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Wireless sequential dual light delivery for programmed PDT in vivo

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Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： jiayi liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin Gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

Utilizing synergistic effects of bifunctional polymer hydrogel PAM-PAMPS for selective capture of Pb(Ⅱ)from wastewater

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Chinese Chemical Letters 2024年第7期35卷 173-177页

作者： Xin Li Xuan Ding Junkun Zhou Hui Shi Zhenxi Dai jiayi liu Yongcun Ma Penghui Shao Liming Yang Xubiao Luo Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China School of Life Science Jinggangshan UniversityJi’an 343009China

The preparation of hydrogel adsorbents with admirable performance for efficient selective remove Pb(Ⅱ)in complex wastewater still remains a great ***,a novel bifunctional modified polymer hydrogel PAM-PAMPS was prepared by crosslinking acrylamide(AM)and 2-acrylamido-2-methylpropanesulfonic acid(AMPS).Compared with PEG,PAA and PAMPS,PAM-PAMPS exhibited both the maximum adsorption capacity of Pb(Ⅱ)(541.90 mg/g)and satisfactory selectivity for Pb(Ⅱ)in multiple heavy metal ions coexistence *** characterizations indicated that–SO3H and–NH2as active sites on PAM-PAMPS occur the synergistic effects of ion-exchange and coordination with Pb(Ⅱ)during the adsorption process,*** adsorption energy Ead(PAM-PAMPS)obtained from density functional theory(DFT)calculations was lower than the other three hydrogels,manifesting that PAMPAMPS formed the most stable complex with Pb(Ⅱ),which further demonstrated that Pb(Ⅱ)preferred to combine with PAM-PAMPS to selective capture of Pb(Ⅱ).The practice utilization of PAM-PAMPS was assessed by wastewater of electroplate containing Pb(Ⅱ).Meanwhile,the removal ratio of PAM-PAMPS was maintained at about 89%after 4 adsorption-desorption *** study establishes a new and effective idea for the design and fabrication of bifunctionalized modified polymer hydrogels.

关键词： Synergistic effects Bifunctional Polymer hydrogel Selective capture Pb(Ⅱ)

Tongue image feature correlation analysis in benign lung nodules and lung cancer

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Digital Chinese Medicine 2024年第2期7卷 120-128页

作者： SHI Yulin liu jiayi CHUN Yi liu Lingshuang XU Jiatuo The Academic Affairs Office Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200032China

Objective To analyze the differences in the correlation of tongue image indicators among patients with benign lung nodules and lung *** From July 1;2020 to March 31;2022;clinical information of lung cancer patients and benign lung nodules patients was collected at the Oncology Department of Longhua Hos-pital Affiliated to Shanghai University of Traditional Chinese Medicine and the Physical Ex-amination Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chi-nese Medicine;*** obtained tongue images from patients with benign lung nod-ules and lung cancer using the TFDA-1 digital tongue diagnosis instrument;and analyzed these images with the TDAS V2.0 *** extracted indicators included color space pa-rameters in the Lab system for both the tongue body(TB)and tongue coating(TC)(TB/TC-L;TB/TC-a;and TB/TC-b);textural parameters[TB/TC-contrast(CON);TB/TC-angular second moment(ASM);TB/TC-entropy(ENT);and TB/TC-MEAN];as well as TC parameters(perAll and perPart).The bivariate correlation of TB and TC features was analyzed using Pearson’s or Spearman’s correlation analysis;and the overall correlation was analyzed using canonical correlation analysis(CCA).Results Samples from 307 patients with benign lung nodules and 276 lung cancer patients were included after excluding outliers and extreme *** correlation analysis indi-cated that the correlation of TB-L with TC-L;TB-b with TC-b;and TB-b with perAll in lung cancer group was higher than that in benign nodules ***;the correlation of TB-a with TC-a;TB-a with perAll;and the texture parameters of the TB(TB-CON;TB-ASM;TB-ENT;and TB-MEAN)with the texture parameters of the TC(TC-CON;TC-ASM;TC-ENT;and TC-MEAN)in benign nodules group was higher than lung cancer *** further demon-strated a strong correlation between the TB and TC parameters in lung cancer group;with the first and second pairs of typical variables in benign nodules and lung cancer groups in

关键词： Benign lung nodules Lung cancer Tongue image Correlation analysis Differential diagnosis

RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2

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Science China(Life Sciences) 2024年第10期67卷 2186-2197页

