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Improved Nonlinear Equation Method for Numerical Prediction of Jominy End-Quench Curves

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Journal of Iron and Steel Research International 2007年第1期14卷 37-41页

作者： SONG Yue-peng liu Guo-quan liu Sheng-xin liu jian-tao FENG Cheng-ming School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Mechanical and Electronic Engineering College Shandong Agricultural University Tai＇an 271018 Shandong China School of Materials Science and Engineering Hebei University of Science and Technology Shijiazhuang 050054 Hebei China

Without considering the effects of alloying interaction on the Jominy end-quench curves, the prediction resuits obtained by YU Bai-hai＇s nonlinear equation method for multi-alloying steels were different from those experimental ones reported in literature. Some alloying elements have marked influence on Jominy end-quench curves of steels. An improved mathematical model for simulating the Jominy end-quench curves is proposed by introducing a parameter named alloying interactions equivalent （Le）. With the improved model, the Jominy end-quench curves of steels so obtained agree very well with the experimental ones.

关键词： Jominy end-quench curve nonlinear equation method alloying interaction parameter computer simulation

Combustion aerosols and suspended dust with controlled processes in Lhasa:Elemental analysis and size distribution characteristics

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Journal of Environmental Sciences 2025年第2期148卷 591-601页

作者： Jinglin Li Zhuoga Deqing Jie Liang tao Guo jian Yao Wei liu Shanghai Institute of Applied Physics Chinese Academy of ScienceShanghai 201800China University of Chinese Academy of Science Beijing 100049China Meteorological Bureau of Tibet Autonomous Region Lhasa 850000China

To explore air contamination resulting from special biomass combustion and suspended dust in Lhasa,the present study focused on the size distribution and chemical characteristics of particulate matter(PM)emission resulting from 7 types of non-fossil pollution *** investigated the concentration and size distribution of trace elements from 7 pollution sources collected in *** Lhasa’s atmospheric particulate matter data,enrichment factors(EFs)have been calculated to examine the potential impact of those pollution sources on the atmosphere quality of *** highest mass concentration of total elements of biomass combustion appeared at PM_(0.4),and the second highest concentration existed in the size fraction 0.4-1μm;the higher proportion(12%)of toxicmetals was produced by biomass *** elemental composition of suspended dust and atmospheric particulate matter was close(except for As and Cd);the highest concentration of elements was all noted in PM_(2.5-10)(PM3-10).Potassium was found to be one of the main biomass *** proportion of Cu in suspended dust is significantly lower than that of atmospheric particulate matter(0.53%and 3.75%),which indicates that there are other anthropogenic *** EFs analysis showed that the Cr,Cu,Zn,and Pb produced by biomass combustion were highly enriched(EFs>100)in all particle *** EFs of most trace elements increased with decreasing particle size,indicating the greater influence of humanfactors on smaller particles.

关键词： Size distribution Trace elements Particulate matter Enrichment factors Lhasa

700℃长时时效对FGH97合金组织与力学性能的影响

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材料热处理学报 2014年第7期35卷 107-113页

作者：刘建涛张义文陶宇韩寿波贾建钢铁研究总院高温材料研究所北京100081 高温合金新材料北京市重点实验室北京100081

针对涡轮盘的使用温度,研究了FGH97合金在700℃度下长时时效过程中的显微组织和力学性能变化。利用扫描电镜、物理化学相分析、热力学计算等方法研究了长时时效处理过程中析出相的演变。结果表明,合金中的一次和二γ'相组织稳定性良好,... 详细信息

针对涡轮盘的使用温度,研究了FGH97合金在700℃度下长时时效过程中的显微组织和力学性能变化。利用扫描电镜、物理化学相分析、热力学计算等方法研究了长时时效处理过程中析出相的演变。结果表明,合金中的一次和二γ'相组织稳定性良好,三次γ'相发生了较明显的粗化,合金中未发现明显的的TCP相析出。对合金2000 h和5000 h长时时效处理后的力学性能测试表明,长时时效后合金的综合力学性能优异。

