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Thermal Inertia of 330 MW Circulating Fluidized Bed Boiler during Load Change

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Journal of Thermal Science 2023年第5期32卷 1771-1783页

作者： SUN Guorui WU Haowen liu Shangzhong liu Tonghua liu jixiang YANG Hairui ZHANG Man Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Wuhan Yongping Science and Technology Co.Ltd. Wuhan 430000China

The operating principles of Circulating Fluidized Bed(CFB)boilers involve a significant amount of heat accumulation,which forms the thermal inertia of the boiler and hinders the improvement of its variable load response *** study aims to characterize the thermal inertia of CFB boilers by evaluating the change in the boiler's heat accumulation corresponding to the change in unit power *** thermal inertia of a 330MW CFB boiler was determined through the collection of operating data under four different operating conditions of 30%,50%,75%,and 100%*** study proposes to substitute the existing refractory material with a metal grille to reduce the thermal inertia of the *** effect of the metal grille on heat transfer was confirmed through verification on a 440 t/h CFB boiler,and its performance change and thermal inertia reduction were further *** results indicate that over 50%of the total thermal inertia of CFB boilers originates from the refractory *** use of metal grille in place of refractory material improved heat transfer in the furnace,resulting in a decrease of the furnace chamber temperature by 13℃in the 330 MW CFB *** reduction of thermal inertia by 30%-35%will facilitate faster load lifting and lowering of the boiler,fulfilling the requirement for flexible peaking.

关键词： CFB boiler refractory thermal inertia heat accumulation

Elaborating Spatiotemporal Associations Between the Built Environment and Urban Vibrancy:A Case of Guangzhou City,China

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Chinese Geographical Science 2022年第3期32卷 480-492页

作者： WANG Bo LEI Yaqin XUE Desheng liu jixiang WEI Chunzhu School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Guangdong Provincial Key Laboratory of Urbanization and Geo-simulation Guangzhou 510275China Department of Urban Planning and Design the University of Hong KongHong Kong 999077China

This study applies multi-source datasets(i.e.,Baidu Heat Map data,points of interest(POIs)data,and floor area and land use data)and geographically and temporally weighted regression(GTWR)models to elaborate the spatiotemporal relationships between the built environment and urban vibrancy on both weekdays and weekends,using Guangzhou City as a ***,we verified the spatially and temporally nonstationary nature of the built environment correlates,which have been largely ignored in previous studies based on local regression *** spatially and temporally heterogeneous effects of the built environment on urban vibrancy are then presented and visualized,based on the GTWR *** found that the elasticity of location(i.e.,distance),land use mix(i.e.,diversity),building intensity and numbers of POIs with various functions(i.e.,density)are different across time(2-h intervals within a day)and space(grids),due to people’s everyday lifestyle,time-space constraints,and geographical context(e.g.,spatial structure).The findings highlight the importance of a better understanding of the local geography on the spatiotemporal relationships for urban planners and local governments so as to put forward decision-making support for fostering and maintaining urban vibrancy.

关键词： urban vibrancy Baidu Heat Map(BHM) built environment heterogeneity geographically and temporally weighted regression

New controlled quantum key agreement protocols based on Bell states

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The Journal of China Universities of Posts and Telecommunications 2022年第4期29卷 42-50页

作者： He Yefeng Yue Yuru Li Guoqing liu jixiang Di Man Pang Yibo School of Cyberspace Security Xi’an University of Posts and TelecommunicationsXi’an 710121China

The controlled quantum key agreement(CQKA)protocol requires a controller to oversee the process of all participants negotiating a key,which can satisfy the needs of certain specific *** CQKA protocols are mostly two-party or three-party,and they do not entirely meet the actual *** address this problem,this paper proposes new CQKA protocols based on Bell states and Bell *** new CQKA protocols can be successfully implemented for any N-party,not just ***,the security and efficiency analyses demonstrate that the new CQKA protocols are not only secure but also more efficient in terms of quantum bit.

