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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin liu Yu shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

新疆阿克苏地区近40 a气候、水文变化特征分析

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干旱区研究 2005年第3期22卷 336-340页

作者：王建丁永建刘时银叶佰生谢昌卫吴锦奎中国科学院寒区旱区环境与工程研究所甘肃兰州730000

近20 a来,阿克苏平原绿洲区气候明显变暖增湿,戈壁区略有变干的迹象。同期,由于气温升高,冰川消融加快,山区降水增多,源流出山口径流量略有增加;根据塔里木河干流阿拉尔水文站监测结果,近40 a来,年径流量呈持续稳定减少趋势。20世纪90年... 详细信息

近20 a来,阿克苏平原绿洲区气候明显变暖增湿,戈壁区略有变干的迹象。同期,由于气温升高,冰川消融加快,山区降水增多,源流出山口径流量略有增加;根据塔里木河干流阿拉尔水文站监测结果,近40 a来,年径流量呈持续稳定减少趋势。20世纪90年代,径流量平均距平为-4.85,径流量减少达10.58%。这主要是人类干预和源流区粗放农业发展,耗水量不断增加,导致汇入塔里木河干流水量不断减少,从而引起中下游生态急剧恶化。

关键词：气候变化径流量人类干预阿克苏新疆

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堆浸法从某低品位难选含铀钼矿中回收钼

有色金属（冶炼部分） 2023年第2期 73-76页

作者：杨剑飞师留印黄永张亚红苏姣姣张引亮核工业北京化工冶金研究院北京101149 中核沽源铀业有限责任公司河北沽源076561

针对某低品位含铀钼矿钼浸出率不高、常规强化搅拌浸出固液分离困难等问题,研究了拌酸熟化-堆浸工艺,提出一种适合处理该矿石的工艺方法。试验考察了堆浸工艺参数矿石粒度、喷淋强度、浸出剂酸度、氧化剂用量和浸出时间对钼浸出率的影响... 详细信息

针对某低品位含铀钼矿钼浸出率不高、常规强化搅拌浸出固液分离困难等问题,研究了拌酸熟化-堆浸工艺,提出一种适合处理该矿石的工艺方法。试验考察了堆浸工艺参数矿石粒度、喷淋强度、浸出剂酸度、氧化剂用量和浸出时间对钼浸出率的影响,结果表明:在矿石粒度-3.2 mm、喷淋强度40~60 L(m^(2)·h),浸出剂酸度5 g L、浸出时间6~8 d的条件下,矿堆渗透性较好,钼浸出率可达73%。

关键词：铀钼矿拌酸熟化-堆浸固液分离

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren ying liu Juntang Yan Congai Chen Yanhui He Yuyu shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 35-41页

作者：夏海艳 HUANG yin YANG Hua WANG Xintian shi Jianping liu Lixia FU Yacheng 全昌云李苏原 Cofoe Medical Technology Company Limited Institute of New Energy Hexi University Chemistry and Chemical Engineering Central South University

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C （CuO/Ag-C） disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM-1·cm-2,and a low limit of detection （0.68 mM） in a wide linear response range of 0.68 mM and 3 mM （signal/noise=3）,*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

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近年来香砂六君丸的研究进展

齐鲁药事 2010年第4期29卷 219-221页

作者：刘印石俊英山东中医药大学药学院山东济南250355

香砂六君丸是临床上治疗脾胃病症的常用方药,对呕吐,脘腹疼痛、便溏或泄泻等症状有明显的疗效。本文对近年来香砂六君丸的药理作用及临床应用等方面的研究进展进行了综述,为下一步香砂六君丸的深入研究提供了参考。

关键词：香砂六君丸药理橙皮苷

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铝合金盘式节点静力性能的有限元参数分析

武汉大学学报（工学版） 2017年第5期50卷 688-696,732页

作者：王元清柳晓晨石永久尹建欧阳元文清华大学土木工程安全与耐久教育部重点实验室北京100084 上海通正铝业工程技术有限公司上海200949

为研究几何参数对盘式节点承载力及刚度的影响,得到影响节点承载力及刚度的关键几何参数,以试验数据为基础,利用大型通用有限元分析软件ABAQUS,针对盘式节点的5个主要几何参数进行抗弯承载性能及初始刚度参数分析.分析结果表明:铝合金... 详细信息

为研究几何参数对盘式节点承载力及刚度的影响,得到影响节点承载力及刚度的关键几何参数,以试验数据为基础,利用大型通用有限元分析软件ABAQUS,针对盘式节点的5个主要几何参数进行抗弯承载性能及初始刚度参数分析.分析结果表明:铝合金工字型杆件腹板高度增加,节点承载力及初始刚度近似成线性提高;腹板厚度增加,节点承载力有所提高,节点初始刚度有所降低,但变化幅度较小;翼缘厚度增加,节点承载力及初始刚度提高,且提高幅度较大;节点盘厚度增加,节点承载力有所提高,节点初始刚度有所降低,变化幅度先大后小;节点盘半径对节点静力性能影响不大.建议通过增大铝合金盘式节点工字型杆件腹板高度及翼缘厚度的方式,改善节点受力性能.

关键词：铝合金盘式节点抗弯承载力节点刚度有限元参数分析