关键词： FGH97合金 700℃长时时效 γ’相组织稳定性力学性能

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： tao SUN QINGHUA SONG HUA liu Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

社会主义核心价值观——重构中国现代文明秩序的时代自觉

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北京师范大学学报（社会科学版） 2015年第5期 5-10页

作者：刘建涛北京师范大学哲学学院北京100875 河北金融学院社科部保定071051

以儒家思想为核心的中国传统价值观念构筑了传统社会的文明秩序,形成了传统社会特有的文明禀赋和价值诉求。随着西方文明的崛起和扩张,中国传统文明秩序渐渐解构,开启了向现代转变的模式。在当代中国社会转型的关键时期,实现中国传统文... 详细信息

以儒家思想为核心的中国传统价值观念构筑了传统社会的文明秩序,形成了传统社会特有的文明禀赋和价值诉求。随着西方文明的崛起和扩张,中国传统文明秩序渐渐解构,开启了向现代转变的模式。在当代中国社会转型的关键时期,实现中国传统文明秩序的现代转型,重构中国现代文明秩序已然成为时代的必需。重构中国现代文明秩序必须正视现代性困境所呈现出的种种问题,提炼符合时代需求的核心价值观念,凝聚价值理想的"最大公约数"。当代中国,社会主义核心价值观的提出契合了中国特色社会主义发展要求,承接中华优秀传统文化和人类文明优秀成果,体现了重构中国现代文明秩序的时代诉求和行动自觉。

关键词：传统文明秩序现代文明秩序社会主义核心价值观时代自觉

电子器件振动特性有限元模型参数的等效计算方法

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电子学报 2010年第8期38卷 1867-1873页

作者：杜平安刘建涛刘孝保电子科技大学机械电子工程学院四川成都611731

基于自由度缩聚技术和模态叠加原理,提出两种电子器件振动特性有限元模型参数的等效计算方法:范数极小值等效法和约束基频等效法.两种方法依据器件质量、约束基频、内部布局等特性,将具有非均匀质量和刚度分布的器件等效为均质长方形质... 详细信息

基于自由度缩聚技术和模态叠加原理,提出两种电子器件振动特性有限元模型参数的等效计算方法:范数极小值等效法和约束基频等效法.两种方法依据器件质量、约束基频、内部布局等特性,将具有非均匀质量和刚度分布的器件等效为均质长方形质量块,使电子器件的网格划分和数值计算大为简化.通过印制板固有特性和响应结果的对比分析,验证了等效方法的有效性和实用性.

关键词：电子器件有限元模型振动特性等效计算方法基频

Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma:1-year results

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 94-102页

作者： Jia-Yin Qin Yan liu tao Wang Department of Ophthalmology Peking University International HospitalBeijing 102206China Beijing Key Laboratory of Ophthalmology and Visual Science Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To evaluate the efficacy and safety of microcatheterassisted 360-degree trabeculotomy combined with trabeculectomy(MATT-Trab)for treating refractory ***:Patients with refractory glaucoma who underwent MATT-Trab were retrospectively *** indicators for research statistics included the intraocular pressure(IOP)level,degree of decrease,changes in medication dosage,and success *** indicators included the best-corrected visual acuity and incidence of ***:This study comprised 31 patients,including 11 males and 20 females,with ages ranging from 8mo to 67y(mean age:29.40±22.10y).The average postoperative IOP at 1d,1wk,1mo,3mo,6mo,1y,and the last followup was significantly lower than the average preoperative IOP(31.33±9.24 mm Hg,P<0.05).The average number of postoperative medications at 1y was 0.48±1.51,which was significantly reduced compared to that used preoperatively(3.77±0.99,P=0.00).The absolute and qualified success rates were 45.16% and 83.87%,*** acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points,except for the first day after *** most common postoperative complications were anterior chamber hemorrhage(25 cases,86.21%)and high IOP(10 cases,34.48%).CONCLUSION:Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