关键词： quantum cryptography quantum key agreement controlled quantum key agreement Bell states controller

A comparison of next-generation sequencing analysis methods for cancer xenograft samples

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Journal of Genetics and Genomics 2018年第7期45卷 345-350页

作者： Wentao Dai jixiang liu Quanxue Li Wei liu Yi-Xue Li Yuan-Yuan Li shanghai center for bioinformation technology Shanghai 201203China shanghai engineering research center of pharmaceutical translation&shanghai industrial technology institute Shanghai 201203China school of biotechnology east china university of science and technologyShanghai 201203China shanghai industrial technology institute Shanghai 200237China

The application of next-generation sequencing （NGS） technology in cancer is influenced by the quality and purity of tissue samples. This issue is especially critical for patient-derived xenograft （PDX） models, which have proven to be by far the best preclinical tool for investigating human tumor biology, because the sensitivity and specificity of NGS analysis in xenograft samples would be compromised by the contamination of mouse DNA and RNA. This definitely affects downstream analyses by causing inaccurate mutation calling and gene expression estimates. The reliability of NGS data analysis for cancer xenograft samples is therefore highly dependent on whether the sequencing reads derived from the xenograft could be distinguished from those originated from the host. That is, each sequence read needs to be accurately assigned to its original species. Here, we review currently available methodologies in this field, including Xenome, Disambiguate, bamcmp and pdxBlacklist, and provide guidelines for users.

关键词： Patient-derived xenograft Next-generation sequencing Host contamination control Alignment

Gene dysregulation analysis builds a mechanistic signature for prognosis and therapeutic benefit in colorectal cancer

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Journal of Molecular Cell Biology 2020年第11期12卷 881-893页

作者： Quanxue Li Wentao Dai jixiang liu Qingqing Sang Yi-Xue Li Yuan-Yuan Li School of Biotechnology East China University of Science and TechnologyShanghai 200237China Shanghai Center for Bioinformation Technology Shanghai 201203China Department of Surgery Shanghai Key Laboratory of Gastric NeoplasmsShanghai Institute of Digestive SurgeryRuijin HospitalShanghai jiao Tong University School of MedicineShanghai 200025China CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Shanghai Engineering Research Center of Pharmaceutical Translation and Shanghai Industrial Technology Institute Shanghai 201203China

The implementation of cancer precision medicine requires biomarkers or signatures for predicting prognosis and therapeutic *** of current efforts in this field are paying much more attention to predictive accuracy than to molecular mechanistic ***-driven strategy has recently emerged,aiming to build signatures with both predictive power and explanatory *** by this strategy,we developed a robust gene dysregulation analysis framework with machine learning algorithms,which is capable of exploring gene dysregulations underlying carcinogenesis from high-dimensional data with cooperativity and synergy between regulators and several other transcriptional regulation rules taken into *** then applied the framework to a colorectal cancer(CRC)cohort from The Cancer Genome *** identified CRC-related dysregulations significantly covered known carcinogenic processes and exhibited good prognostic *** choosing dysregulations with greedy strategy,we built a four-dysregulation(4-DysReg)signature,which has the capability of predicting prognosis and adjuvant chemotherapy benefit.4-DysReg has the potential to explain carcinogenesis in terms of dysfunctional transcriptional *** results demonstrate that our gene dysregulation analysis framework could be used to develop predictive signature with mechanistic interpretability for cancer precision medicine,and furthermore,elucidate the mechanisms of carcinogenesis.

关键词： gene dysregulation analysis mechanistic signature cancer precision medicine prognosis chemotherapy benefit colorectal cancer

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糖族直播间

大学化学 2025年第1期40卷 247-255页

作者：刘吉祥欧阳湘元陈方方西北大学化学与材料科学学院化学国家级实验示范中心西安710127

糖,这一自然赋予的甜蜜礼物,在我们日常生活中扮演着无可替代的角色。然而,其影响力远不止于味蕾的欢愉,更在医药、能源、环境等诸多领域展现着其独特的重要性。本文旨在引领读者深入糖的世界,从其基本结构到其在社会中的广泛应用,探讨... 详细信息

糖,这一自然赋予的甜蜜礼物,在我们日常生活中扮演着无可替代的角色。然而,其影响力远不止于味蕾的欢愉,更在医药、能源、环境等诸多领域展现着其独特的重要性。本文旨在引领读者深入糖的世界,从其基本结构到其在社会中的广泛应用,探讨其在多个领域的创新应用,为读者提供全新的视角和深刻思考。

关键词：葡萄糖甘露糖海藻糖环糊精透明质酸

TGPred:a tumor gene prediction webserver for analyzing structural and functional impacts of variants

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Journal of Molecular Cell Biology 2020年第7期12卷 556-558页

