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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo nan Zhang Yuntao liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing liu Hangxing Wang Aizhen Zuo Cen Jin nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

Theoretical Study on Inverse Sandwich Complexes [E-C5-nH5-nNn-E]+ and [E-C5-nH5-nPn-E]+ (n=1, 2, 3;E=Al, Ga, In, Tl)

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： nan-nan liu yi-hong Ding Chemistry Center College of Food Engineering Harbin University of Commerce Haerbin 150028China State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryJilin University Changchun 130012 China

The inverse sandwiches [E-C5?nH5?nNn-E]+ and [E-C5?nH5?nPn-E]+ (n=1, 2, 3; E=Al, Ga, In, Tl) with low-valent boron group elements are studied. The (η5, η5) coordinated inverse sandwich [E-C5?nH5?nNn-E]+ is unstable in energy or nonexistent. However, the (η5, η5) coordinated [E-C5?nH5?nPn-E]+ is not only stable in energy, but also stable against dissociation. The dissoction stability [E-C5?nH5?nPn-E]+ with the same E element decreases as the number n increases, while for the certain n number, the dissociation energies with different E elements are close to each other. [E-C4H4P-E]+ has similar dissocition stability to the well-known [E-C5H5-E]+. The inteaction between C5?nH5?nPn and low-valent E element is mainly ionic. Since lone pairs of electrons locate on both E and P atoms, the (η5, η5) coordinated inverse sandwich [E-C5?nH5?nPn-E]+ would act as multi electron-donors.

关键词： Low-valent Boron group elements Electron-donor Organometallic Heterocyclic

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扭曲双层石墨烯的层间电导特性研究

原子与分子物理学报 2025年第6期42卷 83-88页

作者：陶懿洲刘超方贺男南京邮电大学电子与光学工程学院南京210023

扭曲双层石墨烯(TBG)由于具有莫特绝缘和非常规超导等新奇的电学特性,在纳米技术领域存在巨大的应用潜力.本文基于光学衍射物理方法,构建了一个适用于TBG的理论模型,并利用该理论模型研究了TBG的层间电导特性.研究结果较好地解释了TBG... 详细信息

扭曲双层石墨烯(TBG)由于具有莫特绝缘和非常规超导等新奇的电学特性,在纳米技术领域存在巨大的应用潜力.本文基于光学衍射物理方法,构建了一个适用于TBG的理论模型,并利用该理论模型研究了TBG的层间电导特性.研究结果较好地解释了TBG层间电导随扭转角变化的实验结果,并阐明了其物理机制.此外,本文还计算了电极参数、隧穿层厚度以及界面势强度等物理因素对层间电导特性的影响.计算结果表明:随着电极化学势的增大,层间电导关于扭转角的变化曲线近似整体向上平移;层间电导随着上层隧穿层厚度的增加而衰减并趋于稳定,而随着下层隧穿层厚度振荡;TBG两层扭转石墨烯的界面势强度越强,则层间电导随扭转角下降得越快.

关键词：低维物理层间电导光学衍射方法扭曲双层石墨烯

Revolutions in algal biochar for different applications:State-of-the-art techniques and future scenarios

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Chinese Chemical Letters 2020年第10期31卷 2591-2602页

作者： yi-Di Chen Feiyu liu nan-Qi ren Shih-Hsin Ho School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

Algae are potential feedstock for the production of bioenergy and valuable *** the extraction of specific value-added products,algal residues can be further conve rted into biogas,biofuel,and biochar through various thermochemical treatments such as conventional pyrolysis,microwave pyrolysis,hydrothermal conversion,and *** compositions and physicochemical characteristics of algal biochar that dete rmine the subsequent applications are compre hensively *** biochar carbonized at high-temperature showed remarkable performance for use as supercapacitors,CO_(2) adsorbents,and persulfate activation,due to its graphitic carbon structure,high electron transport,and specific surface *** algal biochar produced by pyrolysis at mode rate-temperature exhibits high performance for adsorption of pollutants due to combination of miscellaneous functional groups and po rous structures,whereas coal fuel can be obtained fro m algae via torrefaction by pyrolysis at relatively low-tempe *** aim of this review is to study the production of algal biochar in a cost-effective and environmental-friendly method and to reduce the environmental pollution associated with bioenergy *** zero emission enerev production.

关键词： Algae Algal residue Thermochemical processes Pyrolysis Biochar

Validation and application of three-dimensional discontinuous deformation analysis with tetrahedron finite element meshed block

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Acta Mechanica Sinica 2012年第6期28卷 1602-1616页

作者： Jun liu Zheng nan Ping yi School of Hydraulic Engineering Dalian University of Technology School of Civil Engineering Dalian University of Technology

In the last decade, three dimensional discontin- uous deformation analyses （3D DDA） has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a linear displacement function to describe the block movement and deformation, which would cause block expansion under rigid body rotation and thus limit its capability to model block de- formation. In this paper, 3D DDA is coupled with tetrahe- dron finite elements to tackle these two problems. Tetrahe- dron is the simplest in the 3D domain and makes it easy to implement automatic discretization, even for complex topol- ogy shape. Furthermore, element faces will remain planar and element edges will remain straight after deformation for tetrahedron finite elements and polyhedral contact detection schemes can be used directly. The matrices of equilibrium equations for this coupled method are given in detail and an effective contact searching algorithm is suggested. Valida- tion is conducted by comparing the results of the proposed coupled method with that of physical model tests using one of the most common failure modes, i.e., wedge failure. Most of the failure modes predicted by the coupled method agree with the physical model results except for 4 cases out of the total 65 cases. Finally, a complex rockslide example demon- strates the robustness and versatility of the coupled method.