关键词： glaucoma refractor y glaucoma trabeculotomy trabeculectomy microcatheter

Research progress of small-molecule natural medicines for the treatment of ischemic stroke

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Chinese Journal of Natural Medicines 2025年第1期23卷 21-30页

作者： Kui liu Ling Wang tao Pang State Key Laboratory of Natural Medicines New Drug Screening and Pharmacodynamics Evaluation Center China Pharmaceutical University

Stroke is the second leading cause of disability and mortality worldwide, imposing a substantial socioeconomic burden on individuals and healthcare systems. Annually, approximately 14 million people experience stroke, with ischemic stroke comprising nearly 85% of cases, of which 10% to 20% involve large vessel occlusions. Currently, recombinant tissue plasminogen activator(tPA) remains the only approved pharmacological intervention. However, its utility is limited due to a narrow therapeutic window and low recanalization rates, making it applicable to only a minority of patients. Therefore, there is an urgent need for novel therapeutic strategies, including pharmacological advancements and combinatory ***-molecule natural medicines, particularly those derived from traditional Chinese herbs,have demonstrated significant therapeutic potential in ischemic stroke management. These compounds exert multiple neuroprotective effects, such as antioxidation, anti-inflammatory action, and inhibition of apoptosis, all of which are critical in mitigating stroke-induced cerebral damage. This review comprehensively examines the pathophysiology of acute ischemic stroke(AIS) and highlights the recent progress in the development of small-molecule natural medicines as promising therapeutic agents for cerebral ischemic stroke.

关键词： Antioxidants Ischemic stroke Natural medicines Neuroinflammation. Small molecule

Mechanism of AsperosaponinⅥRelated to EGFR/MMP9/AKT/PI3K Pathway in Treatment of Rheumtoid Arthritis

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Chinese Journal of Integrative Medicine 2025年第2期31卷 131-141页

作者： LUO Jin-fang YU Yang liu jian-xin School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Sino-Pakistan Center on Traditional Chinese Medicine China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan ProvinceSchool of Pharmaceutical SciencesHunan University of MedicineHuaihua CityHunan Province(418000)China

Objective:To explore the mechanism of action of asperosaponinⅥ(AⅥ)in the treatment of rheumatoid arthritis(RA)and validate it in ex vivo experiments using network pharmacology and molecular docking ***:The predicted targets of AⅥwere obtained from PharmMaper,UniProt and Swiss Target Prediction platforms,the disease targets were collected from Online Mendelian Inheritance in Man,Therapeutic Target Database and Gene Cards databases,the intersection targets of AⅥand RA were obtained from Venny 2.1.0,and the protein-protein interaction(PPI)network was obtained from STRING database,which was analyzed by Cytoscape software and screened to obtain the core *** software was used to analyze PPI network and screen the core *** on the Database for Annotation,Visualization and Integrated Discovery database,Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed,and Cytoscape software was used to construct the"DiseasePathway-Target-Drug"network,which was finally verified by molecular docking and animal ***:Network pharmacological studies showed that AⅥwas able to modulate 289 targets,with 102 targets for the potential treatment of RA,with the core pathway being the AKT/PI3K signaling pathway,and the core targets being the epidermal growth factor receptor(EGFR)and matrix metalloproteinase 9(MMP9).Molecular docking results showed that AⅥcould produce strong binding with both of the 2 core *** vitro cellular experiments showed that AⅥreduced nitric oxide,prostaglandin E_2,tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1βlevels(P<0.05)and inhibited cyclooxygenase-2,nitric oxide synthase,EGFR,MMP9,phosphorylated phosphoinositide 3-kinase(p-PI3K),and phosphorylated serine-threonine kinase(p-AKT)proteins(P<0.05).The results of in vivo studies showed that AⅥimproved RA score and foot swelling thickness and decreased TNF-α,IL-6,p-PI3K and p-AKT levels in RA rat

关键词： inflammation rheumatoid arthritis network pharmacology asperosaponinⅥ EGFR/MMP9/AKT/PI3K pathway