作者： jixiang liu Wei liu Xue-Ling Li Quanxue Li Wentao Dai Yuan-Yuan Li Shanghai Center for Bioinformation Technology&Shanghai Engineering Research Center of Pharmaceutical Translation Shanghai Industrial Technology InstituteShanghai 201203China Department of Surgery Shanghai Key Laboratory of Gastric NeoplasmsShanghai Institute of Digestive SurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China National Engineering Research Center for Nanotechnology Shanghai University of Medicine and Health SciencesShanghai 201318China School of Biotechnology East China University of Science and TechnologyShanghai 200237China

With the increasing use of high-throughput sequencing technology in tumor research,a large number of somatic variations are being identified and some of them have proved to be responsible for tumorigenesis(Cancer Genome Atlas Research Network et al.,2013).Investigating structural and functional impacts of tumor somatic variants would greatly help to identify causal variations,understand the mechanisms of carcinogenesis,and develop novel anti-tumor ***,many efforts have recently been made to map genomic variations to 3D protein structure,such as G23D(Solomon et al.,2016)and G2S(Wang et al.,2018).

关键词： al. Cancer structural

Conceptual carbon-reduction process design and quantitative sustainable assessment for concentrating high purity ethylene from wasted refinery gas

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Chinese Journal of Chemical Engineering 2023年第5期57卷 290-308页

作者： jixiang liu Xin Zhou Gengfei Yang Hui Zhao Zhibo Zhang Xiang Feng Hao Yan Yibin liu Xiaobo Chen Chaohe Yang State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China

The direct emission of waste refinery gas after combustion will cause a severe greenhouse *** high-value-added ethylene from wasted refinery gas has fundamental economic and environmental significance. Due to the complexity of the composition of refinery waste gas, designing and optimizing the whole recovery process is still a challenging task. Herein, a novel process(SCOAS) was proposed to obtain polymer-grade ethylene from wasted refinery gas through a direct separation process,and heat pump-assisted thermal integration optimization(HPSCOAS) was carried out. The unique feature of the novel approach is that a new stripper and ethylene reabsorber follow the dry gas absorber to ensure ethylene recovery and methane content. An industrial model, shallow cooling oil absorption(SCOA), and concentration combined cold separation system of ethylene unit using wasted refinery gas was established to analyze the technology and environment. Based on the detailed process modeling and simulation results, the quantitative sustainability assessment of economy and environment based on product life cycle process is carried out. The results show that compared with the traditional process when the same product is obtained, the total annual cost of the HPSCOAS process is the lowest, which is 15.4% lower than that of the SCOA process and 6.1% lower than that of the SCOAS process. In addition,compared with the SCOA process and the HPSCOAS process, the SCOAS process has more environmental advantages. The non-renewable energy consumed by SCOAS is reduced by about 24.8% and 6.1%, respectively. The CO_(2) equivalent is reduced by about 38.6% and 23.7%.

关键词： Wasted treatment Computer simulation Optimal design Carbon-reduction Life cycle environment assessment

Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase-induced cell ablation system in zebrafish larvae

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Journal of Genetics and Genomics 2021年第12期48卷 1081-1090页

作者： Siting Lai Ankita Kumari jixiang liu Yiyue Zhang Wenqing Zhang Kuangyu Yen Jin Xu Department of Developmental Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhou 510006China

The Metronidazole(MTZ)/nitroreductase(NTR)-mediated cell ablation system is the most commonly used chemical-genetic cell ablation method in zebrafish. This system can specifically ablate target cells under spatial and temporal control. The MTZ/NTR system has become a widely used cell ablation system in biological, developmental, and functional studies. However, the inadequate cell-ablation ability of some cell types and the side effects of high concentration MTZ impede extensive applications of the MTZ/NTR system. In the present study, the US drug collection library was searched to extend the NTR system. Six MTZ analogs were found, and the cell-ablation ability of these analogs was tested in zebrafish larvae. The results revealed that two of the NTR substrates, Furazolidone and Ronidazole, ablated target cells more efficiently than MTZ at lower concentrations. Furthermore, the working concentration of Ronidazole, but not Furazolidone and MTZ, did not affect axonal bridge formation during spinal cord regeneration. Our results,taken together, indicate that Ronidazole is a superior prodrug to MTZ for the NTR system, especially for the study of neuron regeneration in zebrafish larvae.

关键词： MTZ Ronidazole NTR Cell ablation Regeneration Zebrafish