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Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-ting ZHENG Qi liu lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all P<0.01).Moreover,Scorpiones,Scolopendra and Gekko inhibited the phosphorylation of AKT and ribosomal protein S6 kinase(p70S6K)(P<0.05 or P<0.01).In addition,they also decreased the expression of CD31,MVD,bFGF,TGF-β1 and VEGF compared with the model group(P<0.05 or P<0.01).Conclusion:Scorpiones,Scolopendra and Gekko all showed beneficial effects on lung cancer by ameliorating the hypoxic tumor microenvironment via PI3K/AKT/mTOR/HIF-1αsignaling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

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A multiscale adaptive framework based on convolutional neural network: Application to fluid catalytic cracking product yield prediction

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Petroleum Science 2024年第4期21卷 2849-2869页

作者： Nan liu chun-Meng Zhu Meng-Xuan Zhang Xing-Ying lan State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) College of Artificial Intelligence China University of Petroleum (Beijing)

Since chemical processes are highly non-linear and multiscale, it is vital to deeply mine the multiscale coupling relationships embedded in the massive process data for the prediction and anomaly tracing of crucial process parameters and production indicators. While the integrated method of adaptive signal decomposition combined with time series models could effectively predict process variables, it does have limitations in capturing the high-frequency detail of the operation state when applied to complex chemical processes. In light of this, a novel Multiscale Multi-radius Multi-step Convolutional Neural Network(Msrt Net) is proposed for mining spatiotemporal multiscale information. First, the industrial data from the Fluid Catalytic Cracking(FCC) process decomposition using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN) extract the multi-energy scale information of the feature subset. Then, convolution kernels with varying stride and padding structures are established to decouple the long-period operation process information encapsulated within the multi-energy scale data. Finally, a reconciliation network is trained to reconstruct the multiscale prediction results and obtain the final output. Msrt Net is initially assessed for its capability to untangle the spatiotemporal multiscale relationships among variables in the Tennessee Eastman Process(TEP). Subsequently, the performance of Msrt Net is evaluated in predicting product yield for a 2.80 × 10～6 t/a FCC unit, taking diesel and gasoline yield as examples. In conclusion, Msrt Net can decouple and effectively extract spatiotemporal multiscale information from chemical process data and achieve a approximately reduction of 30% in prediction error compared to other time-series models. Furthermore, its robustness and transferability underscore its promising potential for broader applications.

关键词： Fluid catalytic cracking Product yield Data-driven modeling Multiscale prediction Data decomposition Convolution neural network

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Time Series and Spatial Epidemiological Analysis of the Prevalence of Iodine Deficiency Disorders in China

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Biomedical and Environmental Sciences 2022年第8期35卷 735-745页

作者： FAN Li Jun GAO Yun Yan MENG Fan Gang liu Chang liu lan chun DU Yang liu Li Xiang LI Ming SU Xiao Hui liu Shou Jun liu Peng Institute of lodine DeficiencyDisorders Center for Endemic Disease ControlChinese Center forDisease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina National Health Commission&Education Bureau of Heilongjiang Province Key laboratory of Etiology and EpidemiologyHarbin Medical UniversityHarbin 150081HeilongjiangChina

Objective To recognize the spatial and temporal characteristics of iodine deficiency disorders(IDD),China national IDD surveillance data for the years of 1995–2018 were *** Time series analysis was used to describe and predict the IDD related indicators,and spatial analysis was used to analyze the spatial distribution of salt iodine *** In China,the median urinary iodine concentration increased in 1995–1997,then decreased to adequate levels,and are expected to remain appropriate in 2019–*** goiter rate continually decreased and is expected to be maintained at a low *** 2002,the coverage rates of iodized salt and the consumption rates of qualified iodized salt(the percentage of qualified iodized salt in all tested salt) increased and began to decline in 2012;they are expected to continue to *** epidemiological analysis indicated a positive spatial correlation in 2016–2018 and revealed feature regarding the spatial distribution of salt related indicators in coastal areas and areas near iodine-excess *** Iodine nutrition in China showed gradual ***,a recent decline has been observed in some areas following changes in the iodized salt supply in *** the future,more regulations regarding salt management should be issued to strengthen IDD control and prevention measures,and avoid the recurrence of IDD.

关键词： Salt iodine lodine deficiency disorders Time series analysis Space epidemiology Reform for the salt industry system

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基于科学精神培养的电化学专业实验课程思政“123”实施路径探索

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宜春学院学报 2024年第3期46卷 95-102页

作者：张文彬葛军英刘春兰李砚朱凤宜春学院化学与生物工程学院江西宜春336000

充分挖掘课程的思政资源并在课堂教学中开展实践是落实立德树人根本任务的关键,课程思政需要满足学生成长发展的期待。实验课程是理工科专业人才培养的重要组成部分,实验教学中的共性课程思政主要包括强化研究素养、培养科学精神。本文... 详细信息