关键词： Three-dimensional discontinuous deformation analysis Finite element method Coupled method Valida-tion

Network Coding Anti-eavesdropping Algorithm for Ad hoc Networks

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Chinese Journal of Electronics 2015年第3期24卷 639-641页

作者： liu Jun liu yi'nan liu Hui WANG yingmei School of Information Science Engineering Northeastern University

Aiming at the anti-eavesdrop security demand and potential safety hazard in Ad hoc, a secure random linear network coding algorithm was proposed. The algorithm has secure source coding and protecting the coding vectors. The information source secure coding method and optimizing the finite region is defined to guarantee that the information is properly protected. Different coding vectors protecting schemes were designed for adapting security path and without. We applied the secure random linear network coding algorithm in Ad Hoc Networks to meet the demand on anti-eavesdrop. The anti-eavesdrop algorithm based on network coding is simulated and analyzed in NS2 platform, the results shown that comparing with the encryption algorithm, the anti-eavesdrop algorithm based on network coding has better performance in end-to-end delay and encryption speed.

关键词： Ad hoc networks Security Antieavesdrop Network coding

Effect of powdered activated carbon on Chinese traditional medicine wastewater treatment in submerged membrane bioreactor with electronic control backwashing

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Journal of Environmental Sciences 2007年第9期19卷 1037-1042页

作者： liu Xiao-lei ren nan-qi MA Fang School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China. School of Water Conservancy and Environment Engineering Changchun Institute of Technology Changchun 130012 China

Chinese traditional medicine wastewater, rich in macromolecule and easy to foam in aerobic biodegradation such as Glycosides, was treated by two identical bench-scale aerobic submerged membrane bioreactors （SMBRs） operated in parallel under the same feed, equipped with the same electronic control backwashing device. One was used as the control SMBR （CSMBR） while the other was dosed with powdered activated carbon （PAC）（PAC-amended SMBR, PSMBR）. The backwashing interval was 5 min. One suction period was about 90 min by adjusting preestablished backwashing vacuum and pump frequency. The average flux of CSMBR during a steady periodic state of 24 d （576 h） was 5.87 L/h with average hydraulic residence time （HRT） of 5.97 h and that of PSMBR during a steady periodic state of 30 d （720 h） was 5.85 L/h with average HRT of 5.99 h. The average total chemical oxygen demand （COD） removal efficiency of CSMBR was 89.29% with average organic loading rate （OLR） at 4.16 kg COD/（m^3.d） while that of PSMBR was 89.79% with average OLR at 5.50 kg COD/（m^3.d）. COD concentration in the effluent of both SMBRs achieved the second level of the general wastewater effluent standard GB8978-1996 for the raw medicine material industry （300 mg/L）. Hence, SMBR with electronic control backwashing was a viable process for medium-strength Chinese traditional medicine wastewater treatment. Moreover, the increasing rates of preestablished backwashing vacuum, pump frequency, and vacuum and flux loss caused by mixed liquor in PSMBR all lagged compared to those in CSMBR; thus the actual operating time of the PSMBR system without membrane cleaning was extended by up to 1.25 times in contrast with the CSMBR system, and the average total COD removal efficiency of PSMBR was enhanced with higher average OLR.

关键词： electronic control backwashing powdered activated carbon membrane bioreactor aerobic process wastewater treatment

Boosting cationic and anionic redox activity of Li-rich layered oxide cathodes via Li/Ni disordered regulation

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Journal of Energy Chemistry 2025年第1期 533-543页

作者： Zewen liu Zhen Wu Hao Wang Xudong Zhang Yuanzhen Chen Yongning liu Shengwu Guo Shenghua Chen Yanli nan Yan liu State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University School of Materials Science and Engineering Xi'an University of Architecture and Technology Hefei Advanced Computing Center Operation Management Corp Ltd Network Information Center Xi'an Jiaotong University

Lithium-rich layered oxides （LLOs） are increasingly recognized as promising cathode materials for nextgeneration high-energy-density lithium-ion batteries （LIBs）.However,they suffer from voltage decay and low initial Coulombic efficiency （ICE） due to severe structural degradation caused by irreversible O ***,we introduce a three-in-one strategy of increasing Ni and Mn content,along with Li/Ni disordering and TM–O covalency regulation to boost cationic and anionic redox activity simultaneously and thus enhance the electrochemical activity of *** target material,Li1.2Ni0.168Mn0.558Co0.074O2（L1）,exhibits an improved ICE of 87.2%and specific capacity of 293.2 mA h g-1and minimal voltage decay of less than 0.53 m V cycle-1over 300 cycles at 1C,compared to Li1.2Ni0.13Mn0.54Co0.13O2（Ls）(274.4 mA h g-1for initial capacity,73.8%for ICE and voltage decay of 0.84 mV/cycle over 300 cycles at 1C).Theoretical calculations reveal that the density of states （DOS） area near the Fermi energy level for L1 is larger than that of Ls,indicating higher anionic and cationic redox reactivity than ***,L1 exhibits increased O-vacancy formation energy due to higher Li/Ni disordering of 4.76%（quantified by X-ray diffraction Rietveld refinement） and enhanced TM–O covalency,making lattice O release more difficult and thus improving electrochemical *** increased Li/Ni disordering also leads to more Ni2+presence in the Li layer,which acts as a pillar during Li+de-embedding,improving structural *** research not only presents a viable approach to designing low-Co LLOs with enhanced capacity and ICE but also contributes significantly to the fundamental understanding of structural regulation in high-performance LIB cathodes.

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