作者： Lili Zhi Chaoqun Chen Ge Zhang Tian Huang Wenxia He Jinrui Zhang Dan Chen jiayi liu Jinyao Zhao Yangfan Qi Guiying Wang Wenjing Zhang Yang Wang Sino-US Research Center for Cancer Translational Medicine of the Second Affiliated Hospital of Dalian Medical University&Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116023China Department of Immunology College of Basic Medical SciencesDalian Medical UniversityDalian 116044China Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian Medical UniversityDalian 116011China Department of General Surgery the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China The Second Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma Shijiazhuang 050001China

Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis;however,their specific involvement in colon cancer remains largely *** we report that the splicing factor RBM25 is overexpressed in colon cancer,and this increased expression correlates with a poor prognosis of patients with colon ***,RBM25 ablation suppresses the growth of colon cancer cells both in vitro and in ***,our transcriptome-wide analysis of splicing events revealed that RBM25 regulates a large number of cancer-related alternative splicing events across the human genome in colon ***,RBM25 regulates the splicing of MNK2 by interacting with the poly G rich region in exon 14a,thereby inhibiting the selection of the proximal 3'splice site(ss),resulting in the production of the oncogenic short isoform,*** of RBM25 leads to an increase in the MNK2a isoform and a decrease in the MNK2b ***,re-expression of MNK2b or blocking the 3′ss of the alternative exon 14a with ASO partially reverses the RBM25 knockdown mediated tumor ***,MNK2b levels were significantly increased in colon cancer tissues,which is positively correlated with the expression level of ***,our findings uncover the critical role of RBM25 as a key splicing factor in colon cancer,suggesting its potential as a prognostic marker and therapeutic target.

关键词： RBM25 colon cancer alternative splicing MNK2

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Dual roles of the amygdala-hippocampus circuit in the regulation of rapid eye movement sleep and depression symptoms by repetitive transcranial magnetic stimulation in patients with insomnia

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General Psychiatry 2024年第2期37卷 297-300页

作者： Xiaoyang liu Xumeng Zhao Ziqiang Shao Yongjian Guo Lirong Yue jiayi liu Dahua Yu Xiaona Sheng Yifei Zhu Kai Yuan School of Life Science and Technology Xidian UniversityXi'anShaanxiChina Department of Psychosomatic Medicine The Second Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Inner Mongolia University of Science and Technology BaotouInner MongoliaChina

To the editor:It is commonly reported that people with insomnia often experience comorbid emotional disorders,such as mood and anxiety disorders.12 A study found that fragmented rapid eye movement(REM)sleep in individuals with insomnia is associated with higher Beck Depression Inventory(BDI)scores.3 REM sleep architecture disruption is a typical symptom of insomnia.

关键词： sleep stimulation movement

Comparisons of transcranial alternating current stimulation and repetitive transcranial magnetic stimulation treatment therapy for insomnia:a pilot study

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General Psychiatry 2024年第1期37卷 163-167页

作者： Ziqiang Shao Yongjian Guo Lirong Yue Xiaoyang liu jiayi liu Xumeng Zhao Xiaona Sheng Dahua Yu Yifei Zhu Kai Yuan School of Life Science and Technology Xidian UniversityXi'anShaanxiChina Department of Psychosomatic Medicine The Second Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Information Processing Laboratory School of Information EngineeringInner Mongolia University of Science and TechnologyBaotouInner MongoliaChina

To the editor:Insomnia disorder has a serious and widespread detrimental effect on humans with comorbidity with other mental or physical health *** recent years,noninvasive brain stimulation(NIBS)techniques,especially transcranial magnetic stimulation(TMS)and transcranial electrical stimulation,have been increasingly used for the treatment of brain diseases,including insomnia disorder.

关键词： stimulation transcranial ins

一种确定海底地震仪位置与等效海水速度的多维扫描法

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石油物探 2024年第1期63卷 61-68页

作者：李华刘佳仪同济大学图书馆上海200092 长江大学工程技术学院湖北荆州434022

受海流影响,海底地震仪(OBS及OBN)着底点与投放点的位置存在偏差,水越深偏差越大。OBS及OBN的准确定位对后续地震数据的成像处理至关重要。传统处理方法假设海水速度、海底深度已知,或者采用分部策略依次反演海水速度、海底深度与水平坐... 详细信息