充分挖掘课程的思政资源并在课堂教学中开展实践是落实立德树人根本任务的关键,课程思政需要满足学生成长发展的期待。实验课程是理工科专业人才培养的重要组成部分,实验教学中的共性课程思政主要包括强化研究素养、培养科学精神。本文提出了基于科学精神培养的“123”课程思政实施路径,即一种浸润(科学家精神),两条主线(科学思维形式,思维导图),三个意识(问题意识、证据意识和持续改进意识)。教学实践结果表明,“123”实施路径能够丰富实验教学课程思政的内涵,有效提升本科生的“科学精神”。

关键词：科学精神课程思政电化学实验科学思维 BOPPPS模式

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尿管球囊和前列腺素E2阴道栓剂在足月妊娠引产中的效果比较

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中国医疗器械信息 2024年第5期30卷 123-125页

作者：文依敏刘春兰刘小燕吴桂婵吴翠卿江雨婷刘晗罗丽广州市增城区妇幼保健院妇产科广东广州511300

目的:评估尿管球囊和前列腺素E2(PGE2)阴道栓剂在足月妊娠引产中的效果。方法:筛选2021年3月~2022年2月在本院待产的668例孕妇,将469例经尿管球囊进行引产者设为尿管球囊组,将199例经前列腺素E2阴道栓剂进行引产者设为PGE2组,分析两组... 详细信息

目的:评估尿管球囊和前列腺素E2(PGE2)阴道栓剂在足月妊娠引产中的效果。方法:筛选2021年3月~2022年2月在本院待产的668例孕妇,将469例经尿管球囊进行引产者设为尿管球囊组,将199例经前列腺素E2阴道栓剂进行引产者设为PGE2组,分析两组引产情况。结果:两组分娩方式、引产到分娩时间、剖宫产及阴道助产指征组间比较,差异无显著性意义,P>0.05;尿管球囊组缩宫素使用率高于PGE2组,差异有显著性意义,P0.05。结论:在足月妊娠引产中,尿管球囊以及前列腺素E2阴道栓剂存在各自的优势和劣势,需根据实际情况进行选择。

关键词：尿管球囊前列腺素E2 足月妊娠宫颈成熟引产

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Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： chun-Fang Wang Shi-Wei Zhang lan Huang Yuan-Min Zhu Feng liu Jian-Chuan Wang Li-Ming Tan chun-Yi Zhi Cui-Ping Han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered H_(2)V_(3)O_(8)(HVO)with Zn^(2+)pre-insertion(ZHVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and H_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZHVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials

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甘露寡糖的生理功能及其在反刍动物上的应用研究

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中国奶牛 2024年第1期 11-14页

作者：张少泽刘春兰宫玥张强王封霞陈佩佩苏衍菁光明牧业有限公司上海200436

甘露寡糖(Mannose-oligosaccharide,MOS)作为新型绿色抗生素替代品,目前在畜禽上广泛应用。本文对MOS的理化性质、生理功能以及在反刍动物上的应用研究进行了综述。研究发现,MOS能刺激有益菌群的增殖、抑制肠道病原菌,增强动物免疫力,... 详细信息

甘露寡糖(Mannose-oligosaccharide,MOS)作为新型绿色抗生素替代品,目前在畜禽上广泛应用。本文对MOS的理化性质、生理功能以及在反刍动物上的应用研究进行了综述。研究发现,MOS能刺激有益菌群的增殖、抑制肠道病原菌,增强动物免疫力,在反刍动物上应用有远大前景。

关键词：甘露寡糖生理功能反刍动物应用研究

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Effect of Iodine Supplementation on Iodine Nutrition and Thyroid Function in Pregnant Women:A Cross-Sectional Study

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Biomedical and Environmental Sciences 2022年第7期35卷 641-647页

作者： SUN Rong QIAN Ting Ting liu lan chun ZHAO Meng CHE Wen Jing ZHANG Ling LI Wei Dong JIA Qing Zhen WANG Jian Hui LI Jin Shu CHEN Zhi Hui ZHANG Bi Yun liu Peng Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina Key lab of Etiology and Epidemiology Education Bureau of Heilongjiang Province&Ministry of HealthMicroelement and human health lab of Heilongjiang ProvinceCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina Center for Disease Control and Prevention in Xinjiang Uygur Autonomous Region Urumqi 830002XinjiangChina Center for Disease Control and Prevention in Anhui Province Hefei 238007AnhuiChina Institute for Endemic Disease Control and Prevention in Shanxi Province Linfen 041000ShanxiChina Center for Disease Control and Prevention in Liaoning Province Shenyang 110005LiaoningChina Center for Disease Control and Prevention in Sichuan Province Chengdu 610041SichuanChina Center for Disease Control and Prevention in Fujian Province Fuzhou 350001FujianChina Center for Disease Control and Prevention in Hubei Province Wuhan 430079HubeiChina

This study aimed to describe the situation of iodine supplementation in pregnant women,and to explore the effects of such supplementation measures on iodine nutrition and thyroid *** women in seven provinces were selected by multi-stage *** information was collected and a food frequency questionnaire was *** iodine,urinary iodine,and thyroid function were *** were divided into five groups based on iodine *** pregnant women,the median urinary iodine concentration(MUIC)in seven provinces was 164.3μg/L,and thyroid nodules(15.75%)were a common thyroid ***,iodine supplementation,*** iodine nutrition and thyroid *** with other groups,simultaneous iodine supplementation with iodized salt,iodine-rich foods,and iodine preparations(the ISFP group)was the most effective approach for improving iodine nutrition;supplementation via iodine-rich foods only showed the lowest prevalence of TPOAb-positive(5.48%)and TgAb-positive(1.37%)*** addition,pregnant women with MUIC in the 150–249μg/L range showed higher rates of TPOAb-positive(13.78%)disease and sub-hypothyroidism(5.38%)compared to those with MUIC in the 100–149μg/L range;however,goiter showed the opposite *** results indicate that iodine supplementation needs vary from person to person.

