit rod-like and dendritic-like morphology.Microhardness increases gradually from 321.2 HV for the base alloy to a maximum of 473.3 HV as the reinforcement increases to 25vol.%.Tensile test results indicate that a reinforcement volume fraction above 20% is beneficial for enhancing tensile strength and yield strength at high temperatures,but it has an adverse effect on room temperature elongation.Conversely,if the reinforcement volume fraction is below 20%,it can improve high-temperature elongation when the temperature exceeds 600℃.

关键词： titanium matrix composites microstucture microhardness tensile properties in-situ synthesis

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Recent advances in vacancy engineering for reliable lithiumsulfur batteries

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Rare Metals 2024年第2期43卷 455-477页

作者： Wen-Dong liu Xiao Tang jun-An Feng Chao-Yue Zhang Hao liu Chuan shi Xiao-Xian Zhao Jian-jun Song College of Physics School of Chemistry and Chemical EngineeringQingdao UniversityQingdao266071China Faculty of Science Centre for Clean Energy TechnologySchool of Mathematical and Physical SciencesUniversity of Technology SydneySydneyNSW2007Australia Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding071001China

The high-energy-density and low-cost features endow lithium-sulfur batteries with broad application prospects.However,many drawbacks,especially the detrimental shuttle effect,have hindered the further development of LSBs.In response,a lot of new structures have been applied to suppress the shuttle effect and promote the development of LSBs.Recently,vacancy engineering has gained the attention of researchers due to its unique electronic structure.This review aims to analyze the application of vacancy engineering in LSBs.Firstly,the electrochemistry of LSBs has been systematically discussed and the existing challenges as well as improvement tactics of LSBs have also been presented.Subsequently,the preparation methods and characterization technologies of various vacancies are summarized,including oxygen vacancies,sulfur vacancies,selenium vacancies,other anion vacancies,cation vacancies,etc.The latest applications of vacancy engineering in LSBs are also summarized in this review.Finally,some prospects and insights for further investigation and practical application of vacancy engineering in LSBs are put forward.

关键词： Lithium-sulfur batteries(LSBs) Defects Vacancy engineering Electronic structure Shuttle effect

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