受海流影响,海底地震仪(OBS及OBN)着底点与投放点的位置存在偏差,水越深偏差越大。OBS及OBN的准确定位对后续地震数据的成像处理至关重要。传统处理方法假设海水速度、海底深度已知,或者采用分部策略依次反演海水速度、海底深度与水平坐标,导致误差较大。为此,提出了一种新的OBS及OBN重定位多维扫描方法。利用共检波点道集中拾取的海水直达波震相到达时,经过在水平坐标(x维度和y维度)、海底深度和海水速度4个维度的扫描,确定OBS及OBN着底位置的同时获得海底深度和等效海水速度。与现有技术相比,该方法具有搜索速度快、精度高、原理简单,而且可以同时获得等效海水速度与海底深度等优点。理论模型实验结果表明,在深水情况下用该方法获得的OBS及OBN水平位置误差在20 m以内,海底深度误差在10 m以内;即使拾取的直达波走时存在稍许误差,等效海水速度仍可以被准确地反演出来;以上参数反演精度受扫描密度制约。实际资料处理结果基于重定位结果的直达波线性动校正后同相轴被有效拉平,说明重定位方法的有效性和实用性。此外,基于敏感核函数分析,给出了另外一种不同于前人的分步扫描策略,反演效率再提升2个数量级,但定位精度下降了1个数量级,进一步印证了多维扫描反演方法的优势。数值实验的反演精度是在接近水深3000 m的超深水情况下获得,在浅水情况下,考虑到数据误差与采集孔径更小,扫描密度更高,一定能获得更高的反演精度。

关键词：海底地震仪(OBS) OBS及OBN重定位海底深度等效海水速度海水直达波

激光辅助切削CNTs/AL的数值模拟及参数优化

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组合机床与自动化加工技术 2024年第3期 152-156页

作者：刘佳溢高奇辽宁工业大学机械工程与自动化学院锦州121000

针对碳纳米管铝基复合材料(CNTs/AL)加工过程中加工性差、刀具磨损大等特点,提出采用激光辅助加工的方法进行改善。使用ABAQUS有限元仿真软件进行,对CNTs/AL复合材料的表面损伤形式、亚表面残余应力分布及切削力进行仿真研究,以完成对... 详细信息

针对碳纳米管铝基复合材料(CNTs/AL)加工过程中加工性差、刀具磨损大等特点,提出采用激光辅助加工的方法进行改善。使用ABAQUS有限元仿真软件进行,对CNTs/AL复合材料的表面损伤形式、亚表面残余应力分布及切削力进行仿真研究,以完成对激光辅助加工CNTs/AL的可行性验证。基于响应曲面实验分析切削力与加工参数的关系,并建立了拟合程度良好的切削力模型。结果表明,使用激光辅助加工可以有效减小切削力和表面质量,平均切削力降低34%,但会稍微增大残余应力;3个工艺参数对切削力影响强弱依次为:激光功率、切削速度和切削深度。

关键词：有限元激光辅助加工铝基复合材料切削力

基于InVEST模型的蒲河流域景观格局及生境质量时空演变分析

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水土保持学报 2024年第2期38卷 258-267页

作者：刘佳依许大为徐嘉东北林业大学园林学院哈尔滨150040

[目的]通过对景观生态格局和生境质量的时空动态分析,深入研究沈阳市蒲河流域实施水土保持措施前后的生境质量响应情况,旨在为小型流域的水土保持策略提供科学依据,以促进生态经济的协同增长和区域生态的持续健康发展。[方法]基于蒲河流... 详细信息

[目的]通过对景观生态格局和生境质量的时空动态分析,深入研究沈阳市蒲河流域实施水土保持措施前后的生境质量响应情况,旨在为小型流域的水土保持策略提供科学依据,以促进生态经济的协同增长和区域生态的持续健康发展。[方法]基于蒲河流域2000年、2010年、2020年的土地利用数据和数字高程模型(DEM)等数据,结合FRAGSTATS和InVEST模型,运用土地利用转移矩阵、景观格局指数、生境质量及生境退化度对土地利用变化进行分析,探究响应机理。[结果](1)在2000-2010年期间,蒲河流域的耕地开发活动频繁,导致森林、草地等土地类型的比例显著下降;在2010-2020年期间,蒲河生态廊道的建设推动土地利用的变化,耕地面积流向人造地表、森林和草地。(2)在2000-2020年期间,蒲河流域的整体景观格局经历先趋于完整后破碎化的演变过程,蒲河两岸景观形成多种要素集合的密集格局,城市中心北部边缘地区生境持续破碎化。(3)从流域整体分析,2000年、2010年、2020年的生境平均质量分别为0.349,0.329,0.354,呈现出先降后升的趋势。生境退化平均值分别为0.098,0.112,0.086,与生境质量变化趋势一致。随着蒲河生态廊道建设,2020年生境质量明显改善,生态系统受到的威胁减少。从空间格局分析,东北部与西南部呈现出明显的空间分布特征;东北山区、西南湿地等区域生境质量总体较好,但有着生境退化的威胁。[结论]在水土保持措施的影响下,蒲河流域的景观生态格局得以改善,有效抑制了生境的退化现象。

关键词： InVEST模型生境质量时空动态变化景观格局

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