关键词： function. iodine opposite

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Relationship between Dining Place, Iodine Source, and Iodine Nutrition in School-Age Children: A Cross-Sectional Study in China

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Biomedical and Environmental Sciences 2023年第1期36卷 10-23页

作者： QIAN Ting Ting SUN Rong liu lan chun CHE Wen Jing ZHAO Meng ZHANG Ling LI Wei Dong JIA Qing Zhen WANG Jian Hui LI Jin Shu CHEN Zhi Hui ZHANG Bi Yun liu Peng Endemic Disease Control Center Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina Key lab of Etiology and Epidemiology Education Bureau of Heilongjiang Province&Ministry of HealthMicroelement and human health lab of Heilongjiang ProvinceCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina Center for Disease Control and Prevention in Xinjiang Uygur Autonomous Region Urumqi 830002XinjiangChina Center for Disease Control and Prevention in Anhui Province Hefei 230601AnhuiChina Institute of Endemic Disease Prevention and Control in Shanxi province Linfen 041000ShanxiChina Center for Disease Control and Prevention in Liaoning Province Shenyang 110000LiaoningChina Center for Disease Control and Prevention in Sichuan Province Chengdu 610041SichuanChina Center for disease control and prevention in Fujian province Fuzhou 350012FujianChina Center for Disease Control and Prevention in Hubei Province Wuhan 430079HubeiChina

Objective This study assesses the impact of iodine-rich processed foods and dining places on the iodine nutritional status of *** School-aged children(SAC) in seven provinces in China were selected by school-based multistage sampling. Urinary iodine, salt iodine, and thyroid volume(TVOL) were determined. Questionnaires were used to investigate dining places and iodine-rich processed foods. The water iodine was from the2017 national survey. Multi-factor regression analysis was used to find correlations between *** Children ate 78.7% of their meals at home, 15.1% at school canteens, and 6.1% at other *** percentage of daily iodine intake from water, iodized salt, iodine-rich processed foods, and cooked food were 1.0%, 79.2%, 1.5%, and 18.4%, respectively. The salt iodine was correlated with the urinary iodine and TVOL, respectively(r = 0.999 and-0.997, P < 0.05). The iodine intake in processed foods was weakly correlated with the TVOL(r = 0.080, P < 0.01). Non-iodized salt used in processed foods or diets when eating out had less effect on children’s iodine nutrition *** Iodized salt remains the primary source of daily iodine intake of SAC, and processed food has less effect on iodine nutrition. Therefore, for children, iodized salt should be a compulsory supplement in their routine diet.

关键词： Dining place Source of iodine Iodine-rich processed foods Urinary iodine

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Pb induced dislocation defects of PtCo systems: Strain-triggered oxygen reduction reaction for PEMFC

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Nano Research 2024年第4期17卷 2462-2472页

作者： chun Jin Qiheng Wang Jingjun liu Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing 100029China Beijing University of Chemical Technology Beijing 100029China

Design and development of advanced electrocatalysts with high performance and low Pt consumption are crucial for reducing the kinetic energy barrier of the cathode oxygen reduction reaction(ORR)and improving the efficiency of proton exchange membrane fuel cells(PEMFC).In this study,we demonstrate a Pb-modulated PtCo system for efficient ORR,in which the inclusion of Pb in ternary alloys induces dislocation defects due to the significant difference in atomic ***-PtCoPb was confirmed to exhibit significantly higher ORR activity and stability in acidic *** practical PEMFC applications,it outperforms the corresponding commercial Pt/C with a mass activity of 0.58 A·mgPt^(-1),making it a promising alternative to state-of-the-art Pt-based *** combination of experimental results and density functional theory(DFT)calculations offers valuable atomic-level insights into the dislocation *** with a larger atomic radius is located in the lattice stretching region below the dislocation slip plane,forming a structure similar to a Cottrell atmosphere,which reduces the dislocation energy and puts the system in a lower energy *** Cottrell atmosphere pins the dislocation structure and stabilizes the ternary *** adjusting the amount of added Pb,a moderate level of dislocation density induces a tuned strain effect,thereby enhancing the electrocatalytic mechanism by optimizing the electronic structure of the alloy surface and the adsorption and desorption of oxygen *** work provides valuable insights into the design and development of lattice dislocation defect structures to trigger strain effects for improving ORR performance.

关键词： dislocation defect strain effect Pb-modulated oxygen reduction reaction

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